High piezoelectric property with exceptional stability in self-poled ferroelectric films.

Ferroelectric films are highly sought-after in micro-electro-mechanical systems, particularly with the trend towards miniaturization. However, their tendency to depolarize and degradation in piezoelectric properties when exposed to packaging procedures at temperatures exceeding 260 °C remains a significant challenge. Here, we reveal the prerequisites for self-poling and leverage these insights to achieve unprecedented macroscopic performance through a two-step approach involving texture construction and hierarchical heterogeneity engineering.

Fully endoscopic neurosurgery using a two-handed technique for cerebellopontine angle tumors via the retrosigmoid approach.

Background: Surgery for tumors in the cerebellopontine angle is always a significant challenge due to the densely packed neurovascular structures, the narrow deep location, and the complex relationship between the lesions and surrounding neurovascular structures. Recently, great attention has been given to the neuroendoscope for its exclusive advantages, which have added a new dimension to many classical microscopic surgeries. However, the feasibility and advisability of fully endoscopic neurosurgery for cerebellopontine angle tumors remain to be further evaluated.

Pan-cancer analysis shows that BCAP31 is a potential prognostic and immunotherapeutic biomarker for multiple cancer types.

Background: B-cell receptor-associated protein 31 (BCAP31) is a widely expressed transmembrane protein primarily located in the endoplasmic reticulum (ER), including the ER-mitochondria associated membranes. Emerging evidence suggests that BCAP31 may play a role in cancer development and progression, although its specific effects across different cancer types remain incompletely understood.

Methods: The raw data on BCAP31 expression in tumor and adjacent non-tumor (paracancerous) samples were obtained from the Broad Institute Cancer Cell Line Encyclopedia (CCLE) and UCSC databases.

Pentraxin 3 promotes microglial M2 polarization and excitatory synapse formation in the hippocampus in depression.

Depression is a prevalent mental illness that significantly impairs individuals' overall quality of life and physical well-being. However, the pathological mechanisms of depression remain unclear, and effective treatment strategies are urgently needed. Pentraxin 3 (PTX3), a long pentraxin protein, plays a significant role in various pathological conditions, including infections, immune responses, and tissue repair.

Recent developments, challenges, and prospects of dietary omega-3 PUFA-fortified foods: Focusing on their effects on cardiovascular diseases.

Dietary omega-3 polyunsaturated fatty acids (Dω-3 PUFAs) have been extensively studied and have been proven to offer notable benefits for heart health. Scientific meta-analysis strongly endorses them as potent bioactive agents capable of preventing and managing cardiovascular diseases (CVDs). Fortification of foods with Dω-3 PUFAs is a potential strategy for enhancing Dω-3 PUFA intake in an effort to continue strengthening public health outcomes.

Association between 25(OH) vitamin D and schizophrenia: shared genetic correlation, pleiotropy, and causality.

Background: This study delves into the complex interplay between genetics, 25-hydroxyvitamin D (25OHD), and schizophrenia (SCZ). It leverages extensive sample data derived from Genome-Wide Association Studies (GWAS) to uncover genetic correlations.

Methods: Employing Linkage Disequilibrium Score Regression (LDSC) and S-LDSC, this study investigates genetic connections between 25OHD and SCZ.

A two-sample Mendelian randomization study reveals the causal effects of statin medication on gut microbiota abundance in the European population.

Background: Observational studies have reported changes in gut microbiota abundance caused by long-term statin medication therapy. However, the causal relation between statin medication and gut microbiota subsets based on genetic variants remains unclear.

Methods: We used genome-wide association study (GWAS) data on statin medication from the FinnGen database and gut microbiota abundance GWAS data from the IEU OpenGWAS project.

Dry solidification of chloride salts and heavy metals in waste incineration fly ash by mayenite.

There are hazardous substances such as chloride salts and heavy metals in the municipal solid waste incineration fly ash (WIFA). During thermal treatment, the concentrated chlorides promote the volatilization of heavy metals, increasing the ecological risk. The water washing method is also employed as a pre-treatment for WIFA, but a substantial volume of wastewater with high chloride content is produced that poses challenges for effective treatment.

Geriatric Nutrition Risk Index is closely associated with sarcopenia and quality of life in gastric cancer patients: a cross-sectional study.

Impaired nutritional status is closely related to the development of sarcopenia and poor quality of life (QoL) in cancer patients. This study aimed to investigate the association of Geriatric Nutritional Risk Index (GNRI) with sarcopenia and QoL in patients with gastric cancer (GC). Sarcopenia was diagnosed based on the Asian Working Group for Sarcopenia 2019 criteria.

The comparison of the risk of neurological deterioration and clinical outcomes in different atherosclerotic stroke patterns.

This study aims to compare the incidences of neurological deterioration (ND) and poor outcome (a modified Ranking scale > 2 points at discharge) among patients with different atherosclerotic stroke patterns. A total of 688 participants were categorized into 4 groups according to atherosclerotic stroke pattern: multiple small infarcts (MSI), single subcortical infarction (SSI), borderzone infarct (BZI) and large infarct groups. Among the 4 groups, MSI group had the lowest incidences of ND and poor outcome (13.

Correlation between dietary calcium intake and eczema in American adult population.

Eczema is a common chronic skin condition. Previous studies indicated the dietary factors, such as calcium intake, might influence the onset and progression of eczema in the population of gravidas and infants. However, there was no studies on the correlation between dietary calcium and the adult population.

Hybrids of copper cysteamine nanosheets and silver nanocluster ensure superior bactericidal capability via enhanced photodynamic effect.

Over the past decades, bacterial infections resulting from the misuse of antibiotics have garnered significant attention. Among the alternative antibacterial strategies, photodynamic therapy (PDT) has emerged as a promising non-antibiotic approach. However, persistent bacterial biofilms, particularly those composed of gram-negative bacteria with their protective outer membranes, have exhibited remarkable resilience to PDT.

Development and assessment of a novel single-drive variable angle spraying machine.

Traditional sprayers are limited to applying spray mixture solely to the upper surfaces of crops. To overcome this limitation, a variable angle spraying machine (VASM) was designed using a linkage system. This machine enables the adjustment of both the spray position and angle through a single input signal, facilitating multi-directional spraying from the top to the bottom of crops.

Vi capsular polysaccharide of Salmonella enterica serovar Typhi disturbs autophagy to increase intracellular survival in macrophages.

The autophagy pathway plays a crucial role in resistance to bacterial infection in the host. Salmonella enterica serovar Typhi (S. Typhi), a human restricted pathogen, causes a systemic infection known as typhoid fever.

New insights into the relationship of mitochondrial metabolism and atherosclerosis.

Atherosclerotic cardiovascular and cerebrovascular diseases are the number one killer of human health. In view of the important role of mitochondria in the formation and evolution of atherosclerosis, our manuscript aims to comprehensively elaborate the relationship between mitochondria and the formation and evolution of atherosclerosis from the aspects of mitochondrial dynamics, mitochondria-organelle interaction (communication), mitochondria and cell death, mitochondria and vascular smooth muscle cell phenotypic switch, etc., which is combined with genome, transcriptome and proteome, in order to provide new ideas for the pathogenesis of atherosclerosis and the diagnosis and treatment of related diseases.

High-performance supercapacitors based on coarse nanofiber bundle and ordered network hydrogels.

Most of the developed flexible hydrogel supercapacitors struggle to maintain their electrochemical stability and structural integrity under tensile strain. Therefore, developing a flexible supercapacitor with excellent mechanical properties and stable electrochemical performance under different strains remains a challenge. Based on the previous cartilage-like structure, we designed a new coarse nanofiber bundle and ordered network.

Biofilm-modified Prussian blue improves memory function in late-stage Alzheimer's disease mice with triple therapy.

Alzheimer's disease (AD) is a neurodegenerative disease that is significantly characterized by cognitive and memory impairments, which worsen significantly with age. In the late stages of AD, metal ion disorders and an imbalance of reactive oxygen species (ROS) levels occur in the brain microenvironment, which causes abnormal aggregation of β-amyloid (Aβ), leading to a significant worsening of the AD symptoms. Therefore, we designed a composite nanomaterial of macrophage membranes-encapsulated Prussian blue nanoparticles (PB NPs/MM).

TiCT MXene nanoribbons@MnO: A novel multifunctional probe for colorimetric and fluorescence dual-response sensing of trichlorfon.

Manganese dioxide nanosheets (MnO NSs) have garnered significant attention in analytical sensing, while the majority of the previous reports suffer from a complex preparation process involving reducing agents, template or high-temperature. In this work, a novel MnO NSs decorated TiCT MXene nanoribbons (TiCTNR@MnO) composite was firstly assemblied via a facile one-step strategy and applied as a bi-signal generator to enable colorimetric and fluorescence (FL) dual-response sensing. During the assembly process, TiCTNR innovatively acted as both reductant and carrier to prevent the aggregation of MnO NSs.

Abnormalities in rich-club connections are associated with an exacerbation of genetic susceptibility to schizophrenia.

Background: Schizophrenia (SZ) is a highly heritable and heterogeneous disorder that is often associated with widespread structural brain abnormalities. However, the causes of interindividual differences in genetic susceptibility remain largely unknown. This study attempted to address this important issue by utilizing a prospective study in which unaffected first-degree relatives of SZ (FH+) were recruited.

Advancements in MRSA treatment: the role of berberine in enhancing antibiotic therapy.

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a significant public health problem. This study investigated the antimicrobial properties and mechanisms of berberine (BBR), a plant alkaloid, against MRSA, evaluating its potential to enhance antibiotic therapy.

Results: Berberine only demonstrated variable but significant inhibitory effects on 50 clinical MRSA strains.

Biomimetic intelligent nanoplatform with cascade amplification effect for tumor synergy therapy.

Tumor heterogeneity, immune-suppressive microenvironment and the precise killing of tumor cells by drugs are important factors affecting tumor treatment. In this study, we developed environment-responsive drug delivery system (FM@IQ/PST&ZIF-8/DOX) based on ZIF-8 for tumor photothermal/immunotherapy/chemotherapy synergistic therapy. The prepared FM@IQ/PST&ZIF-8/DOX nanoplatfrom not only has highly drug loading capacity for chemotherapeutic drug-doxorubicin, but also erythrocyte membrance modified on their surface can endow their immunity-escaping property and prolong their blood circulation time.

Impact of health information seeking behavior and digital health literacy on self-perceived health and depression symptoms among older adults in the United States.

Background: Understanding the impact of digital health literacy and health information-seeking behavior on the self-perceived health and depression symptoms of older adults is crucial, particularly as the number of older internet users is increasing.

Methods: This study utilized data from the Health Information National Trends Survey to examine the relationship between these factors and the health outcomes of adults aged 50 and above.

Results: The study found that digital health literacy has a positive but non-significant relationship with self-perceived health when other factors are considered.

Diabetes mediates the relationship between cardiometabolic index and kidney stones: a cross-sectional study.

Previous studies have shown that diabetes is one of the risk factors for kidney stone formation. The Cardiometabolic Index (CMI) is a composite index used to assess an individual's cardiovascular health and metabolic status. CMI has been associated with several metabolic diseases.

Nondestructive detection of pungent and numbing compounds in spicy hotpot seasoning with hyperspectral imaging and machine learning.

The levels of capsaicin (CAP) and hydroxy-α-sanshool (α-SOH) are crucial for evaluating the spiciness and numbing sensation in spicy hotpot seasoning. Although liquid chromatography can accurately measure these compounds, the method is invasive. This study aimed to utilize hyperspectral imaging (HSI) combined with machine learning for the nondestructive detection of CAP and α-SOH in hotpot seasoning.