A narrative review on sexual wellbeing and dysfunctions: Research in the past 15 years.

Background: Psychosexual health is an important aspect of mental and physical wellbeing. Though Indian culture has a rich history of sexuality, over the years, our population has been reticent in talking about the same. With the advent of technology and new legislations protecting the rights of LGBTQIA population, awareness is also on the rise.

Mitochondrial DNA variants in the pathogenesis and metabolic alterations of diabetes mellitus.

Mitochondrial DNA (mtDNA) variants considerably affect diabetes mellitus by disturbing mitochondrial function, energy metabolism, oxidative stress response, and even insulin secretion. The m.3243 A > G variants is associated with maternally inherited diabetes and deafness (MIDD), where early onset diabetes and hearing loss are prominent features.

Lung function and onset of cardiometabolic diseases in the longitudinal Burden of Obstructive Lung Disease study.

Introduction: Previous population-based studies, mainly from high-income countries, have shown that a higher forced vital capacity (FVC) is associated with a lower risk of developing cardiometabolic diseases. The aim of this study was to assess the longitudinal association between spirometry measures and the onset of cardiometabolic diseases across sites in low-income, middle-income and high-income countries.

Methods: The study population comprised 5916 individuals from 15 countries participating in the Burden of Obstructive Lung Disease baseline and follow-up assessments.

Burden of rheumatic diseases among people with diabetes: A systematic review and meta-analysis.

Diabetes mellitus type 2 (DM2) is a prevalent metabolic condition affecting over 500 million people globally and associated with serious comorbidities, including various rheumatologic conditions. Some studies have reported a significant association between rheumatological conditions and DM2. However, the global burden of rheumatological conditions among people with DM2 remains unknown.

Alcohol use profile, motivation to quit, and attitude toward drinking in participants of a community alcohol de-addiction camp and a clinical setting: A comparative study.

Background: Due to a lack of awareness and inadequate health infrastructure, the treatment gap for any mental illness is increasing in lower- and middle-income countries, including India. As an alternative to institutional treatment, community de-addiction camps play an important role.

Method: This comparative study examined alcohol use profiles, motivation to quit, and attitudes toward drinking in 84 participants, equally divided between a community alcohol de-addiction camp ( = 42) and a clinical setting ( = 42).

Modified Tinea Corporis Score (mTCS) Versus Tinea Corporis Score (TCS): A Comparative, Noninterventional Validation Study.

Background: Tinea corporis (TC) is a common fungal infection affecting 20%-25% of the global population. Though diagnosing TC is straightforward, treatment has become challenging due to the use of certain medications and lack of follow-up, leading to resistance. Andrea et al.

The First-Ever Encounter with Serovar Hvittingfoss Causing Acute Gastroenteritis in India: A Case Report.

serovar Hvittingfoss, a member of the non-typhoidal group, is an important foodborne serovar most frequently identified in regions (Australia, Belgium, and the United States) with active surveillance systems. This serovar has been implicated in outbreaks of foodborne illness. Soft cheese, crab cocktail, beef, and rock melon are commonly involved in these outbreaks.

Lipid-Lowering Therapy Associated Erectile Dysfunction and Testicular Pain: A Rare Case Report.

Lipid-lowering therapy (LLT) includes a diverse group of pharmaceuticals designed to reduce blood levels of cholesterol and triglyceride (TG), helping to prevent cardiovascular diseases like myocardial infarction and stroke. LLT includes treatment with several lipid-lowering drugs (LLD), including hydroxymethylglutaryl (HMG-CoA) reductase inhibitors (statin), PCSK9 Inhibitors, cholesterol-absorbing inhibitors (Ezetimibe), Bile Acid Sequestrants, Fibrates, Niacin (Vitamin B3), Omega-3 Fatty Acids, Bempedoic Acid, and combination therapy. The efficacy and safety of these molecules vary widely.

Uncommon Presentation of Multiple Myeloma: Pleural Effusion and Extensive Extramedullary Involvement.

A 60-year-old female presented with abdominal pain, weight loss, and fatigue. Imaging revealed a pancreatic mass, bilateral pleural effusion, ascites, and lytic bony lesions. Investigations confirmed multiple myeloma with lambda light chain disease.

Dobutamine induced multifocal myoclonus in a patient with chronic kidney disease.

Adverse drug reactions (ADRs) are common in clinical practice, especially among patients with multiple comorbidities and polypharmacy. The ADRs associated with medications may be minor or life-threatening. Many available ADR assessment scales and pharmacovigilance programmes have streamlined the early diagnosis and management of ADRs.

Clinico-Mycological Study of Dermatophytosis among Diabetic and Non-Diabetic Patients in a Tertiary Level Hospital: A Comparative Study.

Background: Dermatophytosis is a major public health concern in India, especially in recent years, with an alarmingly rising trend, particularly in relation to recurrent and chronic infection. The number of studies examining the relationship between an individual's glycemic status and the development of dermatophytosis, and a comparison of the evolving species trend between diabetic and non-diabetic patients infected with dermatophytes, is limited.

Aims And Objectives: To study and compare the clinical and mycological aspects of dermatophytosis among diabetic and non-diabetic patients and to compare the culture isolates in both groups.

Stress, Resilience, Sexual Functioning and Quality of Life in Patients Undergoing Arthroplasty and Arthroscopy.

Background: In India, the incidence of orthopaedic conditions is significantly increasing, with 63 million people suffering from various orthopaedic issues, causing considerable distress to patients. This study aims to assess stress, resilience, sexual functioning, and quality of life in participants who underwent arthroplasty and arthroscopy surgery at baseline, one month, and three months.

Method: This comparative study utilised the Perceived Stress Scale (PSS), Connor-Davidson Resilience Scale, Sexual Function Scale, and the WHO Quality of Life Scale.

Development and validation of the premenstrual dysphoric disorder scale in Indian females.

Background: Premenstrual dysphoric disorder is a mood disorder that has been recognized in the Diagnostic and Statistical Manual for Mental Disorders, Fifth Edition (DSM-5) as a subcategory of depressive disorders. The disorder has a high prevalence rate, and yet no uniform measure is standardized on the Indian population.

Aim: This study aimed to develop a scale to assess premenstrual dysphoric disorder that can be used for screening and for clinical use and that is standardized on the Indian population.

Uropathogenic Pan-Drug-Resistant Providencia rettgeri Infection in a Patient With an Indwelling Urinary Catheter: A Case Report.

This case report details the clinical management and implications of infection with pan-drug-resistant in a 50-year-old male admitted and diagnosed with acute peritonitis due to hollow viscus perforation, highlighting an emerging challenge in healthcare settings. Following emergency laparotomy and intensive care admission, the patient was catheterized to assist urine drainage and subsequent urine bacterial culture which yielded pan-drug-resistant , signifying a notable instance of nosocomial infection by a multi-drug-resistant organism. Despite the organism's resistance to broad-spectrum antibiotics, clinical improvement was observed with levofloxacin treatment, underlining the potential discrepancy between in vitro resistance patterns and in vivo response, particularly in urinary tract infections (UTIs) where urine drug concentrations are pivotal.

Investigating the dynamic relationship of sleep-disordered breathing, orthodontic treatment needs, and dental esthetics in the general population.

Background: Sleep-disordered breathing (SDB) is characterized by upper airway dysfunction and is linked to severe health issues. Individuals with SDB have distinct craniofacial morphology for which orthodontists are most suitable for the management due to their dental expertise.

Aim: This study aims to discern key differences in dental parameters between individuals with and without SDB.

Rapid Shallow Breathing Index and Ultrasonographic Diaphragmatic Parameters as Predictors of Weaning Outcome in Critically Ill Patients on Mechanical Ventilation.

Background: Successful weaning is a crucial element in care toward critically ill patients on mechanical ventilation. An attempt was made to propose and assess a reliable predictor of weaning outcome.

Materials And Methods: A prospective observational study was conducted on 76 patients on mechanical ventilation, assessed by Acute Physiology and Chronic Health Evaluation II (APACHE II) score.

Genetic Characterization of Methicillin-Resistant Staphylococcus aureus Isolated From Diabetic Foot Ulcers in a Tertiary Care Hospital in Mysuru, South India.

Background Diabetic foot ulcers (DFUs) are common complications in diabetes patients, often leading to sepsis and leg amputation. Methicillin-resistant Staphylococcus aureus (MRSA) infections in DFUs pose challenges due to methicillin resistance with and genes. This study aims to assess the prevalence of MRSA in clinical isolates from DFUs, analyze the antibiogram of MRSA isolates, and detect the presence of the and genes among MRSA isolates.

Catatonia in Juvenile Systemic Lupus Erythematosus: A Case Series.

Neuropsychiatric systemic lupus erythematosus (NPSLE) presents a significant diagnostic and therapeutic challenge due to its varied clinical manifestations. The prevalence of NPSLE ranges widely, reported between 37% and 95% in different case series, reflecting this condition's complex and heterogeneous nature. Here we report three cases of juvenile systemic lupus erythematosus (SLE) presenting with catatonia as a rare neuropsychiatric manifestation.

Multicentric Osteolysis Nodulosis and Arthropathy (MONA): A Case Series and Review of the Literature.

Multicentric Osteolysis Nodulosis and Arthropathy (MONA) is a rare skeletal disorder driven by mutations in the MMP2 gene, leading to bone and joint degradation. This case series presents three unique MONA cases, highlighting clinical, radiological, and genetic aspects. These insights shed light on the complexities of MONA, aiding early diagnosis and multidisciplinary management.

Burden of vaso-occlusive crisis, its management and impact on quality of life of Indian sickle cell disease patients.

Sickle cell disease (SCD) with vaso-occlusive pain crisis (VOC) significantly impacts patient well-being and often results in extensive healthcare resource utilization. This study assessed the VOC burden, its management and its impact on patients' quality of life (QoL). A cross-sectional observational study was conducted between November 2021 and June 2022, including 1000 SCD patients from high-prevalence states in India.

Study Protocol for Mindfulness-Based Yoga Versus Physical Exercise on the Psychological Well-Being in Students With Early Visual Impairment: A Three-Armed, Multi-Centered, Randomized Controlled Trial.

Background People with visual impairment (VI) tend to face more psychological distress than normally sighted individuals due to mobility restrictions, fear of falling, and sleep disturbances. However, research to address these problems is rare. This study aims to investigate the effect of mindfulness-based yoga versus physical exercise on the psychological well-being of individuals with VI.