1 results match your criteria: "Japan eBrigham and Women's Hospital[Affiliation]"
Clinical effects of single nucleotide polymorphisms on drug-related genes in Japanese metastatic renal cell carcinoma patients treated with sunitinib.
Anticancer Drugs
January 2017
aDepartment of Urology, Akita University Graduate School of Medicine bDepartment of Pharmacy cCenter for Kidney Disease and Transplantation, Akita University Hospital, Akita dDepartment of Urology, Yamagata University Graduate School of Medicine, Yamagata, Japan eBrigham and Women's Hospital, Boston, Massachusetts, USA.
Although sunitinib is a well-established chemotherapeutic for metastatic renal cell carcinoma (mRCC), there are no robust markers that predict efficacy and toxicity. We analyzed the effect of single nucleotide polymorphisms (SNPs) in genes involved in sunitinib pharmacokinetics on clinical outcomes in Japanese patients with mRCC. We analyzed the effect of SNPs in genes involved in sunitinib pharmacokinetics on the clinical outcome in mRCC patients in a Japanese population.
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