Mapping quantitative trait loci regions associated with Marek's disease on chicken autosomes by means of selective DNA pooling.

Marek's Disease (MD), which can result in neurological damage and tumour formation, has large effects on the economy and animal welfare of the poultry industry worldwide. Previously, we mapped autosomal MD QTL regions (QTLRs) by individual genotyping of an F population from a full-sib advanced intercross line. We further mapped MD QTLRs on the chicken Z chromosome (GGZ) using the same F population, and by selective DNA pooling (SDP) of 8 elite egg production lines.

Accurate calculation of the content volume, density and original weight of museum curated eggs.

Worldwide museums hold collections of eggshells representing material for descriptive studies. However, an obstacle to this is the lack of information about the original contents and weight of the entire egg (W). This study aimed to fill this gap though development of a methodological mechanism for calculating the volume of the egg interior (V), its density (D) and W.

Metamaterial-based injection molding for the cost-effective production of whole cuts.

The escalating global demand for meat products has intensified ecological concerns, underscoring the need for sustainable meat alternatives. Although current methods effectively imitate ground meat, mimicking whole cuts, which constitute 54% of the global market, remains challenging due to the lack of scalable technology. Injection molding is a massively scalable manufacturing technology developed for the polymer industry.

modelRxiv: A Platform for the Dissemination and Interactive Display of Models.

Modelling the dynamics of biological processes is ubiquitous across the ecological and evolutionary disciplines. However, the increasing complexity of these models poses a challenge to the dissemination of model-derived results. Often only a small subset of model results are made available to the scientific community, with further exploration of the parameter space relying on local deployment of code supplied by the authors.

Approach to death and dying patients and its relation with death anxiety among medical interns: a multicenter cross-sectional study.

Background: Dealing with death and dying patients is one of the most challenging aspects of medical practice. The purpose of this study was to assess the attitude of medical interns toward death and dying patients as well as their level of death anxiety.

Methods: This cross-sectional study was conducted on medical interns across three countries-Egypt, Jordan, and Palestine-using an online survey created with Google Forms.

Deciphering bacterial protein functions with innovative computational methods.

Bacteria colonize every niche on Earth and play key roles in many environmental and host-associated processes. The sequencing revolution revealed the remarkable bacterial genetic and proteomic diversity and the genomic content of cultured and uncultured bacteria. However, deciphering functions of novel proteins remains a high barrier, often preventing the deep understanding of microbial life and its interaction with the surrounding environment.

Assessment of peri- and post-operative outcomes following apical prolapse repair in octogenarians: A retrospective cohort study.

Objective: To assess the risk of postoperative complications and unanticipated healthcare encounters in octogenarians compared to younger patients following apical prolapse repair.

Design: Retrospective cohort study.

Settings: University-affiliated academic tertiary hospital center.

Fiber optic laryngoscopy findings in pediatric burn patients referred to the pediatric emergency department.

Introduction: Facial burn injuries can compromise the airways in pediatric patients. Because prompt assessment of airway safety is a must, most assessment algorithms rely mainly on clinical judgment. There is little data on the value or utility of Fiber Optic Laryngoscopy (FOL) as an ancillary test.

Comparison of ELISA and IFAT for Leishmania infantum by European and Middle Eastern diagnostic laboratories.

Background: Visceral leishmaniosis (VL) is the most severe form of human leishmaniosis, with an estimated 95% case fatality if left untreated. Dogs act as peridomestic reservoir hosts for the protozoan parasite Leishmania infantum, a causative agent for human leishmaniosis, endemic throughout the Mediterranean basin. To assure consistent and accurate surveillance of canine infection and prevent transmission to people, consistent diagnosis of canine L.

The effect of biological treatment on female fertility: A cohort study of women with rheumatoid arthritis and psoriatic arthritis.

Objectives: To investigate female fertility in patients with rheumatoid arthritis (RA) exposed to biological drugs.

Methods: In this retrospective cohort study, based on an electronic health record database, 4517 women with RA were compared to 1415 patients with psoriatic arthritis (PsA). Patients were 18-40 years-of-age at diagnosis.

Single-nuclei RNA-sequencing fails to detect molecular dysregulation in the preeclamptic placenta.

Introduction: Single-cell RNA-seq (scRNA-seq) revolutionized our understanding of tissue complexity in health and disease and revealed massive transcriptional dysregulation across placental cell classes in early-onset, but not late-onset preeclampsia (PE). However, the multinucleated syncytium is largely inaccessible to cell dissociation. Nuclei isolation and single-nuclei RNA-seq may be preferable in the placenta; not least considering compatibility with long-term tissue storage.

"You Think We are in the Stone Age, but We Have Already Made Progress-Where are You?": A Qualitative Study of Ultra-orthodox Women's Telemedicine Service Usage in Israel.

This study explores Ultra-Orthodox Jewish women's attitudes toward video-consultation usage in Israeli primary care settings. In-depth interviews were conducted with twenty-two women from diverse Ultra-Orthodox communities in Israel, using interpretative phenomenological analysis. Despite traditionally limited digital tool usage, participants showed readiness for video-consultations' adoption through dedicated 'kosher' medical devices.

Evans syndrome as a presentation in systemic lupus erythematous, coexisting with Hashimoto's thyroiditis and pernicious anemia: a case report.

Background: Evans syndrome is a rare disorder characterized by the simultaneous or sequential combination of autoimmune hemolytic anemia and immunological thrombocytopenia, together with a positive direct antiglobulin test. This syndrome, which can be primary or secondary, is a rare initial manifestation of autoimmune diseases, notably systemic lupus erythematosus, with 1.7-2.

Chlorhexidine-loaded microneedles for treatment of oral diseases.

Chlorhexidine (CHX) is a gold standard therapeutic agent against clinical oral pathogens. However, its oral use is limited due to unpleasant taste, alteration in taste buds, staining of teeth and mucous membranes. Therefore, CHX-loaded PLGA microneedles (MNs) were fabricated for local and controlled release in the oral cavity, using a casting mold method.

Exposure therapy consortium: Outcomes of the proof-of-principle study.

Background: This paper reports on the outcomes of a proof-of-principle study for the Exposure Therapy Consortium, a global network of researchers and clinicians who work to improve the effectiveness and uptake of exposure therapy. The study aimed to test the feasibility of the consortium's big-team science approach and test the hypothesis that adding post-exposure processing focused on enhancing threat reappraisal would enhance the efficacy of a one-session large-group interoceptive exposure therapy protocol for reducing anxiety sensitivity.

Methods: The study involved a multi-site cluster-randomized controlled trial comparing exposure with post-processing (ENHANCED), exposure without post-processing (STANDARD), and a stress management intervention (CONTROL) in students with elevated anxiety sensitivity.

Objective and subjective participation mediate the relationship between developmental coordination disorder (DCD) and well-being aspects.

Purpose: Developmental coordination disorder (DCD) is associated with poor well-being and objective participation (i.e., frequency of engagement in activities, performance level) and decreased subjective participation (i.

VarNMF: Non-negative Probabilistic Factorization with Source Variation.

Motivation: Non-negative Matrix Factorization (NMF) is a powerful tool often applied to genomic data, to identify non-negative latent components that constitute linearly mixed samples. It is useful when the observed signal combines contributions from multiple sources, such as cell types in bulk measurements of heterogeneous tissue. NMF accounts for two types of variation between samples-disparities in the proportions of sources and observation noise.

Impact of Race on the Outcomes of Retinoblastoma Treated With Primary Enucleation: A Global Study of 1426 Patients.

Background: To evaluate the clinical presentation, pathological features and outcomes of retinoblastoma based on the race of origin in a global cohort of patients.

Methods: Retrospective collaborative study of 1426 patients who underwent primary enucleation for retinoblastoma.

Results: Patients were grouped into Caucasians (n = 231, 16%), Asians (n = 841, 59%), Hispanics (n = 226, 16%), Arabs (n = 96, 7%) and Others (Africans, African Americans, Indigenous Australians; n = 32, 2%) cohorts.

Pediatric orthopedic surgeons may perform better in terms of surgical outcomes in type 3 supracondylar humerus fractures: a comparative analysis.

Supracondylar fractures of the humerus represent the most common surgical fractures in pediatric patients. There is a discourse regarding the influence of the surgeon training on treatment. Different studies show equivocal effect of subspecialty training.

Galectin-3 secreted by triple-negative breast cancer cells regulates T cell function.

Triple-negative breast cancer (TNBC) is an aggressive subtype that accounts for 10-15 % of breast cancer. Current treatment of high-risk early-stage TNBC includes neoadjuvant chemo-immune therapy. However, the substantial variation in immune response prompts an urgent need for new immune-targeting agents.

New Horizons in Myopia Management: Bridging Epidemiology and Clinical Innovation.

In 1975, Brit J [...

H-SVEST: Validation and Adaptation of the Hebrew Version of the Second Victim Experience and Support Tool.

Background: Adverse medical events not only harm patients and families, but also have a significant negative impact on healthcare providers, with the potential to compromise future professional functioning. These "second victims" may need organizational support and rehabilitation to return to functionality.

Objectives: We analyzed the validity of an adapted tool, the Second Victim Experience and Support Tool (SVEST), on a population in Israel, H-SVEST.

Constructing Dynamical Symmetries for Quantum Computing: Applications to Coherent Dynamics in Coupled Quantum Dots.

Dynamical symmetries, time-dependent operators that almost commute with the Hamiltonian, extend the role of ordinary symmetries. Motivated by progress in quantum technologies, we illustrate a practical algebraic approach to computing such time-dependent operators. Explicitly we expand them as a linear combination of time-independent operators with time-dependent coefficients.

Oral Health of 7- to 9-Year-Old Children Born Prematurely-A Case-Control Observational Study with Randomized Case Selection.

Along with the long-term sequelae of preterm birth for general health, oral health is potentially influenced by prematurity due to developmental and behavioral peculiarities. This study aimed to compare oral health parameters in the mixed dentition of prematurely and full-term born children. Dental caries, developmental defects of enamel (DDE), and gingival inflammation were assessed in 7-to-9-year-old children ( = 38) born preterm (PT) compared to a matched control group born full-term (FT) in Germany.

Novel rehabilitation technologies in pediatric rehabilitation: knowledge towards translation.

Knowledge translation (KT) refers to the process of applying the most promising research outcomes into practice to ensure that new discoveries and innovations improve healthcare accessibility, effectiveness, and accountability. The objective of this perspective paper is to discuss and illustrate via examples how the KT process can be implemented in an era of rapid advancement in rehabilitation technologies that have the potential to significantly impact pediatric healthcare. Using Graham et al.