5 results match your criteria: "JC WILT Infectious Disease Research Center[Affiliation]"
Sci Rep
November 2024
JC WILT Infectious Disease Research Center, National Microbiology Laboratories, Public Health Agency of Canada, Winnipeg, MB, Canada.
Clinical samples are routinely inactivated before molecular assays to prevent pathogen transmission. Antibody-based assays are sensitive to changes in analyte conformation, but the impact of inactivation on the analyte detectability has been overlooked. This study assessed the effects of commonly used inactivation-methods, Triton X-100 (0.
View Article and Find Full Text PDFClin Infect Dis
April 2023
Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Background: Adolescent girls and young women aged 15‒24 years in sub-Saharan Africa are at disproportionate risk of human immunodeficiency virus (HIV) infection. Given the known association between vaginal microbial dysbiosis and HIV susceptibility, we performed an age-stratified analysis of the vaginal microbiome in South African women and compared this to their risk of HIV acquisition.
Methods: Vaginal microbiome data were generated by mass spectrometry-based proteomic analysis of cervicovaginal lavages collected from participants (n = 688) in the Centre for the AIDS Programme of Research in South Africa (CAPRISA) 004 trial.
J Acquir Immune Defic Syndr
May 2018
National Microbiology Laboratory at JC Wilt Infectious Disease Research Center, Public Health Agency of Canada, Winnipeg, Canada.
Proc Natl Acad Sci U S A
August 2017
Global Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, 1015, Switzerland;
Viral respiratory infections are usually mild and self-limiting; still they exceptionally result in life-threatening infections in previously healthy children. To investigate a potential genetic cause, we recruited 120 previously healthy children requiring support in intensive care because of a severe illness caused by a respiratory virus. Using exome and transcriptome sequencing, we identified and characterized three rare loss-of-function variants in which encodes an RIG-I-like receptor involved in the sensing of viral RNA.
View Article and Find Full Text PDFCurr Opin HIV AIDS
March 2016
aDepartment of Pharmaceutics, University of Washington bWashington National Primate Research Center, Seattle, Washington, USA cCentre for the AIDS Programme of Research (CAPRISA), Durban, South Africa dDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba eNational Laboratory for HIV Immunology, JC Wilt Infectious Disease Research Center, Public Health Agency of Canada, Winnipeg, Manitoba, Canada fDepartment of Medicine Solna, Center for Molecular Medicine, Karolinska Institute, Karolinska, Sweden.
Purpose Of Review: This article describes the mechanisms and consequences of both microbial translocation and microbial dysbiosis in HIV infection.
Recent Findings: Microbes in HIV are likely playing a large role in contributing to HIV pathogenesis, morbidities and mortality. Two major disruptions to microbial systems in HIV infection include microbial translocation and microbiome dysbiosis.