1,010 results match your criteria: "Jessa Hospital[Affiliation]"

Clinical outcome after bleeding events following coronary stenting in patients with and without comorbid peripheral arterial disease.

Cardiovasc Interv Ther

December 2024

Department of Cardiology, Thoraxcentrum Twente, Medisch Spectrum Twente, University of Twente, Koningsplein 1, 7512 KZ, Enschede, The Netherlands.

Patients undergoing percutaneous coronary intervention (PCI) may experience bleeding events. Bleeding risk is increased in patients with comorbid peripheral arterial disease (PADs). To evaluate whether PCI patients with PADs have worse outcome after bleeding, we assessed pooled patient-level data of 5,989 randomized all-comer trial participants and identified those who had a bleeding (BIO-RESORT:NCT01674803, BIONYX:NCT02508714).

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Genetics, Fitness and Left Ventricular Remodeling: The Current State of Play.

Can J Cardiol

December 2024

Heart, Exercise and Research Trials, St Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia; Cardiology Department, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia; The University of Melbourne, Parkville, Victoria, Australia; Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia. Electronic address:

Cardiorespiratory fitness (CRF) exists on a spectrum and is driven by a constellation of factors including genetic and environmental differences. This results in wide inter-individual variation in baseline CRF and the ability to improve CRF with regular endurance exercise training. As opposed to monogenic conditions, CRF is described as a complex genetic trait as it is believed to be influenced by multiple common genetic variants in addition to exogenous factors.

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Background Context: Spondylodiscitis management presents significant clinical challenges, particularly in critically ill patients, where the risks and benefits of surgical intervention must be carefully balanced. The optimal timing of surgery in this context remains a subject of debate.

Purpose: This study aims to evaluate the effectiveness of early surgery versus delayed surgery or conservative management in critically ill patients with de novo pyogenic spondylodiscitis.

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Article Synopsis
  • The study aimed to analyze pre- and intraoperative factors influencing the integrity of corporal bodies after placing an inflatable penile prosthesis (IPP), focusing on the occurrence of intraoperative and postoperative complications.
  • Researchers reviewed a database of over 5,400 IPP surgeries conducted between 2016 and 2021, identifying significant predictors for complications linked to corporal integrity.
  • Key predictors for complications included revision surgery, older age, and medical conditions like coronary artery disease or peripheral vascular disease, indicating the need for consideration of these factors during IPP placement to reduce risks.
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Daratumumab or Active Monitoring for High-Risk Smoldering Multiple Myeloma.

N Engl J Med

December 2024

From Alexandra General Hospital, National and Kapodistrian University of Athens, Athens (M.A.D.); Levine Cancer Institute, Atrium Health Wake Forest University School of Medicine, Charlotte, NC (P.M.V.); Oslo Myeloma Center, Department of Hematology, Oslo University Hospital, Oslo (F.S.); Tel-Aviv Sourasky (Ichilov) Medical Center and Tel Aviv University, Tel Aviv, Israel (Y.C.C.); Clínica Medica São Germano, São Paulo (V.H.); Cross Cancer Institute, University of Alberta, Edmonton, Canada (I. Sandhu); Kent and Canterbury Hospital, Canterbury, United Kingdom (J.L.); Perth Blood Institute, Murdoch University, Perth, WA, Australia (R.I.B.); Japanese Red Cross Medical Center, Tokyo (K.S.); Ogaki Municipal Hospital, Ogaki City, Japan (H.K.); Albert Schweitzer Hospital, Dordrecht, the Netherlands (M.-D.L.); Ankara University, Ankara, Turkey (M.B.); Washington University School of Medicine, St. Louis (K.S.-G.); Institut Català d'Oncologia and Institut Josep Carreras, Hospital Germans Trias i Pujol, Barcelona (A.O.); South Pest Central Hospital, National Institute for Hematology and Infectious Diseases, Budapest, Hungary (G.M.); Hospital Alemán, Buenos Aires (G.G.); Jessa Hospital, Hasselt, Belgium (K.T.); Charles University and General Hospital, Prague, Czech Republic (I. Spicka); Rigshospitalet, University of Copenhagen, Copenhagen (A.K.M.); SSD Clinical Trials in Oncol-ematologia e Mieloma Multiplo, AOU Città della Salute e della Scienza di Torino, Turin, Italy (S.B.); Medical Unit Hematology, Karolinska University Hospital, Stockholm (K.U.); Institute of Hematology and Transfusion Medicine, Warsaw, Poland (B.P.); Knight Cancer Institute, Oregon Health and Science University, Portland (E.M.); University of Washington and Fred Hutchinson Cancer Center, Seattle (A.J.C.); University Hospital Hôtel-Dieu, Nantes, France (P.M.); University Hospital of Salamanca, IBSAL, and Cancer Research Center, IBMCC, Salamanca, Spain (M.-V.M.); GMMG Study Group at University Hospital Heidelberg, Internal Medicine V, Heidelberg, Germany (H.G.); Genmab US, Plainsboro, NJ (T.A.); Janssen Research and Development, Shanghai, China (L.S., L.L.); Janssen Scientific Affairs, Horsham, PA (A.C.); Janssen Research and Development, Raritan, NJ (E.G.K., R.M.D.); Janssen Research and Development, Beerse, Belgium (E.R.); Janssen Research and Development, Spring House, PA (R.C.); and Mayo Clinic, Rochester, MN (S.V.R.).

Background: Daratumumab, an anti-CD38 monoclonal antibody, has been approved for the treatment of multiple myeloma. Data are needed regarding the use of daratumumab for high-risk smoldering multiple myeloma, a precursor disease of active multiple myeloma for which no treatments have been approved.

Methods: In this phase 3 trial, we randomly assigned patients with high-risk smoldering multiple myeloma to receive either subcutaneous daratumumab monotherapy or active monitoring.

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A rare case of spinal myeloid sarcoma.

Surg Neurol Int

November 2024

Limburg Clinical Research Centre (LCRC), University of Hasselt, Hasselt, Belgium.

Background: Myeloid sarcoma (MS), a rare extramedullary tumor composed of myeloid blast cells, is classified by the World Health Organization as a subtype of acute myeloid leukemia (AML). Isolated, primary, or nonleukemic MS has an incidence of 2/1,000,000 adults and constitutes only 0.7% of all AML cases.

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Aims: Uncertainty exists about defining true iron deficiency (ID) in heart failure (HF) patients. We assessed the relationship of different ID definitions with cardiac structure and function, congestion, exercise capacity, and prognosis in HF outpatients.

Methods And Results: Iron deficiency was defined according to guidelines (G-ID: ferritin <100 ng/ml or ferritin 100-299 ng/ml with transferrin saturation [TSAT] <20%).

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Noninfectious Complications of Dorsal Root Ganglion Stimulation: A Systematic Review and Meta-Analysis.

Neuromodulation

November 2024

Faculty of Medicine and Life Science, Hasselt University, Hasselt, Belgium; Department of Neurosurgery Jessa Hospital, Hasselt, Belgium; Study and Training Centre Neurosurgery Virga Jesse, Hasselt, Belgium.

Introduction: Dorsal root ganglion stimulation (DRGS) has emerged as a promising treatment for chronic neuropathic pain. However, its safety and complications are not fully understood, with existing literature primarily based on case reports, observational studies, and data base analyses. This systematic review and meta-analysis aims to assess the prevalence of noninfectious complications associated with DRGS, focusing on the trial phase, postimplantation period, and revisions, while identifying risk factors for these outcomes.

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Background: While various treatment modalities exist, penile prosthesis (PP) implantation offers a permanent solution for patients that do not respond to or are not suitable for other treatment options for erectile dysfunction.

Aim: The aim of this study was to establish stretched penile length before surgery as a reliable determining factor of penile length after penile implant surgery.

Methods: For this study, data on penile length before and after PP surgery from three European centers was analyzed.

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The mechanistic interaction between mechanical dyssynchrony and filling pressure in cardiac resynchronization therapy candidates.

Eur Heart J Cardiovasc Imaging

November 2024

Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC+), Maastricht, the Netherlands.

Background: Both left ventricular (LV) mechanical dyssynchrony and filling pressure have been shown to be associated with outcome in heart failure patient treated with cardiac resynchronization therapy (CRT).

Objectives: To investigate the mechanistic link between mechanical dyssynchrony and filling pressure and to assess their combined prognostic value in CRT candidates.

Methods: Left atrial pressure (LAP) estimation and quantification of mechanical dyssynchrony were retrospectively performed in 219 CRT patients using echocardiography.

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Enhanced Recovery After Craniotomy: Global Practices, Challenges, and Perspectives.

J Neurosurg Anesthesiol

November 2024

Department of Anesthesia and Pain Medicine, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada.

The global demand for hospital care, driven by population growth and medical advances, emphasizes the importance of optimized resource management. Enhanced Recovery After Surgery (ERAS) protocols aim to expedite patient recovery and reduce health care costs without compromising patient safety or satisfaction. Its principles have been adopted in various surgical specialties but have not fully encompassed all areas of neurosurgery, including craniotomy.

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Aims: Low cardiorespiratory fitness (CRF) is associated with functional disability, heart failure and mortality. Left ventricular (LV) end-diastolic volume (LVEDV) has been linked with CRF, but its utility as a diagnostic marker of low CRF has not been tested.

Methods: This multi-center international cohort examined the relationship between LV size on echocardiography and CRF (peak oxygen uptake [peak VO2] from cardiopulmonary exercise testing) in individuals with LV ejection fraction ≥50%.

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Most published prediction models for Coronavirus Disease 2019 (COVID-19) were poorly reported, at high risk of bias, and heterogeneous in model performance. To tackle methodological challenges faced in previous prediction studies, we investigated whether model updating and extending improves mortality prediction, using the Intensive Care Unit (ICU) as a proxy. All COVID-19 patients admitted to seven ICUs in the Euregio-Meuse Rhine during the first pandemic wave were included.

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Mapping bacterial extracellular vesicle research: insights, best practices and knowledge gaps.

Nat Commun

October 2024

Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.

Article Synopsis
  • Bacterial extracellular vesicles (BEVs) play a crucial role in bacterial communication and could potentially be used as biomarkers and treatments in both ecological and medical contexts.
  • The analysis of 845 publications from 2015-2021 highlights the complexity of BEV research due to variations in their composition and features, with over 3338 related experiments documented.
  • The authors stress the importance of transparent reporting in BEV studies, identify existing knowledge gaps, and suggest best practices to enhance research quality and hasten the application of BEVs in various fields.
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The role of immunosuppressive therapy on SARS-CoV-2 infection risk and COVID-19 severity remains unclear in unvaccinated solid organ transplant recipients. We included 1957 organ transplant recipients between July 2020 and April 2021 to analyze whether baseline immunosuppressive therapy and other risk factors are associated with SARS-CoV-2 infection and severe COVID-19. In total, 247 (12.

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Reply to: importance of accounting for repeated measure designs when evaluating treatment effects at multiple postoperative days.

Eur J Anaesthesiol

December 2024

From the Department of Anaesthesiology and Pain Medicine, Jessa Hospital, Hasselt, Belgium (BS, IC), UHasselt, Faculty of Medicine and Life Sciences, Diepenbeek, Belgium (BS, IC), Data Science Institute, UHasselt, Diepenbeek, Belgium (ZP), and Department of Anaesthesiology and Pain Medicine, University Hospital, Leuven, Belgium (MVdeV).

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Article Synopsis
  • Topotecan is the standard treatment for relapsed small-cell lung cancer (SCLC), with both oral and intravenous forms being equally effective, but oral treatment has fewer side effects.
  • A case study presented a patient with stable disease after using oral topotecan; however, when switched to intravenous topotecan due to supply issues, the patient experienced significant disease regression after one dose.
  • This report highlights the first known instance of intravenous topotecan showing a better response than oral topotecan, with no clear reasons found for this difference.
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Temporal trend and regional disparity in the investigations for stable chest pain in Europe: An insight from the PIONEER IV trial.

J Cardiovasc Comput Tomogr

October 2024

Corrib Research Centre for Advanced Imaging and Core Laboratory, University of Galway, Galway, Ireland; Department of Cardiology, Saolta Group, Galway University Hospital Health Service Executive and University of Galway, Galway, Ireland.

Article Synopsis
  • - The ACC/AHA Chest Pain guidelines support the use of Coronary CT Angiography (CCTA) and FFRCT for better diagnosing coronary artery disease (CAD), yet many healthcare providers are not following these recommendations.
  • - In a study involving 673 stable chest pain patients across five European countries, CCTA emerged as the most frequently used noninvasive test, but nearly 40% of patients still received immediate CAD treatment without prior testing.
  • - The study revealed a lack of progress in improving adherence to CCTA and a low usage of FFRCT, underscoring the need for better diagnostic practices and updates to reimbursement policies.
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Article Synopsis
  • The study focuses on SARS-CoV-2 lineage B.1.214.2, identified in Belgium in January 2021, which has a mutation that may affect its transmissibility and immune evasion, similar to the Omicron variant.
  • This variant spread significantly in Central Africa and Europe, with its origin traced back to the Republic of the Congo, and its transmission correlated with human travel patterns.
  • In Belgian nursing homes, the variant led to moderately severe outcomes, and unique immune responses in elderly patients suggest a need for targeted nasal vaccine strategies against emerging variants.
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Chronic low back pain (CLBP) is one of the most common chronic musculoskeletal disorders worldwide. Guidelines recommend exercise therapy (ET) in CLBP management, but more research is needed to investigate specific ET modalities and their underlying mechanisms. The primary goal of this study is to evaluate the short-term and long-term effectiveness of a time-contingent individualised high-intensity training (HIT) protocol on disability compared with a time-contingent moderate-intensity training (MIT) as used in usual care, in persons with severely disabling CLBP.

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