Association Between Atopic Dermatitis and Meniere's Disease: Nationwide Cohort Study.

Objectives: Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by relapsing and remitting episodes. Although AD is well-known for its association with other allergic conditions, its relationship with Meniere's disease has not been thoroughly investigated. This study aimed to explore the potential correlation between AD and Meniere's disease.

Functionalized Triangular Carbon Quantum Dot Stabilized Gold Nanoparticles Decorated Boron Nitride Nanosheets Interfaced for Electrochemical Detection of Cardiac Troponin T.

The fast, and highly sensitive estimation of cardiac troponin T (cTnT) is crucial for the early identification of acute myocardial infarction (AMI). The electrochemical immunoassay-based (EIB) sensors are highly promising for this purpose, as they offer precise measurements and can be directly assessed in intricate matrices, including blood. To increase sensitivity, EIB sensors use nanomaterials or amplification processes, which can be laborious to develop.

Structural and Phase Engineering of a Hierarchical 2D-2D Nickel MOF/Hydroxide-Derived NiSe/NiTe Heterointerface for Robust HER, OER, and Overall Water Splitting.

The development of a nonnoble metal-based cost-effective, efficient, and durable bifunctional electrocatalyst is crucial to achieving the goal of carbon neutrality. In this study, a structural and interfacial engineering approach is employed to design a 2D-2D hierarchical nickel MOF/nickel hydroxide-derived nickel selenide/nickel telluride dual-phase material through a single-step selenotellurization process. The rational design of highly ordered nanoarchitectures provides well-defined voids and ample pathways for ion diffusion.

Fermented Gold Kiwi Improves Gastrointestinal Motility and Functional Constipation: An Animal Study and Human Randomized Clinical Test.

Constipation is a functional disorder of the gastrointestinal system characterized by difficult bowel movements, infrequent defecation, reduced water content, and hard stools. This study aims to evaluate the preventive effects of fermented gold kiwis (FGK) on loperamide-induced constipation in rats and investigate its efficacy in improving constipation symptoms in human patients through a randomized clinical trial. In the animal study, FGK was administered orally at doses of 50, 125, and 250 mg/kg to constipated rats for two weeks, resulting in significant improvements in constipation parameters.

Protective Effects of Plum on Liver and Gut Injury in Metabolic Dysfunction-Associated Fatty Liver Disease.

Metabolic dysfunction-associated fatty liver disease (MASLD), a persistent liver condition associated with metabolic syndrome, is primarily caused by excessive fructose intake and a typical Western diet. Because there is currently only one approved treatment, lifestyle and dietary interventions are crucial. This study assessed the effects of dietary intervention involving freeze-dried plum (FDP), a natural source of antioxidants containing diverse polyphenols.

Evaluation of the Accuracy of 3D Printed Patient-Specific Brain Biopsy Guide Using 3D Volume Rendering Technique in Canine Cadavers.

The objective of this study was to evaluate the accuracy of a CT-based, 3D-printed, patient-specific brain biopsy guide (3D-psBBG) through the application of a transfrontal approach in canine cadavers. A total of ten canine cadavers, with weights ranging from 4.36 to 14.

Effect of Preheating Parameters on Extrusion Welding of High-Density Polyethylene Materials.

High-density polyethylene (HDPE) has emerged as a promising alternative to fiber-reinforced plastic (FRP) for small vessel manufacturing due to its durability, chemical resistance, lightweight properties, and recyclability. However, while thermoplastic polymers like HDPE have been extensively used in gas and water pipelines, their application in large, complex marine structures remains underexplored, particularly in terms of joining methods. Existing techniques, such as ultrasonic welding, laser welding, and friction stir welding, are unsuitable for large-scale HDPE components, where extrusion welding is more viable.

Neural Radiance Fields for Fisheye Driving Scenes Using Edge-Aware Integrated Depth Supervision.

Neural radiance fields (NeRF) have become an effective method for encoding scenes into neural representations, allowing for the synthesis of photorealistic views of unseen views from given input images. However, the applicability of traditional NeRF is significantly limited by its assumption that images are captured for object-centric scenes with a pinhole camera. Expanding these boundaries, we focus on driving scenarios using a fisheye camera, which offers the advantage of capturing visual information from a wide field of view.

Hybrid Functional ITO/Silver Nanowire Transparent Conductive Electrodes for Enhanced Output Efficiency of Ultraviolet GaN-Based Light-Emitting Diodes.

We investigated hybrid functional transparent conductive electrodes (HFTCEs) composed of indium-tin-oxide (ITO) and silver nanowires (AgNWs) for the enhancement of output efficiency in GaN-based ultraviolet light-emitting diodes (UVLEDs). The HFTCEs demonstrated an optical transmittance of 69.5% at a wavelength of 380 nm and a sheet resistance of 16.

Evaluation of Reusable Thermal Protection System Materials Using a High-Velocity Oxygen Fuel Torch.

We studied a candidate TPS (thermal protection system) material for reusable re-entry space vehicle applications. The material was based on a high-temperature-resistant material called Cerakwool. A total of six specimens were fabricated with substrate densities of 0.

Korea-Registries to Overcome Dementia and Accelerate Dementia Research (K-ROAD): A Cohort for Dementia Research and Ethnic-Specific Insights.

Background And Purpose: Dementia, particularly Alzheimer's disease, is a significant global health concern, with early diagnosis and treatment development being critical goals. While numerous cohorts have advanced dementia research, there is a lack of comprehensive data on ethnic differences, particularly for the Korean population. The Korea-Registries to Overcome Dementia and Accelerate Dementia Research (K-ROAD) aims to establish a large-scale, hospital-based dementia cohort to address this gap, with a focus on understanding disease progression, developing early diagnostics, and supporting treatment advancements specific to the Korean population.

Physically crosslinked chitosan/αβ-glycerophosphate hydrogels enhanced by surface-modified cyclodextrin: An efficient strategy for controlled drug release.

This study reports physically crosslinked chitosan/αβ-glycerophosphate (CS/GP) hydrogels containing surface-modified cyclodextrin for efficient controlled drug release. Highly water-soluble β-cyclodextrin-grafted L-serine (CD-g-Ser) compounds were synthesized, and employed as an effective carrier of berberine hydrochloride (Ber) for CS/GP hydrogels. Various characterizations, including gelation time determination, scanning electron microscopy, and viscosity measurement, indicated that the introduction of CD-g-Ser led to increased crosslinking degree, improved temperature sensitivity, and shortened sol-gel phase transition time of the hydrogel.

Identification of Novel Genetic Loci Affecting Age at Onset of Parkinson's Disease: A Genome-wide Association Study.

Background: The age at onset (AAO) of Parkinson's disease (PD) varies widely among individuals and significantly influences disease progression and prognosis. However, few genome-wide association studies (GWASs) have investigated genetic variants determining AAO, particularly in East Asian populations.

Objectives: To identify single-nucleotide polymorphisms (SNPs) affecting AAO of PD in Korean patients.

Reduction of neck pain severity in patients with medication-overuse headache.

Background: Neck pain and primary headache disorders are highly prevalent in populations and clinical cohorts. Medication-overuse headache (MOH) is a treatable secondary headache, mainly developing in migraine sufferers, that accounts for the majority of patients presenting to headache clinics. Nevertheless, the association between neck pain and MOH has not been reported.

Targeting uridine diphosphate glucuronosyltransferase 1A1 in liver disease: Current research and future directions.

The current letter to the editor pertains to the manuscript entitled 'Uridine diphosphate glucuronosyltransferase 1A1 prevents the progression of liver injury'. Increased levels of uridine diphosphate glucuronosyltransferase 1A1 during liver injury could mitigate damage by reducing endoplasmic reticulum stress, oxidative stress, and dysregulated lipid metabolism, impeding hepatocyte apoptosis and necroptosis.

Premenstrual Symptoms Risk Factors Among Newly Graduated Nurses in Shift Work: A Prospective Longitudinal Study.

Purpose: The premenstrual symptoms (PMSs) are a common health issue affecting women of reproductive age and are associated with various physiological, psychological, and situational factors. Newly graduated nurses, when suddenly exposed to excessive workloads and shift work, may experience disturbances such as sleep disorders, fatigue, depression, and stress. These factors are related to PMS, and their occurrence varies.

Protonation-Driven Polarization Retention Failure in Nano-Columnar Lead-Free Ferroelectric Thin Films.

Understanding microscopic mechanisms of polarization retention characteristics in ferroelectric thin films is of great significance for exploring unusual physical phenomena inaccessible in the bulk counterparts and for realizing thin-film-based functional electronic devices. Perovskite (K,Na)NbO is an excellent class of lead-free ferroelectric oxides attracting tremendous interest thanks to its potential applications to nonvolatile memory and eco-friendly energy harvester/storage. Nonetheless, in-depth investigation of ferroelectric properties of (K,Na)NbO films and the following developments of nano-devices are limited due to challenging thin-film fabrication associated with nonstoichiometry by volatile K and Na atoms.