Ovarian nesfatin-1 in Hemidactylus flaviviridis: Reproductive phase-dependent expression, role and hormonal regulation.

Nesfatin-1 has recently emerged as a modulator of ovarian functions in mammals. Studies in non-mammalian vertebrates, though limited and majorly restricted to fishes, have evidenced a role of this peptide in the regulation of ovarian steroidogenesis and oocyte maturation. Interestingly, nesfatin-1 remains completely unexplored in reptiles.

Modeling and simulation of multifaceted properties of XNaIO (X = Ca and Sr) double perovskite oxides for advanced technological applications.

Context: In this study, the authors have investigated the structural, optoelectronic, thermoelectric, and thermodynamic properties of CaNaIO and SrNaIO double perovskite oxides. Both materials exhibit semiconductor behavior with direct band gaps (E) of 0.353 eV and 0.

Quantum dots: a tool for the detection of explosives/nitro derivatives.

Nitro derivatives are considered as major environmental pollutants and issues of health concern. In current times, a variety of methods and techniques have been utilized for the sensing of these nitro derivatives. In view of this, the remarkable fluorescence properties of quantum dots (QDs) provide a great opportunity to detect these nitro derivatives.

A rare case of perforating chest wall including pericardial sac with penetrating trivial injury: A case report and literature review.

Unlabelled: Perforating chest wall injuries involving the pericardial sac in pediatric patients are exceedingly rare and pose a unique clinical challenge. Thoracic trauma in the pediatric population remains a significant cause of morbidity and mortality. We present a case of an 8-year-old boy with an acute history of a sharp injection needle embedded in his chest wall presented with severe chest pain and diaphoresis.

Synthesis and characterization of piperic acid conjugates with homochiral and heterochiral dipeptides containing phenylalanine and their application in skin cancer.

The current work demonstrates the synthesis and characterization of piperic acid conjugates with homochiral/heterochiral dipeptides containing phenylalanine as anti-skin cancer agents. The conjugates PA-Phe-Phe-OH, FC-1; PA-Phe-Phe-OH, FC-2; PA-Phe-Phe-OH, FC-3; and PA-Phe-Phe-OH, FC-4 were synthesized, characterized and assessed for cytotoxicity against melanoma cell lines of human and murine origin. Among all, PA-Phe-Phe-OH (FC-3) conjugate was identified as a potential cytotoxic lead against melanoma cells by delineating the anti-proliferative and anti-migratory potential together with its anti-inflammatory potential against pro-inflammatory interleukins (IL-1β, IL-6, and IL-8).

Comprehensive analysis of genes associated with migraine in the Indian population: a meta-analysis of genetic association studies with trial sequential analysis.

Migraine is a complex disorder with multigenic inheritance and is characterized by the cardinal symptom of unilateral headache. Many genes are responsible for increasing the susceptibility of disease within different populations. Therefore, our primary aim in this review was to catalog the many genes that have been studied in India and after collecting the necessary information, we calculated a more precise risk relationship between an identified variation and migraine.

Impact of pharmaceutical industry wastewater on stress physiological responses of Spirodela polyrhiza (L.) Schleiden.

Impact of pharmaceutical wastewater collected from aeration tank on aquatic macrophyte Spirodela polyrhiza (L.) Schleiden was studied in the present study. Various plant parameters such as chlorophyll, protein, and proline content of wastewater-exposed plants were examined to determine the toxic impacts of pharmaceutical wastewater.

Socio-economic and environmental vulnerability of urban slums: a case study of slums at Jammu (India).

Rapid urban population growth, the urbanization of poverty, and the proliferation of slums are being driven to a great extent by this dynamic form of globalization. Consequently, the multifaceted effects of globalization on the poor and low-income populations in the cities need to be better understood in this context, both at the individual level and within the community. Therefore, the present study was conducted to highlight the various determinants affecting the lives and enhancing the vulnerability of the dwellers of four slum settlements present in various areas of Jammu City, India.

Spatio-temporal evaluation of surface water quality of Tawi watershed in the Himalayan region of Jammu (J&K, UT) using algal pollution indices: a geospatial approach.

In the present work, an investigation was performed based on the genera and species stated in Palmer pollution index to show the extent of organic pollution in the surface water of the Tawi watershed in the Jammu province of the Union Territory of Jammu and Kashmir using algal pollution indices. Sampling was carried out for two seasons, pre-monsoon (PRM) and post-monsoon (POM), at 16 locations distributed over the entire Tawi watershed. The physico-chemical variables like water temperature, pH, electrical conductivity, TDS, total alkalinity, total hardness, DO, BOD, COD, nitrate, and phosphate were analyzed.

A Comprehensive Investigation of Risk Association Between the -786 T > C, + 884 G > A, VNTR, rs743506, rs3918226 of eNOS and Susceptibility of Migraine: A Updated Meta-Analysis Utilizing Trial Sequential Analysis.

With a feature of complex pathogenic mechanisms, migraine is a well-known common neurovascular disorder. Multiple genes are responsible for hindering the susceptibility of pain threshold one of which is the eNOS gene and its variants. Multiple independent observational studies with case-control design produced conflicting findings, which can be attributed to a variety of factors including varying sample sizes, demographic stratification, technique application, etc.

Evaluation of Morpho-Physiological and Yield-Associated Traits of Rice ( L.) Landraces Combined with Marker-Assisted Selection under High-Temperature Stress and Elevated Atmospheric CO Levels.

Rice ( L.) is an important cereal crop worldwide due to its long domestication history. North-Eastern India (NEI) is one of the origins of rice and contains various native landraces that can withstand climatic changes.

Transcriptional Regulation of Small Heat Shock Protein 17 (sHSP-17) by Transcription Factor Confers Tolerance in under Heat Stress.

Heat shock transcription factors (HSFs) contribute significantly to thermotolerance acclimation. Here, we identified and cloned a putative HSF gene () of 1218 nucleotide (acc. no.

Designer probiotics: Opening the new horizon in diagnosis and prevention of human diseases.

Probiotic microorganisms have been used for therapeutic purposes for over a century, and recent advances in biotechnology and genetic engineering have opened up new possibilities for developing therapeutic approaches using indigenous probiotic microorganisms. Diseases are often related to metabolic and immunological factors, which play a critical role in their onset. With the help of advanced genetic tools, probiotics can be modified to produce or secrete important therapeutic peptides directly into mucosal sites, increasing their effectiveness.

Plant salinity stress, sensing, and its mitigation through WRKY.

Salinity or salt stress has deleterious effects on plant growth and development. It imposes osmotic, ionic, and secondary stresses, including oxidative stress on the plants and is responsible for the reduction of overall crop productivity and therefore challenges global food security. Plants respond to salinity, by triggering homoeostatic mechanisms that counter salt-triggered disturbances in the physiology and biochemistry of plants.

An emerging role of heterotrimeric G-proteins in nodulation and nitrogen sensing.

A comprehensive understanding of nitrogen signaling cascades involving heterotrimeric G-proteins and their putative receptors can assist in the production of nitrogen-efficient plants. Plants are immobile in nature, so they must endure abiotic stresses including nutrient stress. Plant development and agricultural productivity are frequently constrained by the restricted availability of nitrogen in the soil.

A Comprehensive Investigation into the Association Between Mthfr C677t, A1298c, and Ace I/D Variants and Risk of Migraine: an Updated Meta-Analysis of Genetic Association Studies with Trial Sequential Analysis and Meta-Regression.

Many homeostatic genes are thought to play a role in the susceptibility to migraine, making it a highly complex neurovascular disease. In this meta-analysis, our primary objective was to evaluate whether or not MTHFR variants (such as C677T and A1289C) and ACE I/D were associated with an increased risk of migraine. Using a PRISMA-based systematic literature-review guideline, internet sources such as PubMed and Google Scholar were searched to identify the genes of interest and migraine risk.

Unraveling the plethora of toxicological implications of nanoparticles on living organisms and recent insights into different remediation strategies: A comprehensive review.

Increased use of nanoscale particles have benefited many industries, including medicine, electronics, and environmental cleaning. These particles provide higher material performance, greater reactivity, and improved drug delivery. However, the main concern is the generation of nanowastes that can spread in different environmental matrices, posing threat to our environment and human health.

Machine learning-based predictive modelling for the enhancement of wine quality.

The certification of wine quality is essential to the wine industry. The main goal of this work is to develop a machine learning model to forecast wine quality using the dataset. We utilised samples from the red wine dataset (RWD) with eleven distinct physiochemical properties.

Organocatalytic Asymmetric Synthesis of Carbo- and Oxacyclic Seven-Membered Bridged Biaryls via Nucleophile-Dependent Switchable Domino Processes.

We disclose herein a highly diastereo- and enantioselective divergent synthesis of seven-membered biaryl-bridged carbo- and oxacyclic frameworks by utilizing the catalytic ability of bifunctional hydrogen-bonding squaramide organocatalysts. Starting with the same biaryl substrate bearing two distinct acceptor sites and by choosing soft or hard nucleophiles, we readily accessed the dibenzocycloheptanes or 5,7-dihydrodibenzo[]oxepines bearing multiple elements of chirality via a domino 1,4/1,2-addition or 1,2/oxa-Michael addition sequence, respectively.

Electronic structure, theoretical power conversion efficiency, and thermoelectric properties of bismuth-based alkaline earth antiperovskites.

Context: This research paper investigates the properties and potential applications of antiperovskite materials. Antiperovskites are a class of materials with a unique crystal structure, where the central atom is surrounded by a cage of anions. We review recent research on antiperovskite-based materials for energy storage, photovoltaics, catalysis, and sensors.