Quantitative Trait Loci Mappings for the Sulfur Utilization Efficiency-Related Traits at the Seedling Stage of Wheat.

Background: Sulfur (S) is a vital element for the normal growth and development of plants, performing crucial biological functions in various life processes.

Methods: This study investigated thirteen S utilization efficiency (SUE)-related traits at the seedling stage of wheat using a recombinant inbred line (RIL) population. The quantitative trait loci (QTLs) were mapped by genetic mapping.

S-Nitrosylation of Dexras1 Controls Post-Stroke Recovery via Regulation of Neuronal Excitability and Dendritic Remodeling.

Aims: Stroke is a major public health concern leading to high rates of death and disability worldwide, unfortunately with no effective treatment available for stroke recovery during the repair phase.

Methods: Photothrombotic stroke was induced in mice. Adeno-associated viruses (AAV) were microinjected into the peri-infarct cortex immediately after photothrombotic stroke.

[Solid-phase extraction coupled with high performance liquid chromatography-triple quadrupole mass spectrometry for simultaneous determination of seven coumarins in water samples from drinking water treatment plants].

Chlorinated coumarins, which are as cytotoxic as highly toxic halobenzoquinones toward CHO-K1 cells, have recently been identified as disinfection byproducts in drinking water disinfection processes. Therefore, detecting coumarins in water samples collected at various stages from drinking water treatment plants helps assess the formation of chlorinated coumarins in drinking water. Hence, a simple, rapid, accurate, and sensitive method for quantifying coumarins in water samples is required.

Melatonin-priming ameliorates aluminum accumulation and toxicity in rice through enhancing aluminum exclusion and maintaining redox homeostasis.

Seed priming can effectively enhance the plant's ability to withstand stress during subsequent growth and development; however, the role of melatonin-priming in attenuating aluminum (Al) toxicity remain unknown. In this study, 10, 50 and 100 μM melatonin were selected for rice seed priming to investigate the protective effects and potential mechanisms of melatonin against Al toxicity. Al stress inhibited seed germination by induction of abscisic acid (ABA) accumulation and reduction of α-amylase activity.

An artesunate-modified half-sandwich iridium(iii) complex inhibits colon cancer cell proliferation and metastasis through the STAT3 pathway.

Colon cancer is one of the most commonly diagnosed cancers and is recognized as the most aggressive tumor of the digestive system. Aberrant activation of signal transducer and activator of transcription 3 (STAT3) is associated with proliferation, metastasis and immunosuppression of the tumor cells. Here, to inhibit the STAT3 pathway and suppress metastasis in colon cancer cells, the half-sandwich iridium complex Ir-ART containing an artesunate-derived ligand was synthesized.

Wind and solar energy in Small Island Developing States for mitigating global climate change.

Despite contributing less than 1% of global greenhouse gas (GHG) emissions, Small Island Developing States (SIDS) have the potential to drive global mitigation actions by advocating for ambitious emission reduction targets, promoting renewable energy solutions, and advancing sustainable development practices. The adoption of onshore-offshore wind and solar energy in 39 SIDS, which are currently experiencing the adverse effects of climate change, presents a significant opportunity. By harnessing renewable energy sources, these countries can effectively mitigate GHG emissions, enhance energy security, and build resilience.

The Occurrence of Myxomycete Communities in Forests: Influence of Substrates and Seasons.

Myxomycete communities in forests and the influence of substrates and seasons on myxomycete diversity were studied. In total, 80 substrates (40 living barks and 40 litters) were collected from the sample site in winter, spring, summer and autumn of 2023, followed by moist chamber cultures. A total of 733 records representing 34 myxomycete species in 21 genera were obtained.

Trametinib and M17, a novel small molecule inhibitor of AKT, display a synergistic antitumor effect in triple negative breast cancer cells through the AKT/mTOR and MEK/ERK pathways.

Triple negative breast cancer (TNBC) is associated with a poor prognosis and limited response to traditional chemotherapy, necessitating the exploration of novel treatment approaches. Recent researches have highlighted the interconnected roles of the PI3K/AKT pathway and MAPK pathway in TNBC cells, contributing to the efficacy of treatments. Therefore, the concurrent inhibition of both pathways presents a potential new therapeutic strategy for TNBC patients.

Effects of blended learning in physical education on university students' exercise attitudes and basketball skills: a cluster randomized controlled trial.

Background: The importance of physical education in higher education is widely recognized, as it improves not only exercise attitudes and motor skills but also physical fitness, social skills, and academic performance. However, physical education courses in Chinese colleges and universities face various constraints, such as a shortage of teachers, limited teaching methods, and insufficient resources, resulting in low student motor skills, negative attitudes toward sports, and low participation rates. This study explores the effectiveness of a blended learning model, which integrates traditional face-to-face instruction with online learning components, in improving university students' exercise attitudes and basketball skills.

Integrative analysis of single-cell and bulk multi-omics data to reveal subtype-specific characteristics and therapeutic strategies in clear cell renal cell carcinoma patients.

Kidney renal clear cell carcinoma (KIRC) is the most prevalent subtype of malignant renal cell carcinoma and is well known as a common genitourinary cancer. Stratifying tumors based on heterogeneity is essential for better treatment options. In this study, consensus clusters were constructed based on gene expression, DNA methylation, and gene mutation data, which were combined with multiple clustering algorithms.

High-pressure phase transitions of series of catenated nitrogen energetic crystals N (x = 4, 8, 10): A comparative DFT-D study.

Context: High-pressure chemistry has advantages in exploring novel energetic materials and is the key to the development of new high-energy materials. The complexity and danger of experimental processes require a deeper understanding by advanced simulation techniques. Therefore, a high-precision comparative DFT-D study was performed to investigate the effect of pressure on series of catenated nitrogen energetic crystals.

Decision Transformer-Based Efficient Data Offloading in LEO-IoT.

Recently, the Internet of Things (IoT) has witnessed rapid development. However, the scarcity of computing resources on the ground has constrained the application scenarios of IoT. Low Earth Orbit (LEO) satellites have drawn people's attention due to their broader coverage and shorter transmission delay.

Regulating the 3d-orbital occupancy on Ni sites enables high-rate and durable Ni(OH) cathode for alkaline Zn batteries.

The capacity and cycling stability of β-Ni(OH)-based cathodes in aqueous alkaline Ni-Zn batteries are still unsatisfactory due to their undesirable OH adsorption/desorption dynamics during the electrochemical redox process. To settle this issue, we introduce a new atomic-level strategy to finely modulate the OH adsorption/desorption of β-Ni(OH) through tailoring the 3d-orbital occupancy of Ni center by Co/Cu co-doping (denoted as Co-Cu-Ni(OH)). Both experimental outcomes and density functional theory calculations validate that the co-doping of Co and Cu endows the Ni species in Co-Cu-Ni(OH) with appropriate proportion of the unoccupied 3d-orbital, leading to optimized adsorption/desorption strength of OH.

A deep learning approach for deriving wheat phenology from near-surface RGB image series using spatiotemporal fusion.

Accurate monitoring of wheat phenological stages is essential for effective crop management and informed agricultural decision-making. Traditional methods often rely on labour-intensive field surveys, which are prone to subjective bias and limited temporal resolution. To address these challenges, this study explores the potential of near-surface cameras combined with an advanced deep-learning approach to derive wheat phenological stages from high-quality, real-time RGB image series.

Social Media and Adolescents' Prosocial Behavior: Evidence of the Interaction Between Short Videos and Social Value Orientation.

Background/objective: Social media significantly influences adolescents' prosocial behavior. With smartphones becoming ubiquitous, short videos have emerged as the predominant social media format for adolescents. However, the effects of adolescents' engagement with short videos on their prosocial behavior remain uncertain.

Engineered IRES-mediated promoter-free insulin-producing cells reverse hyperglycemia.

Background: Endogenous insulin supplementation is essential for individuals with type 1 diabetes (T1D). However, current treatments, including pancreas transplantation, insulin injections, and oral medications, have significant limitations. The development of engineered cells that can secrete endogenous insulin offers a promising new therapeutic strategy for type 1 diabetes (T1D).

Research on the economic effects of housing support expenditures under the perspective of consumption heterogeneity: Evidence from China.

What kind of impact does the government's housing support expenditure have on residents' consumption? This is a topic that deserves in-depth study and is of practical significance. This study constructs provincial equilibrium panel data based on China's guaranteed housing construction and financial expenditures on housing support data from 1999-2009 and 2000-2021. It applies the systematic GMM method to estimate the impact of government housing support expenditures on residents' consumption.

Functional fitness and physical independence in later years: cut-off values and validation.

Background: To establish and validate the criterion-referenced standards of functional fitness in predicting physical independence in 80 + years.

Methods: A group of 2,749 older community dwellers (60-84 years) were recruited, and 2,050 were identified with moderate-to-high independent living ability according to the proposed minimum composite physical function score. The Senior Fitness Test battery was applied to measure functional fitness at five-year intervals.

Ammonia-sensitive halide CsCuI film for gas sensor and stimuli-responsive anti-counterfeiting.

Eco-friendly lead-free halide perovskites have emerged as promising materials for multiple applications due to their unique optoelectronic properties. In this work, we investigate the ammonia (NH)-sensitive CsCuI film for its potential in NH sensor and stimuli-responsive fluorescence anti-counterfeiting. CsCuI-based NH sensor demonstrates a high response to NH (△R/R = 1.

Interaction and band structure-determined inhibition of negative Cr (VI) and positive Fe (III) for antibiotic photodegradation by nitrogen-doped dissolved black carbon.

The influences of the positive Fe and the negative CrO on the tetracycline (TC) photodegradation by N-doped dissolved black carbon (NDBC) have been investigated in this work. A series of samples (NDBC300, NDBC400 and NDBC500) have been extracted from the corresponding biochar. NDBC400 has the best photodegradation performance (79%) for TC under visible light irradiation.