Acute Vision Loss as the Sole Presenting Symptom of Posterior Reversible Encephalopathy Syndrome.

A 45-year-old female with poorly controlled HTN presented with sudden, painless bilateral vision loss over 12 hours. On examination, she had only light perception in both eyes, with normal fundoscopy and no focal neurological deficits. Laboratory tests revealed mildly elevated creatinine and proteinuria.

Model compression for real-time object detection using rigorous gradation pruning.

Achieving lightweight real-time object detection necessitates balancing model compression with detection accuracy, a difficulty exacerbated by low redundancy and uneven contributions from convolutional layers. As an alternative to traditional methods, we propose Rigorous Gradation Pruning (RGP), which uses a desensitized first-order Taylor approximation to assess filter importance, enabling precise pruning of redundant kernels. This approach includes the iterative reassessment of layer significance to protect essential layers, ensuring effective detection performance.

Association Between Severities of Obstructive Sleep Apnea and COVID-19 Outcomes.

Introduction Obstructive sleep apnea (OSA) is characterized by repetitive upper airway collapse resulting in episodes of apnea and hypopnea. Studies have shown worsened coronavirus disease 2019 (COVID-19) severity due to coexisting respiratory conditions and suggest increased severity of COVID-19 in patients with or at high risk of OSA. However, the extent of this correlation is unclear.

Prevalence of Osteoporosis and Osteopenia in Patients With Type 2 Diabetes at King Abdulaziz University Hospital: A Retrospective Analysis.

Introduction Osteoporosis mainly affects postmenopausal women and is characterized by decreasing bone mass and an increased risk of fracture. As populations age, it becomes more common and is frequently missed until fractures happen. Simultaneously, there is conflicting evidence about the relationship between bone health and diabetes, a chronic metabolic illness, with varying effects on the skeletal system.

Incidence of Communicating Hydrocephalus Following Intraventricular Hemorrhage Among Adult Patients Treated at a Hospital in Jeddah, Saudi Arabia: A Retrospective Study.

Introduction Intraventricular hemorrhage is a severe condition caused by bleeding within the brain ventricles. It is often due to trauma, tumors, vascular malformation, aneurysm, oxygen deprivation, or idiopathic. A common complication associated with intraventricular hemorrhage is hydrocephalus, which is the accumulation of cerebrospinal fluid in the ventricles.

The Predictive Factors of Acne Scarring and Post-Inflammatory Hyperpigmentation: A Retrospective Cohort Study.

Introduction: Acne vulgaris, a prevalent dermatological condition, often results in long-term complications such as scarring and hyperpigmentation. While extensive research has focused on treatment modalities, there is a notable gap in understanding the factors contributing to the development of acne scarring and post-inflammatory hyperpigmentation (PIH).

Purpose: This study was conducted to identify the factors contributing to the development of acne scarring and post-inflammatory hyperpigmentation (PIH).

Value of routine blood count surveillance in detecting relapse in acute lymphoblastic leukemia.

Background: Children with acute lymphoblastic leukemia (ALL) have excellent outcomes, with >85% survival without relapse following contemporary therapies. Clinical and complete blood count (CBC) assessments are commonly used surveillance methods to detect relapses. We aimed to evaluate the efficacy of routine blood testing for detecting relapse using a systematic method of assessing normal and abnormal results.

Exploring lifestyle and dietary pattern shifts among Saudi adults during COVID-19 pandemic: insights from a cross-sectional examination.

Background: Since the emergence of COVID-19 and the subsequent imposition of lockdown and movement restrictions, the world has witnessed fundamental lifestyle changes including alterations in dietary patterns and food consumption habits. Here, we investigated how the COVID-19 lockdown impacted dietary patterns and eating behaviors in the Saudi population.

Methodology: This cross-sectional study enrolled 427 participants aged 18 years or more, with 258 of them completing the survey.

Untangling the complex mechanisms associated with Alzheimer's disease in elderly patients using high-throughput RNA sequencing data and next-generation knowledge discovery methods: Focus on potential gene signatures and drugs for dementia.

Objectives: Alzheimer's disease (AD) is a complex neurodegenerative disorder that primarily affects elderly individuals. This study aimed to elucidate the intricate mechanisms underlying AD in elderly patients compared with healthy aged individuals using high-throughput RNA sequencing (RNA-seq) data and next-generation knowledge discovery methods (NGKD), with a focus on identifying potential therapeutic agents.

Methods: High-throughput RNA-seq data were obtained from the Gene Expression Omnibus (GEO) database (accession number: GSE104704).

Evaluating palliative care's role in symptom management for CKD patients in Egypt: A quasi-experimental approach.

Objectives: Chronic kidney disease (CKD) is a global health challenge that affects patients' symptom burden and quality of life. Palliative care interventions show promise in addressing the multiple needs of CKD patients, focusing on symptom management, psychosocial support, and advance care planning. This study aimed to evaluate the effectiveness of palliative care interventions in improving symptom management in patients with CKD.

Functional neurological disorder treated with psychoeducation: A case report.

Rationale: Psychogenic tremor (PT) is the most common subtype of psychogenic movement disorder, characterized by involuntary movement, and is usually related to occupational injuries or accidents. Psychogenic movement disorder falls under the category of functional neurological disorders, which are diagnosed based on the criteria outlined in the Diagnostic and Statistical Manual of Mental Disorders.

Patient Concerns: A 25-year-old Saudi male with a history of recurrent superior ventricular tachycardia presented to the emergency department with tremors affecting all his extremities for 8 days.

Enhancing Syagrus romanzoffiana lignocellulosic fibers' properties by ecological treatment with sodium bicarbonate for applications in sustainable lightweight biocomposites.

Investigating the fascinating world of natural fibers, where Syagrus romanzoffiana fibers (SrFs) are promising substitutes for glass and synthetic fibers in composite materials, is more than interesting. The improvement of SrFs through an environmentally friendly treatment employing sodium bicarbonate (NaHCO₃) at different concentrations (5 %, 10 %, 20 %, and 30 % by weight) over various durations (24, 72, and 168 h) is the subject of this study. The objective is to provide a sustainable and economical approach to enhancing fiber characteristics.

Ecological and health risk assessment of Sharm El-sheikh beach sediments, Red Sea coast.

Sharm El-Sheikh, located at the southern entrance of the Gulf of Aqaba, is a key tourist destination known for its mild climate and commitment to environmental initiatives, notably hosting COP27 in 2022. This study evaluates heavy metal contamination in beach sediments to assess environmental and human risks. Sampling was conducted at Sharm Port and El-Maya Bay, both popular tourist areas.

Molecular cloning, sequencing, expression and purification of Alkhumra hemorrhagic fever virus capsid protein in Saudi Arabia.

Introduction: Alkhumra hemorrhagic fever virus (AHFV) is a newly discovered virus in the Flaviviridae family. It was discovered in 1995 among animal handlers in Saudi Arabia. AHFV spreads through close contact with infected animals and tick bites.

Targeting senescence and GATA4 in age-related cardiovascular disease: a comprehensive approach.

The growing prevalence of age-related cardiovascular diseases (CVDs) poses significant health challenges, necessitating the formulation of novel treatment approaches. GATA4, a vital transcription factor identified for modulating cardiovascular biology and cellular senescence, is recognized for its critical involvement in CVD pathogenesis. This review collected relevant studies from PubMed, Google Scholar, and Science Direct using search terms like 'GATA4,' 'cellular senescence,' 'coronary artery diseases,' 'hypertension,' 'heart failure,' 'arrhythmias,' 'congenital heart diseases,' 'cardiomyopathy,' and 'cardiovascular disease.

Acaricidal and insecticidal activities of entomopathogenic nematodes combined with rosemary essential oil and bacterium-synthesized silver nanoparticles against camel tick, and wax moth, .

An innovative approach to ticks and insect pests management is necessary to mitigate the challenges posed by the indiscriminate use of chemical pesticides, which can lead to resistance development and environmental pollution. Despite their great potential, biological control agents have significant manufacturing, application, and stability limitations. Currently, using phytochemicals, biosynthesized nanoparticles, and bioagents to get rid of arthropods might be a good alternative that would make farmers less worried about residues and resistance.

Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies.

Luteolin is widely distributed phytochemical, a flavonoid, in kingdom plantae. Luteolin with potential antioxidant activity prevent ROS-induced damages and reduce oxidative stress which is mainly responsible in pathogenesis of many diseases. Several chemo preventive activities and therapeutic benefits are associated with luteolin.

Intravenous Lipid Emulsion for Managing Local Anesthetic Toxicity in a Three-Month-Old Patient.

Local anesthetic systemic toxicity (LAST) is a well-known life-threatening local anesthetics complication, especially if given in inappropriate doses or routes. Therefore, physicians should be aware of LAST symptoms, such as neurological and cardiac symptoms. In addition, they should always consider it in the differential diagnosis when they encounter similar symptoms.

Exploring the Association Between Hypothyroidism, Mean Platelet Volume, and Red Cell Distribution Width: A Case-Control Study.

Background: Thyroid hormones are important in regulating hematopoiesis. Recent research has suggested that red cell distribution width (RDW) and mean platelet volume (MPV) may be useful inflammatory markers in various disorders, including thyroid disorders. Hence, the study aimed to evaluate the association between hypothyroidism, RDW, and MPV.

Efficacy of Probiotics in the Management of Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis.

Irritable bowel syndrome (IBS) significantly impacts quality of life. Probiotics offer relief by modulating gut microbiota, but variability in outcomes necessitates a systematic evaluation of their efficacy. This study aims to evaluate the efficacy of probiotics in improving symptoms of IBS through a systematic review and meta-analysis.

Comparative efficacy of minoxidil alone versus minoxidil combined with low-level laser therapy in the treatment of androgenic alopecia: a systematic review and meta-analysis.

Objective: This systematic review evaluates the efficacy of minoxidil alone versus minoxidil with low-level laser therapy (LLLT) for androgenic alopecia.

Study Design: systematic review and meta-analysis.

Methods: An online search of PubMed, Web of Science, and MEDLINE was conducted.

Knockdown-resistant mutations in head lice (Pediculus humanus capitis) collected from schoolchildren in Riyadh, Saudi Arabia.

Head lice infestation remains one of the most common child problems. This problem is not only attributed to the ability of head lice to spread rapidly but also because of the head lice resistance that develops from incomplete or improper treatment. Pyrethroids are a group of medications that have been widely used for the treatment of head lice.

Designing sustained release from nanofiber patch for paclitaxel as prospective localized nanotherapeutic delivery in breast cancer.

The second most prevalent cause of mortality among women is breast cancer, and paclitaxel (PTX) is an effective drug for its treatment. The present work aims to develop patch-based poly(ε-caprolactone) (PCL) nanofibers incorporating PTX as a localized and sustained drug delivery system. The co-deposition of poly(vinyl alcohol) (PVA) fibers during electrospinning was allowed to improve water absorption by the scaffold, which in turn facilitated the release of drug molecules.

Pregnancy, delivery, and neonatal outcomes among women with beta-thalassemia major: a population-based study of a large US database.

Purpose: We explored the effect of beta-thalassemia major on pregnancy and delivery outcomes in non-endemic area, utilizing USA population database.

Methods: This is a retrospective study utilizing data from the Healthcare Cost and Utilization Project-Nationwide Inpatient Sample. A cohort of all deliveries between 2011 and 2014 was created using ICD-9 codes.