1 results match your criteria: "Japan. Electronic address: tanakayo@college.fdcnet.ac.jp.[Affiliation]"
Pathobiont-responsive Th17 cells in gut-mouth axis provoke inflammatory oral disease and are modulated by intestinal microbiome.
Cell Rep
September 2022
Section of Infection Biology, Department of Functional Bioscience, Fukuoka Dental College, Fukuoka 814-0193, Japan; Oral Medicine Research Center, Fukuoka Dental College, Fukuoka 814-0193, Japan. Electronic address:
Article Synopsis
- Th17 cells play a crucial role in the immune response against oral pathogens, particularly in the development of periodontitis.
- The oral pathobiont Porphyromonas gingivalis exacerbates periodontitis by promoting Th17 cell differentiation, which occurs in Peyer's patches and allows these cells to migrate to oral tissues.
- The study shows that the intestinal microbiome influences Th17 cell response, with antibiotic treatment altering the microbiome potentially impacting the progression of periodontitis.