870 results match your criteria: "JSS College of Pharmacy JSS Academy of Higher Education & Research[Affiliation]"

Navigating health policies and programs in India: exploring opportunities to improve rare disease management and orphan drug research.

Orphanet J Rare Dis

November 2024

Centre of Excellence in Regulatory Sciences (CeRES), Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, SS Nagara, Mysuru, Karnataka, 570015, India.

Background: Rare disease (RD) management and orphan drug development in India face various hurdles regarding the implementation and adoption of comprehensive policies, lack of dedicated regulatory frameworks, and absence of epidemiological data. Current rare disease policy focuses more on strengthening the diagnostics and lacks a proper comprehensive treatment framework to ensure favorable clinical outcomes. Indian patients are largely excluded from global orphan drug clinical trials.

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  • * The article reviews the limitations of current therapies and explores various nanoparticle (NP) based approaches for treating HCC, highlighting types like liposomes and carbon nanotubes.
  • * It emphasizes the effectiveness of NP technologies in photothermal and photodynamic therapies, while also discussing recent patents and clinical studies that show promise for enhancing treatment outcomes for HCC.
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  • * There is ongoing research exploring how diabetic neuropathy is related to cognitive dysfunction and gut health, though the exact mechanisms are not fully understood.
  • * The review highlights the complex relationship between diabetic neuropathy, cognitive impairment, and the role of an imbalanced gut microbiome in their development and progression.
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Synthesis and evaluation of novel ethyl ferulate derivatives as potent Keap1 inhibitors to activate the Nrf2/ARE pathway in Parkinson's disease.

Toxicol Appl Pharmacol

January 2025

Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, Nilgiris, Tamil Nadu, India. Electronic address:

The Kelch-like ECH-associated protein 1/Nuclear factor erythroid 2 related factor 2/Antioxidant Response Elements (Keap1/Nrf2/ARE) pathway is essential for neuronal resilience against the complex pathogenesis of Parkinson's disease (PD). Activating this pathway by covalently modifying Keap1 cysteine residues is a promising strategy for regulating neuroprotective gene expression. Our study aimed to identify phytochemicals that could irreversibly inhibit Keap1.

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Background/objectives: Loading of natural products into poly-(lactide-co-glycolic) acid (PLGA) nanoparticles as drug delivery systems for the treatment of diseases, such as tuberculosis (TB), has been widely explored. The current study investigated the use of PLGA nanoparticles with 7-methyljuglone (7-MJ), an active pure compound, isolated from the roots of A. DC.

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In pursuit of novel antidiabetic agents to combat type II diabetes mellitus, our study focused on identifying pharmacophoric features responsible for PPAR-γ expression, a key regulator of glucose homeostasis and lipid metabolism. This goal was achieved through pharmacophore model generation and screening of rationally designed library of thiazolidine-2,4-dione hybrids (7a-7f). The top hits were synthesized, characterized, and evaluated for their in vitro and in vivo antidiabetic activities.

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Harnessing Simple Animal Models to Decode Sleep Mysteries.

Mol Biotechnol

November 2024

Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, 570015, Karnataka, India.

Whether it involves human subjects or non-human animals, basic, translational, or clinical sleep research poses significant ethical challenges for researchers and ethical committees alike. Sleep research greatly benefits from using diverse animal models, each offering unique insights into sleep control mechanisms. The fruit fly (Drosophila melanogaster) is a superior genetic model due to its quick generation period, large progenies, and rich genetic tools.

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The effect of a poly-herbal plant extract on the adhesion of Streptococcus mutans to tooth enamel.

BMC Complement Med Ther

November 2024

Department of Plant and Soil Science, Faculty of Natural and Agriculture Sciences, University of Pretoria, Pretoria, 0002, South Africa.

Background: Dental caries, also known as tooth decay or cavity formation, is one of the world's most widespread dental conditions. It is a plaque-related infection caused mainly by Streptococcus mutans. People have relied on several plant species to treat oral infections; Heteropyxis natalensis, for example, has been used to treat toothache and gum infections.

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  • Many countries have increased focus on physical education and sports, yet there's been a notable rise in injuries, particularly Achilles tendon ruptures, which make up 47% of such cases.
  • The review aims to identify risk factors for Achilles tendon ruptures and propose personalized prevention strategies based on extensive database research.
  • It highlights non-modifiable factors like genetics and age as well as modifiable factors such as nutrition and exercise habits, emphasizing the importance of early treatment and the latest advancements in injury management.
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Glioblastoma multiforme (GBM), the most aggressive form of brain cancer, poses substantial challenges to effective treatment due to its complex and infiltrative nature, making it difficult to manage. Photodynamic therapy (PDT) and sonodynamic therapy (SDT), have emerged as promising individual treatment options against GBM due to their least-invasive approach. However, both PDT and SDT have drawbacks that require careful consideration.

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Donepezil and Memantine-Induced Second-Degree Atrioventricular Block: A Case Report.

Hosp Pharm

October 2024

Department of Psychiatry, JSS Medical College & Hospital, JSS Academy of Higher Education and Research, Mysore, Karnataka, India.

Article Synopsis
  • Donepezil and memantine are second-generation medications used for managing mild to moderate Alzheimer's disease, acting on different neural pathways to help with cognitive decline.
  • Donepezil inhibits acetylcholinesterase, while memantine blocks NMDA receptors, both targeting the central nervous system.
  • A case study of an 81-year-old male with Alzheimer's and schizophrenia revealed he developed a second-degree atrioventricular block after taking these drugs, but his condition improved within 2 to 3 weeks after stopping the medications and receiving short-term treatment.
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  • Neurological illnesses are tough to treat due to the blood-brain barrier (BBB), but polymeric nanocarriers (PNCs) show promise in enhancing medication delivery to the brain.
  • PNCs use various methods, including passive and active targeting strategies through structures like micelles and dendrimers, to improve drug permeability across the BBB.
  • The review discusses the manufacturing and design of PNCs, their effectiveness in treating conditions like Alzheimer's and Parkinson's, and potential safety concerns, highlighting their revolutionary potential in central nervous system (CNS) drug delivery.
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Background: Stevens-Johnson Syndrome (SJS) is an infrequent yet severe mucocutaneous reaction that involves less than 10% of the Body Surface Area (BSA). It is predominantly induced by certain medications, including anticonvulsants (e.g.

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Androgen therapy has been shown to alleviate type 2 diabetes mellitus (T2DM) but is also associated with severe side effects such as prostate cancer. The present study aims to identify the best hit selective androgen (AR) modulator by studies and then investigates its antidiabetic effects in high-fat diet- and streptozotocin (STZ)-induced T2DM male rat model. Molecular docking and molecular dynamics (MD) studies were carried out using Maestro 13.

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  • * Diabetic wounds (DWs) are serious complications for DM patients, and existing treatments are often inadequate due to their complex nature.
  • * Innovative nanoparticles are being explored for treating DWs, as they can scavenge reactive oxygen species, promote blood vessel growth, fight infections, and support tissue structure, offering promising avenues for healing and regeneration.
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Background: Altered vaccine demands and uneven utilization patterns in childhood immunization are evident nationwide. These variabilities may stem from a range of internal and external factors influencing parental preferences. Regular checks and balances are necessary to ensure equal accessibility for all sections of society.

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Cutting-Edge Strategies for Overcoming Therapeutic Barriers in Alzheimer's Disease.

Curr Pharm Des

November 2024

Department of Pharmacy, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad (UP) 244001, India.

Alzheimer's disease (AD) remains one of the hardest neurodegenerative diseases to treat due to its enduring cognitive deterioration and memory loss. Despite extensive research, few viable treatment approaches have been found; these are mostly due to several barriers, such as the disease's complex biology, limited pharmaceutical efficacy, and the BBB. This presentation discusses current strategies for addressing these therapeutic barriers to enhance AD treatment.

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Recent advancements in research have significantly enhanced our comprehension of the intricate immune components that contribute to multiple sclerosis (MS) pathogenesis. By conducting an in-depth analysis of complex molecular interactions involved in the immunological cascade of the disease, researchers have successfully identified novel therapeutic targets, leading to the development of innovative therapies. Leveraging pioneering technologies in proteomics, genomics, and the assessment of environmental factors has expedited our understanding of the vulnerability and impact of these factors on the progression of MS.

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14-3-3 protein and its isoforms: A common diagnostic marker for Alzheimer's disease, Parkinson's disease and glaucomatous neurodegeneration.

Ageing Res Rev

December 2024

Department of Cariology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.

There is a molecular coupling between neurodegenerative diseases, including glaucomatous neurodegeneration (GN), Alzheimer's disease (AD), and Parkinson's disease (PD). Many cells in the eye and the brain have the right amount of 14-3-3 proteins (14-3-3 s) and their isoforms, such as β, ε, γ, η, θ, π, and γ. These cells include keratocytes, endothelial cells, corneal epithelial cells, and primary conjunctival epithelial cells.

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Precision medicine advances in cystic fibrosis: Exploring genetic pathways for targeted therapies.

Life Sci

December 2024

Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Shivarathreeshwara Nagara, Mysuru, India.

Personalized medicine has transformed the treatment of cystic fibrosis (CF), providing customized therapeutic approaches based on individual genetic profiles. This review explores the genetic foundations of CF, focusing on mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and their implications for the development of the disease. The advent of genetic testing has enabled the association of specific mutations to disease severity, leading to the development of CFTR modulators like Ivacaftor, Lumacaftor, and Tezacaftor.

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Sulfasalazine-Induced Agranulocytosis: A Case Series and Review of Literature.

Mediterr J Rheumatol

September 2024

Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Sri Shivarathreeshwara Nagar, Mysuru, Karnataka, India.

Article Synopsis
  • * Rarely, SSZ can cause agranulocytosis, a serious condition where white blood cell counts drop dangerously low, as seen in two reported cases after six weeks of SSZ treatment.
  • * Monitoring blood counts regularly after starting SSZ is crucial, as patients showed recovery after stopping the drug and receiving additional treatments like colony-stimulating factors and antibiotics.
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Injectable, in situ-forming hydrogels, both biocompatible and biodegradable, have garnered significant attention in tissue engineering due to their potential for creating adaptable scaffolds. The adaptability of these hydrogels, made from natural proteins and polysaccharides, opens up a world of possibilities. In this study, sodium alginate was used to synthesize alginate di-aldehyde (ADA) through periodate oxidation, resulting in a lower molecular weight and reduced viscosity, with different degrees of oxidation (54% and 70%).

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Navigating the therapeutic landscape for breast cancer: targeting breast cancer stem cells.

Naunyn Schmiedebergs Arch Pharmacol

October 2024

Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, 570015, India.

Breast cancer is a common and deadly malignancy that affects women globally, and breast cancer stem cells (BCSCs) play an important role in tumorigenesis, development, metastasis, and recurrence. Traditional therapies often fail to eliminate BCSCs, leading to treatment resistance and relapse. This review explores the therapeutic strategies which are designed to target BCSCs, including inhibition of key signaling pathway and targeting receptor.

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Novel PPAR-γ agonists as potential neuroprotective agents against Alzheimer's disease: rational design, synthesis evaluation, PPAR-γ binding assay and transactivation and expression studies.

RSC Adv

October 2024

Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research Sri Shivarathreeshwara Nagara Mysuru 570015 India +91-821-2548359 +91-821-2548353.

Alzheimer's disease (AD) is a neurological disorder. It is caused by accumulation of amyloid beta (Aβ) plaques and tau tangles, which gradually leads to cognitive decline and memory loss. Peroxisome proliferator-activated receptor gamma (PPAR-γ), a nuclear receptor, plays a significant role in regulating genes responsible for metabolism and inflammation.

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