Severity: Warning
Message: fopen(/var/lib/php/sessions/ci_session7ffvcrgkg8atqt1h8u9otkherfc3afig): Failed to open stream: No space left on device
Filename: drivers/Session_files_driver.php
Line Number: 177
Backtrace:
File: /var/www/html/index.php
Line: 316
Function: require_once
Severity: Warning
Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)
Filename: Session/Session.php
Line Number: 137
Backtrace:
File: /var/www/html/index.php
Line: 316
Function: require_once
176 results match your criteria: "Jilin Province People's Hospital[Affiliation]"
EClinicalMedicine
November 2023
Kidney Disease Center, The First Affiliated Hospital, Medical School of Zhejiang University, Hangzhou, China.
Background: Pegmolesatide, a synthetic peptide-based erythropoietin (EPO) receptor agonist, is being evaluated as an alternative to epoetin alfa for treating anemia of chronic kidney disease (CKD) in Chinese dialysis patients. There is a critical need for a long-acting, cost-effective erythropoiesis-stimulating agent that does not produce EPO antibodies.
Methods: A randomized, open-label, active-comparator, non-inferiority phase three trial was conducted at 43 dialysis centers in China between May 17th, 2019, and March 28th, 2022.
World J Clin Cases
September 2023
Department of Ophthalmology, The Second Hospital of Jilin University, Changchun 130022, Jilin Province, China.
Background: An unusual case of acute acquired concomitant esotropia (AACE) with congenital paralytic strabismus in the right eye is reported.
Case Summary: A 23-year-old woman presented with complaints of binocular diplopia and esotropia of the right eye lasting 4 years and head tilt to the left since 1 year after birth. The Bielschowsky head tilt test showed right hypertropia on a right head tilt.
Front Genet
October 2023
Department of Hepatobiliary and Pancreatic Surgery, The Second Hospital of Jilin University, Changchun, China.
Single-cell sequencing (SCS) technology is changing our understanding of cellular components, functions, and interactions across organisms, because of its inherent advantage of avoiding noise resulting from genotypic and phenotypic heterogeneity across numerous samples. By directly and individually measuring multiple molecular characteristics of thousands to millions of single cells, SCS technology can characterize multiple cell types and uncover the mechanisms of gene regulatory networks, the dynamics of transcription, and the functional state of proteomic profiling. In this context, we conducted systematic research on SCS techniques, including the fundamental concepts, procedural steps, and applications of scDNA, scRNA, scATAC, scCITE, and scSNARE methods, focusing on the unique clinical advantages of SCS, particularly in cancer therapy.
View Article and Find Full Text PDFFront Neurorobot
October 2023
Rehabilitation Therapeutics, School of Nursing, Jilin University, Changchun, China.
The brain-computer interface (BCI)-mediated rehabilitation is emerging as a solution to restore motor skills in paretic patients after stroke. In the human brain, cortical motor neurons not only fire when actions are carried out but are also activated in a wired manner through many cognitive processes related to movement such as imagining, perceiving, and observing the actions. Moreover, the recruitment of motor cortexes can usually be regulated by environmental conditions, forming a closed-loop through neurofeedback.
View Article and Find Full Text PDFAm J Stem Cells
August 2023
Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong Hong Kong SAR, China.
Objective: This study investigated if silver nanoparticles (AgNps) could promote the proliferation and osteogenic differentiation of mouse embryonic fibroblasts.
Methods: Mouse embryonic fibroblasts were divided into two groups: Group 1 cells were cultured in DMEM/F12 medium and Group 2 cells were cultured in osteogenic medium. Both groups were then treated with 16, 32, or 100 μM AgNps.
BMC Ophthalmol
September 2023
Ophthalmology Department, Zhongshan Hospital Affiliated to Xiamen University, No.201-209 Hubinnan Road, Siming District, 361004, Xiamen, China.
Background: Maresin-1 plays an important role in diabetic illnesses and ferroptosis is associated with pathogenic processes of diabetic retinopathy (DR). The goal of this study is to explore the influence of maresin-1 on ferroptosis and its molecular mechanism in DR.
Methods: ARPE-19 cells were exposed to high glucose (HG) condition for developing a cellular model of DR.
Mol Neurobiol
February 2024
Department of Spine Surgery, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Street, Changchun, 130033, People's Republic of China.
This study aimed to investigate the molecular mechanisms underlying spinal cord ischemia-reperfusion (SCI/R) injury. Through RNA-Seq high-throughput sequencing and bioinformatics analysis, we found that EGFR was downregulated in the spinal cord of SCI/R mice and may function via mediating the JAK2/STAT3 signaling pathway. In vitro cell experiments indicated that overexpression of EGFR activated the JAK2/STAT3 signaling pathway and reduced neuronal apoptosis levels.
View Article and Find Full Text PDFZhonghua Nei Ke Za Zhi
September 2023
Department of Neurology, Jilin Province People's Hospital, Changchun 130021, China.
CNS Neurosci Ther
December 2023
Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, China.
Curr Probl Cardiol
January 2024
Department of Thoracic Surgery, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, Guangdong Province, China. Electronic address:
This study examines the impact of sugar-sweetened beverage (SSB) consumption on cardiovascular diseases (CVDs) and aims to provide evidence for preventive measures. The analysis involved a comprehensive scrutiny of CVD-related data from 1990 to 2019. Temporal trends of ASMR and ASDR were assessed using the Estimated Annual Percentage Change (EAPC).
View Article and Find Full Text PDFClin Cosmet Investig Dermatol
August 2023
Department of Dermatology, The Second Hospital of Jilin University, Changchun, 130041, People's Republic of China.
Introduction: Bowen's disease (BD) commonly occurs in sites of chronic sunlight exposure such as head, neck and extremities. It rarely distributes on the nipple and areola.
Case Presentation: A 59-year-old female presented with crusted plaque on the right breast for over 1 month.
Biomed Pharmacother
September 2023
Institute of Translational Medicine, The First Hospital of Jilin University, Changchun, Jilin 130001, China. Electronic address:
Objective: Acetaminophen (APAP) is one of the world's popular and safe painkillers, and overdose can cause severe liver damage and even acute liver failure. The effect and mechanism of the xanthohumol on acetaminophen-induced hepatotoxicity remains unclear.
Methods: The hepatoprotective effects of xanthohumol were studied using APAP-induced HepG2 cells and acute liver injury of mouse, seperately.
JAMA Neurol
August 2023
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Importance: DL-3-n-butylphthalide (NBP) is a drug for treating acute ischemic stroke and may play a neuroprotective role by acting on multiple active targets. The efficacy of NBP in patients with acute ischemic stroke receiving reperfusion therapy remains unknown.
Objective: To assess the efficacy and safety of NBP in patients with acute ischemic stroke receiving reperfusion therapy of intravenous thrombolysis and/or endovascular treatment.
J Ethnopharmacol
December 2023
College of Pharmacy, Changchun University of Chinese Medicine, Jilin, PR China. Electronic address:
Ethnopharmacological Relevance: Tiaogan Jiejiu Tongluo Formula (TJTF), a traditional Chinese medicine formula, is modified from the well-known ancient prescription Danzhi-Xiaoyao Powder (DXP). Owing to its ability to regulate liver, strengthen spleen, detoxicating, and dredge collaterals in Chinese medicine, TJTF is usually used to treat anxiety, hypertension, alcoholic fatty liver disease in clinical application. However, the protective effect and potential molecular mechanism of TJTF on alcoholic liver injury has not fully been clarified.
View Article and Find Full Text PDFChildhood obesity is one of the biggest public health challenges globally. It is associated with various adverse health consequences throughout life. Prevention and early intervention represent the most reasonable and cost-effective approaches.
View Article and Find Full Text PDFFood Funct
June 2023
Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun, China.
: Precocious puberty, one of the common pediatric endocrine system diseases, has been related to reduced adult height, adverse psychological outcomes and long-term health consequences. Previous findings have found that low levels of vitamin D appear to be associated with the characteristics of precocious puberty such as early menarche. However, the effect of vitamin D on precocious puberty remains controversial.
View Article and Find Full Text PDFOrthop Surg
June 2023
Department of Orthopaedics, the Second Hospital of Jilin University, Changchun, China.
Objectives: Osteochondral lesions of the talus (OLTs) are common injuries in the general population. Abnormal mechanical conditions applied to defected cartilage are believed to be the culprits to deteriorating OLTs. This study aims to investigate the biomechanical effects of defect size of talar cartilage on OLTs during ankle movements.
View Article and Find Full Text PDFAsian J Surg
September 2023
Department of Ultrasound Jilin Province People's Hospital, Changchun, 130021, China. Electronic address:
Front Endocrinol (Lausanne)
April 2023
Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, China.
Background: Many clinical studies have shown a correlation between plasma cortisol and neurological disorders. This study explored the causal relationship between plasma cortisol and dementia, epilepsy and multiple sclerosis based on Mendelian randomization (MR) method.
Methods: Data were taken from the summary statistics of a genome-wide association study, FinnGen consortium and United Kingdom Biobank.
Front Aging Neurosci
March 2023
Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, China.
Background: Dementia is a clinical syndrome commonly seen in the elderly individuals. With the prevalence of dementia, the incidence of neuropsychiatric symptoms in dementia patients is increasing annually. Agitation, as one of the neuropsychiatric symptoms, has a serious impact on the quality of life of patients with dementia.
View Article and Find Full Text PDFLab Invest
June 2023
Department of Gastroenterology, The First Hospital of Jilin University, Changchun, Jilin, China. Electronic address:
The transcription factor Krüppel-like factor (KLF) 3 is one of the members of the KLF family, which plays an important role in tumor progression. Nevertheless, the role of KLF3 in the growth and metastasis of gastric cancer (GC) still needs to be elucidated. Bioinformatics analysis showed that KLF3 was overexpressed in patients with GC, and the high expression of KLF3 was correlated with poor survival.
View Article and Find Full Text PDFFront Pharmacol
February 2023
Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Fibroblasts activation is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis pathogenesis, and transforming growth factor (TGF)-β1 plays a key regulatory role in fibroblast activation. It has been reported that metformin (MET) alleviated bleomycin (BLM)-induced pulmonary fibrosis (PF) by regulating TGF-β1-induced fibroblasts activation, but the underlying mechanisms still deserve further investigations. In this study, MET blocked α-smooth muscle actin (α-SMA) accumulation accompanied with S100A4 expression and STAT3 phosphorylation inhibition, resulting in attenuating the progression of lung fibrosis after BLM administration.
View Article and Find Full Text PDFPhytomedicine
April 2023
Beijing hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, PR China. Electronic address:
Objective: Coronavirus disease 2019 (COVID-19) is still spreading worldwide. COVID-19 close contact is a key point of this epidemic. However, no medication is now available for close contact.
View Article and Find Full Text PDFAm J Gastroenterol
July 2023
Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Introduction: The therapeutic effect of probiotics for irritable bowel syndrome (IBS) was controversial. This study aims to evaluate the short-term efficacy of Bifidobacterium quadruple viable tablet in patients with diarrhea-predominant IBS and explore factors associated with response to probiotics.
Methods: A randomized, double-blind, placebo-controlled, multicenter trial was performed in 15 hospitals.
BMC Musculoskelet Disord
December 2022
Departments of Orthopedics, China-Japan Union Hospital of Jilin University, No.126 Xiantai Street, Changchun, 130033, Jilin, P.R. China.
Background: With the growing number of traditional posterior open surgery, the incidence of failed back surgery syndrome (FBSS) increases gradually. We aimed to investigate the incidence and risk factors for FBSS following open posterior lumbar surgery for degenerative lumbar disease (DLD).
Method: A multivariable regression analysis was performed for 333 consecutive patients to identify potential risk factors for FBSS.