23 results match your criteria: "Japan Community Health Care Organization Sapporo Hokushin Hospital[Affiliation]"
Association between Relative Bradycardia and Adult-onset Still Disease.
JMA J
July 2024
Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Japan.
Trastuzumab Deruxtecan in Advanced Solid Tumors With Human Epidermal Growth Factor Receptor 2 Amplification Identified by Plasma Cell-Free DNA Testing: A Multicenter, Single-Arm, Phase II Basket Trial.
J Clin Oncol
November 2024
Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Article Synopsis
- The HERALD/EPOC1806 trial evaluated trastuzumab deruxtecan (T-DXd) for patients with progressive solid tumors that were identified as HER2-amplified through cell-free DNA (cfDNA) testing rather than traditional methods.
- A total of 4,734 patients underwent cfDNA testing, with 252 showing HER2 amplification; the study ultimately included 62 patients from various cancer types, who received T-DXd treatment every three weeks.
- The trial reported a 56.5% overall response rate (ORR), with a median progression-free survival of 7 months and noted interstitial lung diseases in 26% of patients, primarily mild to moderate cases.
Molecular evolutionary analysis of novel NSP4 mono-reassortant G1P[8]-E2 rotavirus strains that caused a discontinuous epidemic in Japan in 2015 and 2018.
Front Microbiol
July 2024
Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
Article Synopsis
- In the 2010s, new rotavirus strains led to global epidemics, prompting a study in Japan that analyzed 489 rotavirus-positive stool samples from 2014 to 2019 using next-generation sequencing.
- Nine different rotavirus genotypes were identified, with the dominant strain changing each year; notable strains included G8P[8] and G1P[8] in the early years, and G9P[8] becoming prevalent in 2016 and 2019.
- The study revealed that certain strains, particularly G1P[8]-E2, may have emerged from independent genetic reassortment events and exhibited distinct mutations in VP7 proteins, which could help the virus evade immune
A significant outbreak of respiratory human adenovirus infections among children aged 3-6 years in Hokkaido, Japan, in 2023.
J Med Virol
July 2024
Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan.
Human adenovirus (HAdV) infections present diverse clinical manifestations upon infecting individuals, with respiratory infections predominating in children. We surveyed pediatric hospitalizations due to respiratory HAdV infections across 18 hospitals in Hokkaido Prefecture, Japan, from July 2019 to March 2024, recording 473 admissions. While hospitalizations remained below five cases per week from July 2019 to September 2023, a notable surge occurred in late October 2023, with weekly admissions peaking at 15-20 cases from November to December.
View Article and Find Full Text PDFResurgence of human metapneumovirus infection and influenza after three seasons of inactivity in the post-COVID-19 era in Hokkaido, Japan, 2022-2023.
J Med Virol
December 2023
Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan.
Following the coronavirus disease 2019 (COVID-19) outbreak in February 2020, incidences of various infectious diseases decreased notably in Hokkaido Prefecture, Japan. However, Japan began gradually easing COVID-19 infection control measures in 2022. Here, we conducted a survey of children hospitalized with human metapneumovirus (hMPV), influenza A and B, and respiratory syncytial virus infections in 18 hospitals across Hokkaido Prefecture, Japan, spanning from July 2019 to June 2023.
View Article and Find Full Text PDFDramatical increase in articles mentioning "directed acyclic graph."
View Article and Find Full Text PDFLow Baseline CXCL9 Predicts Early Progressive Disease in Unresectable HCC with Atezolizumab Plus Bevacizumab Treatment.
Liver Cancer
June 2023
Departments of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Article Synopsis
- Atezolizumab plus bevacizumab shows effectiveness in treating unresectable hepatocellular carcinoma (HCC), but about 20% of patients may experience progressive disease (PD) shortly after starting treatment, highlighting the need for early detection methods.
- In a study, patients' serum was analyzed to identify biomarkers related to early PD; results indicated a significant difference in the cytokine CXCL9 levels between patients who developed early PD and those who did not.
- Lower serum CXCL9 levels (<333 pg/mL) were found to be predictive of early PD, with patients with these lower levels experiencing shorter progression-free survival compared to those without early PD.
Changing Patterns of Infectious Diseases Among Hospitalized Children in Hokkaido, Japan, in the Post-COVID-19 Era, July 2019 to June 2022.
Pediatr Infect Dis J
September 2023
Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan.
Background: Many reports have reported a reduction in respiratory infectious diseases and infectious gastroenteritis immediately after the coronavirus disease 2019 (COVID-19) pandemic, but data continuing into 2022 are very limited. We sought to understand the current situation of various infectious diseases among children in Japan as of July 2022 to improve public health in the post-COVID-19 era.
Methods: We collected data on children hospitalized with infectious diseases in 18 hospitals in Japan from July 2019 to June 2022.
The Clinical Utility of Relative Bradycardia for Identifying Cases of Coronavirus Disease 2019 Pneumonia: A Retrospective Pneumonia Cohort Study.
Intern Med
July 2023
Center for Environmental and Health Sciences, Hokkaido University, Japan.
Objective Both coronavirus disease 2019 (COVID-19) pneumonia and relative bradycardia are common conditions among clinicians; however, the association between these has not been well studied. The present study assessed whether or not relative bradycardia on admission was more predominant in patients with COVID-19 pneumonia than in those with other infectious pneumonia. Methods For this single-center, retrospective cohort study, we collected data through electronic medical records and examined the occurrence of relative bradycardia on admission.
View Article and Find Full Text PDFA case report involving suppressed nuclear receptor transcription factors 4a1 and Stevens-Johnson syndrome induced by a single dose of pembrolizumab and successfully treated with early steroid administration, resulting in complete remission of stage III lung cancer.
J Pharm Health Care Sci
December 2022
Department of Pharmacy and Respiratory Medicine, Japan Community Health Care Organization Sapporo Hokushin Hospital, 2-6-2-1 Atsubetsu Chou Atsubetsu, Sapporo, Hokkaido, 004-8618, Japan.
Article Synopsis
- A 68-year-old male with stage IIIb squamous cell lung cancer developed Stevens-Johnson syndrome (SJS) after receiving a single dose of the immunotherapy drug pembrolizumab, which was treated successfully with steroids, leading to complete cancer remission for over a year.
- The onset of SJS was correlated with significant changes in immune markers, including increased levels of IFN-γ and IL-17, and decreased IL-10, which were linked to lower expression of the Nr4a1 mRNA transcription factor.
- This case suggests that suppressing Nr4a1 may enhance the activity of cytotoxic T cells while reducing regulatory T cell function, potentially improving the effectiveness
Self-assessment scale for the community-based and emergency practice.
BMC Med Educ
November 2022
Department of General Medicine, Sapporo Medical University, S1 W17, Chuo-ku, Sapporo, 060-8556, Japan.
Background: For current medical education, community-based primary care for the elderly is an essential topic. This study aimed to establish a scale of community-based assessment for clinical and emergency practice (C-CEP).
Methods: A self-assessment scale for C-CEP was developed according to four steps.
The Clinical Significance of Otolaryngology Manifestations in COVID-19 Pneumonia: A Single-center Retrospective Cohort Study.
Intern Med
December 2022
Department of Pediatrics, Japan Community Health-care Organization Sapporo Hokushin Hospital, Japan.
Objective Although the absence of a runny nose and sore throat, both ear-nose-throat (ENT) symptoms, suggests community-acquired pneumonia (CAP), the association between ENT symptoms and coronavirus disease 2019 (COVID-19) pneumonia remains unclear. We therefore investigated the association between ENT symptoms and COVID-19 pneumonia. Methods We retrospectively recruited consecutive confirmed COVID-19 inpatients with and without pneumonia admitted to a single institution from April 1, 2020, to July 31, 2021.
View Article and Find Full Text PDFLiver metastasis 13 years after the resection of a malignant triton tumor originating in the duodenum.
Int Cancer Conf J
July 2022
Department of Gastroenterological Surgery I, Hokkaido University Hospital, Kita-ku, Kita 15, Nishi 7, Sapporo, Hokkaido 060-8638 Japan.
This is an additional case report of a malignant triton tumor arising in the duodenum that was removed by pancreatoduodenectomy. Liver and gallbladder dysfunctions were detected in a regular blood examination during a follow-up for hypertension in a 62-year-old woman with a previous surgical history for a malignant Triton tumor in the duodenum 13 years ago. Further examinations revealed a metastatic liver tumor originating from the malignant triton tumor in the duodenum.
View Article and Find Full Text PDFEmbedding Research Culture in Community Hospitals.
Intern Med
October 2022
Department of Clinical Pharmacology and Therapeutics, Graduate School of Medicine, University of the Ryukyus, Japan.
Background: Although bacteremia is one of the most pressing situation in the field of hospital medicine, little is known about the differences between community- and hospital-acquired bacteremia (CAB and HAB, respectively).
Methods: Objective is to know the epidemiologic characteristics of CAB and HAB. Study design is a single-center retrospective cohort study.
Genomic profiling of intestinal/mixed-type superficial non-ampullary duodenal epithelial tumors.
JGH Open
September 2021
Article Synopsis
- The study investigates the genomic features of superficial non-ampullary duodenal epithelial tumors (SNADETs) through next-generation sequencing (NGS) on small lesions treated endoscopically.
- A total of 20 patients with SNADETs under 20 mm were analyzed, revealing varying classifications from low-grade to high-grade dysplasia, with alterations in genes such as APC, KRAS, BRAF, and TP53 found in the majority of samples.
- The research highlights the presence of significant genomic alterations in small SNADETs, suggesting potential underlying mechanisms of carcinogenesis even in low-grade dysplasia cases.
Surveillance in hospitalized children with infectious diseases in Japan: Pre- and post-coronavirus disease 2019.
J Infect Chemother
November 2021
Department of Pediatrics, Sapporo Medical University School of Medicine, South-1, West-16 Chuo-ku, Sapporo, Hokkaido, 060-8543, Japan.
Introduction: The epidemic of coronavirus disease 2019 (COVID-19) rapidly spread worldwide, and the various infection control measures have a significant influence on the spread of many infectious diseases. However, there have been no multicenter studies on how the number of hospitalized children with various infectious diseases changed before and after the outbreak of COVID-19 in Japan.
Methods: We conducted a multicenter, prospective survey for hospitalized pediatric patients in 18 hospitals in Hokkaido Prefecture, Japan, from July 2019 to February 2021.
New method of endoscopic injection sclerosis for esophageal varices using by modified endoscopic hood.
Dig Endosc
July 2020
Department of Gastroenterology, Japan Community Health Care Organization Sapporo Hokushin Hospital, Hokkaido, Japan.
Intravenous abatacept in Japanese patients with polyarticular-course juvenile idiopathic arthritis: results from a phase III open-label study.
Pediatr Rheumatol Online J
April 2019
Fuji Toranomon Orthopaedics Hospital, 1067-1 Kawashimata, Gotenba-shi, Shizuoka, 412-0045, Japan.
Article Synopsis
- A study was conducted to assess the effectiveness and safety of intravenous abatacept in Japanese children aged 4-17 with active polyarticular-course juvenile idiopathic arthritis (pJIA) who had previously received inadequate treatment.
- In a phase III trial involving 20 patients, the primary outcome showed a 90% response rate (JIA-ACR30) after 16 weeks of treatment, with significant improvements in other response rates over time.
- By Week 52, high levels of efficacy were maintained, with notable improvements in disease activity and function as measured by various clinical endpoints.
Malignant triton tumor of the duodenum: report of a case.
Int Cancer Conf J
April 2018
Department of Gastroenterological Surgery, Japan Community Health Care Organization Sapporo Hokushin Hospital, Atsubetsu-ku, Chuoh 2-jo, 6-2-1, Sapporo, 004-8618 Japan.
We report a case of malignant triton tumor of the duodenum, which is extremely rare. A submucosal malignant tumor was detected in the duodenum of a 49-year-old woman. The tumor was completely resected by performing pancreaticoduodenectomy.
View Article and Find Full Text PDFDermoscopic features of tungiasis.
J Eur Acad Dermatol Venereol
August 2018
Department of Dermatology, Hokkaido University Graduate School of Medicine, North 15 West 7, Kita-ku, Sapporo, 060-8638, Japan.
Ovarian high-grade endometrioid stromal sarcoma with YWHAE and NUTM2B rearrangements.
Pathol Int
June 2017
Department of Surgical Pathology, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan.
A Prospective Observational Study on Effect of Short-Term Periodic Steroid Premedication on Bone Metabolism in Gastrointestinal Cancer (ESPRESSO-01).
Oncologist
May 2017
Division of Cancer Chemotherapy, Hokkaido University Hospital Cancer Center, Sapporo, Japan.
Background: A multicenter prospective observational study evaluated the effect of gastrointestinal cancer chemotherapy with short-term periodic steroid premedication on bone metabolism.
Patients And Methods: Seventy-four patients undergoing chemotherapy for gastrointestinal cancer were studied. The primary endpoints were changes in bone mineral densities (BMDs) and metabolic bone turnover 16 weeks after initiation of chemotherapy.