9 results match your criteria: "Jinhua Eye Hospital[Affiliation]"

Purpose: This study aimed to compare and analyze the efficacy of repeated low-level red-light therapy and orthokeratology lenses for myopia control in children.

Methods: Exactly 138 participants were enrolled in this retrospective study. Comprehensive eye examinations were performed prior to treatment.

View Article and Find Full Text PDF
Article Synopsis
  • - The purpose of the study was to assess how effective repeated low-level red-light therapy is when combined with different types of optical lenses in managing myopia in kids and teens.
  • - Researchers analyzed 108 participants who were divided into four groups receiving various combinations of red-light therapy and optical lenses, measuring changes in vision before and after the treatment.
  • - Results showed that the combination of RLRL therapy with orthokeratology lenses, defocus distributed multi-point lenses, and single-vision spectacles significantly improved vision recovery compared to a control group.
View Article and Find Full Text PDF

Purpose: The regulatory effect of microRNA on diseases has been confirmed. This study aimed to evaluate the expression of microRNA-210-3p in age-related cataracts and assess the effect of abnormal miR-210-3p expressions on H2O2-induced SAR01/04 cells.

Methods: Reverse-transcription quantitative polymerase chain reaction method was performed to assess the levels of miR-210-3p in aqueous humor samples.

View Article and Find Full Text PDF

Purpose: To identify the relationship between the increase in axial length (AL) and height in school-age children and explore the influence of refractive status on such a relationship.

Methods: In this 5-year cohort study, 414 Chinese children (237 boys) aged 6-9 years (mean 7.12) underwent measurements annually.

View Article and Find Full Text PDF

A novel missense mutation of RPGR identified from retinitis pigmentosa affects splicing of the ORF15 region and causes loss of transcript heterogeneity.

Biochem Biophys Res Commun

October 2020

Laboratory of Genomic and Precision Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China; Joint Primate Research Center for Chronic Diseases, Jiangnan University and Guangdong Institute of Applied Biological Resources, Jiangnan University, Wuxi, Jiangsu, China; Guangdong Institute of Applied Biological Resources, Guangzhou, Guangdong, China. Electronic address:

Mutations in the retinitis pigmentosa GTPase regulator (RPGR) gene, are the major cause of X-linked retinitis pigmentosa (RP), in which exon open reading frame 15 (ORF15) of RPGR has been implicated to play a substantial role. We identified a novel hemizygous missense mutation E585K of RPGR from whole-exome sequencing of RP. RNA-Seq analysis and functional study were conducted to investigate the underlying pathogenic mechanism of the mutation.

View Article and Find Full Text PDF

Objective: To investigate the effect of latanoprost on intraocular pressure (IOP), visual acuity and C-reactive protein (CRP) in patients with primary open-angle glaucoma (POAG).

Methods: A total of 163 POAG patients (266 eyes) admitted to our hospital from February 2015 to July 2017 were selected and divided into observation group (81 cases, 132 eyes, latanoprost eye drops) and control group (82 cases, 134 eyes, timolol maleate eye drops) according to different treatment plans. The clinical efficacy of the two groups after treatment was evaluated.

View Article and Find Full Text PDF

To newly describe the clinical and histopathological characteristics of epibulbar complex cartilaginous choristoma incidentally observed in a series of pterygium excision patients.Noncomparative case series with chart review of 8 patients.During a 4-year period, we identified 8 cases of conventional unilateral nasal subpterygial cartilaginous choristoma in 1799 pterygium patients and analyzed their clinicopathological features.

View Article and Find Full Text PDF

Wnt signaling in form deprivation myopia of the mice retina.

PLoS One

January 2015

Department of Ophthalmology, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai, China; Shanghai Key Laboratory of Fundus Disease, Shanghai, China.

Background: The canonical Wnt signaling pathway plays important roles in cellular proliferation and differentiation, axonal outgrowth, cellular maintenance in retinas. Here we test the hypothesis that elements of the Wnt signaling pathway are involved in the regulation of eye growth and prevention of myopia, in the mouse form-deprivation myopia model.

Methodology/principal Findings: (1) One hundred twenty-five C57BL/6 mice were randomly distributed into form-deprivation myopia and control groups.

View Article and Find Full Text PDF