Organocatalytic [4+2] Benzannulation Between 1,4-Dithiane-Based Enal and Nitroolefins to Access 2-Nitrobiaryls.

A simple method for constructing unsymmetrical 2-nitrobiaryls has been developed between substituted 1,4-dithiine-2-carbaldehyde and nitroolefins under metal-free conditions. To gain the advantage of the HOMO-raising effect of temporary substitutions on in situ generated dienamine intermediate, the present protocol established [4+2] benzannulation of 1,4-dithiane-tethered enals with nitroolefin. Further, easy unmasking of 1,4-dithiine units results in a benzannulation product like that of unsubstituted enals, which are difficult to access.

Emerging Trends in Neuroblastoma Diagnosis, Therapeutics, and Research.

This review explores the current understanding and recent advancements in neuroblastoma, one of the most common extracranial solid pediatric cancers, accounting for ~ 15% of childhood cancer-related mortality. The hallmarks of NBL, including angiogenesis, metastasis, apoptosis resistance, cell cycle dysregulation, drug resistance, and responses to hypoxia and ROS, underscore its complex biology. The tumor microenvironment's significance in disease progression is acknowledged in this study, along with the pivotal role of cancer stem cells in sustaining tumor growth and heterogeneity.

Nesfatin-1 as a crucial mediator of glucose homeostasis in the reptile, Hemidactylus flaviviridis.

Nesfatin-1 is a crucial regulator of energy homeostasis in mammals and fishes, however, its metabolic role remains completely unexplored in amphibians, reptiles, and birds. Therefore, present study elucidates role of nesfatin-1 in glucose homeostasis in wall lizard wherein fasting stimulated hepatic nucb2/nesfatin-1, glycogen phosphorylase (glyp), phosphoenolpyruvate carboxykinase (pepck), and fructose 1,6-bisphosphatase (fbp), while feeding upregulated pancreatic nucb2/nesfatin-1 and insulin, suggesting towards tissue-specific dual role of nesfatin-1 in glucoregulation. The glycogenolytic/gluconeogenic role of nesfatin-1 was further confirmed by an increase in media glucose levels along with heightened hepatic pepck and fbp expression and concomitant decline in liver glycogen content in nesfatin-1-treated liver of wall lizard.

Local inventories for effective management of alien species: insights from the alien flora of Jammu, Kashmir, and Ladakh, India.

The broad-scale inventories of alien species reveal macroecological patterns, but these often fall short in guiding local-level management strategies. Local authorities, tasked with on-the-ground management, require precise knowledge of the occurrence of invasive species tailored to their jurisdictional boundaries. What proves critical at the local scale may not hold the same significance at national or regional levels.

Structural and functional characterization of genes and enzymes involved in withanolide biosynthesis in Physalis alkekengi L.

Physalis alkekengi L. is recognized as a significant source of various secondary metabolites, particularly C steroidal lactones known as withanolides and physalins, renowned for their therapeutic properties with a rich history in traditional medicine. In this study, we characterized the sequences of key downstream genes (PaFPPS, PaSQS, PaSQE, PaCAS, PaHYD1, and PaDWF5-1) involved in the biosynthesis of withanolides, marking the first characterization of these genes in P.

Morphological Changes of the Apical Foramen in Curved Root Canals After Use of Different Heat Treated NiTi Rotary Files: A Scanning Electron Microscopy Study.

Objective: The present study aimed to evaluate the effect of heat-treated nickel titanium (NiTi) files TruNatomy and XP- Endo Shaper on the major apical foramen deformation and enlargement in curved root canals using area, circularity, and Feret's diameter ratio.

Methods: Sixty mesio-buccal roots of maxillary and mandibular molars with Vertucci type II root canal were selected. The teeth were decoronated using a carborundum disc.

CLOCK gene 3'UTR and exon 9 polymorphisms show a strong association with essential hypertension in a North Indian population.

Background: Hypertension (HTN) is a medical condition characterized by persistent systolic and diastolic blood pressures of ≥ 140 mmHg and ≥ 90 mmHg, respectively. With more than 1200 million adult patients aged 30-79 years worldwide according to the latest WHO data, HTN is a major health risk factor; more importantly, 46% of patients are unaware of this condition. Essential hypertension (EH), also known as primary hypertension, is the predominant subtype and has a complex etiology that involves both genetic and non-genetic factors.

Mitochondrial genetic diversity of pest and vector species, Frankliniella schultzei (Thripidae: Thripinae).

Background: Frankliniella schultzei (Trybom) is a serious pest and a carrier of tospoviruses in major agricultural crops. This species is a historical and unresolved species complex that contains genetically different cryptic species across the globe.

Methods And Results: DNA barcodes were generated from freshly collected specimens of F.

Thrips wedeliae (Priesner) (Thysanoptera: Thripidae) new to India: first description of the male.

Thrips wedeliae (Priesner) was originally described based on a single female from Java, Indonesia. Recently, we have collected males and females of this species from Solanum mauritianum in Uttarakhand state, India. Here, males of T.

Macronutrients-availing microbiomes: biodiversity, mechanisms, and biotechnological applications for agricultural sustainability.

Nitrogen, phosphorus, and potassium are the three most essential micronutrients which play major roles in plant survivability by being a structural or non-structural component of the cell. Plants acquire these nutrients from soil in the fixed (NO, NH) and solubilized forms (K, HPO and HPO). In soil, the fixed and solubilized forms of nutrients are unavailable or available in bare minimum amounts; therefore, agrochemicals were introduced.

Vibrational mode tailoring approach: an efficient route to compute anharmonic molecular vibrations of large molecules.

In this study, an efficient route to compute the multidimensional potential energy surfaces (PESs) for the description of quantum anharmonic molecular vibrations is presented. For large molecular systems, where the number of inter mode coupling terms are substantial, a tailor-made construction of truncated PESs is suggested which suitably avoids computation of full PESs by quantitative assessment of the atomic displacements during the normal mode of vibrations. It is shown that, typically, when two normal modes of vibrations are sharing the same atoms, the mode-mode coupling strength is generally large and can be included for truncated PESs.

Challenges and opportunities in engineering next-generation 3D microelectronic devices: improved performance and higher integration density.

In recent years, nanotechnology and materials science have evolved and matured, making it increasingly easier to design and fabricate next-generation 3D microelectronics. The process has changed drastically from traditional 2D microelectronics, resulting in improved performance, higher integration density, and new functionalities. As applications become more complex and power-intensive, this technology can address the demands of high-performance computing, advanced sensors, and cutting-edge communication systems wearable, flexible devices, To manufacture higher-density microelectronics, recent advances in the fabrication of such 3D devices are discussed.

Genetic Interaction Between F-Box Encoding UCC1 and RRM3 Regulates Growth Rate, Cell Size, and Stress Tolerance in Saccharomyces cerevisiae.

Ucc1, an F-box motif-containing protein of Saccharomyces cerevisiae encoded by UCC1 regulates energy metabolism through proteasomal degradation of citrate synthase Cit2 and inactivation of the glyoxylate cycle when glucose is present as the main carbon source in the growth medium. Rrm3, a Pif1 family DNA helicase, encoded by RRM3 regulates the movement of the replication forks during the DNA replication process. Here in this study, we present evidence of binary genetic interaction between both the genes, UCC1 and RRM3, that determine the growth rate, cell morphology, cell size, apoptosis, and stress response.

Nanoparticle electrochemical biosensors for virus detection.

Viruses pose a significant threat to global public health, underscoring the urgent need for rapid, accurate, and sensitive diagnostic methods for timely detection and intervention. The demand for efficient diagnostics that can detect a wide range of viral pathogens has never been greater. In this context, metal nanoparticle-based biosensors have emerged as a promising solution, offering exceptional sensitivity for detecting various analytes, including nucleic acids (DNA/RNA), proteins, and other biomarkers associated with pathogens.

Genetic Association of the Ins/Del Variant of ACE and Risk of Cardiomyopathy: A Case-Control Study and Updated Meta-Analysis.

Introduction: Cardiomyopathy is a complex condition influenced by multiple genes and environmental factors. It has been suspected that cardiomyopathy is affected by the ACE gene's I/D polymorphism. Our study aimed to evaluate the association between this polymorphism and cardiomyopathy risk in the Jammu population of North India, alongside a meta-analysis to determine the specific risks associated with different types of cardiomyopathy.

Inkjet-Printed FASnPbI-Based Perovskite Solar Cells.

Metal halide perovskite solar cells (PSCs) have gained significant attention in thin-film photovoltaic research for their high power conversion efficiency (PCE) and facile fabrication processes. This study presents the use of inkjet printing to fabricate thin films of combinatorial mixed formamidinium tin-lead perovskites and evaluates their layer quality and device performance. Our findings demonstrate that incorporating Pb up to 50% into FASnI films enhances lattice stability.

Improved thermoelectric performance of PEDOT:PSS/BiTe/reduced graphene oxide ternary composite films for energy harvesting applications.

We report a significant enhancement in the thermoelectric power of PEDOT by fabricating a novel ternary composite film by incorporating BiTe and rGO. A series of five samples of PEDOT:PSS/BiTe/rGO ternary composite films were synthesized using a spin coating method and having different weight% (0.0, 0.

North India Cancer Risk: A Detailed Review with Focus on Jammu and Kashmir Demographics.

Background: Cancer is a global medical challenge, and research is at its peak to understand the unique mechanisms of cancer cells. The expanding field of epidemiology, including molecular and environmental studies, helps us better understand the distribution of molecular changes and environmental risk factors in the population.

Aim: In the present review, we aimed to find out the different genes and environmental factors that are associated with different cancers in the Jammu & Kashmir (J&K) region of the North Indian population.