186 results match your criteria: "Japanese Red Cross Shizuoka Hospital[Affiliation]"

Purpose: This study introduces a new technique, spherical periacetabular osteotomy (SPO), performed via a para-sartorial intermuscular (PSIM) approach with a bikini incision, aiming to optimise the benefits of SPO, including preservation of muscles and providing cosmetic advantages.

Methods: Overall, 57 joints of 52 patients (mean age 36 ± 17 years) underwent SPO via the PSIM approach. Preoperative osteoarthritis was classified according to Tönnis grade, with 34 and 23 hips categorised as grades 0 and 1, respectively.

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Genetic landscape in undiagnosed patients with syndromic hearing loss revealed by whole exome sequencing and phenotype similarity search.

Hum Genet

January 2025

Division of Hearing and Balance Research, National Institute of Sensory Organs, NHO Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-Ku, Tokyo, 152-8902, Japan.

There are hundreds of rare syndromic diseases involving hearing loss, many of which are not targeted for clinical genetic testing. We systematically explored the genetic causes of undiagnosed syndromic hearing loss using a combination of whole exome sequencing (WES) and a phenotype similarity search system called PubCaseFinder. Fifty-five families with syndromic hearing loss of unknown cause were analyzed using WES after prescreening of several deafness genes depending on patient clinical features.

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Background: Despite accumulating evidence and recommendations for management of colonic diverticular bleeding (CDB), the changes in its clinical management and outcomes remain unknown.

Methods: We performed a retrospective tendency analysis on a biennial basis, a propensity score-matched cohort study between the first and latter half groups, and mediation analyses to compare the diagnostic and treatment methods between January 2010 and December 2019 (CODE BLUE-J Study).

Results: A total of 6575 patients with CDB were included.

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Background: Progressive pulmonary fibrosis (PPF) is a critical concern in interstitial lung disease (ILD) management. The HAL score, which incorporates honeycombing (H), age >75 years (A), and serum lactate dehydrogenase >222 U/L (L), can predict acute exacerbations in patients with idiopathic interstitial pneumonia (IIP). This study aims to evaluate the predictive utility of the HAL score for PPF development.

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Introduction: Preoperative estimations of blood loss are important when planning surgery for cervical spine injuries in older adults. The association between ankylosis and blood loss in perioperative management is of particular interest. This multicenter database review aimed to evaluate the impact of ankylosis on surgical blood loss volume in elderly patients with cervical spine injury.

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Background/objectives: The detection of pancreatic cancer (PC) often depends on indirect indicators such as parenchyma atrophy (PPA), main pancreatic duct stenosis, and low echoic areas, particularly when no mass is evident on imaging. While pathological evaluation is the gold standard for differentiating malignant from benign conditions, endoscopic ultrasound-guided fine-needle aspiration/biopsy is not always feasible in such cases. Serial pancreatic juice aspiration cytologic examination (SPACE) via endoscopic nasopancreatic drainage (NPD) has emerged as an alternative diagnostic method, though its accuracy remains underevaluated.

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Background And Aims: We sought to validate the British Society of Gastroenterology (BSG) guidelines for acute lower gastrointestinal bleeding (ALGIB).

Methods: We analyzed 8,956 patients with ALGIB in CODE BLUE-J study and categorized them into four groups based on BSG guidelines. Outcomes included 30-day rebleeding, 30-day mortality, blood transfusion, therapeutic intervention, and severe bleeding.

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Article Synopsis
  • This study analyzed 389 patients aged 65 and older with cervical spinal cord injury (CSCI) but no bone injury to assess the effects of diabetes on neurological recovery.
  • The research found that there were no significant differences in neurological outcomes between diabetic patients and those without diabetes at 6 months post-injury.
  • Additionally, moderate-severe diabetes did not adversely impact recovery, suggesting that diabetic patients had similar improvements in neurological function as their nondiabetic counterparts.
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Background: Map-like redness, pathological intestinal metaplasia, is observed in one-fourth to one-third of patients 1 year after Helicobacter pylori eradication therapy, mainly in the corpus, and is a newly identified endoscopic risk factor for gastric cancer development after eradication. However, it is unclear whether intestinal metaplasia is present before eradication at the site where the map-like redness appears. We aimed to identify endoscopic findings that predict the occurrence of map-like redness before H.

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Background: We have previously shown that static and dynamic resting-state functional connectivity differ between migraineurs with and without photophobia, phonophobia, or osmophobia. Furthermore, some patients with photophobia also experience phonophobia or osmophobia. To investigate the functional connectivity specific to migraineurs with photophobia, we examined the differences in static and dynamic resting-state functional connectivity between patients with and without photophobia, with no phonophobia or osmophobia.

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Article Synopsis
  • - Migraine affects many people aged 20-50 and has serious social and economic consequences, but its underlying causes are still largely unknown; this review focuses on the role of cortical spreading depolarization (CSD) related to migraine aura and potential therapies.
  • - The article outlines how CSD, which leads to significant neuronal changes, is linked to the visual symptoms of migraines and is also found in other neurological disorders, emphasizing its cellular characteristics and effects on the trigeminal nervous system.
  • - Current treatments include prevention strategies and drugs targeting the calcitonin gene-related peptide (CGRP) involved in migraine pain, while new therapies like intranasal insulin-like growth factor 1 and vagus nerve stimulation show promise in reducing
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  • A multicenter study in Japan analyzed the clinical characteristics, headache types, severity, and psychiatric comorbidities of 2,378 patients visiting headache clinics.
  • The predominant headache type among the patients was migraine (78.8%), with tension-type headaches (12.2%) and secondary headaches (5.5%) being less common.
  • Patients with trigeminal autonomic cephalalgias reported the highest levels of headache severity and psychiatric symptoms compared to those with other headache types.
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  • Immune-related pneumonitis (irP) is a significant side effect of immune checkpoint inhibitors, often relapsing after corticosteroid treatment, which complicates cancer therapy.* -
  • A study analyzed 56 patients with irP and found that 39.3% experienced relapses post-prednisolone therapy; significant risk factors included a radiographic pattern of organizing pneumonia and an onset of irP more than 100 days after starting treatment.* -
  • Identifying these risk factors is crucial for better managing irP in patients undergoing treatment, as it could lead to improved outcomes.*
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Migraine is a multifactorial brain disorder characterized by recurrent disabling headaches and their associated features. Several studies have suggested that these features are related to headache impact, pain intensity, and psychiatric conditions. However, differences in the relationship between each associated feature and headache impact, pain intensity, or psychiatric conditions remain unclear.

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Article Synopsis
  • This study investigates interstitial pneumonia with autoimmune features (IPAF) in patients with idiopathic interstitial pneumonia (IIP), aiming to identify serum biomarkers related to autoimmune characteristics and prognosis.
  • An analysis of 222 newly diagnosed IIP patients over three years revealed that high serum levels of CXCL10 were significantly associated with better lung function metrics and acute onset of symptoms, as well as a higher likelihood of IPAF classification.
  • The findings suggest that CXCL10 could serve as a valuable biomarker for evaluating the clinical course of IIP patients, highlighting its potential role in understanding disease progression and patient outcomes.
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Efficacy of galcanezumab in migraine central sensitization.

Sci Rep

September 2024

Headache Center, Department of Neurology, Tominaga Hospital, 1-4-48 Minatomachi, Naniwa Ward, Osaka, Japan.

Galcanezumab, a monoclonal antibody targeting the calcitonin gene-related peptide pathway (CGRP mAb), acts peripherally due to its large size. However, recent studies have suggested that CGRP mAbs may also have a central mode of action. This study aimed to evaluate the central effects of galcanezumab on migraine central sensitization.

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Introduction: Venous thromboembolism (VTE) remains a major complication after total hip arthroplasty (THA), irrespective of the surgical approach. This study investigated the incidence of VTE in patients undergoing THA through intermuscular minimally invasive surgical techniques, which included a direct anterior approach (DAA), an anterolateral approach (AL), and an anterolateral supine approach (ALS), at a single institution.

Methods: A hundred consecutive patients treated with each surgical approach were evaluated.

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To investigate the safety of total body irradiation-based myeloablative conditioning (TBI-MAC) in adolescent and young adult (AYA) Philadelphia chromosome (Ph)-negative acute lymphoblastic leukemia (ALL) patients treated with pediatric protocols, treatment outcomes of 106 AYA patients aged 16-39 years old undergoing allogeneic stem cell transplant (allo-SCT) with TBI-MAC in the first remission were compared according to chemotherapy types before transplant. Pediatric and adult protocols were used in 56 and 50 of the patients, respectively. The cumulative incidence (CI) of non-relapse mortality (NRM) and the overall survival (OS) rates were not significantly different between the pediatric-protocol and adult-protocol group (NRM: 4 % vs.

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Objectives: Endoscopic lithotripsy and elective cholecystectomy, followed by endoscopic retrograde cholangiopancreatography, are the first-line treatments for patients with common bile duct (CBD) stones (CBDS) and gallstones. However, this approach entails acute cholecystitis and recurrent cholangitis risk while patients await surgery. We aimed to identify acute cholecystitis and cholangitis risk factors during the waiting time for elective cholecystectomy.

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Study Design: Retrospective comparative study.

Objective: To evaluate the relationship between pelvic incidence (PI) and proximal junctional kyphosis (PJK) in patients with Lenke type 5 adolescent idiopathic scoliosis (AIS).

Summary Of Background Data: Although PJK is a common complication of sagittal malalignment after posterior correction and fusion surgery (PSF), few studies have assessed its risk factors.

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The misdiagnosis of headache disorders is a serious issue, and AI-based headache model diagnoses with external validation are scarce. We previously developed an artificial intelligence (AI)-based headache diagnosis model using a database of 4000 patients' questionnaires in a headache-specializing clinic and herein performed external validation prospectively. The validation cohort of 59 headache patients was prospectively collected from August 2023 to February 2024 at our or collaborating multicenter institutions.

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Article Synopsis
  • The study examined the link between blood group O and the likelihood of rebleeding in patients with acute lower gastrointestinal bleeding (ALGIB).
  • Out of 2336 patients analyzed, those with blood group O had higher rebleeding rates within 30 days (17.9%) and 1 year (21.9%) compared to non-O patients.
  • Blood group O was found to be an independent risk factor for rebleeding, while rates of thrombosis and mortality were similar between groups.
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Introduction: Precise prediction of hospital stay duration is essential for maximizing resource utilization during surgery. Existing lumbar spinal stenosis (LSS) surgery prediction models lack accuracy and generalizability. Machine learning can improve accuracy by considering preoperative factors.

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Article Synopsis
  • - The study evaluated the effectiveness of a person-centered care program for nurses in acute-care hospitals, comparing it to a dementia-type-specific program over a period from July 2021 to January 2022 across seven hospitals.
  • - Out of 158 participants, those in the intervention group showed significant gains in dementia nursing expertise, medical knowledge, and confidence, along with improvements in ethical sensitivity regarding patient dignity.
  • - The control group also had positive outcomes, particularly in providing care tailored to cognitive function, indicating that both programs have valuable impacts on nursing care in dementia patients.
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Purpose: We evaluated the efficacy and safety of antiemetic therapy with olanzapine, a neurokinin-1 receptor antagonist (RA), a 5-hydroxytryptamine-3 (5-HT) RA, and dexamethasone for preventing chemotherapy-induced nausea and vomiting in patients receiving carboplatin-containing chemotherapy.

Patients And Methods: Chemotherapy-naïve patients scheduled to receive carboplatin (AUC ≥5) were randomly assigned to receive either olanzapine 5 mg once daily (olanzapine group) or placebo (placebo group) in combination with aprepitant, a 5-HT RA, and dexamethasone. The primary end point was the complete response (CR; no vomiting and no rescue therapy) rate in the overall phase (0-120 hours).

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