A polyoxometalate-based heterojunction nanozyme with peroxidase-mimic catalytic activity for sensitive biomolecule detection.

Nanozymes are a class of nanomaterials that can specifically mimic the structures and catalytic activities as well as overcome limitations of natural enzymes and have hence been considered as a competitive alternative to natural enzymes. At present, plenty of nanozymes, especially those with peroxidase (POD)-like catalytic activity, have been extensively explored for biosensing. In this work, we proposed polyoxometalate-based heterojunction GdPWO@WS nanoclusters (NCs) to exert intrinsic POD-like catalytic activity even under harsh catalytic conditions.

PLGA-coated methylene blue nanoparticles for photoacoustic imaging and photodynamic/photothermal cascaded precisely synergistic therapy of tumor.

Photodynamic therapy (PDT) and photothermal therapy (PTT) are synergetic treatment strategies in antitumor treatment to achieve the best anticancer efficacy. Although traditional photosensitizer materials such as methylene blue (MB) have been widely studied for PDT, the photothermal effect is rarely reported. Herein, mono-component nanoparticles lactic--glycolic acid-coated methylene blue (MBNPs) based on methylene blue (MB) and lactic--glycolic acid (PLGA) were prepared by a facile solution-based emulsification method at room temperature.