Carboxyl hybrid monolithic column in-tube solid-phase microextraction coupled with UPLC-QTRAP MS/MS for the determination of amphetamine-type stimulants.

A carboxyl functionalized organic-inorganic hybrid monolithic column (TMOS-co-CES) was applied as in-tube solid-phase microextraction (SPME) sorbent combining with ultra-performance liquid chromatography-triple quadrupole/linear ion trap mass spectrometer for separation and analyzation of seven typical amphetamine-type stimulants (ATSs), including amphetamine (AM), methamphetamine (MAM), cathinone, methcathinone, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine and 3,4-methylenedioxyethylamphetamine. The application potential of TMOS-co-CES material to ATSs was preliminarily confirmed by computational simulation by using cathinone as a representative. The influences of various SPME parameters and analytical performance were investigated systematically.

A critical appraisal of"effects of exercise therapy on disability, mobility, and quality of life in the elderly with chronic low back pain: a systematic review and meta-analysis of randomised controlled trials.".

This response letter addresses the comments received on our paper. The main points of our response include: Clarification of the definitions of primary and secondary indexes; Justification for the use of the RoB2 tool for quality assessment; Measures to improve sensitivity analysis and data consistency; Explanation and improvement plans regarding the timing of Prospero registration. We have provided detailed explanations of the study design and outlined specific measures for future improvements to enhance research transparency and quality.

Hierarchical porous MOF-199 mediated cellulosic paper for selective CO capture.

MOF-199 is considered to be an excellent CO adsorbent owing to its substantial specific surface area, suitable pore structure and abundant sorption sites. However, powdered MOF-199 is prone to agglomeration and has poor recyclability. Herein, we proposed a MOF-199-based adsorbent by combining the MOF synthesis process with traditional papermaking process.

Gender, Sexism, and Police Attitudes Toward Policing Intimate Partner Violence in China.

This study examines the impact of gender and sexism on police officers' attitudes toward policing intimate partner violence (IPV). Data were collected from 826 Chinese police officers through online questionnaires. A hierarchical multiple regression analysis found that male police officers and those with sexist attitudes believe that handling IPV cases is illegitimate; they tend to perceive that the police are not morally bound to regulate such cases.

PVA-based bulk microneedles capable of high insulin loading and pH-triggered degradation for multi-responsive and sustained hypoglycemic therapy.

"Closed-loop" insulin-loaded microneedle patche shows great promise for improving therapeutic outcomes and life quality for diabetes patients. However, it is typically hampered by limited insulin loading capacity, random degradation, and intricate preparation procedures for the independence of the "closed-loop" bulk microneedles. In this study, we combined the solubility of microneedles and "closed-loop" systems and designed poly(vinyl alcohol)-based bulk microneedles (MNs@GI) through photopolymerization for multi-responsive and sustained hypoglycemic therapy, which significantly simplified the preparation process and improved insulin loading.

Quantitative determination of amphetamine-type stimulants in sewage and urine by hybrid monolithic column solid-phase microextraction coupled with UPLC-QTRAP MS/MS.

A needle-solid-phase microextraction (SPME) method based on hybrid monolithic column (HMC) was proposed for simultaneous separation and extraction of seven amphetamine-type stimulants (ATSs) (amphetamine, methamphetamine, cathinone, methcathinone, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine, and 3,4-methylenedioxyethylamphetamine), combining with ultra-performance liquid chromatography-triple quadrupole/linear ion trap mass spectrometer (UPLC-QTRAP MS/MS). Thiol functionalized HMC (T-HMC) showed high extraction efficiency and excellent elution results towards target analytes, among three kinds of single/bi-functionalized HMCs. Various parameters of SPME operation and analytical performance were investigated systematically.

The Impact of Hot Spring Hydrotherapy on Pain Perception and Dysfunction Severity in Patients with Chronic Low Back Pain: A Systematic Review and Meta-Analysis.

Background: Chronic Low Back Pain (CLBP) is a prevalent global health issue, leading to prolonged discomfort and functional limitations. Hot spring hydrotherapy, which utilizes mineral-rich, warm spring water, offers a unique physical therapy that holds promise in alleviating CLBP symptoms.

Objective: This meta-analysis aims to assess the effectiveness of hot spring hydrotherapy in improving CLBP symptoms, encompassing pain intensity, functional disability, quality of life, and medication usage.

Optimized SAR imaging algorithm with SSL constraints for the Azimuth direction.

In order to address the low azimuth imaging problem of traditional Range Doppler (RD) algorithm, a high-resolution imaging algorithm with optimal azimuth sampling sequence length (SSL) constraints is hereby proposed. According to this algorithm, efforts are made to design a formula for the calculation of the initial azimuth SSL on the basis of SAR azimuth imaging parameters. Having obtained the initial SSL and the criteria for the evaluation of SAR imaging performance, we continue to figure out the extreme values of the curve within a reasonable range of variation.

Effects of aquatic exercises on physical fitness and quality of life in postmenopausal women: an updated systematic review and meta-analysis.

Objective: In the present systematic review and meta-analysis, we aimed to evaluate and update the effects of aquatic exercise on physical fitness and quality of life (QoL) in postmenopausal women.

Methods: The databases Cochrane Library, PubMed, Web of Science, and MEDLINE were searched for randomized controlled trials (RCTs) on the topic from inception to July 2022. The GetData software was used to extract data from the published images.

Effects of Different Exercise Modes on Gait Performance of Parkinson's Disease Patients: A Systematic Review and Network Meta-Analysis.

Gait disturbances are among the main symptoms of Parkinson's disease (PD) and can increase fall risk. In this study we aimed to systematically evaluate the effects of different exercise modes on gait indexes of PD patients. We conducted a review and network meta-analysis of randomized controlled trials in studies listed in Web of Science, MEDLINE, EMBASE, PsycINFO, Cochrane Library, ClinicalTrailS.

LC-Q-TOF/MS-based Fragmentation Behavior Study and Metabolites Identification of Nine Benzodiazepines.

Background: Benzodiazepines (BZDs) are compounds that contain one diazepine ring and two benzene rings, and are widely used to treat central nervous system diseases. However, drug abuse and BZDs' illegal addition may affect normal life and even lead to grave social harm. As BZDs may be metabolized and eliminated quickly, it is of great theoretical and practical significance to clarify their metabolic profile.

The establishment of the general microexpression recognition ability and its relevant brain activity.

Microexpressions are very transitory expressions lasting about 1/25∼1/2 s, which can reveal people's true emotions they try to hide or suppress. The PREMERT (pseudorandom ecological microexpression recognition test) could test the individual's microexpression recognition ability with six microexpression s (the mean of accuracy rates of a microexpression type under six expression backgrounds), and six microexpression s (the standard deviation of accuracy rates of this microexpression type under six expression backgrounds), but it and other studies did not explore the general microexpression recognition ability (the GMERA) or could not test the GMERA effectively. Therefore, the current study put forward and established the GMERA with the behavioral data of the PREMERT.

Comparing the effects of different exercises on blood pressure and arterial stiffness in postmenopausal women: A systematic review and meta-analysis.

The present study aimed to compare the efficacy of different exercises on systolic blood pressure (SBP), diastolic blood pressure (DBP), and aortic pulse wave velocity (PWV) in postmenopausal women. We searched the China National Knowledge Infrastructure (CNKI), Wanfang database, Web of Science, PubMed, and Cochrane library databases, up to July 2022. The randomized controlled trials (RCTs) were selected following the inclusion criteria.

Hydrogel-Based Stimuli-Responsive Micromotors for Biomedicine.

The rapid development of medical micromotors draws a beautiful blueprint for the noninvasive or minimally invasive diagnosis and therapy. By combining stimuli-sensitive hydrogel materials, micromotors are bestowed with new characteristics such as stimuli-responsive shape transformation/morphing, excellent biocompatibility and biodegradability, and drug loading ability. Actuated by chemical fuels or external fields (e.

Efficacy and evaluation of therapeutic exercises on adults with Parkinson's disease: a systematic review and network meta-analysis.

Background: Exercises are an effective treatment in Parkinson's disease (PD), but there is still controversy over which types should be used. We aimed to compare and rank the types of exercise that improve PD symptoms by quantifying information from randomised controlled trials.

Methods: We performed a systematic review and network meta-analysis and searched PubMed, MEDLINE, Embase, PsycINFO, Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, and China National Knowledge Infrastructure (CNKI) from their inception date to June 30, 2022.

Characterization and Mechanistic Study of Heavy Metal Adsorption by Facile Synthesized Magnetic Xanthate-Modified Chitosan/Polyacrylic Acid Hydrogels.

A simple method was used to synthesize magnetic xanthate-modified chitosan/polyacrylic acid hydrogels that were used to remove heavy metal ions from an aqueous solution. Xanthate modification of chitosan significantly improved adsorption performance: individual adsorption capacities of the hydrogel for Cu(II), Cd(II), Pb(II), and Co(II) ions were 206, 178, 168, and 140 mg g, respectively. The magnetic hydrogels had good regeneration ability and were effectively separated from the solution by use of a magnet.

Family Support and Hope among People with Substance Use Disorder in China: A Moderated Mediation Model.

Studies have shown that hope is an important protective factor. At present, few of the available studies on hope have been conducted on people undergoing compulsory rehabilitation. This study explores the mediating role of resilience between family support and hope, and whether relapse plays a moderating role between family support, resilience, and hope.

Can situations awaken emotions? The compilation and evaluation of the Emotional Situation Sentence System (ESSS).

We aimed to establish and evaluate a standardized emotional situation sentence system (ESSS) relevant to the lives of college students to supplement prior literature and adapt to the needs of emotional research. Two studies were designed for this research; study 1 examined the effect of words in the ESSS and study 2 involved the use of pictures. For Study 1, 778 items were selected by 607 college students and 15 experts.

(NH ) V O Microbricks as a Novel Anode for Aqueous Lithium-Ion Battery with Good Cyclability.

Searching for novel anode materials to address the issues of poor cycle stability in the aqueous lithium-ion battery system is highly desirable. In this work, ammonium vanadium bronze (NH ) V O with brick-like morphology has been investigated as an anode material for aqueous lithium-ion batteries and Li /Na hybrid ion batteries. The two novel full cell systems (NH ) V O ||Li SO ||LiMn O and (NH ) V O ||Na SO ||LiMn O both demonstrate good rate capability and excellent cycling performance.

MiR-877-5p targets PDK-1 to promote aspirin-induced apoptosis in gastric mucosal cells.

This study aimed to investigate the role of miR-877-5p in aspirin-induced gastric mucosal injury. MiRNA microarray analysis was performed using paired gastric mucosal samples to find differentially expressed miRNAs. miR-877-5p was selected for subsequent analyses.

A visually secure image encryption method based on integer wavelet transform and rhombus prediction.

Traditional image encryption technology usually encrypts a normal image into a noise matrix, which can protect the image in a certain extent, but noise appearance is easy to arouse the suspicion of attackers. To avoid this problem, a method of encrypting image into carrier image with visual meaning is proposed. Inspired by the existing visually secure encryption technique, we proposed an improved method based on the integer wavelet transform (IWT) and prediction scheme.

The relevant resting-state brain activity of ecological microexpression recognition test (EMERT).

Zhang, et al. (2017) established the ecological microexpression recognition test (EMERT), but it only used white models' expressions as microexpressions and backgrounds, and there was no research detecting its relevant brain activity. The current study used white, black and yellow models' expressions as microexpressions and backgrounds to improve the materials ecological validity of EMERT, and it used eyes-closed and eyes-open resting-state fMRI to detect relevant brain activity of EMERT for the first time.