Prolonged tamoxifen treatment induces iron deposition and ferroptosis in the liver.

Tamoxifen is an inhibitor of estrogen receptors and was originally developed for breast cancer therapy. Besides, tamoxifen is widely used for Cre-estrogen receptor-mediated conditional knockout in transgenic mice. However, we found that the 3-month feeding of 0.

The Effect of Molten Salt Composition on Carbon Structure: Preparation of High Value-Added Nano-Carbon Materials by Electrolysis of Carbon Dioxide.

The electrochemical conversion of CO into high value-added carbon materials by molten salt electrolysis offers a promising solution for reducing carbon dioxide emissions. This study focuses on investigating the influence of molten salt composition on the structure of CO direct electroreduction carbon products in chloride molten salt systems. Using CaO as a CO absorber, the adsorption principle of CO in LiCl-CaCl, LiCl-CaCl-NaCl and LiCl-CaCl-KCl molten salts was discussed, and the reasons for the different morphologies and structures of carbon products were analyzed, and it was found that the electrolytic efficiency of the whole process exceeded 85%.

A Three-Component Reaction of Alkenyl Thianthrenium Salts, Cyclopropanols and Sulfur Dioxide.

A three-component reaction of alkenyl thianthrenium salts, cyclopropan-1-ols and DABCO·(SO) under catalyst- and additive-free conditions, is accomplished. This sulfonylation with the insertion of sulfur dioxide works efficiently under very mild conditions, leading to a wide range of 1-substituted vinyl sulfones in moderate to good yields. In this protocol, the scope generality of alkenyl thianthrenium salts and cyclopropyl alcohols is demonstrated.

Photocatalytic CO reduction of Ag/AgS/TiCT heterojunctions with enhanced interfacial charge transfer.

Photocatalytic reduction of CO to produce organic fuels is a promising strategy for addressing carbon reduction and energy scarcity. Transition metal carbides (TiCT ) are of particular interest due to their unique layered structures and excellent electrical conductivity. However, the practical application of TiCT is limited by the poor separation efficiency of photogenerated charge carriers and the low migration ability of photogenerated electrons.

MScanFit and StairFit Motor Unit Number Estimation of the Extensor Digitorum Brevis and Abductor Digiti Minimi Muscles.

Introduction/aims: MScanFit and StairFit are two motor unit number estimation (MUNE) methods derived from a compound muscle action potential (CMAP) scan. This study aims to compare MScanFit and StairFit MUNE values by applying both methods to the same muscles.

Methods: CMAP scans were recorded from the extensor digitorum brevis (EDB) and abductor digiti minimi (ADM) muscles.

Dabie bandavirus and Mycoplasma pneumoniae co-infection: a case report.

Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by Dabie bandavirus (DBV). We report a case of DBV and Mycoplasma pneumoniae (MP) co-infection.

Case Presentation: Here we reported a 57-year-old healthy male who was admitted with the presentations of fever, cough, hemoptysis, and hypotension.

Endoscopic retrograde cholangiopancreatography combined with extracorporeal shock wave lithotripsy for the removal of large gallbladder stones: a pilot study.

Background: Endoscopic gallbladder-preserving cholecystolithotomy (EGPC) has become an alternative option for treating cholecystolithiasis. However, developing a new method of EGPC in which the gallbladder wall is not damaged remains a challenge. This study introduced a new EGPC method called endoscopic retrograde cholangiopancreatography (ERCP) combined with extracorporeal shock wave lithotripsy (ESWL), which preserves the integrity of the gallbladder wall in the treatment of cholecystolithiasis complicated with choledocholithiasis.

Network pharmacology uncovers that secoisolariciresinol diglucoside ameliorate premature ovarian insufficiency via PI3K/Akt pathway.

As one of the essential lignan derivative found in traditional Chinese medicinal herbs, secoisolariciresinol diglucoside (SDG) was proved to promote women's health through its phytoestrogenic properties. Increasingly studies indicated that this compound could be a potential drug capable of preventing estrogen-related diseases. Here, we aimed to investigate whether SDG can counteract cyclophosphamide (CTX) induced premature ovarian insufficiency (POI) and further explore its specific molecular mechanism.

Gaps in knowledge and management of iron deficiency in heart failure: a nationwide survey of cardiologists in China.

Background: Heart failure (HF) guidelines recommend routine testing for iron deficiency (ID) and, for those with ID, intravenous iron if the left ventricular ejection fraction is <50%. Guideline adherence to these recommendations by cardiologists in China is unknown.

Methods And Results: An independent academic web-based survey was designed and distributed via social networks to cardiologists across China.

Design and evaluation of a multi-responsive dual-modality bone-targeted drug delivery vehicle for the treatment of osteosarcoma.

The combination of chemotherapy and photothermal therapy not only improves the therapeutic effect but also limits the side effects of drugs. Herein, a multi-responsive dual-modality bone-targeted drug delivery vehicle for the treatment of osteosarcoma was designed by utilizing alendronate sodium as a bone-targeting ligand for the targeted delivery of doxorubicin (DOX) loaded polydopamine nanoparticles (PDA NPs) coated with γ-polyglutamic acid (APC@PDA/DOX NPs). The average size of spherical NPs was 140.

Fungi, immunosenescence and cancer.

Fungal microbes are a small but immunoreactive component of the human microbiome, which may influence cancer development, progression and therapeutic response. Immunosenescence is a process of immune dysfunction that occurs with aging, including lymphoid organ remodeling, contributing to alterations in the immune system in the elderly, which plays a critical role in many aspects of cancer. There is evidence for the interactions between fungi and immunosenescence in potentially regulating cancer progression and remodeling the tumor microenvironment (TME).

Geographical origins of Angelica sinensis using functional compounds and multielement with machine learning-based fusion approaches.

Ensuring food traceability is essential for maintaining safety and authenticity. Angelica sinensis (Oliv.) Diels (AS), a medicinal food prized for its rich nutritional value and tonic effects, is frequently vulnerable to geographic origin fraud.

ZDHHC3-LYPLA1 regulates PRRSV-2 replication through reversible palmitoylation.

Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly contagious swine pathogen, causing respiratory problems in piglets and reproductive failure in sows. Palmitoylation, catalyzed by zinc finger Asp-His-His-Cys (ZDHHC) domain-containing palmitoyl acyltransferases, plays intricate roles in virus infection. However, whether palmitoylation regulates PRRSV replication is incompletely understood.

Catalytic Assembly of Peptides Mediated by Complex Coacervates.

The assembly of peptides is generally mediated by liquid-liquid phase separation, which enables control over assembly kinetics, final structure, and functions of peptide-based supramolecular materials. Modulating phase separation can alter the assembly kinetics of peptides by changing solvents or introducing external fields. Herein, we demonstrate that the assembly of peptides can be effectively catalyzed by complex coacervates.

Application and Mechanism of Action of a Ketogenic Diet in Antiepileptic Therapy.

Epilepsy is a chronic neurological disorder caused by abnormal discharges of neurons in the brain, which seriously affects the quality of life of patients. Although there are various drug treatments available, many epilepsy patients still experience seizures with the effect of drugs and develop refractory epilepsy. The ketogenic diet can treat drug-refractory epilepsy by regulating the body's metabolism and can enhance the quality of life by improving their cognition, behavior, and sleep quality.

Synthesis and Application of a Novel Multifunctional Nanoprodrug for Synergistic Chemotherapy and Phototherapy with Hydrogen Sulfide Gas.

With the dilemma of limited efficacy of individual therapies, it is crucial to develop innovative combination therapy systems to target the complex pathogenesis of cancer. In this study, we designed a nanoprodrug ISL@MIL-101-ADT to facilitate synergistic delivery of hydrogen sulfide (HS) and prodrug ISL for specific eradication of tumor cells with minimal toxicity and maximal efficacy. The nanoprodrug passively targeted tumors through enhanced permeation and retention effects, followed by disintegration and release of IR780, lonidamine (LND), and HS.

Utility of T2-weighted MRI and contrast-enhanced MRA in locating the fistula level of spinal arteriovenous fistula.

Objective: To investigate the value of routine T2-weighted magnetic resonance imaging (MRI) and contrast-enhanced magnetic resonance angiography (CE-MRA) sequences in locating the fistula level of spinal arteriovenous fistula (SAVF).

Methods: Retrospectively analyzed the radiological findings of patients with SAVF diagnosed by surgery from May 2018 to September 2024. All patients completed spinal CE-MRA and routine T2-weighted MRI.

Association Between Cesarean Scar and Pelvic Floor Muscle Tone at 6-8 Weeks Postpartum.

Introduction And Hypothesis: The relationship between cesarean section scars and active pelvic floor muscle tone lacks sufficient evidence. This study is aimed at investigating the relationship between the severity of cesarean section scars and active pelvic floor muscle tone in postpartum women.

Methods: We conducted a prospective cross-sectional study of 604 women at 6-8 weeks postpartum.

Prognostic and therapeutic implications of measurable residual disease levels during remission induction of childhood ALL.

We evaluated the prognostic and therapeutic significance of measurable residual disease (MRD) during remission induction in pediatric acute lymphoblastic leukemia (ALL) patients. In the CCCG-ALL-2015 protocol, 7640 patients were categorized into low-, intermediate-, or high-risk groups based on clinical and genetic features. Final risk classification was determined by MRD assessed via flow cytometry on Days 19 and 46 of remission induction, with additional intensified chemotherapy for Day 19 MRD ≥1%.

Exploring vimentin's role in breast cancer via PICK1 alternative polyadenylation and the miR-615-3p-PICK1 interaction.

Breast cancer continues to be a major health issue for women worldwide, with vimentin (VIM) identified as a crucial factor in its progression due to its role in cell migration and the epithelial-to-mesenchymal transition (EMT). This study focuses on elucidating VIM's regulatory mechanisms on the miR-615-3p/PICK1 axis. Utilizing the 4T1 breast cancer cell model, we first used RNA-seq and proteomics to investigate the changes in the APA of PICK1 following VIM knockout (KO).

Fibroblasts in heterotopic ossification: mechanisms and therapeutic targets.

Heterotopic ossification (HO) refers to the abnormal formation of bone in non-skeletal tissues. Fibroblasts have traditionally been viewed as stationary cells primarily responsible for producing extracellular matrix during tissue repair and fibrosis. However, recent discoveries regarding their plasticity-encompassing roles in inflammation, extracellular matrix remodeling, and osteogenesis-highlight their potential as key contributors to the development of HO.

A HTO-Type Nonlinear Optical Fluorophosphate with Ultrawide Bandgap.

Compounds having hexagonal tungsten oxides (HTO) topology are of intense research interests owing to their potential functional properties, such as nonlinear optical (NLO) performances. However, most of the reported HTO-type compounds exhibit narrow optical bandgaps because of the d-d electronic transition of compositional d transition metals and lone pair electrons effect of Se/Te, which hinder their applications in the high-energy field, such as deep-ultraviolet (deep-UV) region. In this work, a new fluorophosphate, (NH)[ScF(PO)](POF) exhibiting HTO-topological structures is reported.

[Association between gene polymorphism and the effects of high-intensity interval training on body composition].

This study aimed to analyze the impact of single nucleotide polymorphism (SNP) of (encoding adenylate cyclase 3) on the outcome of high-intensity interval training (HIIT) on body composition and screen genetic markers sensitive to HIIT in Chinese Han youth. A total of 237 non-regular exercise Han college students were recruited in a 12-week HIIT program, attending sessions 3 times a week. Before and after the HIIT program, their body composition was measured.

Impact of Boron Nitride on the Thermoelectric Properties and Service Stability of CuSe.

Improving the thermoelectric performance and service stability is essential for the effective use of cuprous selenide (CuSe). In this study, hexagonal boron nitride (h-BN) was incorporated into nano-CuSe, with the goal of enhancing thermoelectric performance and service stability. It was found that CuSe-0.