Risk prediction of new-onset thrombocytopenia in patients with systemic lupus erythematosus: a multicenter prospective cohort study based on Chinese SLE treatment and research group (CSTAR) registry.

Background: Thrombocytopenia (TP) is a hematological manifestation of systemic lupus erythematosus (SLE) and is associated with unfavorable prognostic outcomes. This study aimed to develop a risk prediction model for new-onset TP in SLE patients.

Methods: Based on the multicenter prospective Chinese SLE Treatment and Research Group (CSTAR) registry, newly diagnosed SLE patients without TP at registration were enrolled.

The relationship between life's essential 8 score and depression symptom severity: evidence from a nationally representative sample of U.S. adults.

Background: Many studies have indicated that adverse cardiovascular health (CVH) behaviors are associated with an elevated risk of depression. However, the dose-response relationship between the two and the relative contributions of individual CVH components to depression risk remain unclear.

Methods: We utilized data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2015 and 2018.

Association between life's essential 8 and periodontitis in U.S. adults.

Periodontitis is closely related to lifestyle habits. Our objective was to examine the relationship between the Life's Essential 8 (LE8) and the prevalence of periodontitis in American adults. This study used data from the 2009-2014 National Health and Nutrition Examination Survey (NHANES).

Self-efficacy and healthy lifestyle behaviors as mediators between COVID-19 care knowledge and health status.

The COVID-19 epidemic has affected the psychological well-being and daily life of college students, leading to a decrease in their quality of life. Health status can be influenced by a variety of factors. This study aims to assess the current health status of university students and explore the relationships among COVID-19 care knowledge, self-efficacy, healthy lifestyle behaviors, and health status and how these factors are influenced.

Investigating steeply inclined abandoned mines for unlocking the secrets of water level recovery.

With the growing emphasis on environmental protection, many coal mines in northern China were closed. However, the cessation of pumping operations in those closed mines has caused a rise in groundwater levels, giving rise to various safety and environmental concerns. Understanding the patterns of water level recovery is vital for effectively managing abandoned mine sites and ensuring the uninterrupted production of adjacent coal mines.

Brassica rapa L. polysaccharide mitigates hypobaric hypoxia-induced oxidation and intestinal damage via microbiome modulation.

The high-altitude, low-pressure, and hypoxia environment poses a significant threat to human health, particularly causing intestinal damage and disrupting gut microbiota. This study investigates the protective effects of Brassica rapa L. crude polysaccharides (BRP) on intestinal damage in mice exposed to hypobaric hypoxic conditions.

Periodic mesoporous organosilica-loaded mincle agonists enhance the immunogenicity of COVID-19 subunit vaccines by dual activation of B cells and dendritic cells.

Effective vaccination is crucial for intervening in the COVID-19 pandemic. However, with the continuous mutation of the SARS-CoV-2, existing vaccines including subunit vaccines cannot effectively prevent virus infections. Hence, there is an urgent need to enhance the immunogenicity of existing vaccines to induce a more potent and durable immune response.

Drug Interaction of SGLT2Is and ARNI on Acute Kidney Injury: A Real-world Pharmacovigilance Analysis Through the FAERS.

Sodium-glucose cotransporter 2 inhibitors (SGLT2Is) and angiotensin receptor-neprilysin inhibitor (ARNI) may cause potential renal damage, the combined impact of SGLT2Is and ARNI on acute kidney injury (AKI) remains unclear. This pharmacovigilance study conducted a disproportionality analysis using reports from the FAERS database. The reporting odds ratio (ROR) was used as an estimate for detecting AKI signal.

Immunogenicity and safety of live attenuated influenza vaccine in children aged 3-17 years in China.

(1) Background: The administration of a live attenuated influenza vaccine (LAIV) has emerged as a viable option for preventing pediatric infections. The LAIV vaccine is available in China based on efficacy results. However, LAIV immunogenicity in children aged 3-17 years old in China has not yet to be studied and reported broadly.

A signal energy approach of acoustic source localization in plate structures using a discrete sensor array.

In the field of engineering structural health monitoring, acoustic source localization (ASL) is a common method to monitor early damage. Most of the existing ASL techniques have high requirements for accurate acquisition of time of arrival, and require complex iterative algorithms or signal processing techniques, which are not conducive to real-time monitoring. In this paper, a signal energy approach of acoustic source localization in plate structures using a discrete sensor array is proposed.

Automatic calculation method for stenosis ratio based on dialysis access ultrasound image segmentation.

Background: Dialysis Access (DA) stenosis impacts hemodialysis efficiency and patient health, necessitating exams for early lesion detection. Ultrasound is widely used due to its non-invasive, cost-effective nature. Assessing all patients in large hemodialysis facilities strains resources and relies on operator expertise.

How to Encourage the Public to Help People With Dementia in the Community: A Scoping Review.

Background: In a response to the lack of public awareness of dementia, 'ageing in place' and 'dementia-friendly community' policies have been proposed, and a number of relevant studies have been carried out.

Aim: To map the evidence of public help for people with dementia in the community.

Design: A scoping review.

Comparative Safety and Efficacy of Non-vitamin K Antagonist Oral Anticoagulants (NOACs) Versus Warfarin in Deep Vein Thrombosis (DVT) Treatment: A Meta-analysis.

Purpose: This meta-analysis aimed to conduct a systematic evaluation of the comparative efficacy and safety of new oral anticoagulants (NOACs) versus warfarin for the treatment of deep venous thrombosis (DVT).

Methods: A systematic computerized search of databases including PubMed, Medline, Web of Science, Embase, Cochrane Library, and www.

Clinicaltrials: gov .

Chinese guidelines for ultrasound-guided thermal ablation of thyroid nodules (2024 Edition).

The Chinese Guidelines for Ultrasound-guided Thermal Ablation of Thyroid Nodules (2024 edition) were jointly initiated by the Ultrasound Committee of Chinese Medical Association, the Interventional Ultrasound Committee of Chinese Association of Ultrasound in Medicine and Engineering, the Ultrasonic Intervention Committee of Chinese Colleges of Interventionalists, the Oncological Intervention Committee of Chinese Research Hospital Association, 37 multidisciplinary experts in interventional ultrasound, ultrasound medicine, endocrinology and thyroid surgery participated in the compilation of this guide, which expanded the depth and breadth of the perspective and enhanced the authority of the guide. Based on the systematic review of literatures related to ultrasound-guided thermal ablation of thyroid nodules and the professional opinions of experts, the guidelines define the indications and contraindications of thermal ablation, including pre-ablation evaluation and preparation, thermal ablation techniques and operational procedures, post-ablation follow-up, therapeutic effect evaluation, complications prevention and treatment, and the writing of medical documents for ablation. According to the Grading of Recommendations Assessment, Development and Evaluation (GRADE), a total of 17 objective and comprehensive recommendations were given.

Silica Waveguide Thermo-Optic Mode Switch with Bimodal S-Bend.

A silica waveguide thermo-optic mode switch with small radius bimodal S-bends is demonstrated in this study. The cascaded multimode interference coupler is adopted to implement the E and E mode selective output. The beam propagation method is used in design optimization.

Silencing LY6K Suppresses CD44 EpCAM HCT116 Human Colon Cancer Stem Cells Growth: Insights from In Vitro and In Vivo Evidence.

Lymphocyte antigen 6 complex, locus K (LY6K) is a putative oncogene in various human cancers, including colorectal cancer, where elevated expression is associated with poor prognosis. This study investigates the antitumor effects of LY6K in colon cancer stem cells (CCSCs) both in vitro and in vivo. EpCAM and CD44 surface markers were used to isolate CCSCs from HCT116 cells, and the expression of LY6K in CCSCs was analyzed by real-time PCR.

Global, regional, and national trends in gastric cancer burden: 1990-2021 and projections to 2040.

Background: Gastric cancer (GC) is a common malignancy of the digestive system, with significant geographical variation in its disease burden.

Methods: This study used data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to analyze three key indicators: incidence, mortality, and disability-adjusted life years (DALYs). Initially, a detailed analysis of the GC burden was conducted from global, regional, national, gender, and age perspectives.

Targeting T cell exhaustion: emerging strategies in non-small cell lung cancer.

Lung cancer continues to be a major contributor to cancer-related deaths globally. Recent advances in immunotherapy have introduced promising treatments targeting T cell functionality. Central to the efficacy of these therapies is the role of T cells, which are often rendered dysfunctional due to continuous antigenic stimulation in the tumor microenvironment-a condition referred to as T cell exhaustion.

Theoretical Design of a Single Cu Atom Supported on 1T-WS2/Graphene Catalyst for Electrocatalytic Nitrate Reduction to Ammonia.

Electrochemical reduction of nitrate to ammonia (NO3RR) offers a promising strategy for renewable ammonia (NH3) synthesis and wastewater treatment, but still suffers from limited activity and NH3 selectivity due to the lack of effective electrocatalyst. Here, we perform a four-steps screening strategy to screen high performance NO3RR catalyst by density functional theory calculations using 23 single transition metals atom doped on 1T-WS2/graphene (TM@1T-WS2/graphene) as candidates. The results show that Cu@1T-WS2/graphene exhibits the highest NO3RR activity among 23 candidates with a low rate determining step energy barrier of 0.

Prognostic implications of increased and final quantitative flow ratios in patients treated with drug-coated balloons physiological evaluation after DCB in de novo lesions.

Background: Few studies investigated the implications of post-PCI QFR and post-PCI ΔQFR (absolute increase of QFR) in de novo lesions of small coronary disease after drug-coated balloon (DCB).

Objectives: We sought to investigate the prognostic implications of post-PCI QFR and post-PCI ΔQFR in patients who received DCB only.

Methods: Patients were divided according to the optimal cutoff value of the post-PCI QFR and the post-PCI ΔQFR.

A Novel Dual Cross-linking Reagent for Dentin Bonding Interface Stability.

The cross-linking reagent has been proposed as a means of modifying dentin collagen, inhibiting matrix metalloproteinase activities, and enhancing bond durability during dentin bonding procedures. This study aimed to synthesize an operation-friendly dual cross-linking reagent-3-(4-formyphenoxy)-2-hydroxypropyl methacrylate (FPA)-to assess its ability to cross-link dentin collagen and reduce enzymatic activity at the bonding interface. Cytotoxicity was evaluated by a cell counting kit-8 test and calcein AM/propidium iodide assay.

Impacts of anthropogenic disturbances on antibiotic resistomes in biological soil crusts on the Qinghai-Tibetan Plateau.

Biological soil crusts (BSCs) are the main landscape on the Qinghai-Tibetan Plateau and an ecological indicator of human disturbance. Information about antibiotic resistomes in BSCs on the Qinghai-Tibetan Plateau can provide baseline for the risk assessment and management of resistomes and yet to be explored. This work investigated the profiles and geographic patterns of antibiotic resistomes in BSCs along the Lhasa River and their response to anthropogenic activities for the first time.

Tailored protein corona behavior in titanium dioxide nanosheet fluorescence biosensor for protein quantification assays.

The spontaneous adsorption of proteins onto nanoparticles, known as the protein corona, provides a unique perspective for designing protein-sensing biosensors. This study proposes a tailored protein corona method mediated by Tween-20 and develops a reverse-capture approach for protein quantification assays. The protein-coated microplate captures titanium dioxide nanosheets (TiO-NS) in a phosphate buffer containing Tween-20 and generates fluorescence signals via the photocatalytic reduction of resazurin to resorufin, thereby indicating the amount of protein.

Carbon Dots-Modified Hollow Mesoporous Photonic Crystal Materials for Sensitivity- and Selectivity-Enhanced Sensing of Chloroform Vapor.

Chloroform and other volatile organic pollutants have garnered widespread attention from the public and researchers, because of their potential harm to the respiratory system, nervous system, skin, and eyes. However, research on chloroform vapor sensing is still in its early stages, primarily due to the lack of specific recognition motif. Here we report a mesoporous photonic crystal sensor incorporating carbon dots-based nanoreceptor (HMSS@CDs-PCs) for enhanced chloroform sensing.

Robust I···H-O Intramolecular Halogen Bond Boosts Reversible I/I Redox Behavior for Sustainable Potassium-Iodine Batteries.

Potassium-iodine batteries show great promise as alternatives for next-generation battery technology, owing to their high power density and environmental sustainability. Nevertheless, they suffer from polyiodide dissolution and the multistep electrode fabrication process, which leads to severe performance degradation and limitations in mass-market adoption. Herein, we report a simple "solution-adsorption" strategy for scale-up production of TiC(OH)-wrapped carbon nanotube paper (CNP), as an economic host for strengthening the iodine encapsulation.