2 results match your criteria: "Japan. Electronic address: johno@college.fdcnet.ac.jp.[Affiliation]"

Effect of DNA/protamine complex paste on bone augmentation of the mandible: A pilot study on dogs.

Arch Oral Biol

July 2020

Research Center for Regenerative Medicine, Fukuoka Dental College, Tamura, Sawara-ku, Fukuoka, Japan; Oral Medicine Research Center, Fukuoka Dental College, Tamura, Sawara-ku, Fukuoka, Japan. Electronic address:

Objective: Our previous studies found that a salmon DNA-based scaffold containing protamine promoted bone regeneration of the calvarial defects of rats. The aim of the present pilot study was to examine the influence of the DNA/protamine (DP) complex on bone regeneration of a saddle type, alveolar ridge defects of the dog mandible.

Design: Alveolar ridge defects were performed in the mandibles of five adult female beagles.

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Osteoinductive scaffolds are required for bone tissue engineering. The aim of the present study was to assess the osteoinductive capacity of deoxyribonucleic acid (DNA)/protamine complexes in a rat model of critical-size calvarial defects. In addition, we investigated whether cultured mesenchymal-like cells (DP-cells) outgrown from DNA/protamine complex engrafted defects could differentiate to become osteogenic cells in vitro.

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