1,640,308 results match your criteria: "Japan; Tohoku-RITM Collaborative Research Center on Emerging and Re-emerging Infectious Diseases[Affiliation]"
Womens Health Rep (New Rochelle)
January 2025
Department of Preventive Medicine, School of Medicine, Hyogo Medical University, Nishinomiya, Japan.
Objective: Patients with polycythemia have a high risk of thrombo-atherosclerotic diseases. However, it remains to be clarified whether a high blood hemoglobin level is related to cardiometabolic risk in women.
Methods: The overall subjects were 18,410 middle-aged women who had received health checkup examinations at their workplaces.
Biochem Biophys Rep
March 2025
Institute for Chronobiology, Foundation for Advancement of International Science (FAIS), 3-24-16 Kasuga, Tsukuba, Ibaraki, 305-0812, Japan.
Gaucher's disease (GD) is a genetic disease characterized by a mutation in the metabolic enzyme glucocerebrosidase (GBA1), leading to the accumulation of glucosylceramide in tissues. We previously discovered that a -inserted mutation in the gene of fruit flies, , mimics human neuronopathic GD (nGD) characteristics, providing a promising model for studying the molecular mechanisms of the disease. We also reported that extremely low-frequency electric fields (ELF-EFs) promote sleep and extend the lifespan of wild-type flies.
View Article and Find Full Text PDFLancet Reg Health West Pac
October 2024
Hills Joint Research Laboratory for Future Preventive Medicine and Wellness, Keio University School of Medicine, #7F Azabudai Hills Mori JP Tower 1-3-1 Azabudai, Minato-ku, Tokyo, 106-0041, Japan.
Cureus
December 2024
Orthodontics and Dentofacial Orthopaedics, Kalinga Institute of Dental Sciences, Bhubaneswar, IND.
Vertical maxillary excess presents a complex challenge in orthodontic treatment, necessitating effective anchorage systems for optimal correction. This research is useful to assess the skeletal anchorage system's (SAS) effectiveness in correcting the vertical maxillary excess among adult patients presenting with gummy smiles. This study includes case reports with English full text and examines the global general adult (18+) human population with vertical maxillary excess (VME).
View Article and Find Full Text PDFFront Pharmacol
January 2025
Department of Pharmacy, Guizhou Provincial People's Hospital, Guiyang, China.
Objective: Several antifungals are available for the treatment of patients with invasive aspergillosis (IA). This study aims to evaluate the relative efficacy and safety of the first-line monotherapies in primary therapy of IA through network meta-analysis (NMA).
Methods: We systematically searched PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure, VIP database, Wanfang database, and China Biology Medicine for randomized controlled trials (RCTs) up to July 2023 that evaluated the efficacy and safety of monotherapies.
Front Med (Lausanne)
January 2025
Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, ON, Canada.
Background: Sarcoidosis is a systemic granulomatous disease of unknown cause. Natural improvement with favorable outcome is common, but a significant number of patients present with difficult to manage and progressive disease. The identification of biomarkers associated with disease activity and progression is warranted.
View Article and Find Full Text PDFFront Med (Lausanne)
January 2025
Hunan Medical College General Hospital, Huaihua, China.
J Cardiol Cases
January 2025
Department of Cardiology, The Jikei University School of Medicine, Tokyo, Japan.
Unlabelled: There are some reports of atrial screw-in lead perforation, but the entire lead body is rarely exposed outside the right atrium at an early stage of the procedure. A man in his 80s had undergone catheter ablation for atrial fibrillation (AF) and had recurrent AF and tachycardia-bradycardia syndrome with 8.8 s of sinus arrest, which caused presyncope.
View Article and Find Full Text PDFFront Neurosci
January 2025
Department of Neurology, Nagoya Ekisaikai Hospital, Nagoya, Japan.
Neuronal intranuclear inclusion disease (NIID) is a rare, progressive neurodegenerative disease with variable clinical manifestations. High signals on diffusion-weighted imaging (DWI) along the corticomedullary junction (CMJ) are a specific feature of NIID. Only a few reports have observed patients for a long period and demonstrated a relationship between magnetic resonance imaging (MRI) features and clinical manifestations.
View Article and Find Full Text PDFR Soc Open Sci
January 2025
School of Biological Sciences, Faculty of Sciences, Engineering and Technology, University of Adelaide, Adelaide, South Australia 5005, Australia.
In mammalian vertebral columns, locomotive ability is expected to be an evolutionary driver of variation in the number of vertebrae; in species evolved to run fast or have a flexible vertebral column, they generally have limited numerical variation and low occurrence of malformed vertebrae to maintain their running performance. Although this hypothesis is supported among species sharing similar locomotive constraints (e.g.
View Article and Find Full Text PDFR Soc Open Sci
January 2025
Department of Chemistry, Jagannath University, Dhaka 1100, Bangladesh.
In this study, three pyridine- and four thiophene-containing chalcone derivatives were synthesized via Claisen-Schmidt condensation reaction, where five derivatives were new. Different spectral analyses (IR, H NMR, HRMS) clarified the structures and these proposed compounds were screened for antimicrobial activity by the agar disc diffusion technique. Compound was conspicuously active against most of the bacterial and fungal strains.
View Article and Find Full Text PDFFront Plant Sci
January 2025
Faculty of Marine Science and Technology, Fukui Prefectural University, Obama, Fukui, Japan.
In this study, we investigated the photoperiodic responses regulating erect thallus formation in (KU-1293). We found that, through critical day length analysis and night break treatment culture experiments, formed erect thalli under short-day conditions, indicating a genuine photoperiodic response. The critical day length for this morphological change was 10-11 h.
View Article and Find Full Text PDFInt J Low Extrem Wounds
January 2025
Department of Plastic Surgery, Kobe University Graduate School of Medicine, Hyogo, Japan.
This retrospective study aimed to evaluate diabetic foot ulcer (DFU) recurrence rates and associated risk factors, focusing on hemodialysis and specific amputation levels. Patients with diabetes treated for DFU between 2003 and 2019 at a wound-care center in Japan were studied. The primary outcome was DFU recurrence, and the factors evaluated included age, sex, hemodialysis treatment, revascularization type, and amputation level.
View Article and Find Full Text PDFJ Phys Chem B
January 2025
Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa Oiwake-Cho, Sakyo-ku, Kyoto 606-8502, Japan.
V-shaped polyaromatic amphiphiles (s) form micelle-like nonbonded self-assemblies in aqueous solution and feature prominent properties of encapsulation and solubilization for various types of hydrophobic molecules. To understand microscopic molecular characteristics underlying the wide capability of solubilization, the atomic-level molecular structures of the self-assemblies of s were investigated by microsecond molecular dynamics (MD) simulations. The MD simulations showed that s spontaneously formed quasi-stable self-assemblies, in close agreement with experimental observations.
View Article and Find Full Text PDFNano Lett
January 2025
Université Paris-Saclay, CNRS, Centre de Nanosciences et de Nanotechnologies (C2N), 91120 Palaiseau, France.
The ability to tune the energy gap in bilayer graphene makes it the perfect playground for the study of the effects of internal electric fields, such as the crystalline field, which are developed when other layered materials are deposited on top of it. Here, we introduce a novel device architecture allowing simultaneous control over the applied displacement field and the crystalline alignment between two materials. Our experimental and numerical results confirm that the crystal field and electrostatic doping due to the interface reflect the 120° symmetry of the bilayer graphene/BN heterostructure and are highly affected by the commensurate state.
View Article and Find Full Text PDFCan J Psychiatry
January 2025
Temerty Centre for Therapeutic Brain Intervention and Campbell Family Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Background: Late-life depression (LLD) is often accompanied by cognitive impairment, which may persist despite antidepressant treatment. Repetitive transcranial magnetic stimulation (rTMS) is an efficacious treatment for depression, with potential benefits on cognitive functioning. However, research on cognitive effects is inconclusive, relatively sparse in LLD, and predominantly focused on group-level cognitive changes.
View Article and Find Full Text PDFGlobal Spine J
January 2025
Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Study Design: A systematic review and meta-analysis.
Objective: This study aimed to determine whether rheumatoid arthritis (RA) is associated with clinical outcomes following spinal surgery for lumbar spinal disorders.
Methods: MEDLINE, Embase, the Cochrane Library, and the International Clinical Trials Registry Platform were comprehensively searched for observational studies comparing clinical outcomes after lumbar spine surgery in patients with and without RA (>18 years).
J Autoimmun
January 2025
Department of Rheumatology, Dokkyo Medical University, Mibu, Tochigi, 321-0293, Japan.
The present study aimed to determine the pulmonary cytokine profiles of patients with anti-RNA synthetase (ARS) and anti-melanoma differentiation-associated protein 5 (MDA5) antibodies. The study included patients with ARS and MDA5 whose serum or bronchoalveolar fluid (BALF) was available. Sandwich enzyme-linked immunoassay microarray multiplex assay was used to measure 18 cytokine levels in serum and BALF.
View Article and Find Full Text PDFClin Radiol
January 2025
Department of Nuclear Medicine, China-Japan Friendship Hospital, Beijing, 100029, China. Electronic address:
Aim: To evaluate the correlation between semi-quantitative analyses and visual scores of pulmonary perfusion Single Photon Emission Computed Tomography (SPECT)/ Computed Tomography (CT) imaging and pulmonary function test parameters (PFTs) in patients with interstitial lung diseases (ILDs).
Materials And Methods: This retrospective study included 35 patients with ILDs from China-Japan Friendship Hospital between January 2020 and December 2022. All patients underwent pulmonary perfusion SPECT/CT imaging and a pulmonary function test.
JMIR Med Inform
January 2025
Department of Endocrinology and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Background: Many tools have been developed to predict the risk of diabetes in a population without diabetes; however, these tools have shortcomings that include the omission of race, inclusion of variables that are not readily available to patients, and low sensitivity or specificity.
Objective: We aimed to develop and validate an easy, systematic index for predicting diabetes risk in the Asian population.
Methods: We collected the data from the NAGALA (NAfld [nonalcoholic fatty liver disease] in the Gifu Area, Longitudinal Analysis) database.
Genes Environ
January 2025
Department of Pharmaceutical Engineering, Faculty of Engineering, Sanyo-Onoda City University, 1-1-1, Daigaku-dori, Sanyo-Onoda City, 756-0884, Yamaguchi, Japan.
The number of alternatives to animal tests (non-animal test methods) for human health developed globally account for more than 40% of the test methods in the Organisation for Economic Co-operation and Development (OECD) Guidelines for the Testing of Chemicals (TGs). Within the TGs, the National Institute of Health Sciences (NIHS) has standardized 16 OECD TGs for human health, implemented four major revisions, and developed one test method for the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) S10 guidelines on photosafety. This review describes trends in the OECD and Japan that mainly focus on international standardizations of non-animal test methods for human health.
View Article and Find Full Text PDFBMC Res Notes
January 2025
Department of Cardiology, Nagoya Ekisaikai Hospital, Nagoya, Japan.
Objective: Patients with cardiovascular disease are considered a high-risk population for heat-related illnesses. This study aimed to describe the difference in physical activity between summer and fall among patients with cardiovascular disease and their recognition of heatstroke prevention in an urban area with high temperature conditions.
Results: We enrolled 56 outpatients who participated in cardiac rehabilitation in the summer of 2022 (median age, 75 years [interquartile range, 68-80]).
J Pharm Health Care Sci
January 2025
Laboratory of Clinical Pharmacy Education, Research and Education Center for Clinical Pharmacy, School of Pharmacy, Kitasato University, 5-9-1, Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
Background: Pharmaceutical formularies play a crucial role in guiding medication use by balancing clinical effectiveness and cost efficiency. Although formulary implementation has been increasing in Japan, comprehensive evaluations of its impact on both clinical and economic outcomes are limited. This study aimed to assess the effect of introducing an antimicrobial formulary at Yokohama City University Hospital on antibiotic usage and treatment outcomes in intra-abdominal infections.
View Article and Find Full Text PDFBiotechnol Biofuels Bioprod
January 2025
Graduate School of Bio-Applications and Systems Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo, 184-8588, Japan.
Background: Fungal pretreatment for partial separation of lignocellulosic components may reduce lignocellulose recalcitrance during the production of biofuels and biochemicals. Quantitative and qualitative modification of plant lignin through genetic engineering or traditional breeding may also reduce the recalcitrance. This study was conducted to examine the effects of combining these two approaches using three white rot fungi and mulberry wood with an altered lignin structure.
View Article and Find Full Text PDFTrop Med Health
January 2025
Department of Medical Research, Ministry of Health, No.5, Ziwaka Road, Dagon Township, Yangon, 11191, Myanmar.
Background: Myanmar is one of the countries in Southeast Asia where serious dengue outbreaks occur and Yangon is among the regions with the highest number of cases in the country. Many infections including dengue are common in Yangon during the rainy season, and co-infections may also occur. Adults are more likely than children to experience co-infections of dengue and other diseases.
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