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Article Synopsis
  • Colorectal carcinoma (CRC) is a prevalent cancer that can evade immune responses through the PD-1/PD-L1 interaction, making immunotherapy with checkpoint inhibitors essential for treatment.
  • A 2-year study analyzed PD-L1 expression in 34 CRC specimens to understand its relationship with various clinicopathological factors.
  • The findings showed PD-L1 positivity in 17.65% of both tumoral cells and immune cells, linking PD-L1 expression with poor prognostic indicators, suggesting its potential utility in targeted therapy for CRC.
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Actinomycosis is an indolent, slowly progressive bacterial infection prevalent in tropical countries, commonly affecting cervicofacial, thoracic, abdominal, or pelvic regions. With early diagnosis and appropriate therapy, the prognosis is excellent. However, late presentation and widespread dissemination can be fatal.

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