Comprehensive profiling of phenolic compounds and triterpenoid saponins from Acanthopanax senticosus and their antioxidant, α-glucosidase inhibitory activities.

Acanthopanax senticosus belongs to Araliaceae family and is traditionally used as a tonic. The roots and stems are mainly used as treatments for hypodynamia, rheumatism, and hypertension, but their frequent use may lead to extinction. However, comprehensive and simultaneous analysis of the remaining parts were still limited.

Simple and Cost-Effective Generation of 3D Cell Sheets and Spheroids Using Curvature-Controlled Paraffin Wax Substrates.

The challenges associated with animal testing in pharmaceutical development have driven the search for alternative in vitro models that mimic human tissues more accurately. In this study, we present a simple and cost-effective method for generating 3D cell sheets and spheroids using curvature-controlled paraffin wax films, which are easily accessible laboratory materials that eliminate the need for extracellular matrix (ECM) components or thermo-responsive polymers. By adjusting the curvature of the paraffin wax film, we successfully generated human periodontal ligament fibroblast (HPdLF) cell sheets and bone marrow-derived mesenchymal stem cell (hBMSC) spheroids.

Development of inorganic-organic CdSe(en)via microwave-assisted method and topotactic transformation into porous CdSe nanosheet photoanode for photoelectrochemical hydrogen production.

In this study, inorganic-organic hybrid CdSe(en) nanosheet (NS) was developed on Cd foil via the microwave-assisted (MW) method with different MW irradiation cycles. Furthermore, the photoelectrochemical (PEC) performance of the mother material was improved through a second hydrothermal method with different time variations (3, 6, and 12 h at 160 °C). After the second hydrothermal, organic moieties were removed, and a porous photoanode was obtained.

The transcription factor BBX regulates phosphate homeostasis through the modulation of FGF23.

Fibroblast growth factor 23 (FGF23) plays an important role in phosphate homeostasis, and increased FGF23 levels result in hypophosphatemia; however, the molecular mechanism underlying increased FGF23 expression has not been fully elucidated. In this study, we found that mice lacking the bobby sox homolog (Bbx) presented increased FGF23 expression and low phosphate levels in the serum and skeletal abnormalities such as a low bone mineral density (BMD) and bone volume (BV), as well as short and weak bones associated with low bone formation. Osteocyte-specific deletion of Bbx using Dmp-1-Cre resulted in similar skeletal abnormalities, elevated serum FGF23 levels, and reduced serum phosphate levels.

Mandibular Condylar Head Regeneration Owing to Remodeling of the Costochondral Graft After Condylectomy for Odontogenic Myxoma.

Odontogenic myxoma of the mandibular condyle is a rare tumor that requires complete surgical resection because of the tendency for recurrence. The right mandibular condyle was resected to remove the myxoma. The author performed immediate condylar reconstruction using a costochondral graft (CCG), and stable temporomandibular joint (TMJ) function and occlusion were achieved.

Improving culprit artery identification with intraprocedural cone-beam CT aortography and its clinical impact in bronchial artery embolization.

Objective: To evaluate the impact of intraprocedural cone-beam CT (CBCT) aortography on culprit artery identification and clinical outcomes in patients undergoing bronchial artery embolization (BAE).

Materials And Methods: Two hundred eighty-two patients with 317 BAE procedures were retrospectively reviewed. Patients who underwent preprocedural chest CT angiography (CTA) without intraprocedural CBCT aortography were categorized as Group A (n = 177).

Electronically Seamless Domain Wall of Chiral Charge Density Wave in 1-TiSe.

Domain walls (DWs) have been recognized to play crucial roles in various interesting properties and functionalities in quantum materials. A notable example is DWs in charge density wave (CDW), which are believed to provide metallic electron channels for emerging superconductivity. However, electronic states of DWs and the microscopic mechanism toward superconductivity have been elusive.

Templates-Built Structural Designs for Piezoelectrochemical Pressure Sensors.

Self-powered sensors, capable of detecting static and dynamic pressure without an external power source, are pivotal for advancements in human-computer interaction, health monitoring, and artificial intelligence. Current sensing technologies, however, often fall short of meeting the growing needs for precise and timely pressure monitoring. This article introduces a novel self-powered pressure sensor utilizing electrochemical reactions.

The Biphasic Activity of Auricularia Auricula-Judae Extract on Bone Homeostasis through Inhibition of Osteoclastogenesis and Modulation of Osteogenic Activity.

Osteoporosis arises from the disturbance of bone homeostasis, a process regulated by osteoblasts and osteoclasts. The treatment and prevention of bone metabolic disorders resulting from an imbalance in bone homeostasis require the use of agents that effectively promote both bone formation and anti-resorptive effects. Therefore, an investigation was carried out to determine the potential of the edible mushroom in modulating bone remodeling by inhibiting RANKL-induced osteoclastogenesis and enhancing BMP-2-stimulated osteoblast differentiation.

Rational Design of Ultrahigh-Loading Ir Single Atoms on Reconstructed Mn─NiOOH for Enhanced Catalytic Performance in Urea-Water Electrolysis.

Investigating advanced electrocatalysts is crucial for improving the efficacy of water splitting to generate environmentally friendly fuel. The discovery of highly effective electrocatalysts, capable of driving oxygen evolution reaction (OER) and urea oxidation reaction (UOR) in urea-alkaline environments, is pivotal for advancing large-scale hydrogen production. This study aims to introduce a new method that involves creating nanosheets of high-loading iridium single atoms embedded in a manganese-containing nickel oxyhydroxide matrix (Ir@Mn─NiOOH).

Supplemental Magnesium Gluconate Enhances Scaffold-Mediated New Bone Formation and Natural Bone Healing by Angiogenic- and Wnt Signal-Associated Osteogenic Activation.

Local implantation or supplementation of magnesium gluconate (MgG) is being investigated as an effective approach to bone repair. Although studies have highlighted the possible mechanisms in Mg ion-stimulated new bone formation, the role of MgG in healing bone defects and the signaling mechanisms are not yet completely understood. In this study, we explored how supplemental MgG has bone-specific beneficial effects by delivering MgG locally and orally in animal models.

Effects of an integrated lifestyle intervention for overweight and obese breast cancer survivors: A quasi-experimental study.

Purpose: This study aimed to identify the effects of an integrated lifestyle intervention on health-promoting behavior, depression, body composition, and quality of life for overweight and obese breast cancer survivors.

Methods: This study used a quasi-experimental design with a non-equivalent control group pretest-posttest. The participants were 42 overweight and obese breast cancer survivors.

Viroids and Satellites and Their Vector Interactions.

Many diseases of unknown etiology with symptoms like those caused by plant viruses but for which no virions could be found were described during the early and mid-20th century [...

The Inhibitory Effect of Essential Oil on the Dental Biofilm.

This study aimed to identify the inhibitory effect of essential oil (AREO) on the cariogenic properties of , which causes dental caries and dental plaque formation. After extracting the AREO, their effects on the growth and acid production of were examined. Furthermore, biofilm formation was observed on the resin teeth surface.

The Potential of Glucosinolates and Their Hydrolysis Products as Inhibitors of Cytokine Storms.

A cytokine storm is an intense inflammatory response characterized by the overproduction of proinflammatory cytokines, resulting in tissue damage, and organ dysfunction. Cytokines play a crucial role in various conditions, such as coronavirus disease, in which the immune system becomes overactive and releases excessive levels of cytokines, including interleukins, tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ). This anomalous response often leads to acute respiratory distress syndrome (ARDS), disseminated intravascular coagulation (DIC), and multiple organ injury (MOI).

Transcriptomic Analysis of the Combined Effects of Methyl Jasmonate and Wounding on Flavonoid and Anthraquinone Biosynthesis in .

Jasmonates, including jasmonic acid (JA) and its derivatives such as methyl jasmonate (MeJA) or jasmonly isoleucine (JA-Ile), regulate plant responses to various biotic and abiotic stresses. In this study, we applied exogenous MeJA onto leaves subjected to wounding and conducted a transcriptome deep sequencing analysis at 1 (T1), 3 (T3), 6 (T6), and 24 (T24) h after MeJA induction, along with the pretreatment control at 0 h (T0). Out of 18,883 mapped genes, we identified 10,048 differentially expressed genes (DEGs) between the T0 time point and at least one of the four treatment times.

Isolation of 5-DSW with Protease Activity from Deep-Sea Mineral Water and Preparation of Functional Active Peptide Fractions from Chia Seeds.

In this study, we successfully isolated strains with high protease activity from deep-sea mineral water in Korea and used them to obtain functional peptide fractions from chia seeds. The obtained strains showed a high similarity of 99% with with a long rod type (named 5-DSW) and high protease activity at 40 °C, and 70% of the activity remained even at 70 °C. The defatted chia seed protein (15-50 kDa) was treated with crude protease from 5-DSW and digested into small peptides below 20 kDa.