Synergetic anaerobic digestion of food waste for enhanced production of biogas and value-added products: strategies, challenges, and techno-economic analysis.

The generation of food waste (FW) is increasing at an alarming rate, contributing to a total of 32% of all the waste produced globally. Anaerobic digestion (AD) is an effective method for dealing with organic wastes of various compositions, like FW. Waste valorization into value-added products has increased due to the conversion of FW into biogas using AD technology.

Exogenous dsRNA trigger RNAi in Venturia inaequalis resulting in down regulation of target genes and growth reduction.

Background: Venturia inaequalis is an apple scab causing fungal pathogen. It is a highly contagious and destructive pathogen which rapidly spreads infection in the surrounding orchards if not managed. The management and control of disease require multiple fungicides to be sprayed at different development stages of the apple.

Nose to Brain Delivery of Transferrin conjugated PLGA nanoparticles for clonidine.

The present work focuses on the development of surface modified transferrin PLGA nanoparticles loaded with clonidine for nose to brain delivery. The CLD-Tf-PLGA-NPs were developed using double emulsification, followed by solvent evaporation and characterization. Particle size, PDI and Zeta potential of the nanoparticles was 199.

Therapeutic Potential of in Gut Dysbiosis TMAO Associated Diabetic Cardiomyopathy.

Background: Dysbiosis of the gastrointestinal microbiota is not only related to the pathogenesis of intestinal disorders but also associated with extra-intestinal diseases. Various studies have revealed the role of an imbalance of intestinal microbiota and their metabolites including bile acids, indole derivatives, polyamines, and trimethylamine in the progression of various diseases. The elevated plasma level of the oxidized form of trimethylamine is associated with the increased risk of cardiovascular diseases.

Agri-food waste as environmental pollutant: Root causes, challenges and solution.

In addition, wet solid waste can be converted to fuel components using hydrothermal liquefaction technology. To minimize the adversity of environmental pollution, some of the preventive measures need to be undertaken by following the principles of 3R's- Reuse, Reduce and Recycle, each one plant one, use of public transportation and adopt the use of carpooling to save fuel.

Household food waste and theory of planned behavior: A systematic review and meta-analysis.

The darker side of food behavior is that millions of tons of food have been shown the doors of garbage. Therefore, food waste behavior needs an eye to look upon. The purpose of this research is to inculcate the concept of systematic literature review along with meta-analysis in order to examine the Theory of Planned Behavior (TPB) with respect to food waste behavior.

Synthesis of a large area ReS thin film by CVD for in-depth investigation of resistive switching: effects of metal electrodes, channel width and noise behaviour.

The anisotropic crystal structure and layer independent electrical and optical properties of ReS make it unique among other two-dimensional materials (2DMs), emphasizing a special need for its synthesis. This work discusses the synthesis and in-depth characterization of a 1 × 1 cm large and few layered ReS film. Vibrational modes and excitonic peaks observed from the Raman and photoluminescence (PL) spectra corroborated the formation of a ReS film with a 1.

SIRC epidemic model with cross-immunity and multiple time delays.

Multi-strain diseases lead to the development of some degree of cross-immunity among people. In the present paper, we propose a multi-delayed SIRC epidemic model with incubation and immunity time delays. Here we aim to examine and investigate the effects of incubation delay [Formula: see text] and the impact of vaccine which provides partial/cross-immunity with immunity delay parameter ([Formula: see text]) on the disease dynamics.

Polysorbate 80 surface modified PLGA nanoparticles: an evaluation of cellular uptake and cytotoxicity on neuro-2a cells.

Aim: Present study focuses on the development of P80 coated PLGA Nanoparticles loaded with drugs, paroxetine (P80-Par-PLGA-NPs) and clonidine (P80-CLD-PLGA-NPs) for evaluation of Cellular Uptake & Cytotoxicity on Neuro-2a cells.

Method: P80-Par-PLGA-NPs and P80-CLD-PLGA-NPs were developed and characterised for zeta size, potential, PDI, EE%, DL%, TEM, SEM, FTIR, DSC, i release, cytotoxicity, histopathological and cell uptake studies using rhodamine loaded P80-NPs.

Result: Mean particle diameter of P80-Par-PLGA-NPs and P80-CLD-PLGA-NPs was 204; 182.

A machine learning and blockchain based secure and cost-effective framework for minor medical consultations.

With the ever-increasing awareness among people regarding their health, visiting a doctor has become quite common. However, with the onset of the COVID-19 pandemic, home-based consultations are gaining popularity. Nevertheless, the worries over privacy and the lack of willingness to assist patients by the medical professionals in the online consultation process have made current models ineffective.

Neuroprotective potential of saroglitazar in 6-OHDA induced Parkinson's disease in rats.

Parkinson's disease (PD) is a neurodegenerative disorder that affects 2%-3% of the population worldwide. Clinical presentation of PD includes motor and non-motor symptoms. The interplay between pathogenic factors such as increased oxidative stress, neuroinflammation, mitochondrial dysfunction and apoptosis are responsible for neurodegeneration in PD.

Are Clinical or Surgical Outcomes Different Based on Whether the Same Surgeon or Hospital System Performs the Spine Revision?

Study Design: Retrospective cohort study.

Objective: To determine the effects of discontinuity in care by changing surgeons, health systems, or increased time to revision surgery on revision spine fusion surgical outcomes and patient-reported outcomes.

Summary Of Background Information: Patients undergoing revision spine fusion experience worse outcomes than those undergoing primary lumbar surgery.

Therapeutic Targeting of Mitochondrial Plasticity and Redox Control to Overcome Cancer Chemoresistance.

Mitochondria are subcellular organelles performing essential metabolic functions contributing to cellular bioenergetics and regulation of cell growth or death. The basic mitochondrial function in fulfilling the need for cell growth and vitality is evidenced whereby cancer cells with depleted mitochondrial DNA (rho zero, p cells) no longer form tumors until newly recruited mitochondria are internalized into the rho zero cells. Herein lies the absolute dependency on mitochondria for tumor growth.

Characterization and in-depth genome analysis of a halotolerant probiotic bacterium Paenibacillus sp. S-12, a multifarious bacterium isolated from Rauvolfia serpentina.

Background: Members of Paenibacillus genus from diverse habitats have attracted great attention due to their multifarious properties. Considering that members of this genus are mostly free-living in soil, we characterized the genome of a halotolerant environmental isolate belonging to the genus Paenibacillus. The genome mining unravelled the presence of CAZymes, probiotic, and stress-protected genes that suggested strain S-12 for industrial and agricultural purposes.

Molecular characterization and in-depth genome analysis of Enterobacter sp. S-16.

Enterobacter species are considered to be an opportunistic human pathogen owing to the existence of antibiotic-resistant strains and drug resides; however, the detailed analysis of the antibiotic resistance and virulence features in environmental isolates is poorly characterized. Here, in the study, we characterized the biochemical characteristics, and genome, pan-genome, and comparative genome analyses of an environmental isolate Enterobacter sp. S-16.

Computational screening of pathogenic missense nsSNPs in heme oxygenase 1 (HMOX1) gene and their structural and functional consequences.

Heme Oxygenase 1 (HMOX1) is a cytoprotective enzyme, exhibiting the highest activity in the spleen, catalyzing the heme ring breakdown into products of biological significance- biliverdin, CO, and Fe. In vascular cells, HMOX1 possesses strong anti-apoptotic, antioxidant, anti-proliferative, anti-inflammatory, and immunomodulatory actions. The majority of these activities are crucial for the prevention of atherogenesis.

A natural small molecule-mediated inhibition of alpha-synuclein aggregation leads to neuroprotection in Caenorhabditis elegans.

Small molecules are being explored intensively for their applications as therapeutic molecules in the management of metabolic and neurological disorders. The natural small molecules can inhibit protein aggregation and underlying cellular pathogenesis of neurodegenerative diseases involving multi-factorial mechanisms of action. Certain natural small molecular inhibitors of pathogenic protein aggregation are highly efficient and have shown promising therapeutic potential.

Comprehensive bioinformatics analysis of structural and functional consequences of deleterious missense mutations in the human QDPR gene.

Quinonoid dihydropteridine reductase (QDPR) is an enzyme that regulates tetrahydrobiopterin (BH4), a cofactor for enzymes involved in neurotransmitter synthesis and blood pressure regulation. Reduced QDPR activity can cause dihydrobiopterin (BH2) accumulation and BH4 depletion, leading to impaired neurotransmitter synthesis, oxidative stress, and increased risk of Parkinson's disease. A total of 10,236 SNPs were identified in the QDPR gene, with 217 being missense SNPs.

Plant -microbe assisted emerging contaminants (ECs) removal and carbon cycling.

Continuous increase in the level of atmospheric CO and environmental contaminates has aggravated various threats resulting from environmental pollution and climate change. Research into plant -microbe interaction has been a central concern of ecology for over the year. However, despite the clear contribution of plant -microbe to the global carbon cycle, the role of plant -microbe interaction in carbon pools, fluxes and emerging contaminants (ECs) removal are still a poorly understood.

Development of rapid and non-destructive electric nose (E-nose) system for shelf life evaluation of different edible seeds.

Shelf life estimation is crucial in ensuring the quality of food products. However, traditional methods are time-consuming and inefficient. Therefore, there is an urgent need for simple, efficient and rapid techniques for quality assessments.

Correction: Gupta et al. Neutrophil Extracellular Traps Promote NLRP3 Inflammasome Activation and Glomerular Endothelial Dysfunction in Diabetic Kidney Disease. 2022, , 2965.

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MATLAB simulation based study on poliovirus sensing through one-dimensional photonic crystal with defect.

The present work, theoretically examined the poliovirus sensor model composed of one-dimensional photonic crystal with defect. The transfer matrix method with the help of MATLAB software has been used to detect poliovirus present in the water sample. The main objective of the present work is to design an efficient sensor by identifying the minute variation in the refractive index of water sample due to change in the poliovirus concentration present in the sample.

A theoretical approach for a new design of an ultrasensitive angular plasmonic chemical sensor using black phosphorus and aluminum oxide architecture.

In this study, the biosensing capabilities of conventional and hybrid multilayer structures were theoretically examined based on surface plasmon resonance (SPR). The transfer matrix method is adopted to obtain the reflectance spectra of the hybrid multilayer structure in the visible region. In this regard, the considered SPR sensor is configured as, [prism (CaF)/AlO/Ag/AlO/2D material/AlO/Sensing medium].

Comparison of efficiency of various DC-DC converters connected to solar photovoltaic module.

In this paper, an attempt is made to build an effective solar photovoltaic (PV) system considering geographical aspects such as irradiance and temperature using the single-diode equation model. Furthermore, a comparative analysis of various DC-DC converters (buck, boost, inverting buck-boost, non-inverting buck-boost (NIBB), Cuk, and single-ended primary inductance converter (SEPIC)) connected to a solar photovoltaic (PV) module was conducted in order to determine the optimal combination of DC-DC converter and solar PV. Moreover, the R, L, and C parameters for the converters have also been proposed to gain optimum efficiency from the solar PV system, and it has been shown that increasing the resistance decreases the ripple value.