Efficacy and safety of repetitive transcranial magnetic stimulation with different frequencies on neuropathic orofacial pain: a systematic literature review and meta-analysis.

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive technique used to treat neuropathic orofacial pain (NOP). This study aimed to evaluate the efficacy and safety of rTMS in managing NOP and reducing health risks. A comprehensive literature search was conducted in various databases, including PubMed, Physiotherapy Evidence Database (PEDro), the Cochrane Library, Web of Science, Embase and Clinical Trials.

Degraded products generated by iron stent inhibit the vascular smooth muscle cell proliferation by downregulating AP-1.

In-stent restenosis (ISR) following interventional therapy is a fatal clinical complication. Current evidence indicates that neointimal hyperplasia driven by uncontrolled proliferation of vascular smooth muscle cells (VSMC) is a major cause of restenosis. This implies that inhibiting VSMC proliferation may be an attractive approach for preventing in-stent restenosis.

Lipid metabolism and microbial regulation analyses provide insights into the energy-saving strategies of hibernating snakes.

Hibernation is a necessary means for animals to maintain survival while coping with low temperatures and food shortages. While most studies have largely focused on mammalian hibernation, its reptilian equivalent has been less studied. In order to provide insights into the energy metabolism and potential microbial regulatory mechanisms in hibernating snakes, the serum, liver, gut content samples were measured by multi-omic methods.

Medium entropy-derived flower-like FeCeCu nanozyme with excellent oxidase-like activity for on-site and visual detection of carbosulfan.

Background: Carbosulfan residues in environment is very harmful to human health. The rapid and high sensitive detection of carbosulfan residues is particularly important to guarantee human health and safety. The conventional chromatographic techniques and enzyme inhibition strategies cannot realize on-site and visual detection of carbosulfan.

Reducing radiation-induced hypothyroidism by modified delineation of cervical lymphatic drainage area for nasopharyngeal carcinoma treated by intensity-modulated radiation Therapy: 3 years' experience.

Background And Purpose: Radiation-induced hypothyroidism (RIHT) is a late complication of intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma (NPC). We evaluated thyroid protection in NPC patients receiving IMRT using modified delineation (MD) of cervical lymphatic drainage areas, sparing the common carotid artery within the clinical target volume (CTV), to assess its impact on thyroid function and survival outcomes.

Materials And Methods: This retrospective cohort study included patients without metastatic lymph nodes at levels III and IV who received neck irradiation.

Smilax china L. polyphenols inhibit LPS-induced macrophage M1 polarization to alleviate inflammation through NF-κB signaling pathway in vitro and in vivo.

Ethnopharmacological Relevance: As an important component of the cell wall of Gram-negative bacteria, lipopolysaccharide (LPS) is an important inducer of inflammation in humans. Smilax china L. is known for its diverse bioactive functions, particularly its anti-inflammatory effects.

Characterization of Choerospondias axillaris polysaccharide‑iron (III) complex and its effect on iron deficiency anemia mice.

Iron deficiency anemia (IDA) is a prevalent nutritional deficiency problem. This study aimed to investigate the characteristics of Choerospondias axillaris polysaccharide-Fe (III) complex and its effect on IDA mice. CAP-Fe (III) complex was synthesized by co-thermal synthesis method with an iron content of 27.

Sovleplenib in patients with primary or secondary warm autoimmune haemolytic anaemia: results from phase 2 of a randomised, double-blind, placebo-controlled, phase 2/3 study.

Background: Spleen tyrosine kinase inhibitors are potential treatment options for warm autoimmune haemolytic anaemia. This study aimed to assess the preliminary efficacy and safety of sovleplenib-an oral spleen tyrosine kinase inhibitor-in patients with warm autoimmune haemolytic anaemia in China. Here we report on the phase 2 results.

VPT: Video portraits transformer for realistic talking face generation.

Talking face generation is a promising approach within various domains, such as digital assistants, video editing, and virtual video conferences. Previous works with audio-driven talking faces focused primarily on the synchronization between audio and video. However, existing methods still have certain limitations in synthesizing photo-realistic video with high identity preservation, audiovisual synchronization, and facial details like blink movements.

Determination of five alternaria toxins in peppermint by dispersive solid-phase extraction coupled with ultra-high performance liquid chromatography-tandem mass spectrometry based on MOF-808-TFA.

An efficient and rapid ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MSMS) method was developed for simultaneous determination of 5 alternaria toxins (ATs) in edible and medicinal plant - peppermint using MOF-808-trifluoroacetic acid (MOF-808-TFA) as the adsorbent. Characterization methods such as scanning electron microscopy (SEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and N adsorption-desorption demonstrated that the synthesized MOF-808-TFA had a regular ortho-octahedral configuration and high specific surface area. Under the optimal conditions, the 5 ATs showed good linearity (R ≥ 0.

Clinical and molecular analysis of ESBL, carbapenemase, and colistin-resistant bacteria in UTI patients.

Uropathogens, particularly bacteria, can infect any part of the urinary tract and cause bacteriuria. Our study aimed to examine the antibiotic-resistant profile, associated risk factors, and phenotypic and genotypic features of ESBL, carbapenemase, and mcr resistance genes in multidrug-resistant bacteria. Samples were inoculated on culture media, identified using standard biochemical tests, and species confirmation was performed via 16S rRNA gene amplification.

Effects of continuous positive airway pressure treatment on arterial stiffness and inflammatory factors in patients with coronary heart disease complicated with obstructive sleep apnea.

Background: Continuous Positive Airway Pressure (CPAP) treatment brings more benefits than risks to most coronary heart disease (CHD) patients with obstructive sleep apnea (OSA). However, the pathophysiological mechanism by which CPAP treatment improves the prognosis of patients with CHD and OSA remains unclear. The purpose of this study was to clarify whether CPAP can improve arterial stiffness and inflammatory factor levels in CHD patients with OSA, and to further improve prognosis.

Surrogate-assisted global and distributed local collaborative optimization algorithm for expensive constrained optimization problems.

This paper presents a surrogate-assisted global and distributed local collaborative optimization (SGDLCO) algorithm for expensive constrained optimization problems where two surrogate optimization phases are executed collaboratively at each generation. As the complexity of optimization problems and the cost of solutions increase in practical applications, how to efficiently solve expensive constrained optimization problems with limited computational resources has become an important area of research. Traditional optimization algorithms often struggle to balance the efficiency of global and local searches, especially when dealing with high-dimensional and complex constraint conditions.

Adsorption-desorption of propyrisulfuron in six typical agricultural soils of China: Kinetics, thermodynamics, influence of 38 environmental factors and its mechanisms.

Propyrisulfuron, a novel sulfonylurea herbicide, effectively suppresses intracellular acetolactate synthase activity for weed control, but its adsorption behavior in the soil environment remains unclear. To assess potential agroecosystem risks, the adsorption-desorption behavior and mechanism of propyrisulfuron in six typical agricultural soils of China were investigated using a batch equilibrium method, Density Functional Theory (DFT), Fourier Transform Infrared Spectroscopy (FTIR), and Scanning Electron Microscopy equipped with Energy Dispersive X-ray (SEM-EDX) techniques. It is indicated that the adsorption-desorption of propyrisulfuron in six soils reached equilibrium at 36 h under the optimum water-to-soil ratio (WSr) of 5:1.

Potential role of TRAF2 in pulmonary hypertension in broiler chickens and preparation and specificity analysis of its polyclonal antibody.

Due to the lack of specific antibody anti-chicken tumor necrosis factor receptor-associated factor 2 (TRAF2), it is difficult to further explore the role of TRAF2 in pulmonary artery remodeling in pulmonary hypertension(PH) in broilers. In this experiment, we prepared a polyclonal antibody to TRAF2 by constructing a TRAF2 recombinant protein prokaryotic expression vector and analyzed the expression of TRAF2 in in vivo and in vitro models of pulmonary hypertension in broiler chickens and the effect of TRAF2 on the activity and apoptosis of PASMCs. The results showed that after immunization with TRAF2 recombinant protein we obtained high titers of polyclonal antibodies, and astragalus polysaccharide as an immune adjuvant could enhance the effect of immunization.

The advancement of targeted regulation of hepatic stellate cells using traditional Chinese medicine for the treatment of liver fibrosis.

Ethnopharmacological Relevance: Liver fibrosis, which is a precursor to cirrhosis in chronic liver diseases, is driven by various factors. The activation and proliferation of hepatic stellate cells (HSCs) are recognized as a crucial phase in the progression of liver fibrosis. Compared with western drug therapy, Traditional Chinese medicine (TCM) and herbal medicine not only have the advantages of multi-target and multi-pathways in the treatment of liver fibrosis, but also have high safety without toxic side effects.

CRISPR detection of cardiac tumor-associated microRNAs.

As multiple imaging modalities cannot reliably diagnose cardiac tumors, the molecular approach offers alternative ways to detect rare ones. One such molecular approach is CRISPR-based diagnostics (CRISPR-Dx). CRISPR-Dx enables visual readout, portable diagnostics, and rapid and multiplex detection of nucleic acids such as microRNA (miRNA).

A Wenzel Interfaces Design for Homogeneous Solute Distribution Obtains Efficient and Stable Perovskite Solar Cells.

The coffee-ring effect, caused by uneven deposition of colloidal particles in perovskite precursor solutions, leads to poor uniformity in perovskite films prepared through large-area printing. In this work, the surface of SnO is roughened to construct a Wenzel model, successfully achieving a super-hydrophilic interface. This modification significantly accelerates the spreading of the perovskite precursor solution, reducing the response delay time of perovskite colloidal particles during the printing process.

Bird Species Detection Net: Bird Species Detection Based on the Extraction of Local Details and Global Information Using a Dual-Feature Mixer.

Bird species detection is critical for applications such as the analysis of bird population dynamics and species diversity. However, this task remains challenging due to local structural similarities and class imbalances among bird species. Currently, most deep learning algorithms focus on designing local feature extraction modules while ignoring the importance of global information.

Hierarchical Optimization Segmentation and Parameter Extraction of Street Trees Based on Topology Checking and Boundary Analysis from LiDAR Point Clouds.

Roadside tree segmentation and parameter extraction play an essential role in completing the virtual simulation of road scenes. Point cloud data of roadside trees collected by LiDAR provide important data support for achieving assisted autonomous driving. Due to the interference from trees and other ground objects in street scenes caused by mobile laser scanning, there may be a small number of missing points in the roadside tree point cloud, which makes it familiar for under-segmentation and over-segmentation phenomena to occur in the roadside tree segmentation process.

Synergistic Synbiotic-Containing and Fructo-Oligosaccharide Alleviate the Allergenicity of Mice Induced by Soy Protein.

Prebiotics and probiotics have key roles in the intervention and treatment of food allergies. This study assesses the effect of synergistic fructo-oligosaccharide (Lp-FOS) intervention using an allergic mouse model induced by soy protein. The results showed that Lp synergistic FOS significantly decreased clinical allergy scores, inhibited specific antibodies (IgE, IgG, and IgG1), IL-4, IL-6, and IL-17A levels, and increased IFN-γ and IL-10 levels.

Xenia Effect on Nutritional and Flavor Components of 'Jingbaili' Pear.

The 'Jingbaili' pear is a national geographical indication product of China, featuring an oblate shape and being rich in nutrients. But the quality of the 'Jingbaili' pear is unstable. Xenia can cause changes in the quality of pears, but the effect of xenia on the 'Jingbaili' pear is unknown, and its mechanism is still unclear.

Interfacial Properties and Structure of Emulsions and Foams Co-Stabilized by Span Emulsifiers of Varying Carbon Chain Lengths and Egg Yolk Granules.

Interfacial properties significantly influence emulsifying and foaming stability. We here explore the interfacial behavior of egg yolk granules (EYGs) combined with various Span emulsifiers (Span 20, 40, 60, 80) to assess their solution properties, interface dynamics, and effects on emulsifying and foaming stability. The results unveiled that as the Span concentration increased, particle size decreased from 7028 to 1200 nm, absolute zeta potential increased from 4.

The Impact of Cooking on Antioxidant and Enzyme Activities in Ruichang Yam Polyphenols.

In this study, the total polyphenol content (TPC), total flavonoid content (TFC), and biological activity of yam polyphenols (including free phenolics, conjugated phenolics, and bound phenolics) were investigated during home cooking. Polyphenol components were preliminary detected in raw yam by HPLC, including 2, 4-dihydroxybenzoic acid, syringic acid, vanillic acid, 4-coumaric acid, and sinapic acid. TPC and TFC of soluble conjugated polyphenols were the main phenolic compounds in Ruichang yam.