Molecular characterization and zoonotic risk assessment of spp. in Philippine bats.

is a genus of parasitic protozoa known to cause diarrheal disease that impacts both humans and animals through infection of various vertebrate species. Bats are recognized as reservoirs for zoonotic pathogens, including . The Philippines, renowned for its rich biodiversity, is home to diverse bat species, providing a unique ecological setting to investigate infection dynamics.

Outcome of basal cell carcinoma excision with 2 mm surgical margin in Japanese patients: A retrospective study of one-step surgery.

Background: Basal cell carcinoma is the most common skin malignancy. The standard treatment is surgical excision with predetermined margins. Some argue that the currently recommended surgical margins are excessive, and it is questionable whether such wide surgical margins should be applied to all lesions.

Corticosteroid therapy and long-term outcomes in patients with cardiac sarcoidosis stratified by left ventricular ejection fraction.

Aims: This study aimed to investigate the relationship between corticosteroid therapy and long-term outcomes in patients with cardiac sarcoidosis, stratified by left ventricular ejection fraction (LVEF) at diagnosis.

Methods And Results: This study conducted a analysis of the ILLUstration of the Management and prognosIs of JapaNese PATiEnts with Cardiac Sarcoidosis, a retrospective multicentre registry. Cardiac sarcoidosis was diagnosed based on the 2016 Japanese Circulation Society and 2014 Heart Rhythm Society criteria.

Refractory and Relapsing Laryngeal Edema Possibly Associated With Chronic Tonsillitis and Mycoplasma Infection, Requiring Reintubation and Tracheostomy.

Relapsing epiglottitis has rarely been reported, and its etiology is not well established. A 44-year-old previously healthy Japanese man presented with a quickly progressing choking sensation. He had been experiencing refractory and relapsing laryngeal edema and probably acute epiglottitis (three episodes within 2 weeks), with rash and elevated pancreatic amylase.

Recommended Occupational Exposure Limits for GMA Using Benchmark Dose and Bayesian Model Averaging.

Introduction: Glycidyl methacrylate (GMA) is a widely used industrial polymerization material. Current occupational exposure limits (OELs) for GMA in China show significant disparities compared to those established by international regulatory bodies, including the United States, the European Union, and Japan. A comprehensive revision of GMA exposure limits is crucial for ensuring optimal worker protection.

A case of sclerosing angiomatoid nodular transformation with central calcification.

Sclerosing angiomatoid nodular transformation (SANT) is a rare benign vascular disease and mostly discovered incidentally in asymptomatic patients. Since SANT grows over time and it is often difficult to rule out malignancy on imaging, splenectomy is frequently the treatment of choice. Image findings of SANT have been reported as low signal intensity on T2-weighted magnetic resonance (MR) images and a characteristic enhancement pattern on dynamic contrast-enhanced computed tomography (CT) and MR images.

A new species of the genus Komatsu, 1970 (Araneae, Leptonetidae) from Jilin, China.

Background: Komatsu, 1970 comprises 68 species, distributed in Japan (28), Korea (31) and southeast of China (9). This genus has not been recorded in the north-eastern part of China.

New Information: A new species: sp.

Theoretical atomic momentum spectroscopy of diatomic, triatomic and polyatomic molecules.

We present a general theory of quantum chemistry-based atomic momentum spectroscopy (QC-AMS) for predicting electron-atom Compton profiles due to the intramolecular motion of each atom in diatomic, triatomic and polyatomic molecules. The atomic motion is assumed to be decomposable into normal-mode molecular vibrations and molecular rotations, and the latter are treated classically. An accuracy assessment of the general theory is performed through comparisons with the AMS Compton profiles of HD and NO, predicted by the full quantum chemistry-based AMS theory that is precise but can work only for diatomic molecules.

Analysis of Social Performance and Action Units During Social Skills Training: Focus Group Study of Adults With Autism Spectrum Disorder and Schizophrenia.

Background: Social communication is a crucial factor influencing human social life. Quantifying the degree of difficulty faced in social communication is necessary for understanding developmental and neurological disorders and for creating systems used in automatic symptom screening and assistive methods such as social skills training (SST). SST by a human trainer is a well-established method.

Monomeric tri-coordinated bis(ferrocenyl)haloalumanes.

The reactions of the sterically demanding ferrocenyl lithium dimer (Fc*Li) (Fc* = 2,5-bis(3,5-di--butyl-phenyl)-1-ferrocenyl) with aluminum trihalides (AlCl, AlBr, and AlI) to furnish the corresponding monomeric bis(ferrocenyl)haloalumanes are reported. In the case of the reaction with AlI, an unexpected intramolecular 1,1'-aluminum migration in the ferrocenyl moiety was found to occur. Their monomeric structures with a tri-coordinated aluminum atom show affinitive Al⋯Fe interactions.

Multistate Transition Metal Carbonyl Bonding Beyond Minimum Energy Pathway: Nonlocality of Spin-Orbit Interaction.

Transition metal carbonyl and transition metal dinitrogen are fundamental chemical complexes in many important biological and catalytic processes. Interestingly, binding between a transition metal (TM) atom and carbonyl or dinitrogen results in spin state change. However, no study has evaluated the spin-orbit (SO) effect along the association pathway of any TM-CO or TM-N bond.

Enhancing Proton Mobility in Silicophosphoric Acid by Replacing Si with Al.

Electrochemical devices that can operate at temperatures of 200-300 °C are expected to become the next-generation energy conversion devices in fuel cells and electrosynthesis, which are important for achieving carbon neutrality. Proton conductors based on phosphate glasses are being developed as candidate materials for such devices. We recently developed a glass proton conductor by using silicophosphoric acid based on the idea of solidifying phosphoric acid with silicon as a cross-linking glass framework.

Theoretical and machine learning models for reaction-barrier predictions: acrylate and methacrylate radical reactions.

We propose density functional theory (DFT)- and random forest (RF)-based theoretical and machine learning (ML) models, respectively, for predicting reaction barriers (Δ) using acrylate and methacrylate radical reactions as representatives. DFT is used to determine 100 transition state (TS) structures of both radicals, after which the obtained data are used to determine theoretical relationships (explained with Bell-Evans-Polanyi or Brønsted-Evans-Polanyi (BEP) and Marcus-like models) between Δ and stabilization energy of the product. Next, we construct several theoretical regression models for predicting Δ of the representative reactions based on our theoretical analyses, presenting an RF-based ML model that eases Δ predictions by circumventing time-consuming DFT calculations.

Counterregulatory roles of GLI2 and GLI3 in osteogenic differentiation via Gli1 expression.

The GLI1/GLI2/GLI3 transcription factors mediate Hedgehog (Hh) signaling, which is crucial for bone development. During intramembranous ossification, mesenchymal stem cells (MSCs) are directly differentiated into osteoblasts. Under basal and Hh pathway-stimulated conditions, primary cilia play essential roles in proteolytic processing of GLI3 to its repressor form (GLI3R), and in activation of GLI2.

Efficient Data Sampling Scheme to Reduce Acquisition Time in Statistical ALCHEMI.

The distribution of dopants in host crystals significantly influences the chemical and electronic properties of materials. Therefore, determining this distribution is crucial for optimizing material performance. The previously developed statistical ALCHEMI (St-ALCHEMI), an extension of the atom-location by channeling-enhanced microanalysis (ALCHEMI) technique, utilizes variations in electron channeling based on the beam direction relative to the crystal orientation.

A guide to CNN-based dense segmentation of neuronal EM images.

Large-scale reconstitution of neuronal circuits from volumetric electron microscopy images is a remarkable research goal in neuroanatomy. However, the large-scale reconstruction is a result of automatic segmentation using convolutional neural networks (CNNs), which is still challenging for general researchers to perform. This review focuses on two representative CNNs for dense neuronal segmentation: flood-filling networks (FFN) and local shape descriptors (LSD)-predicting U-Net (LSD network).

Exploring the Vibrational Coherences in the Ultrafast Electronic Relaxation of Pyrimidine Nucleobases and Nucleosides.

We studied the vibrational coherences during the ultrafast internal conversions (ICs) of pyrimidine nucleobases and -sides in aqueous solutions and the gas phase with an instrumental resolution of 14 fs. The coherence of the same ring-breathing vibrational mode with a frequency of 750 cm was observed. In the gas phase, the vibrational coherence was transferred during IC from the ππ* to the nπ* state, and it survived for approximately 1 ps.

Disease activity and glucocorticoid tapering patterns in Japanese patients with systemic lupus erythematosus treated with anifrolumab: post hoc analysis of the Japanese subpopulation of the TULIP-2 study.

Objectives: To investigate the efficacy of anifrolumab on disease activity and glucocorticoid tapering patterns in Japanese patients with systemic lupus erythematosus (SLE).

Methods: We analysed disease activity and glucocorticoid tapering in the Japanese subpopulation (anifrolumab, n = 24; placebo, n = 19) of the TULIP-2 trial, which showed the efficacy and safety of anifrolumab in patients with moderate-to-severe active SLE.

Results: The percentage of patients who achieved a British Isles Lupus Assessment Group-based Composite Lupus Assessment response at Week 52 was greater in the anifrolumab group than placebo [50.

Clinical evaluation and outcome in heart failure patients receiving chemotherapy with different anti-cancer agents.

Background: The optimal strategy for modern chemotherapy should be based on a comprehensive approach for cancer patients with cardiovascular diseases. Therefore, cardio-oncology has received increasing attention owing to the cardiotoxic effects of anti-cancer therapies.

Objectives: We aimed to evaluate the clinical characteristics and outcomes of patients with heart failure (HF) who received chemotherapy compared with those of a matched cohort with HF who did not receive chemotherapy, using real-world HF data.

Adaptable Blueprint for Non-metal Near-Infrared Organic Photocatalysts by Aromatic Sulfones.

We present a versatile approach to designing and utilizing high-performance nonmetal near-infrared (NIR) organic photocatalysts based on aromatic sulfones. Current NIR photocatalysts are mainly metal complexes and inorganic materials, while the few reported nonmetal organic NIR photocatalysts primarily use photosensitization to produce active species such as singlet oxygen. Our sulfone-rosamine-based redox photocatalyst demonstrates exceptional capabilities, including high ability for metal-free photo-oxidative bromination, intrinsically oxygen-independent redox reactions, and remarkable photostability with a turnover number (TON) exceeding 2800.

Temperature Dependence of Intermolecular Dynamics and Liquid Properties of Deep Eutectic Solvent, Reline.

We investigated the temperature dependence of the intermolecular dynamics, including intermolecular vibrations and collective orientational relaxation, of one of the most typical deep eutectic solvents, reline, using femtosecond Raman-induced Kerr effect spectroscopy (fs-RIKES), subpicosecond optical Kerr effect spectroscopy (ps-OKES), and molecular dynamics (MD) simulations. According to fs-RIKES results, the temperature-dependent intermolecular vibrational band peak at ∼90 cm exhibited a redshift with increasing temperature. The density-of-state (DOS) spectrum of reline by MD simulations reproduced this fs-RIKES spectral feature.

Potential role of signal transducer and activator of transcription 3 in the amygdala in mitigating stress-induced high blood pressure via exercise in rats.

Aim: Chronic stress elevates blood pressure, whereas regular exercise exerts antistress and antihypertensive effects. However, the mechanisms of stress-induced hypertension and preventive effects through exercise remain unknown. Thus, we investigated the molecular basis involved in autonomic blood pressure regulation within the amygdala.