142 results match your criteria: "JIS University[Affiliation]"
Tissue Cell
December 2024
School of Pharmacy & Technology Management, SVKM's Narsee Monjee Institute of Management Studies (NMIMS), Polepally SEZ, TSIIC, Jadcherla, Mahbubnagar, Hyderabad 509301, India.
In this study, we investigated the efficacy of oxymatrine, a phytochemical alkaloid, in reducing inflammation and fibrosis in a rat model of IgA nephropathy (IgAN) through modulation of the TGF-β/SMAD signaling pathway. Thirty Sprague Dawley rats were randomized into control, IgAN, and treatment groups, the latter receiving oxymatrine postinduction of IgAN. Induced by bovine serum albumin, carbon tetrachloride, and lipopolysaccharides, the disease model was validated by immunofluorescence and histopathological analyses, confirming significant renal deposition of IgA and increased fibrosis markers (IL-6, TGF-β, SMAD 3, and α-SMA).
View Article and Find Full Text PDFJ Mater Chem B
December 2024
Centre for Health Science & Technology, JIS Institute of Advanced Studies & Research (JISIASR) Kolkata, JIS University, GP Block, Sector-5, Salt Lake, Kolkata 700091, West Bengal, India.
Amyloidosis is a condition marked by misfolded proteins that build up in tissues and eventually destroy organs. It has been connected to a number of fatal illnesses, including non-neuropathic and neurodegenerative conditions, which in turn have a significant influence on the worldwide health sector. The inability to identify the underlying etiology of amyloidosis has hampered efforts to find a treatment for the condition.
View Article and Find Full Text PDF3 Biotech
December 2024
Department of Biosciences, JIS University, Agarpara, Kolkata, 700109 India.
Xenobiotic compounds are artificial substances that are essential in our lives. These substances have a negative impact on the environment because they are long-lasting and biodegrade slowly or not at all in ecosystems. When xenobiotics leak into the ecosystem, they enter the food chain and negatively impact animals' and people's health across all trophic levels.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Laboratory of Drug Design and Discovery, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, West Bengal, India. Electronic address:
Histone deacetylase 8 (HDAC8) inhibitors play a pivotal role in epigenetic regulation. Numerous HDAC8 inhibitors (HDAC8is), that are non-hydroxamates have been identified to date, and a few of them exhibit antiproliferative activity that is on par with hydroxamates. While many non-hydroxamate-based HDAC8is have demonstrated selectivity, hydroxamate-based HDAC8is, like Vorinostat and TSA, have a tendency of non-specificity among the different HDAC isoforms.
View Article and Find Full Text PDFJ Biomol Struct Dyn
November 2024
Biological Sciences, Bose Institute, Kolkata, India.
Fragments of α-synuclein, an intrinsically disordered protein, whose misfolding and aggregation are responsible for diseases like Parkinson's disease and others, can co-exist in different polymorphs like 'rod' and 'twister'. Their apparently stable structures have different degrees of tolerance to perturbations like point mutations. The molecular basis of this is investigated using molecular dynamics-based conformational sampling.
View Article and Find Full Text PDFComput Biol Med
October 2023
Centre for Health Science and Technology, JIS Institute of Advanced Studies and Research, JIS University, Kolkata, WB, India. Electronic address:
Novel methodologies are now essential for identification of antibiotic resistant pathogens in order to resist them. Here, we are presenting a model, MACI (Machine learning-based Antibiotic resistance gene-specific drug Class Identification) that can take metagenomic fragments as input and predict the drug class of antibiotic resistant genes. In our study, we trained a model using the Comprehensive Antibiotic Resistance Database, containing 5138 representative sequences across 134 drug classes.
View Article and Find Full Text PDFCell Biochem Funct
December 2024
JIS University, Kolkata, West Bengal, India.
Staphylococcus aureus, one of the most notorious pathogens, develops antibiotic resistance by the formation of a thick layer of exopolysaccharides known as biofilms. Sortase A, a transpeptidase responsible for biofilm formation and attachment to the host surface, has emerged as an important drug target for development of anti-virulence agents. A number of sortase A inhibitors, both peptide and non-peptides are reported which involved the use of several experiments which may provide insights regarding binding affinity, specificity, safety, and efficacy of ligands.
View Article and Find Full Text PDFCell Mol Immunol
December 2024
Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea.
Regulatory T cells (Tregs) establish dominant immune tolerance but obstruct tumor immune surveillance, warranting context-specific mechanistic insights into the functions of tumor-infiltrating Tregs (TIL-Tregs). We show that enhanced posttranslational O-linked N-acetylglucosamine modification (O-GlcNAcylation) of cellular factors is a molecular feature that promotes a tumor-specific gene expression signature and distinguishes TIL-Tregs from their systemic counterparts. We found that altered glucose utilization through the glucose transporter Glut3 is a major facilitator of this process.
View Article and Find Full Text PDFChem Biodivers
October 2024
Department of Pharmaceutical Chemistry, National University of Science and Technology, PC-130, Azaiba, Bousher, Muscat, PO-620, Sultanate of Oman.
ACS Appl Bio Mater
November 2024
Biomaterials and Tissue Engineering Laboratory, School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur 721302, West Bengal, India.
Stress shielding in dental and orthopedic implants is a long-standing hurdle, and trabecular porous architecture to improve bone ingrowth is deemed to be a potential solution. Fabricating TiAlV components with dense-porous bilayer structures is complicated with limited lab-scale and commercial success. Here, a green dough-forming technique with metal powders is successfully explored to develop heterogeneous structures with a monolith-like dense-porous interface.
View Article and Find Full Text PDFSAR QSAR Environ Res
September 2024
Department of Pharmaceutical Technology, JIS University, Kolkata, India.
Fraction unbound in plasma () of drugs is an significant factor for drug delivery and other biological incidences related to the pharmacokinetic behaviours of drugs. Exploration of different molecular fragments for of different small molecules/agents can facilitate in identification of suitable candidates in the preliminary stage of drug discovery. Different researchers have implemented strategies to build several prediction models for of different drugs.
View Article and Find Full Text PDFInt J Biol Macromol
November 2024
Centre for Interdisciplinary Sciences, JIS Institute of Advanced Studies and Research (JISIASR) Kolkata, JIS University, GP Block, Salt Lake, Sector-5, WB-700091, India. Electronic address:
Several advances in skin tissue engineering have been made to restore skin damage, facilitating wound healing. Bacterial cellulose (BC), a naturally occurring polymer, has gained attention as a potential material in wound healing due to its unique physical and biological properties. In recent years, with the advent of 3D bio-printing technology, new avenues have opened for fabricating customized wound dressings and scaffolds for tissue engineering purposes.
View Article and Find Full Text PDFPhys Chem Chem Phys
September 2024
Department of Physics, Jadavpur University, Kolkata 700032, West Bengal, India.
Cr-doped ZnO (CZ) nanoparticles are prepared using hydrothermal and co-precipitation techniques. The desired crystallographic phase of the nanoparticles is confirmed using X-ray diffraction study. Rod-shaped and spherical morphologies of CZ nanoparticles prepared using hydrothermal and co-precipitation techniques were confirmed through FESEM observation.
View Article and Find Full Text PDFBiomimetics (Basel)
August 2024
Center for Interdisciplinary Science (CIS), JIS Institute of Advanced Studies and Research (JISIASR), JIS University, Kolkata 700091, India.
The emergence of 4D printing has become a pivotal tool to produce complex structures in biomedical applications such as tissue engineering and regenerative medicine. This chapter provides a concise overview of the current state of the field and its immense potential to better understand the involved technologies to build sophisticated 4D-printed structures. These structures have the capability to sense and respond to a diverse range of stimuli, which include changes in temperature, humidity, or electricity/magnetics.
View Article and Find Full Text PDFInt Rev Cell Mol Biol
August 2024
Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, Kolkata, India; Homi Bhabha National Institute, Mumbai, India. Electronic address:
The DNA damage response (DDR) is a critical cellular mechanism that safeguards genome integrity and prevents the accumulation of harmful DNA lesions. Increasing evidence highlights the intersection between DDR signaling and epigenetic regulation, offering profound insights into various aspects of cellular function including oncogenesis. This comprehensive review explores the intricate relationship between the epigenetic modifications and DDR activation, with a specific focus on the impact of viral infections.
View Article and Find Full Text PDFMicrob Pathog
September 2024
Department of Biosciences, JIS University, Kolkata, India. Electronic address:
ESKAPE pathogens, a notorious consortium comprising Enterococcusfaecium, Staphylococcusaureus, Klebsiellapneumoniae, Acinetobacterbaumannii, Pseudomonasaeruginosa, and Enterobacter species, pose formidable challenges in healthcare settings due to their multidrug-resistant nature. The increasing global cases of antimicrobial-resistant ESKAPE pathogens are closely related to their remarkable ability to form biofilms. Thus, understanding the unique mechanisms of antimicrobial resistance of ESKAPE pathogens and the innate resilience of biofilms against traditional antimicrobial agents is important for developing innovative strategies to establish effective control methods against them.
View Article and Find Full Text PDFNephrology (Carlton)
November 2024
Department of Pharmaceutical Sciences, Sanaka Educational Trust's Group of Institutions, Durgapur, West Bengal, India.
Aim: Rutin is a flavonoid glycoside obtained from the plant Ruta graveolens. It was known to have immunosuppressant activities. This study was focused on effect of rutin against immunoglobulin A (IgA) nephropathy.
View Article and Find Full Text PDFComput Biol Chem
October 2024
Department of Pharmaceutical Technology, JIS University, 81, Nilgunj Road, Agarpara, Kolkata, West Bengal 700109, India. Electronic address:
Int J Mol Sci
June 2024
Enikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences, 70 Profsoyuznaya St., Moscow 117393, Russia.
SAR QSAR Environ Res
June 2024
Department of Pharmaceutical Technology, JIS University, Kolkata, West Bengal, India.
Dipeptidyl peptidase-4 (DPP-4) inhibitors belong to a prominent group of pharmaceutical agents that are used in the governance of type 2 diabetes mellitus (T2DM). They exert their antidiabetic effects by inhibiting the incretin hormones like glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide which, play a pivotal role in the regulation of blood glucose homoeostasis in our body. DPP-4 inhibitors have emerged as an important class of oral antidiabetic drugs for the treatment of T2DM.
View Article and Find Full Text PDFMol Divers
August 2024
Laboratory of Drug Design and Discovery, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700032, India.
Mol Divers
June 2024
Department of Pharmaceutical Chemistry, National University of Science and Technology, PC 130, Azaiba, Bousher, PO 620, Muscat, Sultanate of Oman.
Cancer is the world's leading cause of death impacting millions of lives globally. The increasing research over the past several decades has focused on the development of new anticancer drugs, but still cancer continues to be a global health challenge. Thus, several new alternative therapeutic strategies have been tried for the drug design and discovery.
View Article and Find Full Text PDFJ Microencapsul
August 2024
Department of Pharmaceutical Technology, JIS University, Kolkata, India.
Aim: The work reports a novel nanophytosomal gel encapsulating (L.) Willd leaf essential oil to treat periodontal infections.
Methods: Alpinia oil-loaded nanophytosomes (ANPs) were formulated by lipid layer hydration technique and were evaluated by FESEM, cryo-TEM, loading efficiency, zeta potential, particle size, release profile etc.
Biochem Pharmacol
July 2024
Laboratory of Drug Design and Discovery, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, West Bengal, India. Electronic address:
Histone deacetylase 11 (HDAC11), a member of the HDAC family, has emerged as a critical regulator in numerous physiological as well as pathological processes. Due to its diverse roles, HDAC11 has been a focal point of research in recent times. Different non-selective inhibitors are already approved, and research is going on to find selective HDAC11 inhibitors.
View Article and Find Full Text PDFChem Biodivers
July 2024
Department of Pharmaceutical Chemistry, National University of Science and Technology, PO 620, PC 130, Azaiba, Bousher, Muscat, Sultanate of Oman.
Sulfur-containing heterocyclic derivatives have been disclosed for binding with a wide range of cancer-specific protein targets. Various interesting derivatives of sulfur-containing heterocyclics such as benzothiazole, thiazole, thiophene, thiazolidinedione, benzothiophene, and phenothiazine, etc have been shown to inhibit diverse signaling pathways implicated in cancer. Significant progress has also been made in molecular targeted therapy against specific enzymes such as kinase receptors due to potential binding interactions inside the ATP pocket.
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