The association between obesity indicators and mortality among individuals with hyperlipidemia: evidence from the NHANES 2003-2018.

Background: Obesity is linked to a variety of metabolic issues, with hyperlipidemia being a crucial adjustable risk element for cardiovascular diseases (CVD). However, the connection between indicators of obesity with overall and CVD mortality in American adults with hyperlipidemia remains unknown.

Methods: This research employed an extensive cohort drawn from the National Health and Nutrition Examination Survey (NHANES) (2003-2018).

Organ-specific immune-related adverse events and prognosis in cancer patients receiving immune checkpoint inhibitors.

Background: Patients who developed immune-related adverse events (irAEs) could benefit more from treatment with immune checkpoint inhibitors (ICIs) than those who did not develop irAEs. This study was designed to assess whether the occurrence of irAEs or their characteristics are correlated with survival in advanced patients treated with ICIs.

Methods: This retrospective cohort study enrolled a panel of cancer patients who received ICIs at a single institute.

Identification and expression analysis of P-type ATPase IIIA subfamily in Puccinia Striiformis f. sp. tritici.

Background: Puccinia striiformis f. sp. tritici (Pst) causes wheat stripe (yellow) rust disease, which is one of the most destructive diseases affecting wheat worldwide.

Maize kernel nutritional quality-an old challenge for modern breeders.

This article offers a comprehensive overview of the starch, protein, oil, and carotenoids content in maize kernels, while also outlining future directions for research in this area. Maize is one of the most important cereal crops globally. Maize kernels serve as a vital source of feed and food, and their nutritional quality directly impacts the dietary intake of both animals and humans.

Association of novel metabolic status with asymptomatic intracranial arterial stenosis: A cross-sectional study.

Objectives: To investigate the association of metabolic status newly defined or obesity with asymptomatic intracranial arterial stenosis (aICAS) among populations in rural China.

Methods: The cross-sectional study is based on the Rose asymptomatic IntraCranial Artery Stenosis (RICAS) cohort, which enrolled 2005 participants aged 40 years or older without a history of clinical stroke or transient ischemic attack. Metabolically healthy status (MH) was defined by a newly proposed criterion: (1) systolic blood pressure (SBP) < 130 mmHg and without antihypertensive medication; (2) a waist-to-hip ratio (WHR) below 1.

Longitudinal investigation of albumin-to-globulin ratio for human cancers demonstrates benefit in postoperative serial remeasurement.

Previous studies on serum albumin-to-globulin ratio (AGR) in human cancers were limited to its preoperative level, with postoperative serial AGR remeasurements ignored. In this study, 2844 CRC patients, 2267 NSCLC patients and 507 HCC patients who underwent curative resection were included. Postoperative AGR was a prognostic factor independent to preoperative AGR, performing a L shaped relation with OS.

Multiomic machine learning on lactylation for molecular typing and prognosis of lung adenocarcinoma.

To integrate machine learning and multiomic data on lactylation-related genes (LRGs) for molecular typing and prognosis prediction in lung adenocarcinoma (LUAD). LRG mRNA and long non-coding RNA transcriptomes, epigenetic methylation data, and somatic mutation data from The Cancer Genome Atlas LUAD cohort were analyzed to identify lactylation cancer subtypes (CSs) using 10 multiomics ensemble clustering techniques. The findings were then validated using the GSE31210 and GSE13213 LUAD cohorts.

Silicon-based all-solid-state batteries operating free from external pressure.

Silicon-based all-solid-state batteries offer high energy density and safety but face significant application challenges due to the requirement of high external pressure. In this study, a LiSi/Si-LiSi double-layered anode is developed for all-solid-state batteries operating free from external pressure. Under the cold-pressed sintering of LiSi alloys, the anode forms a top layer (LiSi layer) with mixed ionic/electronic conduction and a bottom layer (Si-LiSi layer) containing a three-dimensional continuous conductive network.

A scalable solar-driven photocatalytic system for separated H and O production from water.

Solar-driven photocatalytic water splitting offers a sustainable pathway to produce green hydrogen, yet its practical application encounters several challenges including inefficient photocatalysts, sluggish water oxidation, severe reverse reactions and the necessity of separating produced hydrogen and oxygen gases. Herein, we design and develop a photocatalytic system composed of two separate reaction parts: a hydrogen evolution cell containing halide perovskite photocatalysts (MoSe-loaded CH(NH)PbBrI) and an oxygen evolution cell containing NiFe-layered double hydroxide modified BiVO photocatalysts. These components are bridged by a I/I redox couple to facilitate electron transfer, realizing efficient overall water splitting with a solar-to-hydrogen conversion efficiency of 2.

Curvularin derivatives from hydrothermal vent sediment fungus Penicillium sp. HL-50 guided by molecular networking and their anti-inflammatory activity.

Guided by molecular networking, nine novel curvularin derivatives (1-9) and 16 known analogs (10-25) were isolated from the hydrothermal vent sediment fungus Penicillium sp. HL-50. Notably, compounds 5-7 represented a hybrid of curvularin and purine.

Genomic analysis of Marinobacter sp. M5B reveals its role in alginate biosynthesis.

Alginate is a natural marine polysaccharide and an important marine organic carbon source, which is mainly produced by marine brown algae. Marinobacter sp. M5B, a Gram-negative and aerobic bacterium, was isolated from the surface seawater samples collected from the Mariana Trench.

Light-dependent Br-org production in terrestrial plants under acetaminophen stress and the bromination mechanisms mediated by photosystem.

Due to the endocrine toxicity, neurotoxic, and reproductive toxicity to organisms, the sources and risks of brominated organic pollutants have attracted widespread attention. However, knowledge gaps remain in the bromination processes of emerging phenolic pollutants in plants, which may increase the potential health risk associated with food exposure. Our study discovered that light induced generation and accumulation of more toxic brominated organic compounds (Br-org) in lettuce leaves under the stress of acetaminophen (ACE) than that without light, as evidenced by an increase in C-Br bond intensity in FTIR analysis.

Child exposure to N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) and its derived quinone (6PPDQ) in e-waste areas: Urinary concentrations, sources, and health effect assessment.

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6PPDQ) and its parent 6PPD are ubiquitous in the environment and may induce multi-endpoint toxicity. Electronic waste (e-waste) dismantling is an under-recognized source of 6PPD and 6PPDQ emissions, and there is a lack of epidemiological investigations into their presence and health effects in local populations. This study aimed to determine the urinary concentrations of 6PPD and 6PPDQ in children aged 2-7 years from e-waste dismantling areas and evaluate their potential risk to physical growth.

The Evaluation of Urinary HE4, CEA, ProGRP, CYFRA 21-1 and NSE in the Diagnosis of Lung Cancer.

Objective: Urinary proteins are effective tumor biomarkers. Human epididymis protein 4 (HE4), progastrin-releasing peptide (ProGRP), carcinoembryonic antigen (CEA), cytokeratin-19 fragment 21-1(CYFRA 21-1), and neuron-specific enolase (NSE) in serum, were proposed as tumor biomarkers of lung cancer. Our aim was to identify the urine protein biomarkers that can distinguish patients with lung cancer from healthy individuals and/or patients with benign lung disease with a high level of sensitivity and specificity.

The effect of stressful life events on depressive symptoms in Chinese university students: Moderated mediating effect of interpersonal relationship and gender.

Background: This study aimed to examine the impact of stressful life events on the depressive symptoms of Chinese first-year university students, while considering the influence of interpersonal relationships and gender on this association.

Methods: A total of 8079 first-year Chinese university students were surveyed using the Adolescent Self-Rating Life Events Check List (ASLEC), Beck Depression Inventory (BDI), and Comprehensive Diagnostic Scale of Interpersonal Relationship (CDSIR).

Results: Stressful life event were positively correlated with interpersonal relationships, depressive symptoms, and gender (r = 0.

Structural characteristics of linear dextrin and in vitro digestion of lauric acid complexes generated via gradient alcohol precipitation.

Linear dextrin (LD), a low-molecular-weight carbohydrate, regarded as a type of short amylose, can form resistant starch when combined with fatty acids. This study investigated the structural properties and in vitro digestion of linear dextrins and their complexes with lauric acid (LA). Four groups of linear dextrins were prepared by pretreating gelatinized high-amylose maize starch (HAMS) with pullulanase followed by gradient ethanol precipitation at concentrations of 0 %, 50 %, 60 %, and 70 % (v/v).

Chondroitin sulfate-based dissolvable microneedles loaded with NIR-II photothermal and natural anticancer agents for synergistic melanoma therapy.

Melanoma is characterized by its aggressiveness, high metastatic potential, and numerous mutations, which limit the effectiveness of current treatments. To address this issue, we developed a dissolvable microneedle (MN) system composed of poly(2-ethyl-2-oxazoline) (PEtOz) and chondroitin sulfate (CS). This MN system was loaded with liposomes containing both a NIR-II photothermal small molecule (IRLy) and the natural anticancer agent Gambogic acid (GA), forming Lip(IRLy + GA) MNs.

Dual effects of exogenous ferulic acid bound in rice starch as 3D printable food ink: Structural fluidity and antimicrobial activity.

Starch-ferulic acid (FA) composites have been developed for medical and food fields, while little focus is caused on their use in functional products by 3D printing. In this work, dynamic high-pressure microfluidization was employed to treat starch at various concentrations, for preparing modified starch-FA composites. The high-performance liquid chromatography results showed that an increased starch concentration was conducive to a high yield of composite with enhanced binding of FA.

WTAP suppresses STAT3 via m6A methylation to regulate autophagy and inflammation in central nervous system injury.

Central nervous system (CNS) repair after injury is a challenging process limited by inflammation and neuronal apoptosis. This study identifies Wilms' tumor 1-associating protein (WTAP) as a pivotal regulator of neuronal protection and repair through m6A methylation of STAT3 mRNA. By employing spinal cord injury (SCI) as a representative model of CNS injury, transcriptomic analyses reveal WTAP as a key mediator of pathways related to neuronal autophagy and inflammation regulation.

Nitrogen transformation and bacterial community response in O-SBR process for treating nitrogen-containing heterocyclic antibiotics.

Nitrogen heterocyclic antibiotics (NHAs) pollution poses a significant threat to aquatic ecosystems. Ozonation (O) pretreatment is beneficial for the removal of total nitrogen (TN) in antibiotics by facilitating subsequent biological treatment. However, nitrogen transformation and bacterial community responses when treating NHAs by O-coupled biological processes remain unclear.

Comparative study of Baduanjin and brisk walking on balance and stability in older adults.

Objective: To investigate the impact of practicing the health Qigong-Baduanjin exercise on lower limb balance among elderly individuals.

Methods: Two intervention methods, Baduanjin and brisk walking, were applied to study the effect of exercise on senior balancing. Sixty elderly individuals aged 65 to 79 were selected and randomly divided into the Baduanjin group, the brisk walking group, and the control group that did not engage in exercise.

Phospholipase C epsilon 1 as a therapeutic target in cardiovascular diseases.

Background: Phospholipase C epsilon 1 (PLCε1) can hydrolyze phosphatidylinositol-4,5-bisphosphate and phosphatidylinositol-4-phosphate at the plasma membrane and perinuclear membrane in the cardiovascular system, producing lipid-derived second messengers. These messengers are considered prominent triggers for various signal transduction processes. Notably, diverse cardiac phenotypes have been observed in cardiac-specific and global Plce1 knockout mice under conditions of pathological stress.

Independent genetic strategies define the scope and limits of CDKL5 deficiency disorder reversal.

Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a neurodevelopmental syndrome caused by mutations in the X-linked CDKL5 gene. The early onset of CDD suggests that CDKL5 is essential during development, but post-developmental re-expression rescues multiple CDD-related phenotypes in hemizygous male mice. Since most patients are heterozygous females, studies in clinically relevant female models are essential.

Enzymatic synthesis of stachyose-derived fatty acid mono-esters, the evaluation of their surface and interfacial properties and the capacity of certain derived emulsions to deliver resveratrol.

The nutritional characteristics of the tetrasaccharide stachyose prompted its incorporation into biosurfactants through esterification with fatty acid derivatives embodying 12-22 carbon chains. The resulting esters were evaluated for their surface active effects, emulsifying properties and capacities to form emulsions capable of the selective delivery of the anti-oxidant resveratrol. While such studies have revealed that those congeners embodying longer side-chains have higher critical micelle concentrations (CMC) and lower interfacial tensions, their hydrophilic-lipophilic balance (HLB) values fell within a tight range.