Unveiling the Anticancer Potential of Phytocompounds: Pioneering Future Cancer Therapies.

Cancer epidemiological studies highlight the critical need for identifying better treatment options against cancer. Plants have been widely studied to obtain their efficacy as potent therapeutic agents to treat several diseases, including cancer. Interestingly, some phytocompounds, such as flavonoids, terpenoids, alkaloids, phenolics, and organosulphur compounds [OSCs], have been demonstrating their potential role in combating several pathologies, including the second most devasting disease, cancer, which contributes a significant portion of annual mortality cases.

Cell death-associated lncRNAs in cancer immunopathogenesis: An exploration of molecular mechanisms and signaling pathways.

Cancer remains one of the foremost causes of mortality worldwide, highlighting the urgent need for novel therapeutic targets due to the insufficient efficacy and adverse side effects associated with existing cancer treatments. Long non-coding RNAs (lncRNAs), defined as RNA transcripts longer than 200 nucleotides, have emerged as pivotal regulators in the initiation and progression of various malignancies. In oncology, programmed cell death (PCD) serves as the primary mechanism for tumor cell elimination, comprising processes such as apoptosis, pyroptosis, autophagy, and ferroptosis.

Impact of whey protein on lipid profiles: A systematic review and meta-analysis.

Aims: This research delved into a comprehensive examination and detailed analysis of the effects of whey protein (WP) supplementation on lipid profile in adults.

Data Synthesis: Data used in this research was obtained from diverse clinical trials. Thorough searches were carried out on multiple electronic platforms including PubMed, Embase, Web of Science, Scopus, Google Scholar, and the Cochrane Library from their inception until May 2024.

Surface-Engineered 2D Bimetallic FeNi-MOFs Derived from Layered Double Hydroxides for Photocatalytic Membranes with Enhanced Dye Fixation in Wastewater Treatment.

FeNi-based layered double hydroxides (LDHs) are used as precursors to derive bimetallic FeNi-metal organic frameworks (D-FeNi MOFs) with terephthalic acid ligands, offering enhanced properties compared to conventionally prepared FeNi-MOFs (C-FeNi MOFs). D-FeNi MOFs exhibited superior structural, surface, and electrochemical features, confirmed by density functional theory (DFT) studies, which also predicted their catalytic mechanism. Band edge potential calculations through Mott-Schottky analysis revealed their favorable redox potential, enhanced charge transfer, and reduced recombination resistance, explaining their superior photocatalytic efficiency.

The Microbiota-Gut-Brain Axis in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Narrative Review of an Emerging Field.

The intricate relationship between gut microbiota and the brain has emerged as a pivotal area of research, particularly in understanding myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This complex condition is characterized by debilitating fatigue, cognitive dysfunction, and a wide array of systemic manifestations, posing significant challenges for diagnosis and treatment. Recent studies highlight the microbiota-gut-brain axis as a crucial pathway in ME/CFS pathophysiology, suggesting that alterations in gut microbial composition may impact immune responses, neurochemical signaling, and neuronal health.

Long non-coding RNAs (lncRNAs) in cancer development: new insight from STAT3 signaling pathway to immune evasion.

Overcoming cancer and enhancing patient survival are becoming increasingly challenging due to the uncontrolled growth and metastasis of colorectal cancer cells. In order to provide effective cancer treatment and minimize the malignancy of cancer cells, it is necessary to understand how complex signaling networks contribute to their invasion and proliferation. The signal transducer and activator of transcription 3 (STAT3) is a promising target due to its involvement in various cellular functions, including apoptosis, immunosuppression, cell invasion, migration, and proliferation.

Synaptic plasticity and neuroprotection: The molecular impact of flavonoids on neurodegenerative disease progression.

Flavonoids are a broad family of polyphenolic chemicals that are present in a wide variety of fruits, vegetables, and medicinal plants. Because of their neuroprotective qualities, flavonoids have attracted a lot of interest. The potential of flavonoids to control synaptic plasticity-a crucial process underlying memory, learning, and cognitive function-is becoming more and more clear.

Mechanisms behind the LncRNAs-mediated regulation of paclitaxel (PTX) resistance in human malignancies.

Paclitaxel (PTX) is extensively used to treat various cancers, including those of the breast, ovary, lung, esophagus, stomach, pancreas, and neck. However, despite its effectiveness in clinical settings, patients often experience cancer recurrence due to the emergence of resistance to PTX. The mechanisms underlying this resistance in cancer cells exposed to PTX involve modifications in β-tubulin, the primary target molecule associated with mitosis, the activation of pathways that facilitate drug efflux, and the dysregulation of apoptosis-related proteins.

Cayley-Purser secured communication and jackknife correlative classification for COVID patient data analysis.

Internet of Medical Things (IoMT) is a group of medical devices that connect the healthcare information technology to minimize the redundant hospital visit and healthcare system troubles. IoMT connect the patients to the doctor and transmit the medical data over the network. The spread of corona virus has put the people at high risk.

Enhancing feature selection for multi-pose facial expression recognition using a hybrid of quantum inspired firefly algorithm and artificial bee colony algorithm.

Facial expression recognition (FER) has advanced applications in various disciplines, including computer vision, Internet of Things, and artificial intelligence, supporting diverse domains such as medical escort services, learning analysis, fatigue detection, and human-computer interaction. The accuracy of these systems is of utmost concern and depends on effective feature selection, which directly impacts their ability to accurately detect facial expressions across various poses. This research proposes a new hybrid approach called QIFABC (Hybrid Quantum-Inspired Firefly and Artificial Bee Colony Algorithm), which combines the Quantum-Inspired Firefly Algorithm (QIFA) with the Artificial Bee Colony (ABC) method to enhance feature selection for a multi-pose facial expression recognition system.

Burden and regional disparities of chronic obstructive pulmonary disease in India: Insights from the global burden of disease data and projections for future incidence.

Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality globally, particularly in low- and middle-income countries like India. This study aims to analyze regional trends and project future burden of COPD in India using data from the Global Burden of Disease (GBD) 1990-2021.

Methods: This analysis utilized data from the GBD study to assess age-standardized prevalence (ASPR), incidence (ASIR), disability-adjusted life years (DALYs) (ASDR), and mortality rates (ASMR) for COPD across Indian states.

Magnetically recoverable catalysts for efficient multicomponent synthesis of organosulfur compounds.

This manuscript introduces a groundbreaking study on the development and application of magnetically recoverable catalysts for the efficient multicomponent synthesis of organosulfur compounds. Capitalizing on the unique advantages of magnetic recovery, these catalysts streamline the synthesis process, offering an innovative solution that marries efficiency with environmental sustainability. By facilitating the multicomponent reaction of key precursors in the presence of sulfur sources, the catalysts enable the straightforward synthesis of various valuable organosulfur compounds, crucial in numerous pharmaceutical, agricultural, and material science applications.

Ophthalmic Manifestations of the Mpox Virus: A Systematic Review and Meta-Analysis.

Background: Recent outbreaks of monkeypox (Mpox) have raised concerns about its complications, including ophthalmic manifestations such as conjunctivitis, keratitis, and potential vision impairment. The lack of comprehensive data on these ocular complications hinders the development of effective clinical guidelines. This review aim to synthesize existing evidence on the prevalence and characteristics of Mpox-related ocular complications.

Insights into the Morphological Effects of 1D, 2D, and 3D CoV-Layered Double Hydroxides on Their Electrochemical Performance in Supercapacitors.

In this study, bimetallic cobalt-vanadium-based layered double hydroxide (CoV-LDH) systems were developed by varying the Co/V molar ratios (1:1 and 2:1) and hydrothermal temperatures (120 and 180 °C). Structural analysis by X-ray diffraction (XRD), Raman, and Fourier-transform infrared (FTIR) spectroscopy indicated the successful formation of CoV-LDH with a unique structure and lattice distortions, reflecting the influence of both the metal concentrations and temperature on the crystal and chemical structures of the developed bimetallic systems. Similarly, the field-emission scanning electron microscopy (FESEM) and high resolution transmission electron microscopy (HRTEM) images revealed a flaky 2D nanosheet-like structure for the bimetallic CoV-LDH with a 1:1 ratio prepared at 120 °C (CVL1-120), whereas one-dimensional (1D) and three-dimensional (3D) morphologies were observed for other bimetallic CoV-LDH systems prepared with a different molar ratio (2:1) and/or temperature (180 °C).

Innovations in cellulose-based hydrogels for enhanced wastewater treatment through adsorption.

Cellulose-based hydrogels are versatile and biodegradable materials derived from renewable cellulose sources. These hydrogels possess unique properties, such as high water absorption capacity, tunable mechanical strength and excellent biocompatibility. Their porous structure and functional groups enable effective interactions with contaminants and making them ideal candidates for water purification.

The interplay of p16INK4a and non-coding RNAs: bridging cellular senescence, aging, and cancer.

p16INK4a is a crucial tumor suppressor and regulator of cellular senescence, forming a molecular bridge between aging and cancer. Dysregulated p16INK4a expression is linked to both premature aging and cancer progression, where non-coding RNAs (ncRNAs) such as long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and small interfering RNAs (siRNAs) play key roles in modulating its function. These ncRNAs interact with p16INK4a through complex post-transcriptional and epigenetic mechanisms, influencing pathways critical to senescence and tumor suppression.

Effects of Coenzyme Q10 Supplementation on Metabolic Indicators in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis.

Background: Coenzyme Q10 (CoQ10) is a naturally occurring antioxidant that has been suggested to have beneficial effects on lipid profiles and blood pressure. This systematic review and meta-analysis aim to evaluate the effects of CoQ10 supplementation on these parameters in patients with Type 2 Diabetes (T2D).

Objective: To assess the impact of CoQ10 supplementation on lipid profiles and blood pressure in individuals diagnosed with Type 2 Diabetes.

Developing a highly sensitive electrochemical sensor for malathion detection based on green g-CN@LiCoO nanocomposites.

Nowadays, developing pesticide-free agriculture is highly demanded by society. The development of electrochemical sensors to monitor and control pesticides is an effective step toward this desired goal. The current research has faced this issue by modifying of glassy carbon electrodes (GCEs) with green g-CN@LiCoO nanocomposites to probe malathion, an organophosphate pesticide.

A Review Unveiling the Ferroptosis-Regulated Cell Signalling Pathways in Breast Cancer to Elucidate Potent Targets for Cancer Management.

Recent research suggests that targeting ferroptosis exhibits promise as a potent treatment approach for breast carcinoma. Specific subtypes of tumor cells exhibit heightened vulnerability to ferroptosis-inducing chemicals, which selectively trigger tumor stem cells' demise, enhance tumor cells' sensitivity to chemotherapeutic drugs, and eliminate cancerous cells. Ferroptosis plays a dual role in breast cancer progression, emerging as both a stimulating and inhibitory component.

MicroRNAs as behind-the-scenes molecules in breast cancer metastasis and their therapeutic role through novel microRNA-based delivery strategies.

Breast cancer is the primary cause of cancer-related death and the most frequent malignancy among women in Western countries. Although there have been advancements in combination treatments and targeted therapies for the metastatic diseases management, metastatic breast cancer is still the second most common cause of cancer-related deaths among U.S.

Nanomaterial sensors for enhanced detection of serotonin.

The detection of serotonin (5-HT), a critical neurotransmitter, has garnered significant attention in biosensor research because of its pivotal role in neurological and physiological processes. This narrative review highlights advancements in nanomaterial-based sensors designed to increase the sensitivity, specificity, and functionality of serotonin detection. Carbon-based nanomaterials, including carbon nanotubes (CNTs), graphene derivatives, and carbon nanofibers (CNFs), have demonstrated remarkable potential owing to their large surface area, superior electrical conductivity, and biocompatibility.

The role of exosomal non-coding RNAs in the breast cancer tumor microenvironment.

The leading form of cancer affecting females globally is breast cancer, characterized by an unregulated growth of cells within the breast. Therefore, examining breast tissue is crucial in accurately identifying and treating this disease. Exosomes are very small enclosures bounded by a layer of cells and produced by a variety of cells present in the cancerous tissue surroundings.

Pomegranate as a natural remedy for gastric ulcers prevention: a review of its gastroprotective mechanisms and pharmacological benefits.

Gastric ulcers (GUs) represent a common gastrointestinal disorder characterized by mucosal damage and inflammation, often precipitated by factors such as Helicobacter pylori infection and the consumption of COX inhibitors. This comprehensive review investigates the role of oxidative stress and inflammation in the pathogenesis of GUs and assesses the potential therapeutic effects of Punica granatum (pomegranate, Pg) supplementation. Utilizing a series of experimental models, including indomethacin, aspirin, and alcohol-induced ulcers, we demonstrate that Pg extracts possess significant gastroprotective properties.

-mutated AML: immune evasion through exosome-mediated mechanisms and innovative combination therapies targeting immune escape.

Introduction: Acute Myeloid Leukemia is a heterogeneous hematological malignancy characterized by the uncontrolled proliferation of abnormal myeloid cells. Besides several other genetic abnormalities developed in AML, FLT3 mutations are significant due to their worse prognostic impacts and therapeutic resistance. As a result, these mutations enable AML cells to develop mechanisms for evading immune surveillance.