Shensu IV maintains the integrity of the glomerular filtration barrier and exerts renal protective effects by regulating endogenous hydrogen sulfide levels.

Background: Nephrotic syndrome has a significant impact on global health, often leading to cardiovascular disease and high mortality due to limited effective treatments. This study investigates the efficacy of Shensu IV in a puromycin aminonucleoside (PAN)-induced rat model of nephropathy.

Methods: Rat models and podocyte PAN nephropathy models were established with PAN and treated with Shensu IV.

Effective Bone Tissue Fabrication Using 3D-Printed Citrate-Based Nanocomposite Scaffolds Laden with BMP9-Stimulated Human Urine Stem Cells.

Effective repair of large bone defects through bone tissue engineering (BTE) remains an unmet clinical challenge. Successful BTE requires optimal and synergistic interactions among biocompatible scaffolds, osteogenic factors, and osteoprogenitors to form a highly vascularized microenvironment for bone regeneration and osseointegration. We sought to develop a highly effective BTE system by using 3D printed citrate-based mPOC/hydroxyapatite (HA) composites laden with BMP9-stimulated human urine stem cells (USCs).

Research Hotspots and Trends of NK Cell Immunotherapy for Acute Myeloid Leukemia: A Bibliometric Analysis From 2000 to 2023.

Background: Natural killer (NK) cell immunotherapy has shown promising therapeutic potential for acute myeloid leukemia (AML), especially with advancements in chimeric antigen receptor-engineered NK cells (CAR-NK) and artificial intelligence (AI). Despite these developments, the field lacks comprehensive bibliometric analyses to identify research hotspots and trends, which could guide future precision treatments.

Methods: A bibliometric analysis of NK cell immunotherapy for AML was conducted using literature from 2000 to 2023 retrieved from the Web of Science Core Collection database.

Cancer phenomics research hotspots and development trends: a bibliometric analysis from 2000 to 2023.

The emerging field of cancer phenomics provides comprehensive insights into tumor heterogeneity, promoting advances in personalized oncology. This study explores current research hotspots and future development trends in cancer phenomics through a bibliometric analysis of research from 2000 to 2023. Using data from the Web of Science Core Collection, we analyzed 1260 publications to identify global contributions and collaborative networks.

The efficacy and safety of acupuncture in the treatment of sudden sensorineural hearing loss: A systematic review and meta-analysis.

Background: Despite numerous pharmacological and therapeutic options for sudden sensorineural hearing loss(SSNHL), treatment remains challenging due to various side effects and suboptimal efficacy. Acupuncture, as a complementary and alternative therapy, has achieved some success in this field. The objective of this study was to systematically evaluate the efficacy and safety of acupuncture for SSNHL, and to seek robust evidence-based medical evidence for the therapeutic effect of acupuncture.

Risk factors in immune-related recurrent spontaneous abortion and construction of predictive models.

Objectives: To explore the risk factors associated with immune-related recurrent spontaneous abortion (IRSA) and to develop a predictive model to identify high-risk individuals, aiming to provide theoretical guidance for RSA prevention.

Methods: This retrospective study included 120 patients with RSA who were treated at Jiangxi University of Traditional Chinese Medicine Hospital between January 2022 and January 2024. Patients were divided into two groups based on the nature of their miscarriages: the IRSA group (observation group, n=58) and the non-IRSA group (control group, n=62).

Acupuncture Treats Sepsis through Immune Modulation and Organ Protection.

Sepsis is a secondary condition resulting from severe systemic infections. It is a significant contributor to mortality in critically ill patients with rapid onset and severe symptoms. Acupuncture is a traditional Chinese medical treatment.

In-Situ Repair Strategies for Defects in Perovskite Solar Cells.

Perovskite solar cells have achieved significant progress in recent years. However, they still have challenges in photovoltaic conversion efficiency and long-term stability. Widespread defects in perovskite films are one of the most important factors leading to their poor performance.

Causal effects of vitamin D on leukemia risk: insights from two-sample Mendelian randomization analysis.

Background: vitamin D plays a crucial role in immune regulation, anti-inflammatory processes, and tumor suppression, but its relationship with leukemia risk remains unclear. This study aims to evaluate the causal relationship between vitamin D levels and the risk of different types of leukemia through a two-sample Mendelian randomization (MR) analysis.

Methods: data from large-scale genome-wide association studies (GWAS) were used, and genetic variants associated with vitamin D were selected as instrumental variables.

Causal relationship between branched-chain amino acids and leukemia risk: insights from a two-sample Mendelian randomization study.

Background: Branched-chain amino acids (BCAAs), including leucine, isoleucine, and valine, are essential amino acids involved in protein synthesis, energy metabolism, and immune regulation. While BCAAs are known to influence cancer biology, their role in leukemia remains unclear. This study employs Mendelian randomization (MR) analysis to explore the causal relationship between BCAA levels and four leukemia subtypes: acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), and chronic myeloid leukemia (CML).

Development and Validation of a Nomogram for Predicting Systemic Inflammatory Response Syndrome Following Percutaneous Nephrolithotomy.

To develop and validate a nomogram for predicting the occurrence of systemic inflammatory response syndrome (SIRS) following percutaneous nephrolithotomy (PCNL), aiming to enhance clinical decision-making and treatment planning. Clinical data of 1,047 patients undergoing PCNL at a single-center hospital between 2017 and 2023 were retrospectively analyzed. Independent risk factors influencing SIRS occurrence were identified through multi-variable logistic regression analysis, and a predictive model was constructed.

Siwu decoction mitigates radiation-induced immune senescence by attenuating hematopoietic damage.

Background: To investigate the long term effects of ionizing radiation (IR) on hematopoietic stem/progenitor cells (HSPCs), immune tissues and cells, and the effects of Siwu decoction (SWD) on immune senescence mice.

Methods: C57BL/6 J mice were exposed to 6.0 Gy Co γ irradiation.

Gut Microbiota's role in lipoma development: evidence from mendelian randomization.

Background: Lipoma, a benign tumor derived from mesenchymal tissue, significantly affects patients' physical and psychological wellbeing. Increasing evidence points to a strong link between the gut microbiome (GM) and lipoma incidence. This study utilizes Mendelian Randomization (MR) to assess the potential causal relationships between the GM and lipoma development.

A longitudinal study on the impact of perceived stress on academic engagement among deaf college students: the moderating effect of positive emotions.

Introduction: This longitudinal study sought to examine the dynamic influence of perceived stress on academic engagement among deaf college students, as well as assess the moderating role of positive emotions in this relationship. Given the unique challenges faced by deaf students in educational environments, understanding these dynamics becomes crucial for developing effective support strategies.

Methods: Across a seven-month period, encompassing two semesters, 223 deaf college students were evaluated three times using the Perceived Stress Questionnaire, the Academic Engagement Questionnaire, and the Positive Emotions Questionnaire.

Lactobacillus johnsonii GLJ001 prevents DSS-induced colitis in mice by inhibiting M1 macrophage polarization via gut microbiota-SCFAs axis.

Inflammatory Bowel Disease (IBD) is increasing worldwide and has become a global emergent disease. Probiotics have been reported to be effective in relieving colitis. Previous studies found ripened Pu-erh tea (RPT) promoted gut microbiota resilience against dextran sulfate sodium (DSS)-induced colitis in mice by increasing relative abundance of Lactobacillus.

ROC-guided virtual screening, molecular dynamics simulation, and bioactivity validation assessment Z195914464 as a 3CL Mpro inhibitor.

Discovering novel class anti-SARS-CoV-2 compounds with novel backbones is essential for preventing and controlling SARS-CoV-2 transmission, which poses a substantial threat to the health and social sustainable development of the global population because of its high pathogenicity and high transmissibility. Although the potential mutation of SARS-CoV-2 might diminish the therapeutic efficacy of drugs, 3CL Mpro is the target highly conservative in contrast with other targets. It is an essential enzyme for coronavirus replication.

Mechanism of atorvastatin in treating hepatocellular carcinoma: a study based on network pharmacology, molecular docking, and bioinformatics analysis.

Hepatocellular carcinoma (HCC) is a tumor with high morbidity and mortality. Current research suggests that statins may aid in its prevention and treatment, while studies on the associated mechanisms remain limited. Therefore, we aim to reveal the mechanism of atorvastatin treatment for HCC by using network pharmacology and bioinformatics methods.

Probing Different Lengths of the Tertiary Amine Head Group on Triglyceride-Mimetic Ionizable Lipid-Mediated siRNA Delivery.

Lipid nanoparticles (LNPs) have been utilized to deliver small interfering RNA (siRNA) to treat acute liver injury. However, LNPs exhibit suboptimal lysosomal escape capabilities and biodegradability. To address these limitations, we have designed triglyceride-mimetic ionizable lipids by conjugating ,-dimethyl tertiary amine head groups to the sn-2 position of triglyceride (TG) through ester bonds.

Transcriptomics integrated with targeted metabolomics reveals endogenous hormone changes in tuberous root expansion of Pueraria.

Background: Pueraria is a widely cultivated medicinal and edible homologous plant in Asia, and its tuberous roots are commonly used in the food, nutraceutical, and pharmaceutical industries. "Gange No. 5" is a local variety of Pueraria montana var.

[Clinical efficacy observation of heat-sensitive moxibustion combined with intrapleural perfusion of cisplatin in treatment of malignant pleural effusion].

Objectives: To investigate the clinical efficacy of heat-sensitive moxibustion combined with intrapleural perfusion of cisplatin in comparison with simple intrapleural perfusion of cisplatin on malignant pleural effusion (MPE).

Methods: Forty patients with MPE, in compliance with the inclusion criteria, were randomly divided into an observation group (20 cases) and a control group (20 cases). In the control group, cisplatin solution (60 mg/m) was injected into the thoracic cavity after pleural drainage under B-ultrasound positioning, once a week for 4 weeks.

Research Hotspots and Trends in Global Cancer immunometabolism:A Bibliometric Analysis from 2000 to 2023.

Background: Cancer poses a major global health challenge, and immunotherapy, known as the third revolution in cancer treatment, has brought new hope to patients. The emerging field of immunometabolism has further enhanced the safety and efficacy of immunotherapy. Over the past two decades, this field has rapidly evolved in oncology, leading to numerous significant findings.