Radiation inhibits salivary gland function by promoting STIM1 cleavage by caspase-3 and loss of SOCE through a TRPM2-dependent pathway.

Store-operated Ca entry (SOCE) is critical for salivary gland fluid secretion. We report that radiation treatment caused persistent salivary gland dysfunction by activating a TRPM2-dependent mitochondrial pathway, leading to caspase-3-mediated cleavage of stromal interaction molecule 1 (STIM1) and loss of SOCE. After irradiation, acinar cells from the submandibular glands of , but not those from mice, displayed an increase in the concentrations of mitochondrial Ca and reactive oxygen species, a decrease in mitochondrial membrane potential, and activation of caspase-3, which was associated with a sustained decrease in STIM1 abundance and attenuation of SOCE.

Free flap reconstruction versus non-free flap reconstruction in treating elderly patients with advanced oral cancer.

Purpose: Our goal was to evaluate whether elderly patients can benefit from free flaps.

Materials And Methods: The clinical information from the included patients was reviewed, and these patients were asked to complete the University of Washington Quality of Life, version 4, questionnaire. Comparisons of the different scales between the 2 groups were performed.

[Stress analysis of the staggered and straight placement of implants in the mandibular posterior region under the localized load].

Objective: To compare the stress distribution of the staggered and straight placement of implants in the mandibular posterior region.

Methods: Using three-dimensional finite element approach to analyze the stress distribution and variance regularity under the localized load.

Results: Under vertical load, the stress peak value reduced when wide implant was placed straight (min: 3.