A spectrum of segmental multicystic renal dysplasia.

Background: Multicystic renal dysplasia (MCDK) is a common anomaly well described in the literature, but less well described when involving only a portion of a kidney.

Objective: To present the imaging spectrum, natural history and associated anomalies of six kidneys with segmental MCDK.

Materials And Methods: Five children with segmental MCDK (one with bilateral segmental MCDK) referred to our hospital between 1989 and 1996 were reviewed.

Molybdenum requirements in low-birth-weight infants receiving parenteral and enteral nutrition.

Background: Molybdenum (Mo) is an essential trace element required by three enzymatic systems, yet there are no reports of Mo deficiency in infants. Low-birth-weight infants (LBW) might be at risk for Mo deficiency because they are born before adequate stores for Mo can be acquired, they have rapid growth requiring increased intakes, and they frequently receive supplemental parenteral nutrition (SPN) and total parenteral nutrition (TPN) unsupplemented with molybdenum.

Methods: To investigate Mo requirements of LBW infants (n = 16; birth weight, 1336+/-351 g; gestational age, 29.

Seizure exacerbation and developmental regression with carbamazepine.

Background: Unexpected exacerbation of seizures may occur following initiation of treatment with carbamazepine (CBZ). We reviewed the occurrence of such reactions in our patient population at a tertiary care children's hospital.

Methods: A retrospective analysis of our clinic database identified 129/691 (18.

Vertebral and eye anomalies, cutis aplasia, and short stature (VECS): a new syndrome?

We report on a 6-year-old girl with short stature, facial anomalies, cutis aplasia, nasolacrimal duct obstruction, megalocorneae, kyphoscoliosis with multiple segmentation defects of the thoracic vertebrae, and 11 pairs of ribs. These anomalies together may represent a newly recognized syndrome.

Pattern and permanence of phosphate-induced nephrocalcinosis in rabbits.

Objective. The purpose of this study was to observe the pattern and permanence of phosphate-induced nephrocalcinosis (NC) in rabbits. Materials and methods.

Nephrocalcinosis in rabbits--correlation of ultrasound, computed tomography, pathology and renal function.

Objective. The purpose of this study was to induce nephrocalcinosis (NC) in rabbits with phosphate, vitamin D, oxalate and furosemide, to determine the effect on renal function and to correlate detection on ultrasound (US) and computed tomography (CT) with pathology. Materials and methods.

Radiological features of a symptomatic splenic hamartoma.

Symptomatic splenic hamartomas are rare in the pediatric age group, with only four previous reports in the literature. Splenic hamartoma has been reported as a solid homogeneous mass without calcification on CT and ultrasound (US), and only one previous report of the findings on MRI has been published. We report a case of a large symptomatic splenic hamartoma in a 14-year-old girl who presented with splenomegaly, pancytopenia and growth retardation.

Repetitive inhalation endotracheal anaesthesia for cobalt radiotherapy in a child.

Purpose: Provision of general anaesthesia in areas remote from the operating room creates many difficult challenges especially if required for repeated radiotherapy in the prone position. This case illustrates these problems and some innovative solutions.

Clinical Features: A nine-year-old girl with medulloblastoma became extremely distressed whenever cobalt radiotherapy was attempted.

Intrathecal leucovorin after intrathecal methotrexate overdose.

Purpose: Intrathecal methotrexate is a standard and important therapy in acute leukemia. Unfortunately, overdose is a well reported complication of this therapy. We report a fatal event secondary to intrathecal leucovorin.

Interference in glucose and other clinical chemistry assays by thiocyanate and cyanide in a patient treated with nitroprusside.

A 3-year-old patient treated with nitroprusside for congestive heart failure had 6.5 mmol/L thiocyanate (toxic, >1.5 mmol/L) and 110 micromol/L cyanide (toxic, >5 micromol/L) present in her blood.

Sclerosing of recurrent lymphangioma using OK-432.

The authors present two cases of lymphangioma of the cervicofacial region, treated with a new investigational drug in North America, OK-432 (picibanil), a sclerosing agent intralesionally injected. Both patients had been treated surgically and had recurrence of the tumor. Intralesional injection of OK-432 without aspiration was employed for the first patient, and after aspiration in the second patient.

Blood pressure measurement using oscillometric finger cuffs in children and young adults. A comparison with arm cuffs during general anaesthesia.

Arterial blood pressure measurements (y) obtained from forefinger cuffs were compared with standard arm cuff readings (x) in 41 anaesthetised children and young adults. Mean (SD) differences between cuff measurements were -0.21 (9.

Serum pseudocholinesterase and very-low-density lipoprotein metabolism.

Serum pseudocholinesterase (PChE) was discovered in 1932. Since this protein mimics many of the catalytic properties of acetylcholinesterase, it has traditionally been referred to as PChE, even though its true biological function is unknown. Serum PChE is synthesized in the liver and secreted into the circulation as a sialated glycoprotein.

Idiopathic acute portal vein thrombosis: a case report.

There are few reported cases of acute portal vein thrombosis presenting as an acute abdomen in adolescent age group. Most published series concern chronic extrahepatic portal vein thrombosis. Acute portal vein thrombosis is rare, but can develop into serious complications.

The impact of spina bifida on the medical services of Newfoundland and Labrador.

This institution receives all live spina bifida patients from Newfoundland and Labrador. The aim of this study is to determine the outcome of these patients and the impact on the medical system. On a retrospective chart review, 274 patients born between 1967 and 1990 were studied.

Nonrenal cystic masses in neonates and children.

With the increasing use of ultrasonography (US) in children, abdominal cystic masses, many of them nonrenal, are being detected more frequently both before and after birth. Between 1986 and 1991, 20 predominantly cystic abdominal or pelvic masses of nonrenal origin were detected by US in patients less than 10 years of age. Ten of the 20 patients were neonates; in 5 of these the masses were detected antenatally.

Subendocardial abscess as a complication of prolonged central venous access for parenteral nutrition.

Patients with chronic gastrointestinal diseases may require long-term parenteral nutrition. The authors describe a case in which a subendocardial abscess developed in the right atrium in association with staphylococcal septicemia. The patient, a 15-year-old boy, had a malpositioned Silastic catheter, the tip of which was in his right atrium.

Palliative home care program for terminally ill children.

A study conducted for the Dr. Charles A. Janeway Child Health Centre, St.

Relationship between serum pseudocholinesterase and triglycerides in experimentally induced diabetes mellitus in rats.

This study was designed to understand the reasons for the increase in serum pseudocholinesterase activity in diabetes mellitus. Streptozotocin-induced diabetic rats were used for the study. Serum pseudocholinesterase activity increased with the induction of diabetes (381.