Altered fractal behavior and heart rate variability in daily life in neurally mediated syncope.

Autonomic imbalance is thought to play an important role in the pathogenesis of neurally mediated syncope (NMS). Heart rate variability (HRV) indices and fractal dimension derived from 24 h ambulatory electrocardiogram (AECG) reflects the cardiac autonomic activity and provides useful information for understanding the pathogenesis of NMS. In this study, we sought the cardiac autonomic activity and the status of fractal dimension in daily life in patients with NMS.

[Wallerian degeneration demonstrated by MRI and functional outcome in patients suffering from supratentorial cerebrovascular disease].

An early diagnosis of the outcome of patients with cerebrovascular disease is important for selecting the optimal treatment strategy. The purpose of this study was to estimate the prognosis of Wallerian degeneration on MRI in stroke patients with hemiparesis. The subjects consisted of 87 stroke patients, 50 hemorrhagic patients and 37 ischemic patients, who were evaluated by MRI at 1 to 6,275 days after stroke onset.

[Ocular effects of topical instillation of UF-021 ophthalmic solution in healthy volunteers].

Phase I studies, as divided into two stages, were conducted in healthy volunteers with the ophthalmic solution of UF-021, a novel prostaglandin metabolite-related compound, that was reported to exhibit potent intraocular pressure (IOP)-reducing activity in various species of animals. In the first stage, the vehicle as well as UF-021 ophthalmic solutions at concentration of 0.03%, 0.