The Assisted Reproductive Technology Act 2021- Provisions and Implications.

The desire for parenthood among infertile individuals is often fulfilled by resorting to the ever-evolving Assisted Reproductive Techniques (ART). Since the birth of Durga, India's first baby born using ART in 1981, the lucrative fertility industry has grown exponentially in our country. The Government of India passed the Assisted Reproductive Technology (Regulatory) Act in 2021 to provide regulatory support to these services.

Core Procedural Skills to be Taught for III-Year Undergraduate Medical Students: A Modified Delphi Study.

Introduction: While medical students are expected to learn procedural skills during their training, there is no consensus on their level of learning. Further, the most essential procedural skills across medical curricula which need to be taught during their III-year clinical posting are often not considered. The purpose of this study was to identify the core procedural skills needed to be taught during the III-year undergraduate medical students clinical posting.

Transcatheter Closure of Moderate to Large Perimembranous Ventricular Septal Defects in Children Weighing 10 kilograms or less.

Background: Transcatheter device closure of ventricular septal defect (VSD) is an alternative to conventional surgical closure. Device closure of moderate to large perimembranous VSD (pmVSD) is considered technically challenging in smaller children weighing ≤10 kg. Very few studies are published on the outcomes of the same.

Extreme negative remodeling of septal left anterior descending branch masquerading as a bifurcation lesion.

We report a case of severe negative remodelling at the ostium of septal LAD artery. We deferred stenting to avoid the risk of rupture of the vessel and stent fracture.

Decreased baroreflex sensitivity is linked to sympathovagal imbalance, low-grade inflammation, and oxidative stress in pregnancy-induced hypertension.

Pregnancy-induced hypertension (PIH) has been reported as a cardiovascular (CV) risk. We assessed the sympathovagal imbalance (SVI) and the association of inflammation and oxidative stress (OS) with CV risks in PIH. A total of 125 pregnant women having a risk factor for PIH were followed till term and the incidence of PIH was observed.

Is red blood cell a mediator of remote ischaemic preconditioning?

Remote ischaemic preconditioning is emerging as a promising clinical technique which can afford immediate protection against coronary ischaemia. The mechanisms which mediate the signal transduction from remote organ to the heart are still unclear. The role of ATP sensitive potassium channels in ischaemic preconditioning has been established.

Pharmacogenetics of methotrexate in acute lymphoblastic leukaemia: why still at the bench level?

Purpose: The antifolate drug methotrexate (MTX) was introduced into clinical practice about 60 years ago and remains an important component of different acute lymphoblastic leukemia (ALL) treatment protocols. It acts by inhibiting several enzymes in the folate pathway, thereby resulting in the disruption of folate homeostasis. To date, treatment regimens have not been personalized despite there being experimental evidence that gene polymorphisms of folate metabolizing enzymes affect MTX response.

Association of albumin-globulin ratio with sympathovagal imbalance in pregnancy-induced hypertension.

The early prediction of pregnancy-induced hypertension (PIH) is based on the demonstration of increased sympathetic activity in early part of pregnancy. However, the mechanisms that increase sympathetic activity in PIH have not yet been fully elucidated. Therefore, in the present study we have investigated the link of albumin-globulin ratio (AGR) to sympathovagal imbalance in PIH patients.

A new objective scoring system for the prediction of successful induction of labour.

A prospective study was done in 311 women undergoing induction of labour for the formulation of a new score, which will be more objective than the conventional Bishop's score. Pre-induction cervical assessment was done by the transvaginal sonographic parameters followed by the digital examination. Labour induction was successful in 79.

Gender difference in the effect of short-term calorie restriction on body weight and immunological parameters in albino rats.

In the present study, we have assessed the effect of gender on short-term calorie restriction influencing body weight and immunological parameters in albino rats. Adult albino rats (12 females, 12 males) were taken for the study and randomly divided into control and experimental groups of both the genders (n = 6 in each). Following the recording of their basal 24 h food intake and body weight, rats of experimental groups were allowed to undergo food restriction (eat every alternate day) for 21 days, whereas control rats were allowed to eat normally.

Undergraduate orthopedic education: Is it adequate?

Background: Basic musculoskeletal knowledge is essential to the practice of medicine. The purpose of this study was to assess the adequacy of musculoskeletal knowledge of medical students.

Materials And Methods: The validated basic competency examination in musculoskeletal medicine devised by Freidman and Bernstein was administered to final year medical students just prior to their final professional examination.

Reliable site for suction blister induction and harvesting.

Background: Suction blister grafting is a useful modality of treatment of patients with resistant and stable vitiligo. However, there have been no detailed studies to find out the best donor site for blister formation.

Methods: The study was conducted between the period of October 2004 and February 2005 in the dermatology department at a tertiary care center.