81 results match your criteria: "James B. Edwards College of Dental Medicine[Affiliation]"

Purpose: Restoring ferrule-lacking, noncircular canal endodontically treated teeth (ETT) poses challenges owing to the increased susceptibility to root fracture and post dislodgement. We aimed to evaluate the influence of different post and core materials on the stress distribution and maximum Von Mises stress in ETT.

Methods: Four three-dimensional models were generated using different customized post and core materials: gold alloy, resin nanoceramic, polyetheretherketone (PEEK), and polyetherketoneketone (PEKK).

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Despite landmark breakthroughs in cancer research, African American adults (AA) bear the highest cancer burden compared to other racial groups in the United States (US). AA adults have twice the likelihood of dying from prostate and uterine cancers compared to White adults, suggesting that there are fundamental issues yet to be addressed when developing and implementing cancer-preventative programs for AA communities. Community-based participatory research (CBPR) empowers community members to identify and prioritize their health problems and preferred strategies to tackle these issues.

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School-based oral health programs are an effective approach to population-based care and a stalwart of public health, especially in rural and underserved communities. Lessons learned during the COVID-19 pandemic have informed contemporary strategies and policies to ensure integration into the delicate dental safety net in the Carolinas.

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Letter to the Editor.

Eur J Prosthodont Restor Dent

November 2024

State University of Ponta Grossa, Ponta Grossa, Brazil.

The authors wish to acknowledge that the information on the Monet website⁹ has now changed (2024) to reflect that exposures longer than 3 seconds are required for larger restorations and that overlapping exposures should be used. The website now states that for preparation areas that are larger than 5mm in depth and 8mm in diameter, two overlapping spot cures of 3 seconds are recommended (Figure 2). The single 1 and 3x1- second exposure times used in the article are not recommended by the manufacturer and should now be considered 'off-label' use of the Monet.

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Purpose: A newly introduced sintering protocol promises to offer higher translucency while not significantly compromising the flexural strength of the material. However, the effect of the novel sintering protocol has not been thoroughly validated. The purpose of this study was to measure and compare the effect of two sintering protocols on the translucency and flexural strength of two multilayered zirconia materials.

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GPR40/GPR120 Agonist GW9508 Improves Metabolic Syndrome-Exacerbated Periodontitis in Mice.

Int J Mol Sci

September 2024

Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, College of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.

G protein-coupled receptor (GPR)40 and GPR120 are receptors for medium- and long-chain free fatty acids. It has been well documented that GPR40 and GPR120 activation improves metabolic syndrome (MetS) and exerts anti-inflammatory effects. Since chronic periodontitis is a common oral inflammatory disease initiated by periodontal pathogens and exacerbated by MetS, we determined if GPR40 and GPR120 activation with agonists improves MetS-associated periodontitis in animal models in this study.

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This dental student-led study aimed to explore the extent to which an interprofessional intervention can be incorporated within the management of Parkinson's Disease (PD) to address the oral health needs of those living with the condition. Existing integrated or interprofessional (IP) care models lack the inclusion of oral health to improve clinical outcomes. We conducted key informant interviews with five neurologists and four dentists to ascertain their willingness, and the process needed, to facilitate collaborative referral management for patients with PD.

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Mannosidases, Dfg5 and Dcw1, Are Required for Cell Wall Integrity and Pathogenesis.

J Fungi (Basel)

July 2024

Department of Periodontics & Endodontics, School of Dental Medicine, University at Buffalo, Buffalo, NY 14214, USA.

Article Synopsis
  • The text discusses how a fungus, which normally coexists harmlessly in the mouth, can become a harmful pathogen, especially in individuals with weakened immune systems, leading to infections known as candidiasis.
  • It highlights the rising problem of antifungal drug resistance and the urgent need for new treatments, identifying two specific enzymes, Dfg5 and Dcw1, as promising drug targets due to their vital roles in maintaining the fungus's cell wall integrity and shape.
  • The study finds that mutations in Dfg5 and Dcw1 disrupt essential functions related to cell wall integrity and hyphal morphogenesis, affecting the fungus's ability to cause disease in a mouse model of oral candidiasis.
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Are physical and mechanical properties of 3D resins dependent on the manufacturing method?

Odontology

August 2024

Associate Professor, Department of Advanced Specialty Sciences, James B. Edwards College of Dental Medicine, Medical University of South Carolina, Charleston, SC, USA.

This research analyzed the effect of the manufacturing method on the flexural strength and color stability of 3D-printed resins used for producing indirect restorations. For this, two dental restorative biocompatible resin materials, OnX (OnX, SprintRay) and CB (Crown and Bridge, Dentca), were divided into 2 groups according with manufacturing method (printed with a Pro95 3D printer - SprintRay; and not printed, with samples obtained with the fluid resin being poured on PVS molds for further light activation in the post-curing process), and subdivided into 2 groups according to the post-curing method: VG (Valo Grand, Ultradent Products) for 120 s and PC (Procure 2, SprintRay). Bar-shaped samples were used to evaluate the flexural strength 24 h after storage in distilled water at 37 °C using a universal testing machine.

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This longevity of life expectancy has indirectly led to an increase in the number of chronic diseases such as periodontitis, apical periodontitis (AP), and diabetes mellitus (DM) in the aging society, thus affecting people's quality of life. There is an interaction between periodontitis/AP and DM with a two-way relationship. Although type 1 and 2 diabetes (T1DM, T2DM) have different etiologies, glycemic control may affect the infection, inflammation and tissue healing of periodontitis and AP.

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The optimal configuration of a customized implant abutment is crucial for bone remodeling and is influenced by various design parameters. This study introduces an optimization process for designing two-piece zirconia dental implant abutments. The aim is to enhance bone remodeling, increase bone density in the peri-implant region, and reduce the risk of late implant failure.

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Ability of Six Curing Lights to Photocure Four Resin-Based Composites in a MOD-Mold: A Double-Blind Study.

Eur J Prosthodont Restor Dent

September 2024

James B. Edwards College of Dental Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

Objective: The ability of six curing lights to photocure four resin-based composites (RBCs) in a mold simulating a cavity was compared visually.

Materials And Methods: Four RBCs were photocured using the: Woodpecker B for 2x10s, SmartLite Pro 2x10s, Valo Cordless 2x10s, Valo Cordless 2x3s Xtra power, Valo X 2x10s, Valo X 2x5s Xtra power, PowerCure 2x3s mode, Monet 1x1s and Monet 3x1s, in a mold representing a molar Class II restoration. Immediately after photocuring, the RBC specimens were immersed in a solvent to remove the uncured RBC, after which they were photographed and de-identified.

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Effects of pre-heating on physical-mechanical-chemical properties of contemporary resin composites.

Odontology

January 2025

Department of Reconstructive and Rehabilitation Sciences, James B. Edwards College of Dental Medicine, Department of Oral Rehabilitation, Medical University of South Carolina, 173 Ashley Ave, BSB 550E, Charleston, SC, 29425, USA.

This research assessed the effects of pre-heating on the physical-mechanical-chemical properties of different resin composites. For this, resin composites were evaluated in 6 levels: Admira/ADM, Vitra/VIT, Filtek Supreme/FS, Filtek Supreme Flowable/FSF, Filtek One/FO, and Filtek Bulk Fill Flowable/FBF; temperature was evaluated in 4 levels using a composite heater: room temperature/22 ºC, 37 ºC, 54 ºC, and 68 ºC. Response variables were: degree of conversion/DC, flexural strength/FS and color stability/ΔE (immediately after light curing/LC, after 7 days of dark-dry-storage, and after 24 h and 3 days of artificial aging in water at 60 ºC).

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Mechanical and chemical characterization of contemporary occlusal splint materials fabricated with different methods: a systematic review.

Clin Oral Investig

December 2023

Division of Dental Biomaterials, Center for Dental Medicine, Clinic for Reconstructive Dentistry, University of Zurich, Plattenstrasse 11, 8032, Zurich, Switzerland.

Objective: To systematically review studies on various occlusal splint materials and describe their mechanical and chemical properties.

Methods: MEDLINE (PubMed), Scopus, and Web of Science searches were conducted for in vitro studies focusing on occlusal splint materials. Two reviewers performed an assessment of the identified studies and data abstraction independently, and this was complimented by an additional hand search.

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The effect of crowding on the accuracy of 3-dimensional printing.

Am J Orthod Dentofacial Orthop

December 2023

Department of Orthodontics, School of Dentistry, Virginia Commonwealth University, Richmond, Va. Electronic address:

Introduction: The purpose of this study was to evaluate the accuracy of 3-dimensional (3D) printed aligners compared to conventional vacuum-formed thermoplastic aligners with varying levels of dental crowding.

Methods: Digital intraoral scans of 10 cases were assigned to their respective groups (n = 10, each, 30 total) as follows: no crowding (control), moderate crowding, and severe crowding. Digital images of these models were created in standard tessellation language (STL) file format using 3Shape software and randomly 3D printed.

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Statins Modulate Microenvironmental Cues Driving Macrophage Polarization in Simulated Periodontal Inflammation.

Cells

July 2023

Department of Oral Health Sciences, James B. Edwards College of Dental Medicine, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA.

Periodontal disease (PD) is a chronic inflammatory disorder characterized by the destruction of connective tissue, tooth loss, and systemic infections. Clinically, treatment of PD includes control of the etiologic factors via several modalities: initial therapy including scaling and root planing (SRP), corrective phase of surgical treatment, both with and without adjunct antimicrobial/pharmacological agents, followed by a maintenance/supportive periodontal therapy phase. Each treatment phase aims to control oral biofilm by addressing risk factors and etiology.

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African American adults have the highest mortality rate for most cancers in the United States, and meaningful, community-driven research is needed to inform optimal strategies for addressing these disparities. Unfortunately, research mistrust, often driven by historical inequities, is well-documented among African Americans.This study explored trust, attitudes, and preferences regarding participation in cancer research activities among primarily African American and other medically underserved communities in South Carolina from August 2020 to December 2021.

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Background: The objective was to compare physic-mechanical properties of different materials used for temporary restorations.

Material And Methods: Protemp 4/bisacrylic resin, Jet/acrylic resin, and Nexdent C&B/3D-printed resin samples (10mm diameter x 2mm thickness) were analyzed for surface roughness and color stability tests (baseline, after 5 thousand brushing cycles; and after artificial aging in water at 60oC for 24 hours) and Knoop microhardness. All data were checked for normality using Shapiro-Wilk test.

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Clinical studies have shown that periodontitis is associated with non-alcoholic fatty liver disease (NAFLD). However, it remains unclear if periodontitis contributes to the progression of NAFLD. In this study, we generated a mouse model with high-fat diet (HFD)-induced metabolic syndrome (MetS) and NAFLD and oral inoculation-induced periodontitis.

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Response to the Letter by Jonathan A. Mason.

J Endod

June 2023

Department of Oral Rehabilitation, James B. Edwards College of Dental Medicine, Medical University of South Carolina, Charleston, South Carolina.

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Purpose: To evaluate the bonding interface and the remineralization potential of a bioactive restorative material on demineralized dentin compared to a conventional bulk-fill resin composite restoration.

Methods: Twelve caries-free human molars were used in this study. Specimens were randomly divided into two groups according to the type of restorative material used (n=12); an injectable resin-modified glass-ionomer restorative [Activa BioActive-Restorative (ABR) ] and a bulk-fill composite [3M Filtek One Bulk Fill Restorative, (BFC) ].

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Different collagen barrier membranes come in various sources and crosslinking that may affect barrier function and tissue integration. This study investigated barrier function and tissue integration of the three different collagen membranes (Jason: porcine pericardium, GENOSS: bovine tendon, and BioMend Extend: cross-linked bovine tendon) with human gingival fibroblasts. The barrier function and tissue integration properties were determined under confocal microscopy.

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Fungal Lesions of the Oral Mucosa Diagnosis and Management.

Oral Maxillofac Surg Clin North Am

May 2023

Division of Oral and Maxillofacial Pathology, University of Minnesota School of Dentistry, Malcom Moos Health Sciences Tower, 515 Delaware Street, Southeast, Minneapolis, MN 55455, USA.

Oral fungal infections are opportunistic and due to impaired host resistance. The increasing number of immunosuppressed individuals contributes to rising numbers of mycoses worldwide, and the ease of global migration has allowed the geographic range of endemic mycoses to expand. Deep fungal infections can clinically mimic other pathologic conditions including malignancy.

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