Tailored topotactic chemistry unlocks heterostructures of magnetic intercalation compounds.

The construction of thin film heterostructures has been a widely successful archetype for fabricating materials with emergent physical properties. This strategy is of particular importance for the design of multilayer magnetic architectures in which direct interfacial spin-spin interactions between magnetic phases in dissimilar layers lead to emergent and controllable magnetic behavior. However, crystallographic incommensurability and atomic-scale interfacial disorder can severely limit the types of materials amenable to this strategy, as well as the performance of these systems.

Virtual staining from bright-field microscopy for label-free quantitative analysis of plant cell structures.

The applicability of a deep learning model for the virtual staining of plant cell structures using bright-field microscopy was investigated. The training dataset consisted of microscopy images of tobacco BY-2 cells with the plasma membrane stained with the fluorescent dye PlasMem Bright Green and the cell nucleus labeled with Histone-red fluorescent protein. The trained models successfully detected the expansion of cell nuclei upon aphidicolin treatment and a decrease in the cell aspect ratio upon propyzamide treatment, demonstrating its utility in cell morphometry.

Indications for and limitations of laparoscopic anatomical liver resection: assessment of postoperative complications stratified by complexity of liver resection.

Background: Although complex anatomical liver resections are more often being performed laparoscopically, the short-term outcomes following laparoscopic anatomical liver resection (LALR), its optimal indications, and limitations remain unclear. This study aimed to clarify the indications for and limitations of LALR by assessing the short-term outcomes.

Methods: This retrospective study included 233 patients who underwent LALR.

Influence of unfavourable osteotomy on skeletal stability and temporomandibular joint symptoms in sagittal split ramus osteotomy.

This study was performed to investigate the impact of the split line on postoperative stability and temporomandibular joint (TMJ) disorders (TMD) after sagittal split ramus osteotomy. Skeletal Class III malocclusion patients who underwent mandibular osteotomy with/without plate fixation between August 2008 and March 2023 were enrolled retrospectively. The osteotomy lines were divided into original sagittal split ramus (SSRO), short lingual (SLO), and short buccal (SBO) osteotomies.

Immobilization of biofunctional molecule with potential osteoinductive efficacy on titanium implant for promoting early-stage osseointegration.

In the present study, porcine-derived collagen type I was covalently immobilized on the surface of titanium (Ti) implants via carboxyl groups introduced by bonded p-vinylbenzoic acid to investigate its in vitro biocompatibility with gingival stem cells and in vivo bone regeneration behavior in the edentulous ridges of Lanyu small-ear pigs at weeks 2 and 6 (short-term effectiveness) through micro-computed tomography and histological analysis. Analytical results found that gingival stem cells showed effective adhesion and spreading on these collagen-immobilized implant surfaces. After 2 and 6 weeks of healing, significant differences in Hounsfield units were observed among the control (week 2 (674.

Effects of intermittently scanned continuous glucose monitoring on body weight and glycemic variability in overweight individuals with impaired glucose tolerance or mild diabetes: A pilot randomized controlled trial.

Objective: To investigate the effect of visualizing blood glucose variability by intermittently scanned continuous glucose monitoring (isCGM) on weight reduction in overweight individuals with impaired glucose tolerance (IGT) or mild type 2 diabetes mellitus (T2DM).

Materials And Methods: Forty overweight (BMI, ≥25 kg/m2) individuals with IGT or T2DM (drug naïve; HbA1c, ≤7.0 %) were included in this 24-week randomized controlled trial.

Final Overall Survival and Molecular Data Associated with Clinical Outcomes in Patients Receiving Ipatasertib and Abiraterone in the Phase 3 IPATential150 Trial.

Background And Objective: In the phase 3 IPATential150 trial, ipatasertib addition to abiraterone significantly reduced the risk of disease progression in men with metastatic castration-resistant prostate cancer (mCRPC) with PTEN loss on immunohistochemistry (IHC), but not in the intention-to-treat (ITT) population. Here we report the final overall survival (OS) analysis and present results for prespecified and exploratory biomarker analyses.

Methods: Patients were randomized to receive ipatasertib (400 mg once daily) or placebo.

Heterogeneous seafloor deposition of heavy microplastics in the North Pacific estimated over 65 years.

Marine plastic pollution has been a public concern for many decades; however, transport processes of heavy microplastics to the seafloor have long been overlooked given the difficulties in sampling and modeling. The distribution of heavy microplastic deposition on the seafloor in the North Pacific for 65 years since 1951, was estimated using a particle tracking model with 577,143,840 particles. The model revealed that 22 % of heavy microplastics were deposited over 100 km offshore from their release locations.

Postoperative Brace Prescription Practices for Elective Lumbar Spine Surgery: A Questionnaire-Based Study of Spine Surgeons in Japan.

Introduction: The efficacy of postoperative braces for degenerative lumbar disorders has long been debated, with conflicting reports regarding the promotion of bone fusion and pain relief. The current aspects of postoperative brace prescriptions have been previously reported in Western countries but not in Asia. This study aimed to elucidate prescription practices in Japan and identify factors influencing prescription decisions.

Comparative efficacy and safety of stent retrievers as a bailout strategy following failed contact aspiration technique in acute stroke thrombectomy.

Background: The contact aspiration (CA) technique is often used to perform endovascular thrombectomy (EVT) for acute ischemic stroke (AIS); however, rescue strategies are necessary if CA fails to achieve recanalization. This study investigates the outcomes of incorporating stent retriever (SR) thrombectomy in the rescue strategy following failed CA.

Methods: EVT patients with failed CA attempts were identified from a large multicenter registry and stratified by rescue technique: CA alone or incorporating SR in the rescue strategy.

Characterization of human alcohol dehydrogenase 4 and aldehyde dehydrogenase 2 as enzymes involved in the formation of 5-carboxylpirfenidone, a major metabolite of pirfenidone.

Pirfenidone (PIR) is used in the treatment of idiopathic pulmonary fibrosis. After oral administration, it is metabolized by cytochrome P450 1A2 to 5-hydroxylpirfenidone (5-OH PIR) and further oxidized to 5-carboxylpirfenidone (5-COOH PIR), a major metabolite excreted in the urine (90% of the dose). This study aimed to identify enzymes that catalyze the formation of 5-COOH PIR from 5-OH PIR in the human liver.

Kinetics of the Oxidation of the [2Fe-2S] Cluster in SoxR by Redox-Active Compounds as Studied by Pulse Radiolysis.

SoxR containing a [2Fe-2S] cluster required for its transcription activity functions as a bacterial stress-response sensor that is activated through oxidation by redox-active compounds (RACs). SoxR from (EcSoxR) is activated by nearly all RACs nonspecifically. In contrast, nonenteric SoxRs such as (PaSoxR), and (ScSoxR) activate their target genes in response to RAC including endogenously produced metabolites.

[Middle Meningeal Artery Embolization for Chronic Subdural Hematoma].

Middle meningeal artery embolization(MMAE) is an effective treatment for chronic subdural hematoma(CSDH). Retrospective analyses have indicated that MMAE for CSDH is not only minimally invasive but also highly safe, and is associated with a significantly lower recurrence rate than that of conventional treatments. However, there is no consensus regarding treatment strategies, including the patient-selection criteria, embolic materials, and procedural techniques.

[Pathology and Acute Phase Treatment of Osteoporotic Vertebral Fractures:Indications and Techniques for Vertebroplasty].

Vertebroplasty has shown excellent analgesic effects in patients with osteoporotic vertebral fractures. In Japan, percutaneous vertebroplasty, balloon kyphoplasty, and vertebral body stenting are commonly performed. All of these techniques require precise transpedicular vertebral puncture and complete cement filling without leakage.

[Cervical Artificial Disc Replacement].

In Japan, cervical artificial disc replacement was approved by the Pharmaceuticals and Medical Devices Agency in December 2017, and two products, Mobi-C by Zimmer Biomet and Prestige LP by Medtronic, are on the market. Cervical artificial disc replacement preserves cervical motion; however, the device must be place carefully on the midline to take full advantage of its features. In addition, a reliable foraminotomy is required to cure or prevent radiculopathy due to residual foraminal stenosis.

Association Between Relative Hypothermia and Cognitive Function in Older Adults: A Cross-Sectional Study.

Objectives: This study aimed to investigate the association between relative hypothermia measured by a wearable device and cognitive function, and to clarify whether relative hypothermia is a useful indicator for preventing poor cognitive function.

Design: Cross-sectional study.

Setting And Participants: The study included 103 community-dwelling older adults aged 60 to 90 years.

Parenterally administered amino acids decrease acute mortality in fasting patients with aspiration pneumonia: A retrospective study.

Background & Aims: To prevent food aspiration, numerous patients with aspiration pneumonia are restricted from eating early during their hospital stay. Although they receive parenteral nutrition (PN) on a fasting regimen, the optimal dose and composition remain unknown. The current study aimed to investigate whether PN with amino acids (AA) affects 30-day mortality of patients with aspiration pneumonia.

Cluster Analysis of HCC Prognosis Using Preoperative AFP and DCP Levels: A Multi-Institutional Study.

Background: Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, characterized by high recurrence rates post-curative resection. Tumor markers des-gamma-carboxy prothrombin (DCP) and alpha-fetoprotein (AFP) are crucial for HCC diagnosis and prognosis, yet their roles in the modern era of HCC epidemiology require reevaluation.

Methods: This multi-institutional retrospective study analyzed 1,515 patients who underwent hepatectomy for primary HCC.

Exploring the Influence of PCBs Exposure on Neonatal Birth Outcomes and Neurobehavioral Development after 20 years of prohibition.

Despite polychlorinated biphenyls (PCBs) have been banned in Taiwan for two decades, epidemiological studies indicated that prenatal PCBs exposure may still affect newborns and their birth outcomes. The study aimed to investigate the association between PCB concentrations in umbilical cord blood and infants' birth outcomes and neurodevelopment. We recruited 100 pairs of mothers and infants, residing in Changhua and Yunlin countries in Taiwan from 2014-2016.

Preclinical evaluation of new drug-drug interactions of lomitapide: A proposal for novel mechanism of interaction associated with lipid metabolic changes.

Lomitapide, a microsomal triglyceride transfer protein inhibitor, is a lipid-lowering drug that inhibits chylomicron formation in enterocytes and very low-density lipoprotein (VLDL) formation in the liver. Previous studies have shown that very low-density lipoprotein and/or low-density lipoprotein (VLDL/LDL) can deliver certain drugs in addition to lipids. Thus, we hypothesized that serum concentrations of drugs that are more likely to be distributed to VLDL/LDL in the serum (referred to as "VLDL/LDL-philic drugs" in this paper) may be altered by co-administered lomitapide.