A ratiometric luminescence thermometer based on lanthanide encapsulated complexes.

Lanthanide-containing complexes have been widely developed as ratiometric luminescence thermometers, which are non-invasive, contactless and accurate. The synthesis of these Ln complexes generally requires high temperatures, multiple steps and other harsh conditions. Moreover, bimetallic lanthanide complexes, which have been reported to be better thermometers, are even more challenging to synthesize.

Stretchable hierarchical metal wire networks for neuromorphic emulation of nociception and anti-nociception.

Among biomimetic technologies, the incorporation of sensory hardware holds exceptional utility in human-machine interfacing. In this context, devices receptive to nociception and emulating antinociception gain significance as part of pain management. Here we report, a stretchable two-terminal resistive neuromorphic device consisting of a hierarchical Ag microwire network formed using a crack templating protocol.

Supramolecular Guest Exchange in Cucurbit[7]uril for Bioorthogonal Fluorogenic Imaging across the Visible Spectrum.

Fluorogenic probes that unmask fluorescence signals in response to bioorthogonal reactions are a powerful new addition to biological imaging. They can significantly reduce background fluorescence and minimize nonspecific signals, potentially enabling real-time, high-contrast imaging without the need to wash out excess fluorophores. While diverse classes of highly refined synthetic fluorophores are now readily available, integrating them into a bioorthogonal fluorogenic scheme still requires extensive design efforts and customized structural alterations to optimize quenching mechanisms for each specific fluorophore scaffold.

Role of Covalent Cages and Rattler Atoms in Lowering the Thermal Conductivity in Zintl Metal Chalcogenides.

Zintl phases represent a class of compounds, mainly intermetallics, which are characterized by ionic and covalent bonds in the same crystal. Since its discovery in the late 1800s, Zintl phases have found their importance as an academic interest due to their fascinating structure as well as in industry due to their vast applicability. In recent years, the Zintl phase of metal chalcogenides has further demonstrated its ability as a promising thermoelectric material, primarily due to its intrinsically ultralow lattice thermal conductivity (κ).

A fluorescent probe with serum albumin as a signal amplifier for real-time sensing of HSO in solution, mitochondria of animal cells and rice roots.

Endogenous release of HSO during the enzymatic oxidation of sulfur containing amino acids in mitochondria or insufficiency of sulfite oxidase results in the accumulation of sulfite and thiosulfate in biological fluids affecting mitochondrial homeostasis of brain mitochondria associated with serious clinical symptoms related to neurological disorders. The red fluorescent probe MGQ undergoes self-assembly in water and reveals aggregation induced quenching of fluorescence. MGQ reveals 143-fold and 179-fold increases in fluorescence intensity at 645 nm, respectively, in the presence of HSA and BSA and does not significantly differentiate between two albumins.

Modeling High Concentration Bisalt-in-Sulfolane Electrolytes and the Observation of Ligand-Bridged Cation-Pair Complexes.

Despite the abundance of sodium over lithium in Earth's crust and the copious amounts of expensive lithium salt required to make Li-ion high-concentration electrolytes (HCEs), studies of HCEs made from sodium salts remain sparse. A comparative molecular-level study of Li- and Na-ion HCEs and mixed cation or bisalt HCEs in an organic solvent is missing. To fill this gap, we studied model HCEs of pure and mixed Li and Na salts of bis(fluorosulfonyl)amide (FSI) in sulfolane using a confluence of classical molecular dynamics (MD), ab initio MD (AIMD) simulations, and quantum chemical cluster calculations.

Modulating photophysical properties in a flexible porous host by regulating guest-assisted charge transfer interactions.

The 1D array of electron donor-acceptor chromophoric organic molecules is of paramount importance for photovoltaic, catalytic and optoelectronic applications. Herein, we report coordination driven 1D arrays of an electron-donor guest (fluorene, carbazole, dibenzofuran, and dibenzothiophene) and -phen chelator as an acceptor in a Zn-based porous coordination polymer, {[Zn(-phen)(ndc)]·DMF} (PCP-1). All the guest-encapsulated PCPs were characterized by performing single-crystal structure determinations and showed emission driven by charge transfer.

Atomically Precise Fluorescent Gold Nanocluster as a Barrier-Permeable and Brain-Specific Imaging Probe.

Photonic nanomaterials play a crucial role in facilitating the necessary signal for optical brain imaging, presenting a promising avenue for early diagnosis of brain-related disorders. However, the blood-brain barrier (BBB) presents a significant challenge, blocking the entry of most molecules or materials from the bloodstream into the brain. To overcome this, photonic nanocrystals in the form of gold clusters (LAuC) with size less than 3 nm, have been developed, with Levodopa conjugated to LAuC (Dop@LAuC) for targeted brain imaging.

Identification and detection of conserved G-quadruplex in monkeypox virus using conformation specific fluorogenic probe.

Identifying distinct noncanonical structures in pathogenic genomes is crucial for developing new diagnostic tools. This study uncovers stable G-quadruplex (GQ) structures in conserved DNA sequences unique to the monkeypox virus (MPV). Furthermore, we developed a method for the detection of target GQ using a fluorogenic probe.

Multistep Array-Based Sensing of Bioanalytes Using Modified MoS, Fluorescence Proteins, and Cucurbituril.

One pot sensor by multiplexing in the array is an attractive system for rapid discrimination of multiple analytes. Multiplexing can be achieved in two ways, i.e.

p300/CBP KATs Are Critical for Maturation and Differentiation of Adult Neural Progenitors.

Epigenetic modifications play a pivotal role in the process of neurogenesis. Among these modifications, reversible acetylation fine-tunes gene expression for both embryonic and adult neurogenesis. The CBP/KAT3A and its paralogue p300/KAT3B are well-known lysine acetyltransferases with transcriptional coactivation ability that engage in neural plasticity and memory.

Unambiguous Detection of LTR-III G-Quadruplex in the HIV Genome Using a Tailored Fluorogenic Probe-based Assay.

The noncanonical conformations within the genomes of viral pathogens is of significant diagnostic value, due to their unique secondary structures and interactions with specific fluorogenic molecules. In particular, adaptation of the G-quadruplex (GQ) conformation by the specific gene sequence leads to distinct topological features, resulting in unique binding sites that are crucial for the selective recognition of human immunodeficiency virus (HIV) by small molecules. Leveraging the selective fluorescence response of a benzobisthiazole-based fluorogenic probe to the LTR-III GQ target, we developed a GQ-based diagnostic platform for HIV detection.

Effect of AFM ordering on thermoelectric responses of MgX(X: C, Si, Ge) monolayers : a DFT insight.

Two-dimensional materials have gained a lot of attention in the last few decades due to their potential applications in thermoelectric and nano-electronic devices. This study systematically presents the mechanical, electronic and thermoelectric characteristics of two-dimensional honeycomb-kagomeMg3X2(X:C,Si,Ge) structures in the framework of density functional theory computations and by solving semiclassical Boltzmann transport equation. The geometrical stability of these structures is validated by phonon spectrum and molecular dynamics simulations.

Enhancing the antibacterial efficacy of vancomycin analogues: targeting metallo-β-lactamases and cell wall biosynthesis.

Vancomycin is a crucial last-resort antibiotic for tackling Gram-positive bacterial infections. However, its potency fails against the more difficult-to-treat Gram-negative bacteria (GNB). Vancomycin derivatives have shown promise as broad-spectrum antibacterials, but are still underexplored.

Unravelling denaturation, temperature and cosolvent-driven chiroptical switching in peptide self-assembly with switchable piezoelectric responses.

Herein, we explore the intricate pathway complexity, focusing on the dynamic interplay between kinetic and thermodynamic states, during the supramolecular self-assembly of peptides. We uncover a multiresponsive chiroptical switching phenomenon influenced by temperature, denaturation and content of cosolvent in peptide self-assembly through pathway complexity (kinetic thermodynamic state). Particularly noteworthy is the observation of chiroptical switching during the denaturation process, marking an unprecedented phenomenon in the literature.

Lipid-Conjugated Reduced Haloperidol in Association with Glucose-Based Nanospheres: A Strategy for Glioma Treatment.

Aggressive glioma exhibits a poor survival rate. Increased tumor aggression is linked to both tumor cells and tumor-associated macrophages (TAMs), which induce pro-aggression, invasion, and metastasis. Imperatively, for effective treatment, it is important to target both glioma cells and TAMs.

A triazole-based covalent organic framework as a photocatalyst toward visible-light-driven CO reduction to CH.

Solar-light driven reduction of CO to CH is a complex process involving multiple electron and proton transfer processes with various intermediates. Therefore, achieving high CH activity and selectivity remains a significant challenge. Covalent organic frameworks (COFs) represent an emerging class of photoactive semiconductors with molecular level structural tunability, modular band gaps, and high charge carrier generation and transport within the network.

High Performance and Selective Sequestration of Cd(II) from Water by Layered Thiophosphate.

The extensive use of toxic cadmium (Cd) in energy conversion and industrial applications ranging from solar cells and battery appliances to paints and pigments contaminates water bodies. However, the upper limit of Cd contamination in drinking water is to be only 3 ppb by the WHO and 5 ppb by the USA-EPA, which underscores the need for cost-effective, efficient, and ppb level capture of Cd from contaminated water. Leveraging the selectivity due to Lewis's hard-soft acid-base (HSAB) theory, we have achieved swift and highly selective capture of Cd(II) ions from aqueous mediums using layered potassium manganese thiophosphate (K-MnPS).

Energy-efficient resistive switching synaptic devices based on patterned Ag nanotriangles with tunable gaps fabricated using plasma-assisted nanosphere lithography.

The development of synaptic devices featuring metallic nanostructures with brain-analog hierarchical architecture, capable of mimicking cognitive functionalities, has emerged as a focal point in neuromorphic computing. However, existing challenges, such as inconsistent and unpredictable switching, high voltage requirements, unguided filament formation, and detailed fabrication processes, have impeded technological progress in the domain. The present study addresses some of these challenges by leveraging periodic nanostructures of Ag fabricated plasma-assisted nanosphere lithography (NSL).