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Jinan University Guangzhou 510630[Affil... Publications | LitMetric

22 results match your criteria: "Jinan University Guangzhou 510630[Affiliation]"

Background: Di(2-ethylhexyl) phthalate (DEHP) is a commonly used plasticizer known for its toxic effects on the male reproductive system. Green tea polyphenols (GTPs), recognized for their antioxidant and anti-inflammatory properties, have demonstrated protective effects on various organs, but the mechanisms by which GTPs mitigate DEHP-induced testicular damage remain unclear.

Methods: Healthy male C57BL/6 J mice were divided into five groups: Control, DEHP, DEHP + GTP treatment, GTP, and Oil groups.

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Article Synopsis
  • This study aimed to evaluate the combined effect of shock wave-facilitated melatonin and S-nitroso-N-acetyl-DL-penicillamine on improving critical limb ischemia in rats, comparing it to individual treatments.
  • Rats were divided into five groups, including a sham-control and various combinations of CLI with different treatments, with results collected after 14 days.
  • Findings indicated that the combination treatment led to significantly better cell viability, nitric oxide expression, and improved angiogenesis compared to the other groups, suggesting that the combined therapies could be more effective for treating CLI.
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Article Synopsis
  • The study investigates the effects of Kaixin Powder (KXP) on behavior and brain tissue in mice undergoing chemotherapy to understand how it may reduce cognitive impairment related to cancer treatment.
  • Thirty female BALB/c mice with breast cancer were divided into three groups for testing, including behavioral assessments and various pathological examinations to evaluate the impact of KXP compared to chemotherapy.
  • Results showed that KXP significantly improved behavior and cognition in mice, reduced neuroinflammation and cell death in the brain, and altered RNA expression profiles, suggesting its potential to mitigate cognitive damage during chemotherapy.
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Objective: The aim of the study was to investigate the changes and significance of serum fibroblast growth factor 21 (FGF21) in children with primary nephrotic syndrome (PNS) and chronic renal failure.

Methods: Pediatric patients with active PNS and normal renal function (the nephrotic syndrome group), pediatric patients with chronic renal failure (the renal failure group), and children who had healthy physical examinations (the control group) were included. The serum levels of FGF21, total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C) were measured by enzyme-linked immunosorbent assay (ELISA), and the serum albumin and 24 h urine protein were measured in the PNS group.

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Objective: To analyze the effects of behavioral and psychological interventions on the neurological function in Parkinson's disease (PD) patients.

Methods: A total of 103 patients with PD admitted to our hospital were randomly divided into the observation group (OG, n=52) or the control group (CNG, n=51). The CNG was treated with routine nursing, while the OG was treated with behavioral and psychological interventions.

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Metal phosphorous trichalcogenides (MPX) are novel 2D nanomaterials that have recently been exploited as efficient photothermal-chemodynamic agents for cancer therapy. As a representative MPX, FePSe has the potential to be developed as magnetic resonance imaging (MRI) and photoacoustic imaging (PAI) agents due to the composition of Fe and the previously revealed PA signal. Here, a FePSe-based theranostic agent, FePSe@APP@CCM, loaded with anti-PD-1 peptide (APP) as the inner component and CT26 cancer cell membrane (CCM) as the outer shell is reported, which acts as a multifunctional agent for MR and PA imaging and photothermal and immunotherapy against cancer.

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Ras converting CAAX endopeptidase 1 (RCE1) is an integral membrane protease involved in cell proliferation, differentiation, and carcinogenesis. RCE1 plays opposite roles in different tumor types; however, the actual biological function of RCE1 in hepatocellular carcinoma (HCC) is unknown. Here, we aim to investigate the prognostic value and molecular function of RCE1 in HCC.

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This study tested the hypothesis that uremic-toxic substances play a crucial role in enhancing left-common carotid artery (LCCA) stenosis after balloon-denudation of LCCA endothelium (BDLCCAE), and that the adventitial layer plays a complementary role in worsening LCCA stenosis. results showed the protein expressions of inflammation (IL-1β/TNF-α/IL-6), apoptosis (mitochondrial-Bax/cleaved-caspase-3/cleaved-PARP) and autophagy (beclin/Atg5/LC3B-II to LC3B-I ratio) as well as protein (NOX-1/NOX-2/p22phox/oxidized-protein), total cellular (H2DCFDA) and mitochondrial (Mitosox) levels of oxidative stress were significantly increased in p-Cresol-treated umbilical vein endothelial cells (HUVECs) as compared with control, whereas angiogenesis capacity (i.e.

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Glioblastoma multiforme (GBM) is the most common and invasive tumor of the central nervous system. Growth factors and cytokines (GFCKs) play a crucial role in tumor invasion. In the present study, GFCK expression profiles from GBM patients in the Chinese Glioma Genome Atlas were used to perform sample clustering with nonnegative matrix factorization.

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Baicalin rescues hyperglycemia-induced neural tube defects via targeting on retinoic acid signaling.

Am J Transl Res

July 2020

Division of Histology and Embryology, International Joint Laboratory for Embryonic Development & Prenatal Medicine, Medical College, Jinan University Guangzhou 510632, China.

We, in this study, studied whether or not antioxidant activities of Baicalin could reduce the incidence of neural tube defects (NTDs) in the presence of hyperglycemia. Using early chick embryos, we demonstrated that Baicalin at 6 μM dramatically reduced NTDs rate and impaired neurogenesis in E4.5-day and HH10 chick embryo neural tubes induced by high glucose (HG).

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Neuroendocrine carcinoma of the breast (NECB) is a rare type of breast cancer. The clinical features and morphology between NECB and other subtypes of breast cancer are indistinguishable. Currently, the diagnosis of NECB mainly relies on immunohistochemical markers including chromogranin and synaptophysin.

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Long non-coding RNAs (lncRNAs) have been highlighted to play key roles in the gene regulatory network, and the dysregulation of lncRNAs has also been implicated in various malignancies. However, little is known regarding the expression of lncRNA and their functions in the progression of nephroblastoma. Thus, the present study aimed to explore the potential role of homeobox A11 (HOXA11)-AS in nephroblastoma.

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Circular RNAs (circRNAs) play an important regulatory role in a variety of human cancers, including gastric cancer. The mechanisms for the circRNAs in gastric cancers are not fully understood. This study aims to uncover the mechanism by which circRNAs regulate gastric cancer tumorigenesis.

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In breast cancer, the neurotrophin receptor p75NTR is a critical factor that promotes resistance to the drug, however, its mechanism of action remains unclear. In our study, the 10 cases of positive expressions of p75NTR were detected in 86 cases of breast cancer tissues, accounting for 11.6% of cases detected.

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Objective: To investigate whether calcium is involved in downstream signal transduction in neurite outgrowth regulated by Rho kinase.

Methods: primary hippocampal neurons were cultured and treated with Rho kinase agonist (LPA) or antagonist (Y-27632). Then, the cytoskeleton and neurite outgrowth were observed.

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CRMP family proteins (CRMPs) are widely expressed in the developing neurons, mediating a variety of fundamental functions such as growth cone guidance, neuronal polarity and axon elongation. However, whether all the CRMP proteins interact with cytoskeleton remains unknown. In this study, we found that in cultured hippocampal neurons, CRMPs mainly colocalized with tubulin and actin network in neurites.

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Down-regualtion of miR-106b induces epithelial-mesenchymal transition but suppresses metastatic colonization by targeting Prrx1 in colorectal cancer.

Int J Clin Exp Pathol

September 2016

Department of Pathology, School of Basic Medical Sciences, Southern Medical University Guangzhou 510515, Guangdong Province, China ; Department of Pathology, Nanfang Hospital, Southern Medical University Guangzhou 510515, Guangdong Province, China.

Accumulating evidence identified that epithelial-mesenchymal transition (EMT) is acquired during progression to metastatic, but whether it is an absolute requirement is still controversial. MiR-106b has been confirmed to promote cancer cell proliferation; however few studies are available on its functions in EMT and metastasis in colorectal cancer (CRC). In this study, we found that knocking down miR-106b induced EMT conferring migratory and invasive properties.

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Autophagy is an evolutionarily conserved biological process that is activated in response to stress. Increasing evidence indicate that dysregulated miRNAs significantly contribute to autophagy and are thus implicated in various pathological conditions, including hepatic fibrosis. MiR-148a, a member of the miR-148/152 family, has been found to be downregulated in hepatic fibrosis and human hepatocellular carcinoma.

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The aim of this study is to investigate whether partial liver irradiation promotes hepatic regeneration in rat. Left-half liver of rat was irradiated to 10 Gy, and the Right-half to 0, 5, 10 and 15 Gy, respectively. Then, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels were evaluated on 0 day, 15-day, 30-day, 45-day and 60-day after liver irradiation.

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Ovariectomized Sprague-Dawley (SD) and Wistar rats are widely used as animal models for postmenopausal osteoporosis. This study aimed to investigate differences in the long-term effects of ovariectomy on these two breeds of rats. 6-month-old SD and Wistar rats underwent sham operation (Ssham and Wsham) or bilateral ovariectomy (Sovx and Wovx).

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This study is to explore the association of adverse cardiovascular events with B vitamins supplementation. Rev.Man 5.

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Collapsin response mediator proteins (CRMPs) have been reported to control axonal guidance during neuronal development and degeneration. Among these proteins, CRMP-5 has been indicated to play an important role in growth cone development. However, the mechanisms underlying the linkage between growth cone development and the cytoskeleton remain to be elucidated.

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