606 results match your criteria: "Japan C.M.; and Hirakata Kohsai Hospital[Affiliation]"
Eur Spine J
January 2025
Department of Orthopaedic Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Purpose: This study aimed to compare the incidence of radiological adjacent segment disease (R-ASD) at L3/4 between patients with L4/5 degenerative spondylolisthesis (DS) who underwent L4/5 posterior lumbar interbody fusion (PLIF) and those who underwent microscopic bilateral decompression via a unilateral approach (MBDU) at L4/5. Our ultimate goal was to distinguish the course of natural lumbar degeneration from fusion-related degeneration while eliminating L4/5 decompression as a confounder.
Methods: Ninety patients with L4/5 DS who underwent L4/5 PLIF (n = 53) or MBDU (n = 37) and were followed for at least 5 years were retrospectively analyzed.
Drugs Aging
January 2025
The Dementia Centre, HammondCare, St Leonards, NSW, Australia.
Background And Objectives: Despite their limited benefits and serious adverse effects, psychotropics remain frequently prescribed for neuropsychiatric symptoms (NPS) of dementia. Psychotropic polypharmacy, the use of two or more concomitant psychotropic medications, is therefore not recommended for people with dementia. The objectives of this study were to investigate the prevalence of psychotropic polypharmacy in Australians living with dementia whose caregivers sought external NPS support from Dementia Support Australia (DSA; the national provider of NPS support) and the association of psychotropic polypharmacy with their demographics and NPS characteristics.
View Article and Find Full Text PDFSci Total Environ
January 2025
Sarawak Tropical Peat Research Institute, Kota Samarahan, Malaysia.
Tropical peatlands are significant sources of methane (CH₄), but their contribution to the global CH₄ budget remains poorly quantified due to the lack of long-term, continuous and high-frequency flux measurements. To address this gap, we measured net ecosystem CH exchange (NEE-CH) using eddy covariance technique throughout the conversion of a tropical peat swamp forest to an oil palm plantation. This encompassed the periods before, during and after conversion periods from 2014 to 2020, during which substantial environmental shifts were observed.
View Article and Find Full Text PDFMaturitas
February 2025
Hormone Hamburg, Hamburg, Germany. Electronic address:
Objective: To report patient-reported quality-of-life (QOL) outcomes in the DAYLIGHT study.
Study Design: DAYLIGHT was a phase 3b, randomized, double-blind, 24-week, placebo-controlled study. Participants were women aged ≥40 to ≤65 years with moderate to severe vasomotor symptoms (VMS) considered unsuitable for hormone therapy (HT) (contraindications, caution, stoppers, or averse) randomized 1:1 to placebo or fezolinetant 45 mg once daily.
J Am Med Dir Assoc
January 2025
Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Blavatnik Family Women's Health Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Microbiol Immunol
January 2025
Division of Virology, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, Osaka, Japan.
Hepatitis B virus (HBV) infection is a serious global health problem causing acute and chronic hepatitis and related diseases. Approximately, 296 million patients have been chronically infected with the virus, leading to cirrhosis and hepatocellular carcinoma. Although HBV polymerase (HBVpol, pol) plays a pivotal role in HBV replication and must be a definite therapeutic target.
View Article and Find Full Text PDFJ Thromb Haemost
November 2024
Division of General Internal Medicine, Department of Medicine, McMaster University, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada; Division of Hematology and Thromboembolism, Department of Medicine, McMaster University, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada. Electronic address:
Neurology
December 2024
From the Nido Biosciences (S.B.H., A.T.N.T., V.V.), Inc., Boston, MA; Institute of Developmental and Regenerative Medicine (IDRM) (C.R.), University of Oxford; Department of Neuromuscular Diseases (D.J., L.Z., P.F.), University College of London, United Kingdom; Department of Neurosciences (L.B., A.F., G.S.), Neuromuscular Center, University of Padova, Italy; Neurogenetics Branch (A.A., A.K., C.G.), National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD; Copenhagen Neuromuscular Center (J.D., J.V.), Rigshospitalet, University of Copenhagen, Denmark; Fondazione IRCSS (S.F., E.C., A.B., C.M., D.P.), Istituto Neurologico Carlo Besta Milano, Italy; Department of Neurology (T.K., Y.K., S.Y.), Nagoya University Graduate School of Medicine; Department of Neurology and Department of Clinical Research Education (M. Katsuno), Nagoya University Graduate School of Medicine, Japan; Centro Clinico Nemo Adulti-Fondazione Serena onlus (A.C.), Policlinico Universitario Agostino Gemelli IRCCS; Centro Clinico Nemo Adulti-Fondazione Serena onlus (M.S.), Policlinico Universitario Agostino Gemelli IRCCS, Section of Neurology, Department of Neuroscience, Faculty of Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy; and Department of Neurology (M. Kang, J.-S.P.), School of Medicine, Kyungpook National University, Chilgok Hospital, Daegu, Korea.
Background And Objectives: Spinal and bulbar muscular atrophy (SBMA) is a rare, slowly progressive, and debilitating disease without effective treatments available. Lack of reliable biomarkers and sensitive outcome measures makes clinical research conduct challenging. The primary objective of this study was to identify clinically meaningful and statistically sensitive outcome measures enabling the evaluation of therapeutic interventions in late-stage clinical trials.
View Article and Find Full Text PDFTher Adv Med Oncol
November 2024
Department of Urology, Kindai University Faculty of Medicine, Osaka-Sayama 589-8511, Japan.
Heart Rhythm
November 2024
Amsterdam UMC, Amsterdam, The Netherlands.
Neurology
December 2024
From the Department of Neurology (Y.W., S.W., M.L.), West China Hospital, Sichuan University, Chengdu, China; The George Institute for Global Health (Y.W., T.M., S.Y., C.C., L.L., Z.Z., C.D., J.P.C., C.S.A., X.C.), Faculty of Medicine, University of New South Wales, Sydney, Australia; Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre (T.G.R.), Leicester, United Kingdom; University of Sydney (R.I.L.); Department of Clinical Medicine (C.D.), Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia; Division of Neuroimaging Sciences (G.M., J.M.W.), Centre for Clinical Brain Sciences and Centre in the UK Dementia Research Institute, University of Edinburgh, United Kingdom; Department of Neurology (J.P.C., C.S.A.), Royal Prince Alfred Hospital, Sydney Health Partners, Australia; Department of Preventive Medicine and Public Health (H.A.), Faculty of Medicine, Fukuoka University, Fukuoka, Japan; Neurology Department (Y.H.), Peking University First Hospital, Beijing, China; Neurology Department (J.S.K.), Asan Medical Centre, Seoul, South Korea; Neurology and Psychiatry Department (P.M.L.), Clinica Alemana de Santiago, Facultad de Medicina Universidad del Desarrollo, Chile; Neurology Department (T.-H.L.), Chang Gung Memorial Hospital, Taipei, Taiwan; Neurology Department (C.L., M.W.P.), John Hunter Hospital and Hunter Medical Research Institute, Newcastle, Australia; Brazilian Stroke Network (S.C.M.), Hospital de Clínicas de Porto Alegre, Hospital Moinhos de Vento, Brazil; Neurology Department (J.D.P.), Christian Medical College, Ludhiana, India; Department of Neuroscience and Behavioral Sciences (O.M.P.-N.), Ribeirao Preto School of Medicine, Brazil; School of Medicine (V.K.S.), National University of Singapore and Division of Neurology (V.K.S.), National University Hospital, Singapore; Department of Cerebrovascular Disease (T.H.N.), 115 Hospital, Ho Chi Minh City, Vietnam; Shanghai Institute for Hypertension (J.W.), Rui Jin Hospital and Shanghai Jiaotong University; and Institute of Science and Technology for Brain-inspired Intelligence (C.S.A.), Fudan University, Shanghai, China.
Eur J Haematol
February 2025
Division of Hematology, Hospital A Beneficência Portuguesa, São Paulo, Brazil.
Objectives: To evaluate the tolerability of crovalimab versus eculizumab in C5 inhibitor (C5i)-naive and -experienced patients with PNH from COMMODORE 2, 3 and 1 (NCT04434092, NCT04654468 and NCT04432584).
Methods: Pooled safety data were assessed in the total crovalimab and eculizumab populations and by C5i-naive versus C5i-switched status in patients receiving crovalimab. Analyses include 6.
Mol Ther
November 2024
Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany. Electronic address:
Chimeric antigen receptor (CAR)-T cell products, classified as Advanced Therapy Medicinal Products (ATMPs), have shown promising outcomes in cancer immunotherapy. The quality of raw and starting materials used in manufacturing is critical to ensure the efficacy and safety of CAR-T cell products and depends primarily on the selection of the right materials and the right suppliers. It is essential to consider a long-term strategy when selecting raw and starting materials to prevent delays in the supply of innovative, high-quality, and safe therapies to patients.
View Article and Find Full Text PDFNat Commun
November 2024
Protein-Protein Interaction Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Peptidylarginine deiminase IV (PADI4, PAD4) deregulation promotes the development of autoimmunity, cancer, atherosclerosis and age-related tissue fibrosis. PADI4 additionally mediates immune responses and cellular reprogramming, although the full extent of its physiological roles is unexplored. Despite detailed molecular knowledge of PADI4 activation in vitro, we lack understanding of its regulation within cells, largely due to a lack of appropriate systems and tools.
View Article and Find Full Text PDFRespir Res
November 2024
Department of Respiratory Medicine, Faculty of Medical Sciences, University of Fukui, Eiheiji, Japan.
Comprehensive care integrates individual patient needs and is highly valued for patients with pulmonary fibrosis (PF). The importance of a patient-centered care approach is rooted in the unpredictable progressiveness of the disease course in PF. The respiratory impairment associated with PF has a major impact on the quality of life for both patients and their caregivers.
View Article and Find Full Text PDFEpilepsia
December 2024
Department of Neurosciences, School of Translational Medicine, Monash University and Department of Neurology, Alfred Health, Melbourne, Victoria, Australia.
Objective: This study was undertaken to assess long-term safety, tolerability, and efficacy of lacosamide (LCM) as adjunctive therapy for generalized onset tonic-clonic seizures (GTCS) in patients aged ≥4 years with idiopathic generalized epilepsy (IGE).
Methods: EP0012 (NCT02408549) was a phase 3, multicenter, open-label extension (OLE) trial. Patients were enrolled from SP0982 (NCT02408523).
Proc Natl Acad Sci U S A
October 2024
International Arctic Research Center, University of Alaska Fairbanks, Fairbanks, AK 99775-7340.
At the northern high latitudes, rapid warming, associated changes in the hydrological cycle, and rising atmospheric CO concentrations, [CO], are observed at present. Under rapid environmental changes, it is important to understand the current and future trajectories of the CO budget in high-latitude ecosystems. In this study, we present the importance of anomalous wet conditions and rising [CO] on the long-term CO budget based on two decades (2003-2022) of quasicontinuous measurements of CO flux at a poorly drained black spruce forest on permafrost peat in interior Alaska.
View Article and Find Full Text PDFInt J Clin Oncol
January 2025
Department of Gastroenterology, Kanagawa Cancer Center, Yokohama, Japan.
J Cancer
September 2024
University of Hawai'i Cancer Center, 701 Ilalo Street Honolulu, HI 96813, USA.
Cancer-associated macrophage-like cells (CAMLs) are rare, gigantic, and atypical circulating cells found exclusively in the peripheral blood of patients with solid cancers. Obesity-induced hypoxia attracts macrophages to the tumor microenvironment, where they contribute to establishing chronic inflammation, leading to cancer progression. We hypothesized that obese patients with advanced breast cancer may have CAML profiles different from those of nonobese patients, and these profiles may correlate with proinflammatory markers or other macrophage-related markers.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
Introduction: Cerebrospinal fluid (CSF) α-synuclein (α-syn) seed amplification assay (SAA) is a sensitive and specific tool for detecting Lewy body co-pathology in Alzheimer's disease.
Methods: A total of 1637 cross-sectional and 407 longitudinal CSF samples from the Alzheimer's Disease Neuroimaging Initiative (ADNI) were tested with SAA. We examined longitudinal dynamics of amyloid beta (Aβ), α-syn seeds, and phosphorylated tau181 (p-tau181), along with global and domain-specific cognition in stable SAA+, stable SAA-, and those who converted to SAA+ from SAA-.
Nat Med
January 2025
Sarepta Therapeutics, Inc., Cambridge, MA, USA.
Nature
November 2024
Department of Thoracic and Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
J Diabetes Sci Technol
November 2024
University of California San Francisco, San Francisco, CA, USA.
Alzheimers Dement
November 2024
Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri, USA.
Introduction: Biomarkers for Alzheimer's disease neuropathologic change (ADNC) have been instrumental in developing effective disease-modifying therapeutics. However, to prevent/treat dementia effectively, we require biomarkers for non-AD neuropathologies; for this, neuropathologic examinations and annotated tissue samples are essential.
Methods: We conducted clinicopathologic correlation for the first 100 Alzheimer's Disease Neuroimaging Initiative (ADNI) Neuropathology Core (NPC) cases.
Biochim Biophys Acta Gen Subj
November 2024
Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan. Electronic address:
Background: The potency of anesthetics with various structures increases exponentially with lipophilicity, which is the Meyer-Overton (MO) correlation discovered over 120 years ago. The MO correlation was also observed with various biological effects and chemicals, including alcohols; thus, the correlation represents a fundamental relationship between chemicals and organisms. The MO correlation was explained by the lipid and protein theories, although the principle remains unknown because these are still debating.
View Article and Find Full Text PDF