antitubercular, anticancer activities and IL-10 expression in HCT-116 cells of (Lour.) Merr. leaves extract.

Considering the importance of in folklore as immunomodulant, the leaves subjected to cold maceration using ethanol, ethyl acetate and n-hexane and then screened for their antitubercular, anticancer and IL-10 expression (HCT-116) properties using luciferase reporter phage, MTT and flow cytometry assay methods, respectively. The results revealed that ethyl acetate and n-hexane extracts demonstrated the promising (p < 0.05) antitubercular activity with inhibition (%) of 92% and 86%, at 100 µg/ml, respectively and the respective IC values of 63.

Application of computational tools for the designing of Oleuropein loaded nanostructured lipid carrier for brain targeting through nasal route.

Purpose: Meningitis is an inflammation of meninges encircled the brain and spinal cord. Currently it can be treated with second generation cephalosporins which were ended up with an unresolvable problem called Multi Drug Resistance (MDR). Hence, there is a need to develop a better herbal molecule to conflict the MDR.

Bio-Hythane production from organic fraction of municipal solid waste in single and two stage anaerobic digestion processes.

The present study was aimed to examine the Bio-Hythane production in a single and two-stage anaerobic digestion (AD) systems from the organic fraction of municipal solid waste (OFMSW) along with its quantification by gas chromatography (GC). The Bio-Hythane produced in a single-stage is a blend of 6% H, 20% CH and 30% CO in the first run and 5% H, 25% CH and 34% CO in the second run whereas 6% H, 15% CH and 56% CO in the two-stage AD. Statistical analysis concluded that there is a significant difference between both the methods.

Estimation of structural and mechanical properties of Cadmium Sulfide/PVA nanocomposite films.

Cadmium Sulfide (CdS) nanoparticles have been synthesized by hydrothermal method, and dispersed in varying amounts by weight, in Poly Vinyl Alcohol (PVA) matrix. Subsequently, PVA/CdS nanocomposite films have been characterized and analyzed to estimate CdS nanoparticles effect on the properties of PVA films. Both mechanical and structural properties have been considered for the analysis.

Impact of Pharmacist-directed Counseling and Message Reminder Services on Medication Adherence and Clinical Outcomes in Type 2 Diabetes Mellitus.

Introduction: Medication nonadherence is the most common issue observed in the management of diabetes because of complex and lifelong therapy. The study aimed to assess the effect of pharmacist-directed counseling and daily text message reminder on medication adherence and clinical profile of patients with type II diabetes.

Materials And Methods: This prospective, open-labeled, randomized control trial was carried out in outpatient medical department of a secondary care referral hospital.

Association between alcohol-induced oxidative stress and membrane properties in synaptosomes: A protective role of vitamin E.

Chronic and excessive alcohol consumption leads to various neurological diseases. Synaptosomes are ideal organelles to study the functional properties of the brain in alcoholism. This study focuses on the association between oxidative stress and synaptosomal membrane properties in alcohol treated rats.

Effect of directly compressible excipient and treated agar on drug release of clopidogrel oral disintegrating tablets.

Aim: In the present investigation, oral dissolving/dispersible/disintegrating tablets (ODTs) of clopidogrel were designed with a view to enhance the bioavailability and patient compliance by two different methods, namely, direct compression and effervescent methods using directly compressible excipient and treated agar (TAG).

Materials & Methods: In the direct compression method, TAG was used as a disintegrant and another method used a mixture of sodium bicarbonate and tartaric acid along with TAG as disintegrants.

Results: Among the directly compressed tablets, treated agar formulation 3 and among the effervescent tablets, treated agar and effervescent formulation 4 was found to be promising.

Enhanced anticancer efficacy of histone deacetyl inhibitor, suberoylanilide hydroxamic acid, in combination with a phosphodiesterase inhibitor, pentoxifylline, in human cancer cell lines and in-vivo tumor xenografts.

Vorinostat [suberoylanilide hydroxamic acid (SAHA)], a histone deacetylase inhibitor, shows limited clinical activity against solid tumors when used alone. The methyl xanthine drug, pentoxifylline (PENT), has been described to have antitumor properties. The aim of this study was to look for the enhanced anticancer activities of both agents when used in combination at doses lower than their respective efficacy dose when used alone.

Enhancement of Loperamide Dissolution Rate by Liquisolid Compact Technique.

The aim of present study was to improve the dissolution rate of poorly soluble drug Loperamide (LPM) by liquisolid compact technique. Liquisolid compacts of LPM were prepared using Propylene glycol (PG) as a solvent, Avicel pH 102 as carrier, Aerosil as coating material and Sodium Starch Glycolate (SSG) as superdisintegrant. Interactions between the drug and excipients were examined by Fourier Transform Infrared (FTIR) spectroscopy.

Association of The Common CYP1A1*2C Variant (Ile462Val Polymorphism) with Chronic Myeloid Leukemia (CML) in Patients Undergoing Imatinib Therapy.

Objective: Cytochrome P450 is one of the major drug metabolizing enzyme families and its role in metabolism of cancer drugs cannot be less emphasized. The association be- tween single nucleotide polymorphisms (SNPs) in CYP1A1 and pathogenesis of chronic myeloid leukemia (CML) has been investigated in several studies, but the results observed vary based on varied risk factors. The objective of this study was to investigate the risk factors associated with the CYP1A1*2C [rs1048943: A>G] polymorphism in CML patients and its role in therapeutic response to imatinib mesylate (IM) affecting clinico-pathological parameters, in the Indian population.

Phosphodiesterase inhibitor, pentoxifylline enhances anticancer activity of histone deacetylase inhibitor, MS-275 in human breast cancer in vitro and in vivo.

MS-275, a histone deacetylase inhibitor (HDACi), is undergoing clinical trials for treatment of various cancers. Pentoxifylline, a nonselective phosphodiesterase (PDE) inhibitor, has been shown to increase the effectiveness of antitumor chemotherapy. In the present study, the potential anti-cancer activity of MS-275 in combination with pentoxifylline in panel of cell lines and human breast cancer xenograft model were examined.

Hydroxamates of para-aminobenzoic acid as selective inhibitors of HDAC8.

A series of hydroxamates (4a-4l) were prepared from p-aminobenzoic acid to inhibit HDAC8. The idea is to substitute rigid aromatic ring in place of less rigid piperazine ring of hydroxamates reported earlier by our group. It is expected to increase potency retaining the selectivity.

Bioanalytical method development and validation of milnacipran in rat plasma by LC-MS/MS detection and its application to a pharmacokinetic study.

A simple, sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the quantification of milnacipran (MC) in rat plasma by using the liquid-liquid extraction method. Milnacipran-d10 (MCD10) was used as an internal standard (IS). Chromatographic separation was achieved on Zorbax SB-CN (4.

A validated specific stability-indicating RP-HPLC assay method for Ambrisentan and its related substances.

A validated specific stability-indicating reverse-phase liquid chromatographic method was developed for the quantitative determination of Ambrisentan as well as its related substances in bulk samples, pharmaceutical dosage forms in the presence of degradation products and its related impurities. Forced degradation studies were performed on bulk samples of Ambrisentan as per the ICH-prescribed stress conditions using acid, base, oxidative, thermal stress and photolytic degradation to show the stability-indicating power of the LC method. Significant degradation in acidic, basic stress conditions was observed and no degradation was observed in other stress conditions.