1 results match your criteria: "Jiangxi Headquater Hospital of Chinese People's Armed Police Forces[Affiliation]"
[Effects of nitric oxide synthase inhibitor on dentate gyrus neurogenesis after diffuse brain injury in adult rats].
Di Yi Jun Yi Da Xue Xue Bao
October 2003
Department of Neurosurgery, Jiangxi Headquater Hospital of Chinese People's Armed Police Forces, Nanchang 330001, China.
Objective: To investigate the effects of selective nitric oxide synthase (NOS) inhibitors on dentate gyrus (DG) neurogenesis after diffuse brain injury (DBI) in adult rats.
Methods: DBI models were established in adult male SD rats, followed by systemic bromodeoxyuridine (BrdU) labeling of the dividing cells and immunohistochemical assay of the proliferation rates of neural precursor cells in the DG for comparison between NOS inhibitor (7-nitroindazole and Aminoguanidine) groups and the corresponding control groups at various time points after DBI.
Results: Intraperitoneal administration of 7-nitroindazole significantly reduced the number of BrdU-labeled cells in the DG of adult rats 2, 4 and 6 d after DBI (P<0.