2 results match your criteria: "Jesse Brown VA Med Center[Affiliation]"
Interleukin-4 Downregulation of Involucrin Expression in Human Epidermal Keratinocytes Involves Stat6 Sequestration of the Coactivator CREB-Binding Protein.
J Interferon Cytokine Res
June 2016
1 Department of Dermatology, University of Illinois at Chicago, Chicago, Illinois.
Skin barrier defects play an important role in atopic dermatitis (AD). Involucrin, an important barrier protein suppressed in human AD, is downregulated by interleukin-4 (IL-4). However, the molecular mechanism for IL-4 downregulation of involucrin has not been delineated, and especially how Stat6, a transcriptional activator, represses involucrin expression is unknown.
View Article and Find Full Text PDFDifferential expression of inflammation-related genes in IL-4 transgenic mice before and after the onset of atopic dermatitis skin lesions.
Mol Cell Probes
February 2016
Department of Dermatology, University of Illinois, Chicago, IL, USA; Department of Microbiology/Immunology, University of Illinois, Chicago, IL, USA; Medical Service, Jesse Brown VA Med Center, Chicago, IL, USA. Electronic address:
IL-4 plays an important role in the pathogenesis of atopic dermatitis (AD), a common chronic inflammatory skin disease. We have generated IL-4 transgenic (Tg) mice by over-expressing IL-4 in the epidermis. These mice spontaneously develop chronic pruritic inflammatory skin lesions, which meet the clinical and histological diagnostic criteria for human AD.
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