Effect of madecassic acid on retinal oxidative stress, inflammation and Growth Factors in streptozotocin-induced diabetic rats.

Diabetic retinopathy (DR) is the leading cause of blindness and visual loss in people with diabetes. It has been suggested that the progression of DR is associated with chronic inflammation and oxidative stress. The aim of the present work was to evaluate the ability of the natural compound madecassic acid (MEA) to reverse the negative impact of streptozotocin (STZ) on retinal injury in rats.

Direct regeneration of LiFePO cathode by inherent impurities in spent lithium-ion batteries.

The direct regeneration method, recognized for its cost-effectiveness, has garnered considerable attentions in the field of battery recycling. In this study, a novel direct regeneration strategy is proposed to repair spent LiFePO (S-LFP) cathodes without the need for impurity removal. Instead, the residual conductive carbon and polyvinylidene fluoride (PVDF) in S-LFP are employed as inherent reductive agents.

Peroxynitrite scavenger FeTPPS binds with hCT to effectively inhibit its amyloid aggregation.

Human calcitonin (hCT) is an endogenous polypeptide commonly employed in treating bone resorption-related illnesses, but its clinical application is limited due to its high aggregation tendency. Metalloporphyrins are effective in suppressing amyloid fibrillation, positioning them as potential drug candidates for amyloidogenic disorders like Alzheimer's and type 2 diabetes. In this work, we investigated the effects of Fe(III) -tetra(4-sulfonatophenyl)porphine chloride (FeTPPS), a highly efficient ONOO decomposition catalyst, on hCT aggregation.

Quantum Chemical Approaches for Manipulation and Evaluation of Intracage Microelectric Field Strength of Molecular Containers in Y@C and Y@CX (X = Cl, F, and H, Y = NHCl, HO-Cl, and 2HO).

The effect of an oriented external electric field (EEF) on materials has led to the ongoing development, which stimulates us to consider whether intracage microelectric fields (IMEFs) can be used to substitute for the EEF. Focusing on the manipulation and evaluation of the IMEF of asymmetric molecular containers, the host-guest compounds of interesting pineapple-shaped Y@CX (X = vacant, Cl, F, and H; Y = NHCl, HO-Cl, and 2HO) are theoretically constructed and the strength of the IMEF was evaluated by the intrapotential energy surface analysis by using the point charge ( = +1) scanning method. Interestingly, the left and right halves of each cage are like two IMEFs connected in reverse series.

MaxEnt Modeling for Predicting the Potential Geographical Distribution of since the Last Interglacial and under Future Climate Scenarios.

is a perennial herb found in southeastern and southern Asia. In China, it is only found in Hainan Province. With global climate change, studying the impact of climate change on the distribution of can provide a theoretical basis for the scientific protection of this species.

Prohibitin 2 orchestrates long noncoding RNA and gene transcription to accelerate tumorigenesis.

The spatial co-presence of aberrant long non-coding RNAs (lncRNAs) and abnormal coding genes contributes to malignancy development in various tumors. However, precise coordinated mechanisms underlying this phenomenon in tumorigenesis remains incompletely understood. Here, we show that Prohibitin 2 (PHB2) orchestrates the transcription of an oncogenic CASC15-New-Isoform 2 (CANT2) lncRNA and the coding tumor-suppressor gene CCBE1, thereby accelerating melanoma tumorigenesis.

Evolution of the Black solider fly larvae gut antibiotic resistome during kitchen waste disposal.

Kitchen waste (KW) is an important reservoir of antibiotic resistance genes (ARGs). Black solider fly larvae (BSFL) are extensively employed in KW disposal, closely linking to their robust gut microbes. However, antibiotic resistome in BSFL gut during the KW disposal processes and the mechanism remain unclear.

A survey of tube spiders (Araneae, Anyphaenidae) from Jinggangshan National Nature Reserve, Jiangxi Province, China.

Background: Although there have been many recent taxonomic revisions and large-scale faunistic surveys focusing on spiders from Jiangxi Province, many taxa still remain unknown, such as the Anyphaenidae spiders. Therefore, none of the anyphaenid species has been recorded from this Province.

New Information: Anyphaenidae spiders were collected from Jinggangshan National Nature Reserve, Jiangxi Province, China, during the past ten years.

Effect of sponge city facilities on the exposure characteristics and ecological risks of antibiotics in urban inland lakes: A case study at Fuzhou, China.

Antibiotics are increasingly found in urban lakes, posing significant ecological risks to lake ecosystems. The impact of sponge city facilities on urban flood control is significant; however, their influence on the exposure characteristics and risks associated with antibiotics in urban inland lakes remains unclear. This study investigated the exposure characteristics and evaluated the ecological risks of 15 antibiotics across seven lakes of Fuzhou (as the target of sponge city) in different seasons, in comparison to non-sponge cities.

Influences of fatigue and anticipation on female soccer players' biomechanical characteristics during 180° pivot turn: implication for risk and prevention of anterior cruciate ligament injury.

Introduction: Athletes' capability to perform activities with body rotation could be weakened by fatigue accumulation. Making pivot turning in unanticipated scenarios after fatigue may greatly challenge athletes' ability to adapt rational motion strategies, elevating the risk of anterior cruciate ligament (ACL) injury. This study aimed to investigate the effects of fatigue and anticipation on biomechanical risk factors of ACL injury during 180° pivot turns in female soccer players.

Toxicity profiles of immune checkpoint inhibitors in nervous system cancer: a comprehensive disproportionality analysis using FDA adverse event reporting system.

Background: Immune-related adverse events (irAEs) always occur during treatment with immune checkpoint inhibitors (ICIs). Patients with nervous system cancer (NSC) may gain clinical benefit from ICIs, but irAEs in NSC patients are rarely examined. Therefore, our study systematically summarized reports of irAEs in NSC.

Phage-antibiotic synergy suppresses resistance emergence of by altering the evolutionary fitness.

Unlabelled: Phage-antibiotic synergy (PAS) represents a superior treatment strategy for pathogen infections with less probability of resistance development. Here, we aim to understand the molecular mechanism by which PAS suppresses resistance in terms of population evolution. A novel hypervirulent (KP) phage H5 was genetically and structurally characterized.

Perfluorodecanoic acid induces the increase of innate cells in zebrafish embryos by upregulating oxidative stress levels.

Several studies reported that the widespread use of perfluoroalkyl and polyfluoroalkyl substances (PFASs) causes increased environmental pollution, subsequently impacting aquatic organisms. Perfluoroalkyl substances such as perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) reportedly cause cardiotoxicity, neurotoxicity, and developmental toxicity in different organisms. However, whether perfluorodecanoic acid (PFDA), a widely used perfluoroalkyl substance, induces animal embryos developmental toxicity remain unknown.

Stable and antibacterial tannic acid-based covalent polymeric hydrogel for highly selective Pb recovery from lead-acid battery industrial wastewater.

The resource of trace lead (Pb) from wastewater bearing intricate components is imperative for sustainable progression of the lead-acid battery industry. Herein, we fabricated a tannic acid-based covalent polymeric hydrogel (TA@PMAM) with antimicrobial properties and stability via facile Michael addition reaction. The incorporation of tannic acid (TA) through robust covalent bond leads to a stable porous 3D covalent polymer network with almost no loss of mechanical properties even after 20 compression cycles.

Preparation and application of wood-supported piezocatalyst with high efficiency and stability via partial hydrolysis of wood cellulose and hemicellulose with Lewis acid.

The conveniently recoverable piezocatalyst with self-floating and stable performance has drawn wide attention. Herein, MoS was anchored on 1-cm-square eucalyptus wood blocks via a facile hydrothermal/solvothermal process to fabricate two floating piezocatalysts, i.e.

[Clinical Study of Venetoclax Combined with Azacitidine in the Treatment of Patients with Adult Acute Myeloid Leukemia].

Objective: To evaluate the efficacy and side effects of venetoclax combined with azacitidine chemotherapy in the treatment of previously untreated adult patients with acute myeloid leukemia(AML).

Methods: A retrospective analysis was performed on 48 untreated adult AML patients admitted to the Department of Hematology, Affiliated Hospital of Jinggangshan University from January 2020 to December 2022. Among them, 26 patients received venetoclax combined with azacitidine chemotherapy (observation group), and 22 patients received daunorubicin plus cytarabine chemotherapy (control group).

Recent advances on metal-organic framework-based electrochemical sensors for determination of organic small molecules.

Metal-organic frameworks (MOFs) are an extraordinarily versatile class of porous materials renowned for their intricate three-dimensional skeletal architectures and exceptional chemical properties. These extraordinary attributes have pushed MOFs into the vanguard of diverse disciplines such as microporous conduction, catalysis, separation, biomedical engineering, and electrochemical sensing. The focus of this review is to offer a comprehensive summary of recent advancements in designing MOF-based electrochemical sensors for detecting organic small molecules.

Enhancing ozone catalytic decomposition through acid treatment of α-MnO for improved activity and humidity resistance.

Post-etching method using dilute acid solutions is an effective technology to modulate the surface compositions of metal-oxide catalysts. Here the α-MnO catalyst treated with 0.1 mol/L nitric acid exhibits higher ozone decomposition activity at high relative humidity than the counterpart treated with acetic acid.

Computational design and experimental confirmation of a disulfide-stapled YAP helix-trap derived from TEAD4 helical hairpin to selectively capture YAP α1-helix with potent antitumor activity.

Human Hippo signaling pathway is an evolutionarily conserved regulator network that controls organ development and has been implicated in various cancers. Transcriptional enhanced associate domain-4 (TEAD4) is the final nuclear effector of Hippo pathway, which is activated by Yes-associated protein (YAP) through binding to two separated YAP regions of α1-helix and Ω-loop. Previous efforts have all been addressed on deriving peptide inhibitors from the YAP to target TEAD4.

Benzalkonium chloride induces hematopoietic stem cell reduction and immunotoxicity in zebrafish larvae.

Benzalkonium chloride (BAC) is a broad-spectrum antibacterial agent that possesses cleaning and bactericidal properties, but impact of BAC on wellbeing of aquatic organisms remains uncertain. Consequently, in this current study, we have examined the immunotoxic potential of BAC in zebrafish embryos, thus marking it as the pioneering effort in this field. According to the findings, zebrafish embryos exposed to BAC exhibited a decline in yolk area that varied with the concentration, along with a significant decrease in the count of neutrophils, macrophages, red blood cells, and thymus T-cells.