Erlotinib versus gemcitabine plus cisplatin as neoadjuvant treatment of stage IIIA-N2 EGFR-mutant non-small-cell lung cancer: final overall survival analysis of the EMERGING-CTONG 1103 randomised phase II trial.

EMERGING-CTONG 1103 showed improved progression-free survival (PFS) with neoadjuvant erlotinib vs. chemotherapy for patients harbouring EGFR sensibility mutations and R0 resected stage IIIA-N2 non-small cell lung cancer (NSCLC) (NCT01407822). Herein, we report the final results.

The role of TGF-β pathway alterations in immune regulation as a potential pan-cancer biomarker in immunotherapy.

Background: Depending on the context, the transforming growth factor beta (TGF-β) signaling pathway is involved in opposing cell processes of tumor suppression and tumor promotion. However, the effects of TGF-β pathway on immunotherapy efficacy have not yet been systematically investigated.

Methods: In this study, we have extracted the available data of whole-exome sequencing, messenger RNA (mRNA) expression, baseline characterization, and prognosis information of 10,912 pan-cancer patients from The Cancer Genome Atlas to explore the role of TGF-β pathway in immune regulation.

SNHG 6 promotes the progression of Colon and Rectal adenocarcinoma via miR-101-3p and Wnt/β-catenin signaling pathway.

Background: Small nucleolar RNA host gene 6 (SNHG6) regulates diverse biological processes in cancers. Potential function of SNHG6 in human colon and rectal adenocarcinoma (CRC) was evaluated.

Methods: Quantitative real-time polymerase chain reaction, MTT assays, Colony formation assays, Transwell assay, Western Blotting and Luciferase reporter assays were performed to measure the biological functions and potential molecular mechanisms of SNHG6 in CRC.

Erlotinib Versus Gemcitabine Plus Cisplatin as Neoadjuvant Treatment of Stage IIIA-N2 -Mutant Non-Small-Cell Lung Cancer (EMERGING-CTONG 1103): A Randomized Phase II Study.

Purpose: To assess the benefits of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors as neoadjuvant/adjuvant therapies in locally advanced mutation-positive non-small-cell lung cancer.

Patients And Methods: This was a multicenter (17 centers in China), open-label, phase II, randomized controlled trial of erlotinib versus gemcitabine plus cisplatin (GC chemotherapy) as neoadjuvant/adjuvant therapy in patients with stage IIIA-N2 non-small-cell lung cancer with mutations in exon 19 or 21 (EMERGING). Patients received erlotinib 150 mg/d (neoadjuvant therapy, 42 days; adjuvant therapy, up to 12 months) or gemcitabine 1,250 mg/m plus cisplatin 75 mg/m (neoadjuvant therapy, two cycles; adjuvant therapy, up to two cycles).

Different effects of immune stimulation on chronic unpredictable mild stress-induced anxiety- and depression-like behaviors depending on timing of stimulation.

Stressful life events are thought to be triggering factors of numerous neuropsychiatric disorders, including anxiety and depression. However, the interactions between chronic unpredictable mild stress (CUMS) and immune stimulation have not been thoroughly investigated. In the present study, we evaluated the effects of lipopolysaccharide (LPS) challenge at different time points on CUMS-induced anxiety- and depression-like behaviors.

Improved survival with higher radiation dose for esophageal squamous cell carcinoma patients treated with definitive chemoradiotherapy.

Purpose: The optimal radiation dose for patients with esophageal squamous cell carcinoma (ESCC) has long been debated. We undertook the retrospective study to evaluate the survival impact of high dose vs standard dose in patients with stage II-III esophageal cancer treated with definitive chemoradiotherapy (CRT).

Results: A total of 137 patients were included in our study, 63 patients classified as standard-dose group and 74 as high-dose group.

Establishment of patient-derived tumor xenograft (PDTX) models using samples from CT-guided percutaneous biopsy.

This study aimed to investigate the feasibility of the establishment of a human cancer xenograft model using samples from computed tomography (CT)-guided percutaneous biopsy. Fresh tumor tissues obtained from 10 cancer patients by CT-guided percutaneous biopsy were subcutaneously inoculated into NOD-Prkdcem26Il2rgem26Nju (NCG) mice to establish human patient-derived tumor xenograft (PDTX) models. The formation of first and second generation xenografts was observed, and tumor volume was recorded over time.

Evaluation of plasma microRNA levels to predict insensitivity of patients with advanced lung adenocarcinomas to pemetrexed and platinum.

Pemetrexed combined with platinum is a first-line therapy used to treat patients with advanced non-small cell lung cancer (NSCLC) that exhibit negative or unknown epidermal growth factor receptor (EGFR) mutational status or anaplastic lymphoma kinase (ALK) rearrangements. Lung adenocarcinoma (LAC) is the primary type of NSCLC. In order to prevent overtreatment, it is necessary to identify patients with LAC who may not benefit from certain chemotherapies.

A novel method for right one-lung ventilation modeling in rabbits.

There is no standard method by which to establish a right one-lung ventilation (OLV) model in rabbits. In the present study, a novel method is proposed to compare with two other methods. After 0.

Diagnostic accuracy and safety of CT-guided fine needle aspiration biopsy in cavitary pulmonary lesions.

Objective: CT-guided transthoracic biopsy is a well-established method in the cytologic or histologic diagnosis of pulmonary lesions. The knowledge of its diagnostic performance and complications for cavitary pulmonary lesions is limited. The purpose of this study was to determine the diagnostic accuracy and safety of CT-guided fine needle aspiration biopsy (FNAB) in cavitary pulmonary lesions.

Use of CT-guided fine needle aspiration biopsy in epidermal growth factor receptor mutation analysis in patients with advanced lung cancer.

Background: The safety of using a cutting needle when performing a core-needle biopsy is of major concern, in particular for small lung tumors or tumors near the hilum.

Purpose: To investigate the usefulness of CT-guided fine needle aspiration biopsy (FNAB) of the lung in obtaining tumor tissue for epidermal growth factor receptor (EGFR) mutation analysis in advanced lung cancer patients.

Material And Methods: Forty-three patients with stage IIIB-IV lung cancer were enrolled.

[Detection of mutant p53 gene at resection margin of the bronchus and cancer tissues to predict lung cancer recurrence.].

Background: To investigate the mutations of p53 gene at the resection margins of the bronchus and cancer tissues , and to predict lung cancer recurrence.

Methods: PCR-SSCP technique was used to detect mutation of p53 gene at the resection margin of the bronchus (no cancer cells remained by gross pathological examination) , cancer tissue and normal tissue of the lungs in 50 patients with lung cancers and 7 patients with non-cancerous pulmonary diseases. Local recurrence at the resection margin of bronchus and distant metastasis were investigated.

[Diagnostic study of pulmonary mass under ultrasonography guided aspiration biopsy by four types of needle].

One hundred and thirty patients with pulmonary mass were studied under ultrasonography guided aspiration biopsy by four types of needle. The cytological positive cases were 57.1% in fine needle (22G), 79.

[Primary non-Hodgkin's lymphoma of the ovary--report of 5 cases].

Five cases of primary non-Hodgkin's lymphoma of the ovary (OPNHL) are reported. All were B cell lymphomas (1 small cleaved, 2 non-cleaved and 2 cleaved non-cleaved lymphoma) and treated with operation combined with chemotherapy, 2 of whom also received radiotherapy. One case died 15 months after operation, 4 are still alive, and 2 of these 4 have survived for over 3 years.

[Clinical significance of serum CEA determination in the diagnosis of colo-rectal cancer].

Serum CEA levels of 581 specimens obtained from 350 colo-rectal cancer patients and 61 specimens from 54 non-tumor subjects were determined by sandwich method of CEA-EIA McAb kit supplied by the Beijing Institute of Biological Products. In patients with primary colo-rectal cancer, the serum CEA level was 15.0 +/- 52.

[Re-radiation of recurrent nasopharyngeal carcinoma--analysis of 58 cases].

Fifty-eight patients with recurrent nasopharyngeal carcinoma in nasopharynx and/or regional areas were re-radiated from 1972 to 1979 after initial irradiation. 70.7% of the recurrence appeared within 3 years after initial treatment.

[Primary non-Hodgkin's lymphoma of the breast--report of 8 cases].

Eight cases of primary Non-Hodgkin's lymphoma (NHL) of the breast are reported. Almost all presented as a painless movable mass without nipple retraction, edema in the overlying skin, satellite skin nodules or bloody nipple discharge. Most of the cases belonged to B cell lymphoma.

[Radiotherapy for 159 patients with carcinoma of the tonsils].

A series of 159 patients with carcinoma of the tonsil was treated by radiotherapy from Jan. 1970 to Dec. 1980.