Clinical evaluation of the lot-to-lot consistency of an enterovirus 71 vaccine in a commercial-scale phase IV clinical trial.

Objective: To evaluate the immunogenicity, safety and lot-to-lot consistency of an inactivated enterovirus 71 (EV71) vaccine cultured in bioreactors with different specifications after full immunization.

Methods: A randomized, double-blind trial was performed in 3,000 children aged 6 ~ 35 months with six vaccine batches, which were prepared in 40 L and 150 L bioreactors for three consecutive batches respectively. Children were immunized on day 0 and 28, serum samples were collected on day 0 and 56, and neutralizing antibody titers were determined by the microcytopathic method.

Evaluating the Effect of Training Along With Fit Testing on Premolded Earplug Users in a Chinese Petrochemical Plant.

Objectives: To gain insight into the current practice of hearing protection of Chinese workers and the value of hearing protection device (HPD) fit testing.

Design: HPD fit testing was conducted on workers (N = 774) in a petrochemical plant in Eastern China who were on duty during the period of this study. The 3M E-A-Rfit Dual-Ear Validation System was used to measure the personal attenuation ratings (PARs) of a premolded earplug used at the work site.

Evaluating the effect of training along with fit testing on foam earplug users in four factories in China.

Objectives: To gain insight into the hearing protection practice of Chinese workers and the value of hearing protection fit testing.

Design: The Field Attenuation Estimation System (FAES) was used to measure the personal attenuation ratings (PARs) of one foam earplug used at the work sites in China. Intervention was provided to workers who needed it.

[Genetic characterization of norovirus isolated in an outbreak of gastroenteritis in Jiangsu province].

To analyze the genetic characterization of norovirus isolated in an outbreak of gastroenteritis in Jiangsu province. Extracted viral RNA from the swab samples of cases of acute gastroenteritis outbreak in Jiangsu province on December 16-27, 2016 was reversely transcribed to cDNA, and partial RNA-dependent RNA polymerase sequence and complete capsid sequence (VP1) were amplified by RT-PCR. Amplification products were sequenced for the analysis of genetic characteristics.

Comparison of the effect of increased hepatitis B vaccine dosage on immunogenicity in healthy children and adults.

Hepatitis B (HepB) infection remains a global public health problem, particularly in China. Vaccination for children and adult who are unvaccinated is an effective method for preventing the disease. In this study, we aimed to compare the effects of increased dosage of HepB vaccine on immunogenicity in healthy children and adults.

[Molecular characteristics of acute gastroenteritis outbreaks caused by norovirus, in Jiangsu province].

Objective: To study both the epidemiologic and molecular characteristics of outbreaks caused by norovirus (NoV) with its variants, in Jiangsu.

Methods: 67 specimens from seven gastroenteritis outbreaks were collected from October 2012 to March 2013 in Jiangsu. NoV gene group was detected by Real-Time RT-PCR.

[Evaluation on the safety and immunogenicity of Canada split influenza virus vaccine].

Objective: To evaluate the safety and immunogenicity of Canada split influenza virus vaccine.

Methods: Cluster samples were by randomly chosen and divided into split vaccination group and homoimported influenza vaccination group.

Results: After injection, fever-reaction and local reaction rates of 'trial' group were found as 3.