Effect of integrated control intervention on soil-transmitted helminth infections in Jiangxi province in southeast China.

Soil transmitted helminths (STHs) burden was enormous in China several decades ago, however, rigorous control efforts have been successful with appreciable reduction in diseases burden. Here, we assessed provincial-level data derived from cross sectional surveys, executed in 1989, 2002 and 2014, on the prevalence of STHs among populations in Jiangxi province, China. This study, also, reported STHs integrated control intervention aimed at reducing STHs transmission and worm burden among population at county-level.

Distribution pattern of the snail intermediate host of schistosomiasis japonica in the Poyang Lake region of China.

Background: With the closure of the Three Gorges Dam in 2003 the hydrology of Poyang Lake was altered dramatically leading to significant changes in the environment. In order to assess the impact on schistosomiasis this study assessed the spatial and temporal patterns of the snail intermediate host, Oncomelania hupensis in the Poyang Lake tributaries. The results of the study have important implications for future snail control strategies leading to disease elimination.

Evaluation of Prospective HLA-B*13:01 Screening to Prevent Dapsone Hypersensitivity Syndrome in Patients With Leprosy.

Importance: Dapsone hypersensitivity syndrome (DHS) is the most serious adverse reaction associated with dapsone administration and one of the major causes of death in patients with leprosy, whose standard treatment includes multidrug therapy (MDT) with dapsone, rifampicin, and clofazimine. Although the HLA-B*13:01 polymorphism has been identified as the genetic determinant of DHS in the Chinese population, no studies to date have been done to evaluate whether prospective HLA-B*13:01 screening could prevent DHS by identifying patients who should not receive dapsone.

Objective: To evaluate the clinical use of prospective HLA-B*13:01 screening for reduction of the incidence of DHS by excluding dapsone from the treatment for patients with HLA-B*13:01-positive leprosy.

[Challenges and countermeasures of schistosomiasis elimination in Jiangxi Province].

Jiangxi Province was once one of schistosomiasis heavy endemic provinces in China. Thanks for more than 60 years' unremitting effort, great achievements have been obtained in schistosomiasis control in this province. This paper reviews the control history of schistosomiasis, and demonstrates the current epidemic situation of the disease in Jiangxi Province, and its contribution to national schistosomiasis control achievements.

[Experience and insights of schistosomiasis elimination in Yujiang County of Jiangxi Province-Commemoration of the 60th anniversary of publishing Chairman Mao Zedong's two poems"Farewell to the God of Plague"].

Schistosomiasis is one of the major infectious diseases that seriously endanger the health of people, and social and economic development. Before the year of 1949, Yujiang County of Jiangxi Province was one of hyper-endemic regions for schistosomiasis. After the founding of the People's Republic of China, under the leadership and high attention of the Chinese Communist Party and the government, after the arduous struggle with schistosomiasis, Yujiang County became the first county that reached the standard of eradication of schistosomiasis in 1958.

[Study on distribution status of , the intermediate host of in Jiangxi Province Ⅱ Spatial-temporal distribution of snail-infested environments].

Objective: To grasp the status of snail-infested environments in schistosomiasis endemic areas of Jiangxi Province, and establish the spatial database of snail-infested environments with the administrative village as the unit.

Methods: The spatial and temporal distributions of the historical snail environments, existing snail environments, and suspicious snail-infested environments were analyzed by the historical data review and field investigations.

Results: The distribution of snail-infested environments in Jiangxi Province included two popular types of lakeshore and hills.

[Analysis of schistosomiasis prevention and control model of Yujiang: in-sights from governmental supply of rural public goods].

This article analyzes the influencing factors of rural public service supply of schistosomiasis prevention and control in China and the successful experiences of schistosomiasis prevention and pattern of Yujiang from an angle of view of rural public goods. This article points out the short supply of rural public goods in the service of schistosomiasis prevention and control in the traditional small-scale peasant economy, and the possibility of promoting the rural public goods in the cooperation economic model. The essential features of the schistosomiasis prevention and control pattern of Yujiang include strengthening the leadship of the Communist Party of China, improving health education, adjusting the measures to local condition, and so on.

[Challenges and strategies of health education and health promotion in stage of schistosomiasis elimination].

Health education and health promotion are important measures for comprehensive control of schistosomiasis in China, which can improve the compliance rate of residents involved in schistosomiasis control activities, reduce the water contact behavior of the target population, thus avoiding or decreasing the infection of schistosome in endemic areas. In recent years, the comprehensive control of schistosomiasis in China has achieved remarkable results. China has reached the goal of transmission control and is moving toward the transmission interruption or even elimination of schistosomiasis.

[Establishment of response system to emergency parasitic disease affairs in China].

China's prevention and control of parasitic diseases has made remarkable achievements. However, the prevalence and transmission of parasitic diseases is impacted by the complicated natural and social factors of environment, natural disasters, population movements, and so on. Therefore, there are still the risks of the outbreak of emergency parasitic diseases affairs, which may affect the control effectiveness of parasitic diseases and endanger the social stability seriously.

[Clinical features of 14 cases of cerebral schistosomiasis in Jiangxi Province].

Objective: To discuss the clinical features of cerebral schistosomiasis.

Methods: The clinical data of fourteen patients with cerebral schistosomiasis from March 2010 to March 2016 were collected and analyzed retrospectively.

Results: The schistosomiasis immunological tests of sera and cerebrospinal fluids from the fourteen patients were all positive.

[Role of new strategy in transmission control of schistosomiasis in Poyang Lake region].

Objective: To evaluate the role of new strategy in the transmission control of schistosomiasis in Poyang Lake region.

Methods: The information and epidemic data of schistosomiasis control were collected and analyzed in Poyang Lake region from 2005 to 2016.

Results: After eleven years of carrying out the new strategy, thirteen counties achieved the objective of transmission control in Poyang Lake region.

A cross-sectional survey comparing a free treatment program for advanced schistosomiasis japonica to a general assistance program.

The prevalence and intensity of schistosomiasis has dropped dramatically in China due to an effective integrated control program. However, advanced schistosomiasis is becoming a key challenge on the road to elimination. The aims of this study were to compare the disease condition between advanced cases under the general assistance program (GAP) and free treatment program (FTP) and to determine whether the FTP should be popularized to provide an objective reference for policymakers in China's advanced schistosomiasis control program.

Elevated serum antibody against Schistosoma japonicum HSP60 as a promising biomarker for liver pathology in schistosomiasis.

The pathology associated with Schistosoma japonicum (S. japonicum) infection in humans is attributed to parasite egg-induced granulomatous inflammation and fibrosis in the host liver. Currently, a marker that is reliable, cheap, less device-dependent, and can be easily and repeatedly used on a large scale to monitor the progression of liver pathology in schistosomiasis japonica endemic areas is lacking.

Lessons from a 15-year-old boy with advanced schistosomiasis japonica in China: a case report.

Schistosomiasis is a chronic, parasitic disease caused by flukes (trematodes) of the genus Schistosoma, which presents the most important global burden of the 17 neglected tropical diseases listed by the World Health Organization. China has made great achievements in schistosomiasis control, and now China is planning to move forward, to eliminate schistosomiasis within 2020, but the fact cannot be denied that the possibility of schistosome infection is still there in some endemic due to its zoonotic nature as well as wide distribution of its intermediate hosts (snails). Thus, how to interrupt the transmission in areas with distribution of schistosomes and intermediate snails becomes a very serious challenge that China is facing.

Plasma D-dimer Can Effectively Predict the Prospective Occurrence of Ascites in Advanced Schistosomiasis Japonica Patients.

China still has more than 30,000 patients of advanced schistosomiasis while new cases being reported consistently. D-dimer is a fibrin degradation product. As ascites being the dominating symptom in advanced schistosomiasis, the present study aimed to explore a prediction model of ascites with D-dimer and other clinical easy-achievable indicators.

[Study on cut-off value of IHA method for schistosomiasis diagnosis in different endemic areas].

Objective: To explore the cut-off value of the indirect haemagglutination test (IHA) method for schistosomiasis japonica diagnosis in different endemic areas.

Methods: Totally 55 nature villages of the lake-type endemic counties, Yugan and Xinzi, in Poyang Lake Region of Jiangxi Province were chosen as the study fields, and all the villagers over 5 years old were parallelly examined by Kato-Katz method + miracidial hatching test and IHA method. The detection data were analyzed by the correlation analysis, and the threshold values of the IHA method in different endemic areas were decided by the receiver operating characteristic (ROC) curve.

[Analysis of infective status of in Jiangxi Province].

Objective: To understand the current prevalence of clonorchiasis in Jiangxi Province.

Methods: A survey was performed according to the scheme of the 3rd Principal Human Parasites of Jiangxi Province. Based on the ecological regions, a stratified cluster sampling method was applied by the economic and geographic situation.

[Analysis of results of technique competition for parasitic disease diagnosis in Class A tertiary hospitals in Jiangxi Province, 2015].

Objective: To understand the capability of parasitic disease diagnosis among professionals from the clinic laboratory of Class A tertiary hospitals in Jiangxi Province.

Methods: The teams that took part in the competition were formed from 20 Class A tertiary hospitals, with 2 contestants per team. The competition contents included written examination and skill operation.

Assessment of the effect of treatment and assistance program on advanced patients with schistosomiasis japonica in China from 2009 to 2014.

Schistosomiasis is one of the most important zoonoses, threatening approximately 800 million people in 78 countries with a loss of 70 million disability-adjusted life years. Over the past six decades, China has made remarkable achievements in morbidity control, but disability and mortality control remains much to desire; thus, advanced schistosomiasis is a growing problem when on the road to schistosomiasis elimination. Since 2005, China has initiated a national treatment and assistance program to advanced patients, aiming to improve patients' symptoms and quality of life.