Assessing the Influence of Patient Anxiety on the Efficacy of Endodontic Procedures.

Background: Patient anxiety is known to influence various aspects of dental procedures, including endodontic treatments. However, the extent of its impact on the efficacy of such procedures remains uncertain. Understanding this influence is crucial for improving patient outcomes and optimizing treatment protocols.

A novel mucoadhesive paliperidone-nanoemulsion developed using the ultrasonication method in the treatment of schizophrenia.

: To develop paliperidone mucoadhesive-nanoemulsion (PLP-NE) to enhance brain bioavailability. To evaluate comparative effects of PLP-NE and CS-PLP-NE in the treatment of schizophrenia, followed by a toxicity study of opt-NE. : Oil: oleic acid, surfactant: Tween-80, and co-surfactant: Labrasol were chosen based on the solubility and maximum nanoemulsion area.

Systematic computational strategies for identifying protein targets and lead discovery.

Computational algorithms and tools have retrenched the drug discovery and development timeline. The applicability of computational approaches has gained immense relevance owing to the dramatic surge in the structural information of biomacromolecules and their heteromolecular complexes. Computational methods are now extensively used in identifying new protein targets, druggability assessment, pharmacophore mapping, molecular docking, the virtual screening of lead molecules, bioactivity prediction, molecular dynamics of protein-ligand complexes, affinity prediction, and for designing better ligands.

Subclinical leaflet thrombosis and anticoagulation strategy following trans-catheter aortic valve replacement: A systematic review.

Objective: Subclinical leaflet thrombosis (SLT) develops in 15% of patients undergoing trans-catheter aortic valve replacement (TAVR). TAVR is a procedure in which a faulty aortic valve is replaced with a mechanical one. An aortic valve replacement can be done with open-heart surgery; this is called surgical aortic valve replacement (SAVR).

Microsatellite-based analysis reveals populations in the Kingdom of Saudi Arabia result from colonization by both the ancestral African and the global domestic forms.

(Linnaeus, 1762) mosquito is the main vector of dengue, chikungunya and Zika and is well established today all over the world. The species comprises two forms: the ancestral form found throughout Africa and a global domestic form that spread to the rest of the tropics and subtropics. In Saudi Arabia, has been known in the southwest since 1956, and previous genetic studies clustered from Saudi Arabia with the global domestic form.

Case report of congenital neutropenia type 4 with glucose-6-phosphatase catalytic subunit 3 (G6PC3) deficiency.

Congenital neutropenia syndromes encompass a group of genetic disorders characterized by persistent neutropenia and recurrent infections inherited in an autosomal recessive, dominant, or X-linked manner. These syndromes arise from mutations in various genes, and one of the significant genes involved is glucose-6-phosphatase catalytic subunit 3 (), giving rise to a condition known as Dursun syndrome. As per existing knowledge, a total of 92 cases of Dursun syndrome have been reported globally, including eight cases from Saudi Arabia.

Tailoring magnetic Sn-MOFs for efficient amoxicillin antibiotic removal through process optimization.

This study investigated the efficacy of magnetic Sn metal-organic frameworks (MSn-MOFs) in removing the insecticide amoxicillin (AMX) from aqueous solutions. Our thorough experimental investigation showed that MSn-MOFs were an incredibly effective adsorbent for removing AMX. Several methods were used to characterize the material.

An overview of the Leucospidae (Hymenoptera, Chalcidoidea) of the Arabian Peninsula with description of a new species.

An overview of the family Leucospidae (Hymenoptera, Chalcidoidea) is provided for the leucospid fauna of the Arabian Peninsula. Two genera containing four species are identified based on morphometrics and colour patterns. One species, Usman, Anwar & Ahmad, , is described.

Correction: Molecular basis of sulfolactate synthesis by sulfolactaldehyde dehydrogenase from .

[This corrects the article DOI: 10.1039/D3SC01594G.].

Molecular basis of sulfolactate synthesis by sulfolactaldehyde dehydrogenase from .

Sulfolactate (SL) is a short-chain organosulfonate that is an important reservoir of sulfur in the biosphere. SL is produced by oxidation of sulfolactaldehyde (SLA), which in turn derives from sulfoglycolysis of the sulfosugar sulfoquinovose, or through oxidation of 2,3-dihydroxypropanesulfonate. Oxidation of SLA is catalyzed by SLA dehydrogenases belonging to the aldehyde dehydrogenase superfamily.

A highly selective Hg colorimetric sensor and antimicrobial agent based on green synthesized silver nanoparticles using extract.

Plasmonic nanoparticles such as Ag have gained great interest in the biomedical domain and chemical analysis due to their unique optical properties. Herein, we report a simple, cost-effective, and highly selective colorimetric sensor of mercury(ii) based on (horsetail) extract-functionalized Ag nanoparticles (ED-AgNPs). The ED-AgNPs were synthesized by exploiting the coordination of Ag with the various functional groups of ED extract under sunlight exposure for only tens of seconds.

Footcare knowledge and practice among diabetic patients attending primary health care centers in Jazan region, Saudi Arabia.

Background: Diabetic foot is one of the significant complications of diabetes mellitus, associated with a high risk of morbidity and mortality. Patients' knowledge of, and willingness to practice, good footcare are essential and may decrease these risks. This study was conducted to assess adult diabetic patients' knowledge of footcare and willingness to put their knowledge into practice.

Antibacterial activity of the micro and nanostructures of the optical material tris(8-hydroxyquinoline)aluminum and its application as an antimicrobial coating.

Although tris(8-hydroxyquinoline)aluminum (Alq), a fluorescent optical organometallic material, is known for its applications in optoelectronics, it has only few and limited applications in the biological field. In this study, the antibacterial activity of Alq micro and nanostructures was investigated. We prepared Alq nanostructures.

"The pandemic of distance learning": How Arab high school students see online-learning during Covid-19.

Emergency transition to online due to the coronavirus disease 2019 (Covid-19) pandemic has created unprecedented challenges in schooling. There is a dearth of information on the perception of Arab high school students and parents regarding the negative effects of online learning during Covid-19. Qualitative analysis of data from a multisite ethnographic-centered study collected in nine Arab countries.

AI bot to detect fake COVID-19 vaccine certificate.

As the world is now fighting against rampant virus COVID-19, the development of vaccines on a large scale and making it reach millions of people to be immunised has become quintessential. So far 40.9% of the world got vaccinated.

Multirooted supernumerary tooth in the anterior maxilla: A rare presentation.

Multirooted supernumerary tooth is a rare finding, which predisposes to various malocclusion. The present case report depicts the presence of a multirooted supernumerary tooth in the anterior maxilla just adjacent to the midline in a 24-year-old patient.

A long-standing case of desmoplastic fibroblastoma of the face.

The present case report depicts an unusually large desmoplastic fibroblastoma. The diagnosis of the lesion appears to be deceptive clinically. The purpose of this case image is to highlight its size and presenting symptoms, which could easily be mistaken for an odontogenic, salivary gland, or a soft tissue neoplasm.

Acute liver failure due to hepatitis B virus reactivation induced by doxorubicin and cyclophosphamide chemotherapy for adjuvant treatment of breast cancer: A case report.

Acute liver failure developed in a 48-year-old woman within days after she received adjuvant chemotherapy for breast cancer. On arrival at ED, she had severe encephalopathy and jaundice. Serum analyses demonstrated coagulopathy and markedly increased transaminases.

Neonatal intestinal diffuse ganglioneuromatosis with plexiform neurofibromas; Diagnostic and management pitfalls-A case report.

Neonatal intestinal ganglioneuroma and neurofibromatosis are rare in neonates. It is a challenging pathology to diagnose and treat. A 3-week-old full-term newborn with a birth weight of 3.

State-of-the-art developments in carbon-based metal nanocomposites as a catalyst: photocatalysis.

The rapid progress of state-of-the-art carbon-based metals as a catalyst is playing a central role in the research area of chemical and materials engineering for effective visible-light-induced catalytic applications. Numerous admirable catalysts have been fabricated, but significant challenges persist to lower the cost and increase the action of catalysts. The development of carbon-based nanostructured materials (, activated carbon, carbon nitride, graphite, fullerenes, carbon nanotubes, diamond, graphene, ) represents an admirable substitute to out-of-date catalysts.

First contribution to the doryctine fauna (Hymenoptera, Braconidae, Doryctinae) of Farasan Archipelago, Saudi Arabia, with new records and the description of a new species.

The doryctine wasp species (Hymenoptera: Braconidae) of Farasan Archipelago (Saudi Arabia) are studied here for the first time. Six species are reported, of which Edmardash, Gadallah & Soliman is described and illustrated as a new species. sp.

Melamine-based functionalized graphene oxide and zirconium phosphate for high performance removal of mercury and lead ions from water.

Heavy metal ions are highly toxic and widely spread as environmental pollutants. This work reports the development of two novel chelating adsorbents, based on the chemical modifications of graphene oxide and zirconium phosphate by functionalization with melamine-based chelating ligands for the effective and selective extraction of Hg(ii) and Pb(ii) from contaminated water sources. The first adsorbent melamine, thiourea-partially reduced graphene oxide (MT-PRGO) combines the heavier donor atom sulfur with the amine and triazine nitrogen's functional groups attached to the partially reduced GO nanosheets to effectively capture Hg(ii) ions from water.

The first survey of the beetles (Coleoptera) of the Farasan Archipelago of the southern Red Sea, Kingdom of Saudi Arabia.

The Farasan Archipelago is a group of small coral islands and islets in the southern Red Sea, offshore of the southwestern Kingdom of Saudi Arabia (KSA). These islands are internationally important as breeding sites for turtles and bird species and regionally for its threatened, rare, and endemic flora and other fauna. The beetles (Coleoptera) of the Archipelago have not been previously surveyed.

Viromimetic STING Agonist-Loaded Hollow Polymeric Nanoparticles for Safe and Effective Vaccination against Middle East Respiratory Syndrome Coronavirus.

The continued threat of emerging, highly lethal infectious pathogens such as Middle East respiratory syndrome coronavirus (MERS-CoV) calls for the development of novel vaccine technology that offers safe and effective prophylactic measures. Here, a novel nanoparticle vaccine is developed to deliver subunit viral antigens and STING agonists in a virus-like fashion. STING agonists are first encapsulated into capsid-like hollow polymeric nanoparticles, which show multiple favorable attributes, including a pH-responsive release profile, prominent local immune activation, and reduced systemic reactogenicity.