Hyperandrogenism in polycystic ovary syndrome and adrenal hyperplasia: finding differences to make a specific diagnosis.

Purpose: Polycystic Ovary Syndrome (PCOS) and Adrenal hyperplasia (CAH) are two pathologic conditions sharing several clinical features (hirsutism, acne, polycystic ovary morphology, metabolic alterations, ovulatory dysfunctions) and especially hyperandrogenism as a common clinical hallmark. Therefore, making a differential diagnosis of the two conditions still remains a great medical challenge.

Methods: In particular, the comparison discussed in this review referred to non-classical form of adrenal hyperplasia (NCAH), which regards the adult population, and the Endocrine Metabolic Syndrome (EMS), following the new set of PCOS diagnostic criteria proposed by the Experts Group on Inositol and Clinical Research, and on PCOS (EGOI-PCOS).

Disentangling Sources of Momentum Fluctuations in Xe+Xe and Pb+Pb Collisions with the ATLAS Detector.

High-energy nuclear collisions create a quark-gluon plasma, whose initial condition and subsequent expansion vary from event to event, impacting the distribution of the eventwise average transverse momentum [P([p_{T}])]. Disentangling the contributions from fluctuations in the nuclear overlap size (geometrical component) and other sources at a fixed size (intrinsic component) remains a challenge. This problem is addressed by measuring the mean, variance, and skewness of P([p_{T}]) in ^{208}Pb+^{208}Pb and ^{129}Xe+^{129}Xe collisions at sqrt[s_{NN}]=5.

Numerical dosimetry of specific absorption rate of insects exposed to far-field radiofrequency electromagnetic fields.

Purpose: This paper reports a study of electromagnetic field (EMF) exposure of several adult insects: a ladybug, a honey bee worker, a wasp, and a mantis at frequencies ranging from 2.5 to 100 GHz. The purpose was to estimate the specific absorption rate (SAR) in insect tissues, including the brain, in order to predict the possible biological effects caused by EMF energy absorption.

Characteristics and Antitumor Activity of Doxorubicin-Loaded Multifunctional Iron Oxide Nanoparticles in MEC1 and RM1 Cell Lines.

The rapid progress in nanotechnology has introduced multifunctional iron oxide nanoparticles as promising agents in cancer treatment. This research focused on the synthesis and assessment of citric-acid-coated, folic-acid-conjugated nanoparticles loaded with doxorubicin, evaluating their therapeutic potential in tumor models. An advanced automated continuous technology line (CTL) utilizing a controlled co-precipitation method was employed to produce highly dispersive, multifunctional nanofluids with a narrow size distribution.

Love as a Commitment Device : Evidence from a Cross-Cultural Study across 90 Countries.

Given the ubiquitous nature of love, numerous theories have been proposed to explain its existence. One such theory refers to love as a commitment device, suggesting that romantic love evolved to foster commitment between partners and enhance their reproductive success. In the present study, we investigated this hypothesis using a large-scale sample of 86,310 individual responses collected across 90 countries.

INTEGRATED MANAGEMENT OF OVARIAN ENDOMETRIOMAS: PRE- AND POST-SURGICAL USE OF DIENOGEST.

Aim: to evaluate the efficacy of an integrated management approach for ovarian endometriomas using Dienogest administered both before and after laparoscopic cyst enucleation in women with infertility.

Materials And Methods: The prospective, comparative clinical trial included 44 patients aged 18-35 years with ovarian endometriomas and infertility. Patients were randomly divided into two groups: the study group (20 participants) received Dienogest for six months before and after laparoscopic cyst enucleation, while the control group (24 participants) underwent laparoscopic cyst enucleation without additional hormonal treatment.

CORRELATION BETWEEN EJECTION FRACTION AND CORONARY SINUS BLOOD FLOW DURING OFF-PUMP CORONARY ARTERY BYPASS GRAFTING SURGERY.

Introduction: Many studies have shown that coronary artery bypass grafting (CABG) increases the survival rate of patients, but the effect of bypass grafting on cardiac function is still a matter of debate.

Objective: The objective of our study was to determine: a. To what extent can the change in coronary sinus flow be used as an intraoperative criterion for the assessment of adequate revascularization.

STUDY OF ORAL HEALTH AND SUPPORTIVE STRUCTURES FOR PROSTHETIC RESTORATIONS IN METHADONE MAINTENANCE THERAPY BENEFICIARIES AND DRUG USERS.

Introduction: Methadone Maintenance Therapy (MMT) is commonly used to treat opioid addiction but can cause significant oral health issues, including poor oral hygiene, dental caries, periodontal disease, and bone resorption. These issues can negatively impact on overall quality of life, leading to both aesthetic and functional concerns.

Aim Of The Study: This research compares the oral health of individuals in methadone maintenance treatment (MMT) with those starting MMT.

PHAGE-BACTERIA INTERACTIONS UNDER METAL STRESS: A STUDY OF THE NOVEL STENOTROPHOMONAS MALTOPHILIA PHAGE VB_STM18.

Stenotrophomonas maltophilia is a highly adaptable gram-negative bacteria, demonstrating resilience in metal-contaminated environment, which makes it a key subject for understanding microbial survival under heavy metal stress. This study investigates the effects of cadmium ions (Cd²⁺) on the growth dynamics, cadmium uptake, and bacteriophage vB_Stm18-host interactions, with implications for environmental microbiology and applied biotechnology. Growth analysis revealed that S.

EFFECTIVENESS OF COMBINED SURGICAL AND HORMONAL THERAPY IN TREATMENT OF ENDOMETRIOMAS.

Introduction: Endometrial cyst, or endometrioma, is a specific form of endometriosis that often reveals with severe symptoms and requires ongoing treatment. High rate of recurrence after surgical intervention presents a significant challenge in the management of this disease.

Aim Of The Study: Aim of the study was to determine the effectiveness of combined therapy (surgical and hormonal) of endometrioma in terms of development of recurrences, the rate of pregnancy and change in pain intensity.

EVALUATING ORAL AND MAXILLOFACIAL HEALTH CHALLENGES IN INTRAVENOUS DRUG USERS: A CROSS-SECTIONAL STUDY OF DRUG REPLACEMENT THERAPY PARTICIPANTS AND NON-PARTICIPANTS.

Introduction: Intravenous drug use has a significant impact on oral and maxillofacial health, often resulting in complications like tooth loss and osteomyelitis. This study investigates the differences in oral health between drug users enrolled in replacement therapy and those not yet participating, with the goal of assessing the impact of structured treatment programs.

Aim: to evaluate and compare the prevalence of oral and maxillofacial complications among drug users involved in replacement therapy and those newly registering for treatment.

Sclerosing Mucoepidermoid Carcinoma With Eosinophilia of the Thyroid: A Rare Case From Georgia and a Comprehensive Literature Review.

Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) is a rare thyroid malignancy typically linked to chronic lymphocytic thyroiditis. We present the first documented case of SMECE in Georgia, involving a 41-year-old woman with Hashimoto's thyroiditis. A 16 mm hypoechoic thyroid nodule was detected on routine ultrasound, and fine needle aspiration categorized it as Bethesda V.

THE ORAL HEALTH STATUS AND PREVENTIVE MEASUREMENTS FOR CANCER PATIENTS.

Unlabelled: Oncology patients frequently face a variety of oral side effects as a result of cancer treatments like chemotherapy, radiation therapy, and targeted therapy. One common issue is periodontitis. Additionally, patients with COVID-19 have reported a range of oral symptoms, including necrotizing periodontal disease.

SUCCESSFUL EMERGENCY ARTERIAL EMBOLIZATION FOR MASSIVE GASTRODUODENAL BLEEDING IN HIGH-RISK PATIENT. CASE REPORT.

Massive upper gastrointestinal bleeding still remains a challenge, which can cause serious clinical problems especially in high-risk patients. We present a rare case of patient with complex pathology successfully managed by endovascular treatment. A 78-year-old man with a medical history of chronic bronchitis, several minor strokes, type II diabetes, a 30-year history of smoking, and a family history of cardiovascular disease, presented with severe pain on the left side of his chest radiating to his left arm.

USAGE OF SILVER NANOPARTICLES TO RESTORE MOXIFLOXACIN EFFICACY FOR FLUOROQUINOLONE-RESISTANT M. TUBERCULOSIS CULTURES.

Background: Fluoroquinolones are used for the complex treatment of mono-, poly-, and multi-resistant Tuberculosis (TB) and are the most efficient among resistant TB treatment drugs. Disease caused by fluoroquinolone-resistant TB strains, especially pre-extensive TB (pre-XDR) and extensive (XDR) forms are extremely hard to manage, and treatment efficacy is quite low. With the revitalization and extension of resistant TB drugs, one of the main research domains is to study resistance inhibitors aimed at restoring the efficacy of main and priority anti-TB medications.

A Case Report of Folliculotropic Mycosis Fungoides: Diagnostic Criteria and Treatment Strategy.

Folliculotropic mycosis fungoides (F-MF) is considered a unique variant of mycosis fungoides (MF), which is a form of cutaneous T-cell lymphomas (CTCLs). F-MF can appear in various forms, including patches, papules, plaques, nodules, and tumors. It often affects the face and extremities, with some cases involving the eyebrows.

Co-occurrence of Unicornuate Uterus with Noncommunicating Functioning Rudimentary Horn and VACTERL Association-A Case Report.

Introduction: The co-occurrence of a unicornuate uterus with a noncommunicating, functioning rudimentary horn and VACTERL association represents an extremely rare condition, with only 3 similar cases reported in the literature.

Case: The patient, aged 12 years and 9 months, presented with pelvic pain and severe dysmenorrhea, which started shortly after her menarche at 12 years and 4 months. At birth, she exhibited 3 characteristic components of VACTERL association: bronchoesophageal fistula/esophageal atresia, anal atresia, and polydactyly.

Search for the Exclusive W Boson Hadronic Decays W^{±}→π^{±}γ, W^{±}→K^{±}γ and W^{±}→ρ^{±}γ with the ATLAS Detector.

A search for the exclusive hadronic decays W^{±}→π^{±}γ, W^{±}→K^{±}γ, and W^{±}→ρ^{±}γ is performed using up to 140  fb^{-1} of proton-proton collisions recorded with the ATLAS detector at a center-of-mass energy of sqrt[s]=13  TeV. If observed, these rare processes would provide a unique test bench for the quantum chromodynamics factorization formalism used to calculate cross sections at colliders. Additionally, at future colliders, these decays could offer a new way to measure the W boson mass through fully reconstructed decay products.

Living with COPD and its psychological effects on participating in community-based physical activity in Brazil: a qualitative study. Findings from the Breathe Well group.

Physical activity (PA) improves dyspnoea, psychological wellbeing and quality of life (QoL) for people with COPD reducing their risk of exacerbation. However, engagement in PA is low especially amongst those with anxiety and depression, and PA programmes are limited in countries with limited resources such as Brazil. We explored perceptions of 21 people with COPD about the impact of their disease on taking part in community-based PA programmes in Sao Paulo, Brazil through semi-structured telephone interviews from October 2020 to April 2021.

THE RELATIONSHIP BETWEEN FOLLICLE SIZE, OOCYTE MATURATION, BLASTOCYST FORMATION, BLASTOCYST PLOIDY, AND PREGNANCY OUTCOMES IN YOUNG WOMEN UNDERGOING IVF.

Unlabelled: The relationship between follicle size, oocyte quality, and blastocyst ploidy is not fully established. This question becomes especially important for poor responders and older reproductive age women, where optimal follicle size and oocyte quantity cannot always be achieved during ovarian stimulation. The aim of this study is to determine the relationship between follicle size, oocyte maturation, blastocyst formation, blastocyst ploidy, and pregnancy outcomes in young women undergoing in vitro fertilization (IVF).